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| 1 | Pam3CSK4 enhances adaptive immune responses to recombinant Mycobacterium bovis bacille Calmette-Guérin expressing Plasmodium falciparum C-terminus merozoite surface protein-1显示文摘Objective: To determine the effects of toll-like receptor 2(TLR-2) agonist, Pam3 CSK4, on cellular and humoral immune response against recombinant Mycobacterium bovis bacille Calmette-Guérin(rBCG) expressing the C-terminus of merozoite surface protein-1 of Plasmodium falciparum.Methods: Six groups of mice(n=6 per group) received intraperitoneal phosphate buffered saline T80(PBS-T80), BCG or rBCG in the presence or absence of Pam3 CSK4. Enzymelinked immunosorbent assay was carried out to measure serum total IgG, IgG1, IgG2 a, and Ig G2 b production. Spleens were also harvested and splenocytes were co-cultured with rBCG antigen for in vitro determination of IL-4 and IFN-γ via enzyme-linked immunosorbent assay.Results: The production of total IgG and the isotype IgG1, IgG2 a and IgG2 b was significantly higher in rBCG-immunised mice than in the BCG and PBS-T80-immunised mice, and Pam3 CSK4 further enhanced their productions. A similar pattern was also observed in IFN-γ production. Moreover, there was no significant difference in IL-4 production in all groups either in the presence or absence of Pam3 CSK4.Conclusions: We present evidence of the adjuvant effects of TLR-2 agonist in enhancing the production of total IgG, IgG1, IgG2 a, IgG2 b, as well as IFN-γ in response to rBCG. However, the presence or absence of Pam3 CSK4 had no effect on IL-4 production. | Mohamed H Abdikarim Muhammad A Abbas Munirah N Zakaria Robaiza Zakaria Rapeah Suppian | 2019 | Asian Pacific Journal of Tropical Biomedicine2019，9，7： | 3 |
| 2 | 接受他汀治疗患者新发糖尿病风险:人群为基础的研究显示文摘目的 研究接受HMG-CoA还原酶抑制剂(他汀类药物)治疗的患者的新发糖尿病风险。设计 人群为基础的队列研究,以时间事件分析的方法评估各种他汀类药物应用和新发糖尿病风险的相关性分析。计算危害比(hazard ratios,HR)来确定他汀的种类及剂量与新发糖尿病的关系。 | Aleesa A Caner Tara Gomes Ximena Camacho David N Juurlink Baiju R Shah Muhammad M Mamdani 张秀珍(译) 骆斯慧(译) 翁建平(校) | 2013 | 英国医学杂志中文版2013，16，5： | 2 |
| 3 | 对应用选择性环氧酶2抑制剂或传统非甾体类抗炎药物老年患者上消化道出血的观察研究显示文摘目的 对应用选择性环氧酶2(COX 2)抑制剂和非选择性的非甾体类抗炎药(NSAIDs)的老年患者上消化道出血的比率进行比较。 设计 观察性队列研究。 设置 利用来自加拿大安大略2000年4月17日~2001年3月31日的官方数据,以确认基于人群的、初次使用NSAID的队列患者。 对象 年龄≥66岁,开始服用非选择性NSAIDs(n=5391)、双氯芬酸(diclofenac)加米索前列醇(misoprostol)(n=5087)、罗非昔布(rofecoxib)(n=14 583)或塞来昔布(celecoxib)(n=18 908),以及随机选择的没有服用NSAIDs的对照组(n=100 000)。 衡量结局的主要指标 每个药物组因上消化道出血入院的比值比(经过调整潜在的混杂因子)。 结果 与对照组相比,多变量模型表明,在服用非选择性NSAIDs(调整比值比为4.0,95%,可信区间为2.3~6.9,)、双氯芬酸加米索前列醇(3.0,1.7~5.6)以及罗非昔布(1.9,1.3~2.8)时,上消化道出血的短期危险性是增加的,而塞来昔布并没有增加(1.0,0.7~1.6)。与塞来昔布相比,非选择性的NSAIDs(4.4,2.3~8.5)、双氯芬酸加 米索前列醇(3.2,1.6—6.5)以及罗非昔布(1.9,1.2~2.8)的上消化道出血危险性显著增加。与罗非昔布相比,非选择性NSAIDs的上消化道出血危险性显著增加(1.9,1.0~3.5)。 结论 选择性COX | Muhammad Mamdani Paula A Rochon David N Juurlink Alex Kopp Geoffrey M Anderson Gary Naglie Peter C Austin Andreas Laupacis 邓瑞雪 | 2003 | 英国医学杂志中文版2003，6，3： | 2 |
| 4 | Structural, electronic, and optical properties of ZnO_(1-x)Se_x alloys using first-principles calculations显示文摘The structural, electronic, and optical properties of binary ZnO, ZnSe compounds, and their ternary ZnO 1-x Se x alloys are computed using the accurate full potential linearized augmented plane wave plus local orbital (FP-LAPW + lo) method in the rocksalt (B1) and zincblende (B3) crystallographic phases. The electronic band structures, fundamental energy band gaps, and densities of states for ZnO 1-x Se x are evaluated in the range 0 ≤ x ≤ 1 using Wu-Cohen (WC) generalized gradient approximation (GGA) for the exchange-correlation potential. Our calculated results of lattice parameters and bulk modulus reveal a nonlinear variation for pseudo-binary and their ternary alloys in both phases and show a considerable deviation from Vegard's law. It is observed that the predicted lattice parameter and bulk modulus are in good agreement with the available experimental and theoretical data. We establish that the composition dependence of band gap is semi-metallic in B1 phase, while a direct band gap is observed in B3 phase. The calculated density of states is described by taking into account the contribution of Zn 3d, O2p, and Se 4s, and the optical properties are studied in terms of dielectric functions, refractive index, reflectivity, and energy loss function for the B3 phase and are compared with the available experimental data. | Muhammad Rashid Fayyaz Hussain Muhammad Imran S A Ahmad N A Noor M U Sohaib S M Alay-e-Abbas | 2013 | Chinese Physics B2013，22，8： | 2 |
| 5 | Synthesis, chemical characterization, DNA binding, antioxidant, antibacterial, and antifungal activities of ferrocence incorporated selenoureas 显示文摘 | RAJA A H AMIN B MUHAMMAD N T | 2014 | J Biochem Mol Toxico12014，28，2： | 1 |
| 6 | A New Iterative Method for Solving Absolute Value Equations显示文摘 | MUHAMMAD A N JAVED I SANJAY K | 2011 | International Journal of the Physical Sciences2011，6，7： | 1 |
| 7 | On an Iterative Method for Solving Absolute Value Equations 显示文摘 | MUHAMMAD A N JAVED I KHALIDA I N | 2012 | Optim Lett2012，6，5： | 1 |
| 8 | Evaluation of growth and flowering potential of rosa hybrida cuhivars under faisalabad climatic conditions 显示文摘 | Muhammad N Muhammad A K Atif Riaz | 2011 | Pak J Agri Sci2011，，4： | 1 |
| 9 | Comparative nutritional evaluation of fungus and alkali treated rice husk in rat显示文摘 | Belewu M A Muhammad N O Ikuomola B O | 2006 | Moor Journal of Agricultural Research2006，5，2： | 1 |
| 10 | Role of Zr-Co substitution at iron site on structural,magnetieand-eleetrieal properties of Sr-hexaferrites nano-materials synthe-sized by the sol-gel combustion method 显示文摘 | Muhammad N A Muhammad F E Muhammad J L | 2013 | Journal of Magne-tism and Magnetic Materials2013，332，： | 1 |
| 11 | Synthesis, characterization and DNA binding studies of penta - and hexa - coordinated diorganotin(IV) 4 - ( 4 - nitrophenyl) piperazine - 1 - earbodi- thioates 显示文摘 | Rehman ZU Shah A Muhammad N | 2009 | J Organomet Chem2009，694，13： | 1 |
| 12 | A population-based study of the drug interaction between proton pump inhibitors and clopidogrel显示文摘 | Juurlink David N Gomes Tara Ko Dennis T Szmitko Paul E Austin Peter C Tu Jack V Henry David A Kopp Alex Mamdani Muhammad M | 2009 | Canadian Medical Association. Journal2009，，7： | 1 |
| 13 | Picosecond laser micromachining of nitinol and platinum-iredium al- loy for coronary stent applications显示文摘 | Muhammad N Whitehead D Boor A | 2012 | Applied Physics A2012，106，3： | 1 |
| 14 | Picosecond la- ser micromachining of nitinol and platinum-iridium alloy for coronary stent applications 显示文摘 | Muhammad N Whitehead D Boor A | 2012 | Applied Physics A2012，106，3： | 1 |
| 15 | Hautriwaic acid asone of the hepatoprotective constituent of dodonaea viscosa显示文摘 | ALI H KABIR N MUHAMMAD A | 2014 | Phytomedicine2014，21，2： | 1 |
| 16 | Laccase mediated decolorization of vat dyes by Coriolus versicolor IBL-04显示文摘 | Muhammad A Shaheerah B Haq N B | 2008 | International Biodeterioration and Biodegradation2008，62，4： | 1 |
| 17 | Study on the preparation and properties of novel block copolymeric materials based on structurally modified organometallic as well as organic polyamides and polydimethylsiloxane显示文摘 | Muhammad S U K Zareen A Touseef N | 2013 | Polymer International2013，62，： | 1 |
| 18 | Rmoval of Zn( Ⅱ ) ions from aqueous solution using Moringa Oleifera Lam (horseradilish tree) biomass 显示文摘 | Haq N B Beenish M Muhammad A H | 2007 | Process Biochemistry2007，42，： | 1 |
| 19 | Formulation and evaluation of natural gum-based sustained release matrix tablets of flurbiprofen using response surface methodology显示文摘 | Syed N H S Sajid A Muhammad A C | 2009 | Drug Development and Industrial Pharmacy2009，35，12： | 1 |
| 20 | Leaching of metalions from black shale by organic acids produced by Aspergillus niger 显示文摘 | Fozia A Haq N B Muhammad A | 2010 | Ap- plied Clay Science2010，47，34： | 1 |
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