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| 1 | 改性油菜秸秆生物质炭吸附/解吸Cd2+特征显示文摘该研究选用蒸汽爆破油菜秸秆,对其进行羟基磷灰石和KMnO4浸渍处理,再用壳聚糖和NaOH溶液改性所获得的生物质炭改性,以比较表面特性变化和吸附/解吸Cd^2+的特征。结果表明,改性处理可有效地在生物质炭表面负载相应官能团,如羟基磷灰石处理使生物质炭表面磷酸盐增多,比表面积提高至225.68m^2/g;而壳聚糖、KMnO4和NaOH处理,则引入了-NH2和-OH、-COOH等酸性含氧官能团。尽管改性生物质炭表面电荷减少,但Cd^2+吸附容量却提高了13%~315%,其吸附行为可用Langmuir等温吸附式拟合,并符合Pseudo second order吸附动力学方程。改性后,生物质炭对Cd^2+的吸附主要为专性吸附,其初始吸附速率提高了65%~379%,而解吸率降低了17%~91%,表明对Cd2+的吸附更快且更加稳定,具有良好的应用潜力。 | 陈雪娇 林启美 肖弘扬 Muhammad Rizwan 赵小蓉 李贵桐 | 2019 | 农业工程学报2019，35，18： | 16 |
| 2 | Adsorptive removal of phosphate by the bimetallic hydroxide nanocomposites embedded in pomegranate peel显示文摘This study aimed to fabricate new and effective material for the efficiency of phosphate adsorption.Two types of adsorbent materials,the zirconium hydroxides embedded in pomegranate peel(Zr/Peel)and zirconium-lanthanum hydroxides embedded in pomegranate peel(Zr-La/Peel)were developed.Scanning electronic microscopy(SEM),x-ray photoelectron spectroscopy(XPS)and x-ray diffraction(XRD)were evaluated to give insight into the physicochemical properties of these adsorbents.Zr-La/Peel exceeded the adsorption efficiency of Zr/Peel adsorbents in batch adsorption experiments at the same pH level.The peel as a host can strive to have a strong'shielding effect'to increase the steadiness of the entrenched Zr and La elements.La and Zr are hydroxide metals that emit many hydrogen ions during the hydrolysis reaction,which contribute to protonation and electrostatic attraction.The highest adsorption capacity of La-Zr/Peel for phosphate was calculated to be40.21 mg/g,and pseudo second-order equation is very well fitted for kinetic adsorption.Phosphate adsorption efficiency was reduced by an increase of pH.With the background of coexisting Cl-,little effect on adsorption efficiency was observed,while adsorption capacities were reduced by almost 20-30%with the coexistence of SO42-,NO3-and humic acid(HA). | Muhammad Akram Xing Xu Baoyu Gao Qinyan Yue Shang Yanan Rizwan Khan Muhammad Ali Inam | 2020 | Journal of Environmental Sciences2020，32，5： | 8 |
| 3 | Takotsubo cardiomyopathy:Pathophysiology and role of cardiac biomarkers in differential diagnosis显示文摘Takotsubo cardiomyopathy(TC) is characterized by reversible ventricular dysfunction, not limited to the distribution of an epicardial coronary artery. A disease primarily afflicting post-menopausal women, it is frequently mistaken for acute anterior wall myocardial infarction. Alternatively called Stress Cardiomyopathy, physical or emotional triggers are identified in only three fourths of TC patients. Long considered a benign condition, recent findings suggest poor short term prognosis similar to acute coronary syndrome(ACS). Despite the widely recognized pathophysiological role of catecholamine excess, its diagnostic role is uncertain. TC is suspected based on typical wall motion abnormalities in ventriculogram or echocardiogram. Several additional electrocardiographic, laboratory and imaging parameters have been studied with the goal of clinical diagnosis of TC. While several clinical clues differentiate it from ACS, a clinical diagnosis is often elusive leading to avoidable cardiac catheterizations. Natriuretic peptides(NPs), a family of peptide hormones released primarily in response to myocardial stretch, play a significant role in pathophysiology, diagnosis as well as treatment of congestive heart failure. TC with its prominent ventricular dysfunction is associated with a significant elevation of NPs. NPs are elevated in ACS as well but the degree of elevation is typically lesser than in TC. Markers of myocardial injury such as troponin are usually elevated to a higher degree in ACS than in TC. This differential elevation of NPs and markers of myocardial injury may play a role in early clinical recognition of TC. | Prabhakaran Gopalakrishnan Ramsha Zaidi Muhammad Rizwan Sardar | 2017 | World Journal of Cardiology2017，9，9： | 7 |
| 4 | 基于高光谱成像的牧草粗蛋白含量检测研究显示文摘粗蛋白(CP)是评价牧草营养价值和品质参数的关键指标。快速、准确地对牧草中粗蛋白含量进行评估在畜牧业生产研究中具有重要意义。为确定牧草粗蛋白含量的高光谱特征波段及最优检测模型,研究分别于2017年5月至9月间在黑龙江省杜尔伯特自治区的人工牧草场(羊草)内每月随机选取35个样本,5个月共采集175个样本。采样时在样本点处放置1m×1m的样方,将样方内所有牧草全部齐地面收割采集后称重并冷藏保存。将样本带回实验室后,立即进行牧草叶片高光谱图像采集,同时采用凯氏定氮法对采集的牧草样本进行粗蛋白化学值测定,以此建立牧草粗蛋白含量高光谱数据集。研究首先通过Savitzky-Golay卷积平滑(SG)、多元散射校正(MSC)、变量标准化(SNV)、一阶导数(1-Der)和直接正交信号校正(DOSC)方法5种预处理方法对高光谱数据进行处理后分别建立偏最小二乘回归(PLSR)检测模型,从中确定最优预处理方法。利用最优预处理结果,分别采用连续投影算法(SPA)和随机蛙跳算法(RF)进行牧草粗蛋白含量的特征波段选择,并利用选择结果分别进一步建立PLSR模型,以此确定适合粗蛋白含量的特征波段选择方法,确定最优高光谱检测模型。结果表明,在五种高光谱预处理方法中,基于SNV方法预处理后所建立的高光谱PLSR模型表现最优(R2-P=0.929,RMSE-P=6.344mg·g^-1,RPD=4.204)。利用连续投影算法筛选的粗蛋白含量特征波长为30个,分布于530~700和940~1000nm范围内。经随机蛙跳算法确定的粗蛋白含量特征波段为6个,分别为826.544,827.285,828.766,971.012,972.494和973.235nm。因此,该研究中牧草粗蛋白含量最优高光谱检测模型为SNV-RF-PLSR(R2-P=0.933,RMSE-P=6.034mg·g^-1,RPD=4.322),模型精度较高。该研究结果为牧草粗蛋白含量的高光谱检测提供了最优模型和理论基础,同时为指导草业生产开拓了新的技术思路。 | 高睿 李泽东 马铮 孔庆明 Muhammad Rizwan 苏中滨 | 2019 | 光谱学与光谱分析2019，39，10： | 6 |
| 5 | Steam explosion of crop straws improves the characteristics of biochar as a soil amendment显示文摘Five crop straws (wheat, rice, maize, oil-rape, and cotton) were first steam-exploded for 2 min at 210℃, 2.5 MPa and then pyrolyzed at 500℃ for 2 h. Steam explosion (SE) induced 47–95% and 5–16% reduction of hemicellulose and cellulose, respectively, in the crop straws. The biochars derived from SE-treated feedstocks had a lower specific surface area (SSA) and pore volume, compared to those from pristine feedstocks, with one exception that SE enhanced SSA of oil-rape straw biochar by approximately 16 times. After SE, biochars had significant higher anion exchange capacity (AEC) (6.88–11.44 cmol kg–1) and point of zero net charges (PZNC) (pH 3.61–5.32) values. It can thus be speculated that these biochars may have higher potential for anions adsorption. In addition, oil-rape straw might be suitable to SE pretreatment for preparing biochar as a soil amendment and sorbent as well. Further work is required for testing its application in soil. | CHEN Xue-jiao LIN Qi-mei Muhammad Rizwan ZHAO Xiao-rong LI Gui-tong | 2019 | Journal of Integrative Agriculture2019，18，7： | 5 |
| 6 | Duodenal diverticulum and associated pancreatitis:Case report with brief review of literature显示文摘Pancreatitis in the elderly is a problem of increasing occurrence and is associated with severe complications.Periampullary diverticula(PAD) are extraluminal outpouchings of the duodenum rarely associated with pancreatitis.The presence of PAD should be excluded before diagnosing idiopathic pancreatitis,particularly in the elderly.However,when a duodenal diverticulum is found in the absence of any additional pathology,only then should the symptoms be attributed to the diverticulum.We describe a case of duodenal diverticulum presenting with pancreatitis to emphasize the importance of this commonly neglected etiology. | Mian Muhammad Rizwan Harpeet Singh VP Chandar Maria Zulfiqar Veera Singh | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，3： | 3 |
| 7 | Microstructure Evolution and Mechanical Behavior of Laser Melting Deposited TA15 Alloy at 500℃ under In-Situ Tension in SEM显示文摘TA15 alloy fabricated by laser melting deposition was investigated at 500℃ under tensile deformation. The damage behavior of microstructure was analyzed by the real time observation of the microstructure evolution, microcracks initiation and propagation using in-situ tensile equipment fitted in the SEM chamber. Finally, the mechanism of fracture was discussed. The result showed anisotropic mechanical properties in X-and Z-direction. The existence of columnar β grains and its orientation to the tensile direction were the major factors inducing the anisotropic mechanical properties. As compared to Z-direction specimen, high tensile strength was observed in X-direction specimen due to the resistance in slips propagation provided by the prior-β grain boundaries( β GBs). Accumulation of the cracks at prior β GB caused the shear fracture. In case of Z-direction specimen, parallel orientation of prior β GB and GB α with the tensile direction resulted in a homogeneous deformation. The high reduction of cross section showed the enhanced ductile characteristics at high temperature. | Muhammad Rizwan Junxia Lu Fei Chen Ruxia Chai Rafi Ullah Yuefei Zhang Ze Zhang | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，9： | 2 |
| 8 | High sensitive pressure sensors based on multiple coating technique显示文摘A multi-coating technique of reduced graphene oxide(RGO)was proposed to increase the sensitivity of paper-based pressure sensors.The maximum sensitivity of 17.6 kPa^-1 under the 1.4 kPa was achieved.The electrical sensing mechanism is attributed to the percolation effect.Such paper pressure sensors were applied to monitor the motor vibration,which indicates the potential of mechanical flaw detection by analyzing the waveform difference. | Rizwan Zahoor 刘畅 Muhammad Rizwan Anwar 林付艳 胡安琪 郭霞 | 2020 | Chinese Physics B2020，29，2： | 2 |
| 9 | Recent Progress,Challenges,and Prospects in Two‑Dimensional Photo‑Catalyst Materials and Environmental Remediation显示文摘The successful photo-catalyst library gives significant information on feature that affects photo-catalytic performance and proposes new materials.Competency is considerably significant to form multi-functional photo-catalysts with flexible characteristics.Since recently,two-dimensional materials(2DMs)gained much attention from researchers,due to their unique thickness-dependent uses,mainly for photo-catalytic,outstanding chemical and physical properties.Photo-catalytic water splitting and hydrogen(H2)evolution by plentiful compounds as electron(e−)donors is estimated to participate in constructing clean method for solar H2-formation.Heterogeneous photocatalysis received much research attention caused by their applications to tackle numerous energy and environmental issues.This broad review explains progress regarding 2DMs,significance in structure,and catalytic results.We will discuss in detail current progresses of approaches for adjusting 2DMs-based photo-catalysts to assess their photo-activity including doping,hetero-structure scheme,and functional formation assembly.Suggested plans,e.g.,doping and sensitization of semiconducting 2DMs,increasing electrical conductance,improving catalytic active sites,strengthening interface coupling in semiconductors(SCs)2DMs,forming nano-structures,building multi-junction nano-composites,increasing photo-stability of SCs,and using combined results of adapted approaches,are summed up.Hence,to further improve 2DMs photo-catalyst properties,hetero-structure design-based 2DMs’photo-catalyst basic mechanism is also reviewed. | Karim Khan Ayesha Khan Tareen Muhammad Aslam Rizwan Ur Rehman Sagar Bin Zhang Weichun Huang Asif Mahmood Nasir Mahmood Kishwar Khan Han Zhang Zhongyi Guo | 2020 | Nano-Micro Letters2020，12，12： | 2 |
| 10 | Mitochondria-associated endoplasmic reticulum membranes allow adaptation of mitochondrial metabolism to glucose availability in the liver显示文摘Mitochondria-associated endoplasmic reticulum membranes(MAM)play a key role in mitochondrial dynamics and function and in hepatic insulin action.Whereas mitochondria are important regulators of energy metabolism,the nutritional regulation of MAM in the liver and its role in the adaptation of mitochondria physiology to nutrient availability are unknown.In this study,we found that the fasted to postprandial transition reduced the number of endoplasmic reticulum-mitochondria contact points in mouse liver.Screening of potential hormonal/metabolic signals revealed glucose as the main nutritional regulator of hepatic MAM integrity both in vitro and in vivo.Glucose reduced organelle interactions through the pentose phosphate-protein phosphatase 2A(PP-PP2A)pathway,induced mitochondria fission,and impaired respiration.Blocking MAM reduction counteracted glucose-induced mitochondrial alterations.Furthermore,disruption of MAM integrity mimicked effects of glucose on mitochondria dynamics and function.This glucose-sensing system is deficient in the liver of insulin-resistant ob/ob and cyclophilin D-KO mice,both characterized by chronic disruption of MAM integrity,mitochondrial fission,and altered mitochondrial respiration.These data indicate that MAM contribute to the hepatic glucose-sensing system,allowing regulation of mitochondria dynamics and function during nutritional transition.Chronic disruption of MAM may participate in hepatic mitochondrial dysfunction associated with insulin resistance. | Pierre Theurey Emily Tubbs Guillaume Vial Julien Jacquemetton Nadia Bendridi Marie-Agnes Chauvin Muhammad Rizwan Alam Muriel Le Romancer Hubert Vidal Jennifer Rieusset | 2016 | Journal of Molecular Cell Biology2016，8，2： | 2 |
| 11 | Peripheral leukocyte and endometrium molecular biomarkers of inflammation and oxidative stress are altered in peripartal dairy cows supplemented with Zn,Mn,and Cu from amino acid complexes and Co from Co glucoheptonate显示文摘Background: Immune dysfunction and a higher risk of uterine infections are characteristics of the transition into lactation in dairy cows. The supply of complexed trace minerals, which are more bioavailable, could help overcome the greater needs of these nutrients in tissues around parturition and early lactation.Results: Twenty Holstein cows received an oral bolus with a mix of inorganic trace minerals(INO) or complexed trace minerals(AAC) to achieve 75, 65, 11, and 1 ppm supplemental Zn, Mn, Cu, and Co, respectively, in the total diet dry matter from -30 d through +30 d relative to parturition. Blood for polymorphonuclear leukocyte(PMNL) isolation was collected at-30,-15, +10, and + 30 d relative to parturition, whereas endometrium biopsies were performed at +14 and +30 d. Feeding AAC led to greater PMNL expression of genes related with inflammation response(DDX58), oxidative stress response(MPO), eicosanoid metabolism(PLA2G4A and ALOX5AP), transcription regulation(PPARG), and cellular adhesion(TLN1). The upregulation by AAC in endometrium of genes related with inflammation response( TLR2, TLR4, NFKB1, TNF, IL6, IL1 B, IL10, IL8), prostaglandin synthesis(PTGS2, PTGES), and antioxidant responses(NFE2 L2, SOD1) indicated a faster remodeling of uterine tissue and potentially greater capacity to control a local bacterial invasion.Conclusions: Data indicate that trace mineral supplementation from amino acid complexes improves PMNL activity and allows the prompt recovery of uterine tissue during early lactation. As such, the benefits of complexed trace minerals extend beyond an improvement of liver function and productive performance. | Fernanda Batistel Johan S.Osorio Muhammad Rizwan Tariq Cong Li Jessica Caputo Michael T.Socha Juan J.Loor | 2017 | Journal of Animal Science and Biotechnology2017，8，4： | 2 |
| 12 | Morphometry of leaf and shoot variables to assess aboveground biomass structure and carbon sequestration by different varieties of white mulberry(Morus alba L.)显示文摘Mulberry is economically important and can also play a pivotal role in mitigating greenhouse gases.Leaf and shoot traits were measured for Morus alba var.Kanmasi,M.alba var.Karyansuban,M.alba var.Latifolia,and M.alba var.PFI-1 to assess aboveground biomass(AGB)and carbon sequestration.Variety-specific and multivariety allometric AGB models were developed using the equivalent diameter at breast height(EDBH)and plant height(H).The completeharvest method was used to measure leaf and shoot traits and biomass,and the ash method was used to measure organic carbon content.The results showed significant(p<0.01)varietal differences in leaf and shoot traits,AGB and carbon sequestration.PFI-1 variety had the greatest leaf density(mean±SE:1828.3±0.3 leaves tree^(-1)),Karyansuban had the largest mean leaf area(185.94±8.95 cm^(2)).A diminishing return was found between leaf area and leaf density.Latifolia had the highest shoot density per tree(46.6±1.83 shoots tree^(-1)),total shoot length(264.1±2.32 m),dry biomass(16.69±0.58 kg tree^(-1)),carbon sequestration(9.99±0.32 kg tree^(-1))and CO_(2) mitigation(36.67±1.16 kg).The variety-specific AGB models b(EDBH)and b(EDBH)2 showed good fit and reasonable accuracy with a coefficient of determination(R^(2))=0.98-0.99,standard error of estimates(SEE)=0.1125-0.3130 and root mean square error(RMSE)=0.1084-0.3017.The multivariety models bln(EDBH)and(EDBH)0.756 showed good-fitness and accuracy with R^(2)=0.85-0.86,SEE=1.6231-1.6445 and RMSE=1.609-1.630.On the basis of these findings,variety Latifolia has good potential for biomass production,and allometric equations based on EDBH can be used to estimate AGB with a reasonable accuracy. | Ghulam Ali Bajwa Muhammad Umair Yasir Nawab Zahid Rizwan | 2021 | Journal of Forestry Research2021，32，6： | 2 |
| 13 | 基于核密度估计的新浪微博数据地理空间分析:以上海市为例显示文摘为了提取和分析中国上海的社交网络位置数据,通过使用KDE作为空间分析技术来探讨LBSN数据的应用,分析用户参与的新浪微博签到数据与城市特征之间的关系,更重要的是调查上海密集地区的人口密度,以便于相关部门更好地观察和管理。通过使用新浪微博API收集了中国上海10个不同地区在2016年1月~3月期间的数据,并利用核密度估计对基于位置社交网络数据集的新浪微博用户的签到频率进行分析。研究结果表明,核密度估计方法为利用地理空间数据集进行空间模式建模提供了有益的见解。此外,与研究区域的副城区相比,中心城区的密度更大。由此得出结论:通过使用核密度估计技术,可以评估个体的签到行为以及更广泛的总体人口模式。该研究对城市功能及其环境影响、城市可持续性发展和基于城市人口密度的应急响应等领域都有一定的借鉴意义。 | Saqib Ali Haidery 万旺根 曾本冲 Naimat Ullah Khan Muhammad Rizwan Hidayat Ullah | 2019 | 电子测量技术2019，42，21： | 2 |
| 14 | Construction of binary assembled MOF-derived nanocages with dual-band microwave absorbing properties显示文摘It is challenging to prepare a binary assembled metal-organic framework(MOF) by anisotropic epitaxial growth method. Besides, nanocages(NCs) with hollow structures are often constructed to improve microwave absorbing abilities. Herein, we combine the selective epitaxial growth and hollow engineering technologies to fabricate hybrid MOF-derived NCs. Benefiting from the unique nanocage/porous structure,complementary magnetic/dielectric components and suitable impedance matching characteristics, the optimized absorber(CoNi/TiO@PC-NCs) exhibits unique microwave absorbing properties. It is worth noting that the minimum reflection loss(RLmin) of the absorber reaches-65.3 dB, and the overall effective absorption bandwidth(EAB, RL <-10 dB) covers 15.1 GHz(2.9–18 GHz). The maximum EAB under a single thickness covers 4.4 GHz, displaying skipping dual-band coverages at both high and low frequencies. This work might provide a novel perspective for the synthesis of assembled MOF-derived absorbers. | Fei Wu Lingyun Wan Ting Wang Muhammad Rizwan Tariq Tariq Shah Pei Liu Qiuyu Zhang Baoliang Zhang | 2022 | Journal of Materials Science & Technology2022，，22： | 2 |
| 15 | Week Ahead Electricity Power and Price Forecasting Using Improved DenseNet-121 Method显示文摘In the Smart Grid(SG)residential environment,consumers change their power consumption routine according to the price and incentives announced by the utility,which causes the prices to deviate from the initial pattern.Thereby,electricity demand and price forecasting play a significant role and can help in terms of reliability and sustainability.Due to the massive amount of data,big data analytics for forecasting becomes a hot topic in the SG domain.In this paper,the changing and non-linearity of consumer consumption pattern complex data is taken as input.To minimize the computational cost and complexity of the data,the average of the feature engineering approaches includes:Recursive Feature Eliminator(RFE),Extreme Gradient Boosting(XGboost),Random Forest(RF),and are upgraded to extract the most relevant and significant features.To this end,we have proposed the DensetNet-121 network and Support Vector Machine(SVM)ensemble with Aquila Optimizer(AO)to ensure adaptability and handle the complexity of data in the classification.Further,the AO method helps to tune the parameters of DensNet(121 layers)and SVM,which achieves less training loss,computational time,minimized overfitting problems and more training/test accuracy.Performance evaluation metrics and statistical analysis validate the proposed model results are better than the benchmark schemes.Our proposed method has achieved a minimal value of the Mean Average Percentage Error(MAPE)rate i.e.,8%by DenseNet-AO and 6%by SVM-AO and the maximum accurateness rate of 92%and 95%,respectively. | Muhammad Irfan Ali Raza Faisal Althobiani Nasir Ayub Muhammad Idrees Zain Ali Kashif Rizwan Abdullah Saeed Alwadie Saleh Mohammed Ghonaim Hesham Abdushkour Saifur Rahman Omar Alshorman Samar Alqhtani | 2022 | Computers, Materials & Continua2022，，9： | 2 |
| 16 | Modeling and analysis of nonlinear rotordynamics due to higher order deformations in bending显示文摘 | Muhammad Rizwan Alain Berlioz Shad Guilhem Michon | | 0，，35： | 1 |
| 17 | Relationship between Capital Structure and Firms Per- formance: A Case of Textile Sector in Pakistan显示文摘 | Asad Nawaz Rizwan Ali Muhammad Akram Naseem | 2011 | Global Business and Management Research: An International Journal2011，，3： | 1 |
| 18 | Salinity Stress in Wheat:Effects,Mechanisms and Management Strategies显示文摘Salinity stress is a major threat to global food production and its intensity is continuously increasing because of anthropogenic activities.Wheat is a staple food and a source of carbohydrates and calories for the majority of people across the globe.However,wheat productivity is adversely affected by salt stress,which is associated with a reduction in germination,growth,altered reproductive behavior and enzymatic activity,disrupted photosynthesis,hormonal imbalance,oxidative stress,and yield reductions.Thus,a better understanding of wheat(plant)behavior to salinity stress has essential implications to devise counter and alleviation measures to cope with salt stress.Different approaches including the selection of suitable cultivars,conventional breeding,and molecular techniques can be used for facing salt stress tolerance.However,these techniques are tedious,costly,and labor-intensive.Management practices are still helpful to improve the wheat performance under salinity stress.Use of arbuscular mycorrhizal fungi,plant growth-promoting rhizobacteria,and exogenous application of phytohormones,seed priming,and nutrient management are important tools to improve wheat performance under salinity stress.In this paper,we discussed the effect of salinity stress on the wheat crop,possible mechanisms to deal with salinity stress,and management options to improve wheat performance under salinity conditions. | Mahmoud F.Seleiman Muhammad Talha Aslam Bushra Ahmed Alhammad MuhammadUmair Hassan Rizwan Maqbool Muhammad Umer Chattha Imran Khan Harun Ireri Gitari Omer S.Uslu Rana Roy Martin Leonardo Battaglia | 2022 | Phyton-International Journal of Experimental Botany2022，91，4： | 1 |
| 19 | Root cause analysis of primary reformer catastrophic failure: A case study显示文摘 | Naveed Ramzan Shahid Naveed Muhammad Rizwan | 2011 | Process Safety Progress2011，30，1： | 1 |
| 20 | COVID-19 and comorbidities of hepatic diseases in a global perspective显示文摘The worldwide outbreak of coronavirus disease 2019(COVID-19) has challenged the priorities of healthcare system in terms of different clinical management and infection transmission, particularly those related to hepatic-disease comorbidities. Epidemiological data evidenced that COVID-19 patients with altered liver function because of hepatitis infection and cholestasis have an adverse prognosis and experience worse health outcomes. COVID-19-associated liver injury is correlated with various liver diseases following a severe acute respiratory syndrome-coronavirus type 2(SARS-CoV-2) infection that can progress during the treatment of COVID-19 patients with or without pre-existing liver disease. SARS-CoV-2 can induce liver injury in a number of ways including direct cytopathic effect of the virus on cholangiocytes/hepatocytes, immune-mediated damage, hypoxia, and sepsis. Indeed, immediate cytopathogenic effects of SARSCoV-2 via its potential target, the angiotensin-converting enzyme-2 receptor, which is highly expressed in hepatocytes and cholangiocytes, renders the liver as an extra-respiratory organ with increased susceptibility to pathological outcomes. But, underlying COVID-19-linked liver disease pathogenesis with abnormal liver function tests(LFTs) is incompletely understood. Hence, we collated COVID-19-associated liver injuries with increased LFTs at the nexus of pre-existing liver diseases and COVID-19, and defining a plausible pathophysiological triad of COVID-19, hepatocellular damage, and liver disease. This review summarizes recent findings of the exacerbating role of COVID-19 in pre-existing liver disease and vice versa as well as international guidelines of clinical care, management, and treatment recommendations for COVID-19 patients with liver disease. | Aqsa Ahmad Syeda Momna Ishtiaq Junaid Ali Khan Rizwan Aslam Sultan Ali Muhammad Imran Arshad | 2021 | World Journal of Gastroenterology2021，27，13： | 1 |
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