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| 1 | p16 promoter hypermethylation:A useful serum marker for early detection of gastric cancer显示文摘AIM: To determine p16 promoter hypermethylation in gastric tumoral tissue and serum samples, its impact on p16-protein expression, and correlation with clinical and histological features. METHODS: Samples were obtained from 52 histologically confirmed cases of gastric adenocarcinoma. Gastric tissue and serum of 50 age- and sex-matched individuals with normal gastroscopy and biopsy were obtained as control samples. Methylation-specific polymerase chain reaction (MSP) was used to evaluate methylation status of p16 promoter. p16-protein expression was analyzed by immunohistochemical staining on paraffin-embedded sections. RESULTS: Methylation was detected in 44.2% (23/52) of tumoral tissues. 60.9% of them were also methylated in serum, i.e., 26.9% of all patients (14/52). Methylation was not detected in tissue and sera of control samples. p16-protein expression was decreased in 61.5% of cases (32/52), and was significantly associated with promoter hypermethylation (P < 0.001). Methylation was significantly more frequent in higher pathological grades (P < 0.05). Methylation was not associated with other clinicopathological features and environmental factors including H pylori infection and smoking. CONCLUSION: p16 promoter hypermethylation is an important event in gastric carcinogenesis. It is the principle mechanism of p16 gene silencing. It is related to malignant tumor behavior. Detection of DNA methylation in serum may be a biomarker for early detection of gastric cancer. | Mohammad Reza Abbaszadegan Omeed Moaven Hamid Reza Sima Kamran Ghafarzadegan Azadeh A'rabi Mohammad Naser Forghani Hamid Reza Raziee Ali Mashhadinejad Mostafa Jafarzadeh Ehsan Esmaili-Shandiz Ezzat Dadkhah | 2008 | World Journal of Gastroenterology2008，14，13： | 50 |
| 2 | Expression of cell adhesion molecule CD44 in gastric adenocarcinoma and its prognostic importance显示文摘AIM: To evaluate the relation of cluster of differentiation 44 (CD44) expression with clinicopathological features of gastric adenocarcinoma, and also its effect on prognosis with an emphasis on the differences between intestinal and diffuse types. METHODS: From 2000 to 2006, 100 patients with gastric adenocarcinoma, who had undergone total or subtotal gastrectomy without any prior treatment, were studied. Haematoxylin & eosin (HE) staining was used for histological evaluation, including the type (Lauren's classifi cation) and grading of the tumor. The expression of CD44 in the gastric adenocarcinoma mucosa and the adjacent mucosa were determined by immunohistochemistry. The survival analysis was obtained using the Kaplan-Meier test. RESULTS: Of 100 patients, 74 (74%) patients were male. The tumors were categorized as intestinal type (78%) or diffuse type (22%). Sixty-five percent of patients were CD44-positive. CD44 expression was not detected in normal gastric mucosa. Rather, CD44 was more commonly expressed in the intestinal subtype (P = 0.002). A signifi cant relation was seen between the grade of tumor and the expression of CD44 (P = 0.014). The survival analysis showed a poor prognosis of patients with CD44-positive tumors (P = 0.008); and this was more prominent in the intestinal (P = 0.001) rather than diffuse type. CONCLUSION: Cell adhesion molecule CD44 is highly expressed in gastric adenocarcinoma. CD44 expression is correlated with a poor prognosis in patients with the intestinal type of gastric adenocarcinoma. CD44 can, therefore, be utilized as a prognostic marker for this group of patients. | Kamran Ghaffarzadehgan Mostafa Jafarzadeh Hamid Reza Raziee Hamid Reza Sima Ehsan Esmaili-Shandiz Hanieh Hosseinnezhad Ali Taghizadeh Kermani Omeed Moaven Maryam Bahrani | 2008 | World Journal of Gastroenterology2008，14，41： | 18 |
| 3 | Association of p53/p21 expression with cigarette smoking and prognosis in esophageal squamous cell carcinoma patients显示文摘factors,such as cigarette smoking,in esophageal squamous cell carcinoma(ESCC)in northeastern Iran,a region with a high incidence of ESCC.METHODS:The expression of p53 and p21 proteins was investigated immunohistochemically in tumor tissue from 80 ESCC patients and in 60 available paraffinembedded blocks of adjacent normal specimens from the cases,along with normal esophageal tissue from 80 healthy subjects.RESULTS:Positive expression of p53 protein was detected in 56.2%(45/80)of ESCC cases,and in none of the normal esophageal tissue of the control group(P<0.001).Furthermore,73.8%(59/80)of ESCC cases and 43.8%(35/80)of controls had positive expression of p21 protein(P<0.001).Cigarette smoking was significantly associated with p53 over-expression in ESCC cases(P=0.010,OR=3.64;95%CI:1.32-10.02).p21 over-expression was associated with poorer clinical outcome among the ESCC patients(P=0.009).CONCLUSION:Over-expression of p53 in association with cigarette smoking may play a critical role in ESCC carcinogenesis among this high-risk population of northeastern Iran.Furthermore,p21 over-expression was found to be associated with poor prognosis,specifically in the operable ESCC patients. | Noushin Taghavi Firouzeh Biramijamal Masoud Sotoudeh Omeed Moaven Hooman Khademi Mohammad Reza Abbaszadegan Reza Malekzadeh | 2010 | World Journal of Gastroenterology2010，16，39： | 10 |
| 4 | Role of hMLH1 and E-Cadherin Promoter Methylation in Gastric Cancer Progression显示文摘 | Meysam Moghbeli Omeed Moaven Bahram Memar Hamid Reza Raziei Azadeh Aarabi Ezzat Dadkhah Mohammad Mahdi Forghanifard Fatemeh Manzari Mohammad Reza Abbaszadegan | 2014 | Journal of Gastrointestinal Cancer2014，，1： | 2 |
| 5 | Overexpression and interactions of interleukin-10, transforming growth fac- tor beta, and vascular endothelial growth factor in esopha- geal squamous cell carcinoma显示文摘 | Gholamin M Moaven O Memar B | 2009 | World J Surg2009，33，7： | 1 |
| 6 | Role of hMLH1 and E-cadherin promoter methyiation in gastric cancer progression显示文摘 | MOGHBELI M MOAVEN O MEMAR B | 2014 | J Gastrointest Cancer2014，45，1： | 1 |
| 7 | Intestinal Alkaline Phosphatase Prevents Antibiotic-Induced Susceptibility to Enteric Pathogens显示文摘 | Sayeda Nasrin Alam Halim Yammine Omeed Moaven Rizwan Ahmed Angela K. Moss Brishti Biswas Nur Muhammad Rakesh Biswas Atri Raychowdhury Kanakaraju Kaliannan Sathi Ghosh Madhury Ray Sulaiman R. Hamarneh Soumik Barua Nondita S. Malo Atul K. Bhan Madhu S. Malo | 2014 | Annals of Surgery2014，，4： | 1 |
| 8 | Induction of cytotoxic T lymphocytes primed with tumor RNA-loaded dendritic cells in esophageal squamous cell carcinoma:preliminary step for DC vaccine design显示文摘 | Gholamin M Moaven O Farshchian M | | 0，，： | 1 |
| 9 | Role of hMLH1 and E- cadherin promoter methylation in gastric cancer progression 显示文摘 | Moghheli M Moaven O Memar B | 2014 | J Gastrointest Cancer2014，45，1： | 1 |
| 10 | Overexpression and interactions of interleukin-10,Transforming growth factorβ,and vascular endothelial growth factor in esophageal squamous cell carcinoma显示文摘 | Gholamin M Moaven O Memar B | 2009 | World J Surg2009，33，7： | 1 |
| 11 | Parvovirus B19-asso coated red aplasia in combined immunodeficiency with normal immunoglobolins 显示文摘 | Tang ML Kemp AS Moaven LD | 1994 | Pediatr Dis J1994，13，： | 1 |
| 12 | Role of hMLH1 and E-cadherin promoter methylation in gastric cancer progression显示文摘 | Moghbeli M Moaven O Memar B | 2014 | J Gastrointest Cancer2014，45，1： | 1 |
| 13 | Towards a self-adaptive service-oriented methodology based on extended SOMA显示文摘提出一种使用MAPE-K标准模型维护软件架构质量的自适应过程(SAP)。由于其显式地定义了输入与输出,该过程可插入多种软件开发进程和服务导向方法。为此,所述自适应过程在一种双层结构中与服务导向建模和应用(SOMA)方法相融合,构建出一种新方法:自适应服务导向架构方法(SASOAM)。通过不同架构策略组合,SASOAM提供了一种半自动自知方法。此外,通过使用架构和适配模式,提升了服务导向建模和应用的维护活动,达到控制软件架构质量的效果。基于层次分析法(AHP)的评估展示了服务导向建模和应用维护性的改善。案例研究显示了自适应服务导向架构方法的可行性与实用性。 | Alireza PARVIZI-MOSAED Shahrouz MOAVEN Jafar HABIBI Ghazaleh BEIGI Mahdieh NASER-SHARIAT | 2015 | Frontiers of Information Technology & Electronic Engineering2015，16，1： | 0 |
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