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| 1 | OPTICAL PROPERTIES OF GeO_2 AND Ge NANOCRYSTALS显示文摘he co m pound m aterial of n m size particles Ge O2 Si O2 w as synthesied through hydrolysis of Si( O C2 H4) and Ge Cl4 . A heat treatm ent w as carried out for the sa m ples at 100 ~1200 ℃in air . Its optical property w as deter mined by U V Vis spectur m . We have found that theabsorption edge of spectru m shifted progressively to longer w avelengths . The quantu m size ef fect of nanocrystals appears because crystals gro w and energy of optical band gap reduces d ueto the influence of te m perature . By the analysis of X ray diffraction w e have observed theprocess in w hich the structure of particles changed fro m disorder into order . | Y.H.Zhou 1) ,Y.Y.Feng 2) and H.Y.Lu 2) 1)Department of Physics Nanjing Normal University, Nanjing 210097,China 2)Physics and Ch寁O P T I C A L P R O P E R T I E S O F Ge O2 A N D Ge N A N O C R Y S T A L S Y. H. Zhou1) , Y. Y. Feng2) | 1999 | Acta Metallurgica Sinica(English Letters)1999，12，5： | 22 |
| 2 | Gene expression profiling and endothelin in acute experimental pancreatitis显示文摘AIM:To analyze gene expression profiles in an experimental pancreatitis and provide functional reversal of hypersensitivity with candidate gene endothelin-1 antagonists.METHODS:Dibutyltin dichloride(DBTC) is a chemical used as a polyvinyl carbonate stabilizer/catalyzer,biocide in agriculture,antifouling agent in paint and fabric.DBTC induces an acute pancreatitis flare through generation of reactive oxygen species.Lewis-inbred rats received a single i.v.injection with either DBTC or vehicle.Spinal cord and dorsal root ganglia(DRG) were taken at the peak of inflammation and processed for transcriptional profiling with a cDNA microarray biased for rat brain-specific genes.In a second study,groups of animals with DBTC-induced pancreatitis were treated with endothelin(ET) receptor antagonists [ET-A(BQ123) and ET-B BQ788)].Spontaneous pain related mechanical and thermal hypersensitivity were measured.Immunohistochemical analysis was performed using anti-ET-A and ET-B antibodies on sections from pancreatic tissues and DRG of the T10-12 spinal segments.RESULTS:Animals developed acute pancreatic inflammation persisting 7-10 d as confirmed by pathological studies(edema in parenchyma,loss of pancreatic architecture and islets,infiltration of inflammatory cells,neutrophil and mononuclear cells,degeneration,vacuolization and necrosis of acinar cells) and the painrelated behaviors(cutaneous secondary mechanical and thermal hypersensitivity).Gene expression profile was different in the spinal cord from animals with pancreatitis compared to the vehicle control group.Over 260 up-regulated and 60 down-regulated unique genes could be classified into 8 functional gene families:circulatory/acute phase/immunomodulatory;extracellular matrix;structural;channel/receptor/transporter;signaling transduction;transcription/translation-related;antioxidants/chaperones/heat shock;pancreatic and other enzymes.ET-1 was among the 52 candidate genes upregulated greater than 2-fold in animals with pancreatic inflammation and visceral pain-related behavior.Treatments with the ET-A(BQ123) and ET-B(BQ-788) antagonists revealed significant protection against inflammatory pain related mechanical and thermal hypersensitivity behaviors in animals with pancreatitis(P < 0.05).Open field spontaneous behavioral activity(at baseline,day 6 and 30 min after drug treatments(BQ123,BQ788) showed overall stable activity levels indicating that the drugs produced no undesirable effects on normal exploratory behaviors,except for a trend toward reduction of the active time and increase in resting time at the highest dose(300 μmol/L).Immunocytochemical localization revealed that expression of ET-A and ET-B receptors increased in DRG from animals with pancreatitis.Endothelin receptor localization was combined in dual staining with neuronal marker NeuN,and glia marker,glial fibrillary acidic protein.ET-A was expressed in the cell bodies and occasional nuclei of DRG neurons in na ve animals.However,phenotypic expression of ET-A receptor was greatly increased in neurons of all sizes in animals with pancreatitis.Similarly,ET-B receptor was localized in neurons and in the satellite glia,as well as in the Schwann cell glial myelin sheaths surrounding the axons passing through the DRG.CONCLUSION:Endothelin-receptor antagonists protect against inflammatory pain responses without interfering with normal exploratory behaviors.Candidate genes can serve as future biomarkers for diagnosis and/or targeted gene therapy. | Helieh S Oz Ying Lu Louis P Vera-Portocarrero Pei Ge Ada Silos-Santiago Karin N Westlund | 2012 | World Journal of Gastroenterology2012，18，32： | 6 |
| 3 | Preparation of Co3O4 nanoparticles by a polymer combustion route显示文摘 | JIU J T GE Y LI X N | 2002 | Materials Letters2002，54，： | 2 |
| 4 | Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma显示文摘 | Bonertz Andreas Weitz Jürgen Pietsch Dong-Ho Kim Rahbari Nuh N Schlude Christoph Ge Yingzi Juenger Simone Vlodavsky Israel Khazaie Khashayarsha Jaeger Dirk Reissfelder Christoph Antolovic Dalibor Aigner Maximilian Koch Moritz Beckhove Phili | 2009 | Journal of Clinical Investigation2009，，11： | 2 |
| 5 | Hyperglycemia:an independent marker of in-hospital mortality in patients with undiagnosed diabetes显示文摘 | Umpierrez GE Isaacs SD Bazargan N | | J Ciin Endocrinol Metab0，，： | 2 |
| 6 | PANDA software and its preliminary result for positioning and orbit determination 显示文摘 | Liu J N and Ge M R | 2003 | Wuhan University Journal of Natural Science2003，8，2： | 1 |
| 7 | Involvement of chemokine receptors in breast cancer metastasis显示文摘 | Muller A Homey B Soto H Ge N Catron D Buchanan M E | 2001 | Nature2001，410，： | 1 |
| 8 | Hypergl ycemia: AnIndependent marker of in-hospital mortality in patients with undiagnosed diabetes显示文摘 | UMPIERREZ GE ISAACS SD BAZARGAN N | 2002 | J Clin Endocrinol Metab2002，87，： | 1 |
| 9 | Neurodegenerationin the central nervous system of apoE-deficient mice显示文摘 | Masliah E Mallory M Ge N | 1995 | Exp Neurol1995，136，： | 1 |
| 10 | Hyperglycemia:an indepen-dent marker of in hospital mortality in patients with undiagnosed diabetes显示文摘 | UMPIERREZ GE HSAACS SD BAZARGAN N | 2002 | Clin Endocrinol Metab2002，87，： | 1 |
| 11 | Heparanase: a new metastasis-associated antigen recognized in breast cancer patients by spontaneously induced memory T lymphocytes显示文摘 | Sommerfeldt N Beckhove P Ge Y Sehutz F Choi C Bucur M Domsehke C Sohn C Sehneeweis A Rom J Poll- mann D Leneht D Vlodavsky I Sehirrmaeher V | 2006 | Cancer Res2006，66，15： | 1 |
| 12 | The use ofphospholipase A(2)to prepare acellular porcine comeal stromaas a tissue engineering scaffold显示文摘 | Wu Z Zhou Y Li N Huang M Duan H Ge J | 2009 | Biomateriais2009，30，21： | 1 |
| 13 | Kinematic analysis of the cervical spine following implantation of an artificial cervical disc显示文摘 | Pickett GE Rouleau JP Duggal N | | 0，，： | 1 |
| 14 | Simulation of heterogeneous structure in a circulating fluidized-bed riser by combining the two-fluid model with the emms approach显示文摘 | Yang N Wang W Ge W | | 0，，： | 1 |
| 15 | 显示文摘 | Soldatenkova A V Geǐderova L A Akhmatova N K Mikhaǐlova N A | 2013 | Zh Mikrobiol Epidemiol Immunobiol2013，6，： | 1 |
| 16 | A unified quadratic- programming-based dynamical system approach to joint torque optimization of physically constrained redundant manipulators 显示文摘 | ZHANG Y N GE S S LEE T H | 2004 | IEEE Transactions on Systems Man and Cybernetics-Part B: Cybernetics2004，34，5： | 1 |
| 17 | Association of sonographically detected calcification with thyroid carcinoma显示文摘 | WANG N XU Y GE C | 2006 | Head Neck2006，28，： | 1 |
| 18 | Design and analysis of a generalrecurrent neural network model for time-varying matrix in-version显示文摘 | ZHANG Y N GE S S | 2005 | IEEE Transactions on Neural Networks2005，16，6： | 1 |
| 19 | Recombinant canine distem- per virus serves as bivalent live vaccine against rabies and ca- nine distemper显示文摘 | Wang X J Feng N Ge J Y | 2012 | Vaccine2012，30，34： | 1 |
| 20 | TLR3signaling in macrophages is indispensable for the protective immunity of invariant natural killer T cells against enterovirus 71infection显示文摘 | Zhu K Yang J Luo K Yang C Zhang N Xu R Chen J Jin M Xu B Guo N Wang J Chen Z Cui Y Zhao H Wang Y Deng C Bai L Ge B Qin C F Shen H Yang C F Leng Q | 2015 | PLoS Pathog2015，11，10： | 1 |
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