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| 1 | Moxibustion Promotes Formation of Granulation in Wound Healing Process through Induction of Transforming Growth Factor-β in Rats显示文摘Objective:To examine the effect of moxibustion on the wound healing process and its mechanism using a rat wound model.Methods:Sixty male Sprague-Dawley rats were randomly divided into a sham-treated group(n=30,wound surgery only)and a moxibustion group(n=30,wound treated with moxibustion).Circular fullthick ness skin wounds were produced in rats.Moxibustion was applied to the edge of wound and was continued on alternating days till 14 days after surgery,followed by measurement of wound size.Expression of collagens,prolyl-4-hydroxylase(P4H)and transtorming growth factor-β(TGF-β)were evaluated by histochemical study and real-time polymerase chain reaction.Results:The size of the wound lesion was significantly reduced in rats treated with moxibustion as compared to that in sham-treated rats at 4-10 days after wounding(P<0.01).Moxibusti on stimulated mRNA expressi on of collage ns at 4 days(P<0.01),but not at 7 days,accompa nied by enhanced proliferation of P4H-positive fibroblasts.Of importanee,expression of TGF-β in tissue from the wound lesio n treated with moxibusti on was sign ifica ntly in creased as compared to that in sham-treated rats at 4 days(P<0.01 or P<0.05),but not at 7 days.Conclusions:The treatment with moxibustion promoted the wound healing process in the early phase through proliferation of fibroblasts and rapid formation of granulation,possibly mediated by induction of TGF-β which is a key molecule in the physiological process of wound healing.Moxibustion can be expected to be effective as complementary treatment for intractable ulcers. | Hiroshi Kawanami Hirohisa Kawahata Hiroko-Miyuki Mori Motokuni Aoki | 2020 | Chinese Journal of Integrative Medicine2020，26，1： | 3 |
| 2 | Angiogenesis and antifibrotic action by hepatocyte growth factor in cardiomyopathy 显示文摘 | Yoshiaki Taniyama Ryuichi Morishita Motokuni Aoki | 2002 | Hypertension2002，40，1： | 1 |
| 3 | Endothelial apoptosis induced by oxidative stress through activation of NF-κB 显示文摘 | Motokuni Aoki Toshie Nata Ryuichi Morishita | 2002 | Hypertension2002，38，1： | 1 |
| 4 | In vivo transfection of cis element ' decoy' against nuclear factor-roB binding site prevents myocardial infarction 显示文摘 | Ryuichi Morishita Toshiko Sugimoto Motokuni Aoki | 1997 | Nature Medicine1997，3，8： | 1 |
| 5 | A calcium‐channel blocker, benidipine, improves forearm reactive hyperemia in patients with essential hypertension显示文摘 | Hirofumi Makino Motokuni Aoki Naotaka Hashiya Keita Yamasaki Hideo Shimizu Ken Miwa Toshio Ogihara Ryuichi Morishita | 2005 | Blood Pressure2005，，1： | 1 |
| 6 | Endothelial Apoptosis Induced by Oxidative Stress Through Activation of NF-κB: Antiapoptotic Effect of Antioxidant Agents on Endothelial Cells显示文摘 | Motokuni Aoki Toshie Nata Ryuichi Morishita Hidetsugu Matsushita Hironori Nakagami Kei Yamamoto Keita Yamazaki Mari Nakabayashi Toshio Ogihara Yasufumi Kaneda | 2001 | Hypertension: Journal of the American Heart Association2001，，1： | 1 |
| 7 | Therapeutic Angiogenesis Induced by Human Hepatocyte Growth Factor Gene in Rat Diabetic Hind Limb Ischemia Model: Molecular Mechanisms of Delayed Angiogenesis in Diabetes显示文摘 | Yoshiaki Taniyama Ryuichi Morishita Kazuya Hiraoka Motokuni Aoki Hironori Nakagami Keita Yamasaki Kunio Matsumoto Toshikazu Nakamura Yasufumi Kaneda Toshio Ogihara | 2001 | Circulation: Journal of the American Heart Association2001，，19： | 1 |
| 8 | Mitogenic and Antiapoptotic Actions of Hepatocyte Growth Factor Through ERK, STAT3, and Akt in Endothelial Cells显示文摘 | Hironori Nakagami Ryuichi Morishita Kei Yamamoto Yoshiaki Taniyama Motokuni Aoki Kunio Matsumoto Toshikazu Nakamura Yasufumi Kaneda Masatsugu Horiuchi Toshio Ogihara | 2001 | Hypertension: Journal of the American Heart Association ( Part Suppl)2001，，2： | 1 |
| 9 | Endothelial apoptosis induced by oxidative stress through activation of NF-κB:antiapoptotic effect of antioxidant agents on endothelial cells 显示文摘 | Motokuni Aoki Toshie Nata Ryuichi Morishita | 2001 | Hypertension2001，38，： | 1 |
| 10 | A Novel Vascular Modulator, Hepatocyte Growth Factor (HGF), as a Potential Index of the Severity of Hypertension显示文摘 | Shigefumi Nakamura Atsushi Moriguchi Ryuichi Morishita Motokuni Aoki Yoshikage Yo Shin-ichiro Hayashi Nobuaki Nakano Tomohiro Katsuya Sachiko Nakata Seiju Takami Kunio Matsumoto Toshikazu Nakamura Jitsuo Higaki Toshio Ogihara | 1998 | Biochemical and Biophysical Research Communications1998，，1： | 1 |
| 11 | A Vascular Modulator, Hepatocyte Growth Factor, Is Associated With Systolic Pressure显示文摘 | Yoshio Nakamura Ryuichi Morishita Shigefumi Nakamura Motokuni Aoki Atsushi Moriguchi Kunio Matsumoto Toshikazu Nakamura Jitsuo Higaki Toshio Ogihara | 1996 | Hypertension1996，，3： | 1 |
| 12 | Angiogenic Property of Hepatocyte Growth Factor Is Dependent on Upregulation of Essential Transcription Factor for Angiogenesis, ets-1显示文摘 | Naruya Tomita Ryuichi Morishita Yoshiaki Taniyama Hiromi Koike Motokuni Aoki Hideo Shimizu Kunio Matsumoto Toshikazu Nakamura Yasufumi Kaneda Toshio Ogihara | 2003 | Circulation: Journal of the American Heart Association2003，，10： | 1 |
| 13 | Impairment of Collateral Formation in Lipoprotein(a) Transgenic Mice: Therapeutic Angiogenesis Induced by Human Hepatocyte Growth Factor Gene显示文摘 | Ryuichi Morishita Minako Sakaki Kei Yamamoto Sota Iguchi Motokuni Aoki Keita Yamasaki Kunio Matsumoto Toshikazu Nakamura Richard Lawn Toshio Ogihara Yasufumi Kaneda | 2002 | Circulation: Journal of the American Heart Association2002，，： | 1 |
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