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| 1 | Comparative study of the efficacy of gentamicin-coated intramedullary interlocking nail versus regular intramedullary interlocking nail in Gustilo type I and II open tibia fractures显示文摘Purpose:Open tibia fracture is prone to infection,consequently causing significant morbidity and increasing the hospital stay,occupational loss and onset of chronic osteomyelitis.Intramedullary nailing is one choice for treating tibia shaft fractures.To improve the delivery of antibiotics at the tissue-implant interface,many methods have been proposed as a part of prophylaxis against infection.This study was conducted to study the role of gentamicin-impregnated intramedullary interlocking(IMIL)nail in the prevention of infection in Gustilo typeⅠandⅡopen tibia fractures and to compare the results with regular intramedullary nail.Methods:The study included 28 patients with open tibia fractures(Gustilo type 1 or type 2);of them 14 underwent regular IMIL nailing and the other 14 were treated with gentamicin-coated nailing.Randomization was done by alternate allocation of the patients.Follow-up was done postoperatively(day 1),1 week,6 weeks,and 6 months for bone union,erythrocyte sedimentation rate(ESR),hemoglobin and C?reactive protein(CRP).Statistical significance was tested using unpaired t-test.A p value less than 0.05 was considered significant.Results:There were 4 cases of infection in controls(regular IMIL nail)and no infection among patients treated with gentamicin-coated nail during the follow up(Х^2=4.66,p=0.031).At 6 months postoperatively,CRP(p=0.031),ESR(p=0.046)and hemoglobin level(p=0.016)showed significant difference between two groups.The bone healing rate was better with gentamicin-coated nail in comparison to regular IMIL nail at 6 months follow-up(p=0.016).Conclusion:Gentamicin-coated IMIL nail has a positive role in preventing infection in Gustilo typeⅠandⅡopen tibia fractures. | Deepak Pinto K.Manjunatha Amarnath D.Savur Naufal Rizwan Ahmed Sharan Mally V.Ramya | 2019 | Chinese Journal of Traumatology2019，22，5： | 4 |
| 2 | Improved bowel preparation increases polyp detection and unmasks significant polyp miss rate显示文摘AIM: To retrospectively compare previous-day vs splitdose preparation in terms of bowel cleanliness and polyp detection in patients referred for polypectomy. METHODS: Fifty patients underwent two colonoscopies: one diagnostic in a private clinic and a second for polypectomy in a University Hospital. The latter procedures were performed within 12 wk of the index ones. Examinations were accomplished by two experienced endoscopists, different in each facility. Twenty-seven patients underwent screening/surveillance colonoscopy, while the rest were symptomatic. Previous day bowel preparation was utilized initially and splitdose for polypectomy. Colon cleansing was evaluated using the Aronchick scale. We measured the number of detected polyps, and the polyp miss rates per-polyp.RESULTS: Excellent/good preparation was reported in 38 cases with previous-day preparation(76%) vs 46 with split-dose(92%), respectively(P = 0.03). One hundred and twenty-six polyps were detected initially and 169 subsequently(P < 0.0001); 88 vs 126 polyps were diminutive(P < 0.0001), 25 vs 29 small(P = 0.048) and 13 vs 14 equal or larger than 10 mm. The miss rates for total, diminutive, small and large polyps were 25.4%, 30.1%, 13.7% and 6.6%, respectively. Multivariate analysis revealed that split-dose preparation was significantly associated(OR, P) with increased number of polyps detected overall(0.869, P < 0.001), in the right(0.418, P = 0.008) and in the left colon(0.452, P = 0.02). CONCLUSION: Split-dose preparation improved colon cleansing, enhanced polyp detection and unmasked significant polyp miss rates. | Ioannis S Papanikolaou Athanasios D Sioulas Nektarios Magdalinos Iosif Beintaris Lazaros-Dimitrios Lazaridis Dimitrios Polymeros Chrysoula Malli George D Dimitriadis Konstantinos Triantafyllou | 2015 | World Journal of Clinical Cases2015，3，10： | 4 |
| 3 | Confocal endomicroscopy and cyst fluid molecular analysis: Comprehensive evaluation of pancreatic cysts显示文摘Increases in the quality as well as utilization of cross-sectional imaging have led to rising diagnoses of pancreatic cystic lesions(PCL). Accurate presurgical diagnosis enables appropriate triage of PCLs. Unfortunately, current diagnostic approaches have suboptimal accuracy and may lead to unnecessary surgical resections or missed diagnoses of advanced neoplasia. Additionally, early detection represents an opportunity for intervention to prevent the progression to pancreatic adenocarcinoma. Our aim for this review is to systematically review the current literature on confocal endomicroscopy and molecular biomarkers in the evaluation of PCLs. Confocal laser endomicroscopy is a novel technology that allows for real-time in vivo microscopic imaging with multiple clinical trials identifying characteristic endomicroscopy findings of various pancreatic cystic lesions. DNA-based molecular markers have also emerged as another diagnostic modality as the pattern of genetic alternations present in cyst fluid can provide both diagnostic and prognostic data. We propose that both techniques can be utilized to improve patient outcomes. | Feng Li Ahmad Malli Zobeida Cruz-Monserrate Darwin L Conwell Somashekar G Krishna | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，1： | 2 |
| 4 | Mesenchymal stromal cells as potential immunomodulatory players in severe acute respiratory distress syndrome induced by SARSCoV- 2 infection显示文摘Severe acute respiratory syndrome coronavirus-2 and the related coronavirus disease-19(COVID-19)is a worldwide emerging situation,which was initially reported in December 2019 in Wuhan,China.Currently,more than 7258842 new cases,and more than 411879 deaths have been reported globally.This new highly transmitted coronavirus is responsible for the development of severe acute respiratory distress syndrome.Due to this disorder,a great number of patients are hospitalized in the intensive care unit followed by connection to extracorporeal membrane oxygenation for breath supporting and survival.Severe acute respiratory distress syndrome is mostly accompanied by the secretion of proinflammatory cytokines,including interleukin(IL)-2,IL-6,IL-7,granulocyte colony-stimulating factor(GSCF),interferon-inducible protein 10(IP10),monocyte chemotactic protein-1(MCP1),macrophage inflammatory protein 1A(MIP1A),and tumor necrosis factor alpha(TNF-α),an event which is known as“cytokine storm”.Further disease pathology involves a generalized modulation of immune responses,leading to fatal multiorgan failure.Currently,no specific treatment or vaccination against severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)has been developed.Mesenchymal stromal cells(MSCs),which are known for their immunosuppressive actions,could be applied as an alternative co-therapy in critically-ill COVID-19 patients.Specifically,MSCs can regulate the immune responses through the conversion of Th1 to Th2,activation of M2 macrophages,and modulation of dendritic cells maturation.These key immunoregulatory properties of MSCs may be exerted either by produced soluble factors or by cell-cell contact interactions.To date,several clinical trials have been registered to assess the safety,efficacy,and therapeutic potential of MSCs in COVID-19.Moreover,MSC treatment may be effective for the reversion of ground-glass opacity of damaged lungs and reduce the tissue fibrosis.Taking into account the multifunctional properties of MSCs,the proposed stem-cell-based therapy may be proven significantly effective in critically-ill COVID-19 patients.The current therapeutic strategy may improve the patient’s overall condition and in parallel may decrease the mortality rate of the current disease. | Panagiotis Mallis Efstathios Michalopoulos Theofanis Chatzistamatiou Catherine Stavropoulos-Giokas | 2020 | World Journal of Stem Cells2020，12，8： | 2 |
| 5 | Earthplace自然中心显示文摘Earthplace创立于1958年,Earthplace的使命是使公众了解自然和环境以及如何行动起来保护大自然享受大自然,并得到美国博物馆协会授权认可。在这个树木繁茂的保护区中,Earthplace主持开展了各种各样的公众教育,研究,野生动植物康复活动. | David Kamp Julia Mally(图片) 王新伟(翻译) | 2006 | 景观设计2006，，6： | 2 |
| 6 | Early term infants are at increased risk of requiring neonatal intensive care显示文摘Background: Increasing evidence is demonstrating thatinfants born early on during the term period are at increasedrisk of morbidity compared with infants born closer to acomplete 40 week gestational pregnancy. The purpose of thisstudy was to compare early term [gestation age (GA): 37-376/7 weeks] neonatal outcomes with those of other full termneonatal intensive care unit (NICU) admissions.Methods: Retrospective chart review of all term infantsadmitted to the NICU at New York University LangoneMedical Center over a 17 month period. Subjects weregrouped and analyzed according to their GA at birth: 1)early term infants (GA between 37 0/7 to 37 6/7 weeks) and2) other term infants (38 0/7 weeks and older).Results: Early term infants were more likely to requireNICU care than other term infants [relative risk: 1.42,95% confidence interval (CI)=1.07-1.88), P=0.01]. In theNICU, they are more likely to manifest respiratory distresssyndrome [odds ratio (OR)=5.7, 95% CI=1.6-19.8, P<0.01]and hypoglycemia (OR=4.6, 95% CI=2.0-10.4, P<0.001).In addition, early term neonates were more likely to beborn via elective cesarean section than other term neonates(OR=4.1, 95% CI=2.0-8.5, P<0.001).Conclusions: Being born at early term is associatedwith increased risk of respiratory disease and hypoglycemiarequiring neonatal intensive care. Further efforts directedat decreasing early term deliveries may be warranted. | Pradeep Vittal Mally Nickolas Theophilos Agathis Sean Michael Bailey | 2016 | World Journal of Pediatrics2016，12，1： | 2 |
| 7 | Efficient differentiation of vascular smooth muscle cells from Wharton's Jelly mesenchymal stromal cells using human platelet lysate: A potential cell source for small blood vessel engineering显示文摘BACKGROUND The development of fully functional small diameter vascular grafts requires both a properly defined vessel conduit and tissue-specific cellular populations.Mesenchymal stromal cells(MSCs) derived from the Wharton's Jelly(WJ) tissue can be used as a source for obtaining vascular smooth muscle cells(VSMCs),while the human umbilical arteries(h UAs) can serve as a scaffold for blood vessel engineering.AIM To develop VSMCs from WJ-MSCs utilizing umbilical cord blood platelet lysate.METHODS WJ-MSCs were isolated and expanded until passage(P) 4. WJ-MSCs were properly defined according to the criteria of the International Society for Cell and Gene Therapy. Then, these cells were differentiated into VSMCs with the use of platelet lysate from umbilical cord blood in combination with ascorbic acid,followed by evaluation at the gene and protein levels. Specifically, gene expression profile analysis of VSMCs for ACTA2, MYH11, TGLN, MYOCD, SOX9,NANOG homeobox, OCT4 and GAPDH, was performed. In addition,immunofluorescence against ACTA2 and MYH11 in combination with DAPI staining was also performed in VSMCs. HUAs were decellularized and served as scaffolds for possible repopulation by VSMCs. Histological and biochemical analyses were performed in repopulated h UAs.RESULTS WJ-MSCs exhibited fibroblastic morphology, successfully differentiating into'osteocytes', 'adipocytes' and 'chondrocytes', and were characterized by positive expression(> 90%) of CD90, CD73 and CD105. In addition, WJ-MSCs were successfully differentiated into VSMCs with the proposed differentiation protocol. VSMCs successfully expressed ACTA2, MYH11, MYOCD, TGLN and SOX9. Immunofluorescence results indicated the expression of ACTA2 and MYH11 in VSMCs. In order to determine the functionality of VSMCs, h UAs were isolated and decellularized. Based on histological analysis, decellularized h UAs were free of any cellular or nuclear materials, while their extracellular matrix retained intact. Then, repopulation of decellularized h UAs with VSMCs was performed for 3 wk. Decellularized h UAs were repopulated efficiently by the VSMCs. Biochemical analysis revealed the increase of total hydroyproline and s GAG contents in repopulated h UAs with VSMCs. Specifically, total hydroxyproline and s GAG content after the 1 st, 2 nd and 3 rd wk was 71 ± 10, 74 ± 9 and 86 ± 8 μg hydroxyproline/mg of dry tissue weight and 2 ± 1, 3 ± 1 and 3 ± 1μg s GAG/mg of dry tissue weight, respectively. Statistically significant differences were observed between all study groups(P<0.05).CONCLUSION VSMCs were successfully obtained from WJ-MSCs with the proposed differentiation protocol. Furthermore, h UAs were efficiently repopulated by VSMCs. Differentiated VSMCs from WJ-MSCs could provide an alternative source of cells for vascular tissue engineering. | Panagiotis Mallis Aggeliki Papapanagiotou Michalis Katsimpoulas Alkiviadis Kostakis Gerasimos Siasos Eva Kassi Catherine Stavropoulos-Giokas Efstathios Michalopoulos | 2020 | World Journal of Stem Cells2020，12，3： | 2 |
| 8 | Nitrogen fertilization effects on quality of organic matter in a grassland soil显示文摘 | Malli S S Wang Z H Schniter M | 2005 | Nutrient Cycling in Agro-ecosystems2005，73，： | 1 |
| 9 | Aspecial banding techniques increases effectiveness of phosphorus fertilizer on alfalfa显示文摘 | | 1997 | Bette Crops with Plant Food1997，81，4： | 1 |
| 10 | Dependence of ricin toxoid vaccine efficacy on the structure of poly (lactide - co - glycolide ) microparticle carriers 显示文摘 | YAN C RILL W L MALLI R | 1995 | Vaccine1995，13，： | 1 |
| 11 | Aging and oxidation of reactive protein sulphydryls显示文摘 | Thomas J A Mallis R J | | 0，，09： | 1 |
| 12 | Recovery of motor disability and spasticity in post-stroke after repetitive transcranial magnetic stimulation (rTMS)显示文摘 | Mally J Dinya E | | 0，，04： | 1 |
| 13 | Emergence of Escherichia coli sequence type 410 (ST410) with KPC-2 β-lactamase显示文摘 | Angeliki Mavroidi Vivi Miriagou Ergina Malli Angelos Stefos George N. Dalekos Leonidas S. Tzouvelekis Efthymia Petinaki | 2011 | International Journal of Antimicrobial Agents2011，，3： | 1 |
| 14 | Thymidylate synthase inhibitors 显示文摘 | Danenberg PV Malli H Swenson S | 1999 | Semin Oncol1999，26，6： | 1 |
| 15 | Improvement in Parkinsonian symptoms after repetitive transcranial magnetic stimulation显示文摘 | Mally J Stone TW | 1999 | J Neurol Sci1999，162，： | 1 |
| 16 | Leptin, adiponectin, and ghrelin levels in female patients with asthma during stable and exacerbation periods 显示文摘 | Tsaroucha A Daniil Z Malli F | 2013 | J Asthma2013，50，2： | 1 |
| 17 | Effects of epinephrine and vasopressin on end - tidal carbon dioxide tension and mean arterial blood pressure in out - of - hospital cardiopulmonary resuscitation : an observational study 显示文摘 | MALLY S JELATANCEV A GRMEC S | 2007 | Crit Care Med2007，11，2： | 1 |
| 18 | Mitochondria and Ca^2+ signaling:old guests,new functions 显示文摘 | Graier WF Frieden M Malli R | 2007 | Pflugers Arch2007，455，3： | 1 |
| 19 | Aging and oxidation of reactive protein sulphydryls 显示文摘 | Thomas J A Mallis R J | 2001 | Experimental Gerontology2001，36，9： | 1 |
| 20 | Long-term follow-up study with repetitive transcranial magnetic stimulation in Parkinson's disease显示文摘 | Mally J Farkas Trothfalusi | 2004 | Brain Res Bull2004，64，： | 1 |
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