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| 1 | Nat Med:靶向两分子或有助于彻底治愈白血病显示文摘科学家在癌细胞内发现两个信号蛋白能够让癌细胞抵抗化疗。研究表明阻断这两种蛋白能够增强化疗对人类白血病小鼠模型的治疗效果。相关研究结果发表在国际学术期刊NatureMedicine上。研究人员发现在治疗中阻断c-Fos和Dusp1这两个蛋白能够治愈一些受激酶驱动且抵抗治疗的白血病和实体瘤。 | Meenu Kesarwani, Zachary Kincaid, Ahmed Gomaa, Erika Huber, Sara Rohrabaugh, Zain Siddiqui, Muhammad F Bouso, Kakajan Komurov, James C Mulloy, Jose A Cancelas, H Leighton Grimes Mohammad Azam Tahir Latif Ming Xu H Leighton Grimes Mohammad Azam | 2017 | 现代生物医学进展2017，17，17： | 4 |
| 2 | Surface plasmon polariton at the interface of dielectric and graphene medium using Kerr effect显示文摘We theoretically investigate the control of surface plasmon polariton(SPP) generated at the interface of dielectric and graphene medium under Kerr nonlinearity. The controlled Kerr nonlinear signal of probe light beam in a dielectric medium is used to generate SPPs at the interface of dielectric and graphene medium. The positive, negative absorption, and dispersion properties of SPPs are modified and controlled by the control and Kerr fields. A large amplification(negative absorption) is noted for SPPs under the Kerr nonlinearity. The normal/anomalous slope of dispersion and propagation length of SPPs is modified and controlled with Kerr nonlinearity. This leads to significant variation in slow and fast SPP propagation. The controlled slow and fast SPP propagation may predict significant applications in nano-photonics, optical tweezers, photovoltaic devices, plasmonster, and sensing technology. | Bakhtawar Muhammad Haneef B A Bacha H Khan M Atif | 2018 | Chinese Physics B2018，27，11： | 3 |
| 3 | Pam3CSK4 enhances adaptive immune responses to recombinant Mycobacterium bovis bacille Calmette-Guérin expressing Plasmodium falciparum C-terminus merozoite surface protein-1显示文摘Objective: To determine the effects of toll-like receptor 2(TLR-2) agonist, Pam3 CSK4, on cellular and humoral immune response against recombinant Mycobacterium bovis bacille Calmette-Guérin(rBCG) expressing the C-terminus of merozoite surface protein-1 of Plasmodium falciparum.Methods: Six groups of mice(n=6 per group) received intraperitoneal phosphate buffered saline T80(PBS-T80), BCG or rBCG in the presence or absence of Pam3 CSK4. Enzymelinked immunosorbent assay was carried out to measure serum total IgG, IgG1, IgG2 a, and Ig G2 b production. Spleens were also harvested and splenocytes were co-cultured with rBCG antigen for in vitro determination of IL-4 and IFN-γ via enzyme-linked immunosorbent assay.Results: The production of total IgG and the isotype IgG1, IgG2 a and IgG2 b was significantly higher in rBCG-immunised mice than in the BCG and PBS-T80-immunised mice, and Pam3 CSK4 further enhanced their productions. A similar pattern was also observed in IFN-γ production. Moreover, there was no significant difference in IL-4 production in all groups either in the presence or absence of Pam3 CSK4.Conclusions: We present evidence of the adjuvant effects of TLR-2 agonist in enhancing the production of total IgG, IgG1, IgG2 a, IgG2 b, as well as IFN-γ in response to rBCG. However, the presence or absence of Pam3 CSK4 had no effect on IL-4 production. | Mohamed H Abdikarim Muhammad A Abbas Munirah N Zakaria Robaiza Zakaria Rapeah Suppian | 2019 | Asian Pacific Journal of Tropical Biomedicine2019，9，7： | 3 |
| 4 | Physiological and biochemical appraisal for mulching and partial rhizosphere drying of cotton显示文摘Water is the main factor for the healthy life of plant.One of the main negative effects of climate change is the increasing scarcity of water that is lethal for plant.Globally,for water deficit regions(arid and semi-arid),drought is the main factor responsible for low production of agriculture,especially for cotton.Great efforts have been and are being made to find alternatives to water saving practices.This study aimed to examine the effects of partial rhizosphere drying(PRD,half of the root system irrigated at one event,and the other half irrigated in the next event,and so on)with and/or without various mulching treatments on physiological and biochemical traits of cotton.To explore this objective,we laid out experiments in completely randomized design with factorial arrangement in the Islamia University of Bahawalpur,Pakistan in 2016.Two factors included were four mulching treatments(M0,no mulching;M1,black plastic mulching;M2,wheat straw mulching;and M3,cotton sticks mulching)and two irrigation levels(I0,control(full irrigation);and I1,PRD).Fisher's analysis of variance among means of treatments was compared using least significant difference test at 5% probability level.Results revealed that the maximum plant height,leaf area,leaf gas exchange(photosynthetic rate and stomata conductance),chlorophyll,proline and total sugar contents,and enzyme activities were higher under M2 than under other three mulching treatments.As for irrigation levels,higher values of plant height,photosynthesis and water related parameters(leaf water potential,leaf osmotic potential,leaf turgor potential,etc.)were recorded.Contents of total sugar and proline and activities of antioxidant enzymes were significantly higher in PRD-treated plants than in control plants.It was concluded that combined application of PRD and mulching was more effective than the rest of the treatments used in the experiment.Similar study can be conducted in the field by applying irrigation water in alternate rows in semi-arid regions. | Rashid IQBAL Muhammad A S RAZA Muhammad F SALEEM Imran H KHAN Salman AHMAD Muhammad S ZAHEER Muhammad U ASLAM Imran HAIDER | 2019 | Journal of Arid Land2019，11，5： | 2 |
| 5 | Interferon-β induced in female genital epithelium by HIV-1 glycoprotein 120 via Toll-like-receptor 2 pathway acts to protect the mucosal barrier显示文摘More than 40%of HIV infections occur via female reproductive tract(FRT)through heterosexual transmission.Epithelial cells that line the female genital mucosa are the first line of defense against HIV-1 and other sexually transmitted pathogens.These sentient cells recognize and respond to external stimuli by induction of a range of carefully balanced innate immune responses.Previously,we have shown that in response to HIV-1 gp120,the genital epithelial cells(GECs)from upper reproductive tract induce an inflammatory response that may facilitate HIV-1 translocation and infection.In this study,we report that the endometrial and endocervical GECs simultaneously induce biologically active interferon-β(IFNβ)antiviral responses following exposure to HIV-1 that act to protect the epithelial tight junction barrier.The innate antiviral response was directly induced by HIV-1 envelope glycoprotein gp120 and addition of gp120 neutralizing antibody inhibited IFNβproduction.Interferon-βwas induced by gp120 in upper GECs through Toll-like receptor 2 signaling and required presence of heparan sulfate on epithelial cell surface.The induction of IFNβwas dependent upon activation of transcription factor IRF3(interferon regulatory factor 3).The IFNβwas biologically active,had a protective effect on epithelial tight junction barrier and was able to inhibit HIV-1 infection in TZM-bl indicator cells and HIV-1 replication in T cells.This is the first report that recognition of HIV-1 by upper GECs leads to induction of innate antiviral pathways.This could explain the overall low infectivity of HIV-1 in the FRT and could be exploited for HIV-1 prophylaxis. | Aisha Nazli Sara Dizzell Muhammad Atif Zahoor Victor H Ferreira Jessica Kafka Matthew William Woods Michel Ouellet Ali A Ashkar Michel J Tremblay Dawn ME Bowdish Charu Kaushic | 2019 | Cellular & Molecular Immunology2019，16，2： | 2 |
| 6 | One-time password system with infinite nested hash chains显示文摘 | MOHAMED H E MUHAMMAD K K KHALED A | 2010 | Communications in Computer and Information Science2010，122，： | 1 |
| 7 | Synthesis, chemical characterization, DNA binding, antioxidant, antibacterial, and antifungal activities of ferrocence incorporated selenoureas 显示文摘 | RAJA A H AMIN B MUHAMMAD N T | 2014 | J Biochem Mol Toxico12014，28，2： | 1 |
| 8 | Inhibition of α-glucosidase by oleanolic acid and its synthetic derivatives显示文摘 | Muhammad J Syed S H | 2002 | Phytochemistry2002，60，： | 1 |
| 9 | Hyperspectral Remote Sensing:Dimensional Reduction and End Member Extraction显示文摘 | Muhammad A Sungyoung L Ihsan U H | | 0，，02： | 1 |
| 10 | Antibacterial Constituents from the Rhizomes of Ferula communis显示文摘 | AL-YAHYA M A ILIAS MUHAMMAD MIRZA H H | 1998 | Phytotherapy Research1998，12，5： | 1 |
| 11 | Modeling and simulation of maximum power point tracker for photovoltaic system显示文摘 | YUSHAIZAD Y SITI H S MUHAMMAD A L | 2004 | National Power& Energy Conference2004，，2930： | 1 |
| 12 | Effect of salinity on yield and quality of Moringa oleifera seed oil显示文摘 | Farooq A Abdukkah I H Muhammad A | 2006 | Grasas Y Aceites2006，57，4： | 1 |
| 13 | Porous TiNi alloy by metal injection moulding sintering of ele- mental powders: effect of sintering temperature显示文摘 | Muhammad H I Russe 11 G Hywel A | 2012 | materials letters2012，，70： | 1 |
| 14 | Stem cells in normal breast development and breast cancer显示文摘 | Dontu G Muhammad A H Abdallah W M | 2003 | Cell Proliferation2003，36，1： | 1 |
| 15 | Inoculating wheat seedlings with exopolysaccharide-predueing bacteria restricts sodium uptake and stimulates plant growthunder salt stress显示文摘 | Muhammad A Shahida H Odile B | 2004 | Biol Fertil Soils2004，40，： | 1 |
| 16 | Biodegradation of a- and b-endosulfan by soil bacteria显示文摘 | SARFRAZ H MUHAMMAD A MUHAMMAD S | 2007 | Biodegradation2007，18，： | 1 |
| 17 | Preparation and charaterization of novel porous PMMA-SiO2 hybid membranes显示文摘 | Muhammad A Z Mohammad A W Nidal H | 2006 | Desal- ination2006，192，： | 1 |
| 18 | Hautriwaic acid asone of the hepatoprotective constituent of dodonaea viscosa显示文摘 | ALI H KABIR N MUHAMMAD A | 2014 | Phytomedicine2014，21，2： | 1 |
| 19 | Rmoval of Zn( Ⅱ ) ions from aqueous solution using Moringa Oleifera Lam (horseradilish tree) biomass 显示文摘 | Haq N B Beenish M Muhammad A H | 2007 | Process Biochemistry2007，42，： | 1 |
| 20 | Formulation and evaluation of natural gum-based sustained release matrix tablets of flurbiprofen using response surface methodology显示文摘 | Syed N H S Sajid A Muhammad A C | 2009 | Drug Development and Industrial Pharmacy2009，35，12： | 1 |
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