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3篇 您的检索式：作者名="Muhammad Rizwan Alam"

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		题名	作者	年代	出处	被引量
	1	Mitochondria-associated endoplasmic reticulum membranes allow adaptation of mitochondrial metabolism to glucose availability in the liver显示文摘Mitochondria-associated endoplasmic reticulum membranes(MAM)play a key role in mitochondrial dynamics and function and in hepatic insulin action.Whereas mitochondria are important regulators of energy metabolism,the nutritional regulation of MAM in the liver and its role in the adaptation of mitochondria physiology to nutrient availability are unknown.In this study,we found that the fasted to postprandial transition reduced the number of endoplasmic reticulum-mitochondria contact points in mouse liver.Screening of potential hormonal/metabolic signals revealed glucose as the main nutritional regulator of hepatic MAM integrity both in vitro and in vivo.Glucose reduced organelle interactions through the pentose phosphate-protein phosphatase 2A(PP-PP2A)pathway,induced mitochondria fission,and impaired respiration.Blocking MAM reduction counteracted glucose-induced mitochondrial alterations.Furthermore,disruption of MAM integrity mimicked effects of glucose on mitochondria dynamics and function.This glucose-sensing system is deficient in the liver of insulin-resistant ob/ob and cyclophilin D-KO mice,both characterized by chronic disruption of MAM integrity,mitochondrial fission,and altered mitochondrial respiration.These data indicate that MAM contribute to the hepatic glucose-sensing system,allowing regulation of mitochondria dynamics and function during nutritional transition.Chronic disruption of MAM may participate in hepatic mitochondrial dysfunction associated with insulin resistance.	Pierre Theurey Emily Tubbs Guillaume Vial Julien Jacquemetton Nadia Bendridi Marie-Agnes Chauvin Muhammad Rizwan Alam Muriel Le Romancer Hubert Vidal Jennifer Rieusset	2016	Journal of Molecular Cell Biology2016，8，2：	2
	2	Intestinal Alkaline Phosphatase Prevents Antibiotic-Induced Susceptibility to Enteric Pathogens显示文摘	Sayeda Nasrin Alam Halim Yammine Omeed Moaven Rizwan Ahmed Angela K. Moss Brishti Biswas Nur Muhammad Rakesh Biswas Atri Raychowdhury Kanakaraju Kaliannan Sathi Ghosh Madhury Ray Sulaiman R. Hamarneh Soumik Barua Nondita S. Malo Atul K. Bhan Madhu S. Malo	2014	Annals of Surgery2014，，4：	1
	3	Mitochondrial Ca 2+ uniporter (MCU)-dependent and MCU-independent Ca 2+ channels coexist in the inner mitochondrial membrane显示文摘	Alexander I. Bondarenko Claire Jean-Quartier Warisara Parichatikanond Muhammad Rizwan Alam Markus Waldeck-Weiermair Roland Malli Wolfgang F. Graier	2014	Pflügers Archiv - European Journal of Physiology2014，，7：	1

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