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| 1 | Efficacy of peroral endoscopic myotomy vs other achalasia treatments in improving esophageal function显示文摘AIM: To assess and compare the esophageal function after peroral endoscopic myotomy(POEM) vs other conventional treatments in achalasia.METHODS: Chart review of all achalasia patients who underwent POEM, laparoscopic Heller myotomy(LHM) or pneumatic dilation(PD) at our institution between January 2012 and March 2015 was performed. Patient demographics, type of achalasia, prior treatments, pre- and post-treatment timed barium swallow(TBE) and high-resolution esophageal manometry(HREM) findings were compared between the three treatment groups. Patients who had both pre- and 2 mo posttreatment TBE or HREM were included in the final analysis. TBE parameters compared were barium column height, width and volume of barium remaining at 1 and 5 min. HREM parameters compared were basal lower esophageal sphincter(LES) pressures and LES-integrated relaxation pressures(IRP). Data are presented as mean ± SD, median [25th, 75 th percentiles] or frequency(percent). Analysis of variance, KruskalWallis test, Pearsons χ~2 test and Fishers Exact tests were used for analysis.RESULTS: A total of 200 achalasia patients were included of which 36 underwent POEM, 22 underwent PD and 142 underwent LHM. POEM patients were older(55.4 ± 16.8 years vs 46.5 ± 15.7 years, P = 0.013) and had higher BMI than LHM(29.1 ± 5.9 kg/m^2 vs 26 ± 5.1 kg/m^2, P = 0.012). More number of patients in POEM and PD groups had undergone prior treatments compared to LHM group(72.2% vs 68.2% vs 44.3% respectively, P = 0.003). At 2 mo post-treatment, all TBE parameters including barium column height, width and volume remaining at 1 and 5 min improved significantly in all three treatment groups(P = 0.01 to P < 0.001) except the column height at 1 min in PD group(P = 0.11). At 2 mo post-treatment, there was significant improvement in basal LES pressure and LES-IRP in both LHM(40.5 mm Hg vs 14.5 mm Hg and 24 mm Hg vs 7.1 mm Hg respectively, P < 0.001) and POEM groups(38.7 mm Hg vs 11.4 mm Hg and 23.6 mm Hg vs 6.6 mm Hg respectively, P < 0.001). However, when the efficacy of three treatments were compared to each other in terms of improvement in TBE or HREM parameters at 2 mo, there was no significant difference(P > 0.05).CONCLUSION: POEM, PD and LHM were all effective in improving esophageal function in achalasia at shortterm. There was no difference in efficacy between the three treatments. | Madhusudhan R Sanaka Umar Hayat Prashanthi N Thota Ramprasad Jegadeesan Monica Ray Scott L Gabbard Neha Wadhwa Rocio Lopez Mark E Baker Sudish Murthy Siva Raja | 2016 | World Journal of Gastroenterology2016，22，20： | 7 |
| 2 | Gemcitabine-based or capecitabine-based chemoradiotherapy for locally advanced pancreatic cancer (SCALOP): a multicentre, randomised, phase 2 trial显示文摘 | Somnath Mukherjee Christopher N Hurt John Bridgewater Stephen Falk Sebastian Cummins Harpreet Wasan Tom Crosby Catherine Jephcott Rajarshi Roy Ganesh Radhakrishna Alec McDonald Ruby Ray George Joseph John Staffurth Ross A Abrams Gareth Griffiths Tim Maugh | 2013 | Lancet Oncology2013，，4： | 4 |
| 3 | Energy transfer in triton -X 100 micelles : a fluorescence study 显示文摘 | Saha D C Ray K Misra T N | 2000 | Spectrochimica Acta A2000，56，： | 1 |
| 4 | Motion gradient vector flow:an external force for tracking rolling leukocytes with shape and size constrained active contours显示文摘 | Ray N Acton ST | 2004 | IEEE Trans MI2004，23，： | 1 |
| 5 | Influence of probiotics and fibre on the incidence of bacterial infections following major abdominal surgery-results of a prospective trial显示文摘 | Rayes N Seehofer D Muller AR | 2002 | Z Gastroenterol2002，40，10： | 1 |
| 6 | Early enteral supply of fiber and Lactobaeiili versus conventional nutrition: A controlled trial inpatients with major abdominal surgery显示文摘 | Rayes N Hansen S Seehofer D | 2002 | Nutrition2002，18，78： | 1 |
| 7 | Improvement of quality of sesame (Seasamum indicum) seed meal protein with supplemental amino acids in feeds for rohu, Labeo rohita (Hamilton) fingerlings 显示文摘 | Mukhopadhyay N Ray A K | 1999 | Aquaculture Research1999，30，8： | 1 |
| 8 | Knockdown of hTERT and concurrent treatment with interferon-gamma inhibited proliferation and invasion of human glioblastoma cell lines 显示文摘 | George J Banik N L Ray S K | 2010 | Int J Biochem Cell Biol2010，42，7： | 1 |
| 9 | Nolinear control of high purity distillation column under input saturation and parametric uncertainty 显示文摘 | BISWAS P P RAY S SAMANTA A N | 2009 | Journal of Process Control2009，19，1： | 1 |
| 10 | Isolation and characterization of rhamnolipid-producing bacterial strains from a biodiesel facility显示文摘 | ROONEY A P PRICE N P RAY K J | 2009 | FEMS Microbiol Lett2009，295，1： | 1 |
| 11 | An anonymous and failure resilient fair-exchange e-commerce protocol显示文摘 | RAY I NATARAJAN N | 2005 | Decision Support Systems2005，39，3： | 1 |
| 12 | A modified AIDA protocol with anthracycline-based consolidation results in high antileukemic efficacy and reduced toxicity in newly diagnosed PML/RA Ralpha-positive acute promyelocytic leukemia显示文摘 | Sanz M A Martín G Rayón C | 1999 | PETHEMA group Blood1999，94，9： | 1 |
| 13 | Analysis of failed reformer tubes显示文摘 | RAY A K SINHA S K TIWARI Y N | 2003 | Engineering Failure Analysis2003，10，： | 1 |
| 14 | Changes in sleep-wakefulness in the medial preoptic area lesioned rats:role of thermal preference显示文摘 | Ray B Mallick H N Kumar V M | 2005 | Behav Brain Res2005，158，1： | 1 |
| 15 | Abdominal adhesiolysis: inpatient care and expenditures in the United States in 1994显示文摘 | Ray N F Denton W ( Thamer M | 1998 | Journal of American College of Surgeons1998，186，1： | 1 |
| 16 | Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study 显示文摘 | Kumarasamy KK Toleman MA Walsh TR Bagaria J Butt F Balakrishnan R Chaudhary U Doumith M Giske CG Irfan S Krishnan P Kumar AV Maharjan S Mushtaq S Noorie T Paterson DL Pearson A Perry C Pike R Rao B Ray U Sarma JB Sharma M Sheridan E Thirunarayan MA Turton J Upadhyay S Warner M Welfare W Livermore DM Woodford N | 2010 | Lancet Infect Dis2010，10，9： | 1 |
| 17 | Insights into heap bioleaching of low grade chalcopyrite ores--A pilot scale study显示文摘 | PANDA S SAN JAY K SUKLA L B PRADHAN N SUBBAIAH T MISHRA B K PRASAD M S R RAY S K | 2012 | Hydrometallurgy2012，125，： | 1 |
| 18 | Least squares conformal maps for automatic texture atlas generation显示文摘 | Lévy B Petitjean S Ray N | 2002 | ACM Transactions on Graphics2002，21，3： | 1 |
| 19 | Antiviral combination therapy for lamivudine-resistant hepatitis B reinfection after transplantation 显示文摘 | Seehofer D Rayes N Berg T | 2000 | Transpl Int2000，13，10： | 1 |
| 20 | For better or for worse:neural systems supporting the cognitive down-and up-regulation of negative emotion显示文摘 | K N OCHSNER RAY R D ROBERTSON E | | Neuroimage0，，： | 1 |
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