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| 1 | Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis显示文摘AIM:To investigate whether butyrate or glutamine enemas could diminish inflammation in experimental diversion colitis.METHODS:Wistar specific pathogen-free rats were submitted to a Hartmann's end colostomy and treated with enemas containing glutamine,butyrate,or saline.Enemas were administered twice a week in the excluded segment of the colon from 4 to 12 wk after the surgical procedure.Follow-up colonoscopy was performed every 4 wk for 12 wk.The effect of treatment was evaluated using video-endoscopic and histologic scores and measuring interleukin-1β,tumor necrosis factor-alpha,and transforming growth factor beta production in organ cultures by enzyme linked immunosorbent assay.RESULTS:Colonoscopies of the diverted segment showed mucosa with hyperemia,increased number of vessels,bleeding and mucus discharge.Treatment with either glutamine or butyrate induced significant reductions in both colonoscopic(P < 0.02) and histological scores(P < 0.01) and restored the densities of collagen fibers in tissue(P = 0.015;P = 0.001),the number of goblet cells(P = 0.021;P = 0.029),and the rate of apoptosis within the epithelium(P = 0.043;P = 0.011) to normal values.The high levels of cytokines in colon explants from rats with diversion colitis significantly decreased to normal values after treatment with butyrate or glutamine.CONCLUSION:The improvement of experimental diversion colitis following glutamine or butyrate enemas highlights the importance of specific luminal nutrients in the homeostasis of the colonic mucosa and supports their utilization for the treatment of human diversion colitis. | Rodrigo Goulart Pacheco Christiano Costa Esposito Lucas CM Müller Morgana TL Castelo-Branco Leonardo Pereira Quintella Vera Lucia A Chagas Heitor Siffert P de Souza Alberto Schanaider | 2012 | World Journal of Gastroenterology2012，18，32： | 9 |
| 2 | Therapeutic and prophylactic thalidomide in TNBS-induced colitis: Synergistic effects on TNF-α, IL-12 and VEGF production显示文摘AIM: To evaluated the therapeutic and prophylactic effect of thalidomide on 2, 4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis. Thalidomide has been reported to downregulate the expression of tumor necrosis factor a (TNF-α), IL-12, and vascular endothelial growth factor (VEGF), hallmarks of intestinal inflammation in Crohn's disease (CD). METHODS: Male Wistar rats were divided in five groups of ten animals each. Four groups received a rectal infusion of TNBS in ethanol. The first group was sacrificed 7 d after colitis induction. The second and third groups received either thalidomide or placebo by gavage and were sacrificed at 14 d. The fourth group received thalidomide 6 h before TNBS administration, and was sacrificed 7 d after induction. The fifth group acted as the control group and colitis was not induced. Histological inflammatory scores of the colon were performed and lamina propria CD4+ T cells, macrophages, and VEGF+ cells were detected by immunohistochemistry. TNF-a and IL-12 were quantified in the supernatant of organ cultures by ELISA. RESULTS: Significant reduction in the inflammatory score and in the percentage of VEGF+ cells was observed in the group treated with thalidomide compared with animals not treated with thalidomide. Both TNF-αand IL-12 levels were significantly reduced among TNBS induced colitis animals treated with thalidomide compared with animals that did not receive thalidomide. TNF-αlevels were also significantly reduced among the animals receiving thalidomide prophylaxis compared with untreated animals with TNBS-induced colitis. Intestinal levels of TNF-αand IL-12 were significantly correlated with the inflammatory score and the number of VEGF+ cells. CONCLUSION: Thalidomide significantly attenuates TNBS-induced colitis by inhibiting the intestinal production of TNF-α, IL-12, and VEGF. This effect may support the use of thalidomide as an alternate approach in selected patients with CD. | Ana Teresa Carvalho Heitor Souza Antonio Jose Carneiro Morgana Castelo-Branco Kalil Madi Alberto Schanaider Flavia Silva Fernando Antonio Pereira Júnior Márcia G Pereira Cláudio Tortori Ilana Dines Jane Carvalho Eduardo Rocha Celeste Elia | 2007 | World Journal of Gastroenterology2007，13，15： | 6 |
| 3 | Statins Are Associated With a Reduced Risk of Hepatocellular Carcinoma in a Large Cohort of Patients With Diabetes显示文摘 | Hashem B. El–Serag Michael L. Johnson Christine Hachem Robert O. Morgana | 2009 | Gastroenterology2009，，5： | 2 |
| 4 | On the complexity of recognizing tough graphs显示文摘 | Bauer D Morgana A Schmeichel E | 1994 | Discrete Math1994，124，： | 1 |
| 5 | Detection of the origin of Brazilian wines based on the determination of only four elements using high-resolution continuum source flame AAS显示文摘 | Wiliam B Roger T Morgana B | 2013 | Talanta2013，111，15： | 1 |
| 6 | How genetic is school myopia显示文摘 | Morgana I Rose K | 2005 | Prog Retin Eye Res2005，24，1： | 1 |
| 7 | Dependence of yield strain of human trabecular bone on anatomic site显示文摘 | Morgana EF Keaveny TM | 2001 | J Biomech2001，34，： | 1 |
| 8 | Comparison of the elastic and yield properties of human femoral trabecular and cortical bone tissue 显示文摘 | Bayraktar HH Morgana EF Nieburb GL | 2004 | J Biomech2004，37，1： | 1 |
| 9 | Adjuvant radiotherapy following radical prostatectomy for pathologic T3 or margin-positive prostate cancer: A systematic review and meta-analysis显示文摘 | Scott C Morgana B Tricia S | 2008 | Radiotherapy and Ontology2008，88，： | 1 |
| 10 | Role of oxidative stress in the pathophysiology of bipolar disorder 显示文摘 | Amanda V Steckert Samira S Valvassori Morgana Moretti | 2010 | Neurochem Res2010，35，9： | 1 |
| 11 | Development of an analytical method for the determination of arsenic in gasohne samples by hydride generation-graphite furnace atomic absorption spectrometry显示文摘 | Emilene MB Morgana BD Wiliam BD | | 0，，： | 1 |
| 12 | Antidepressant-like effect of α-tocopherol in a mouse model of depressive-like behavior induced by TNF-α显示文摘 | Luana M. Manosso Vivian B. Neis Morgana Moretti Juliana F. Daufenbach Andiara E. Freitas André R. Colla Ana Lúcia S. Rodrigues | 2013 | Progress in Neuropsychopharmacology & Biological Psychiatry2013，，： | 1 |
| 13 | Studies on the potential protective effect of cinnamon against bisphenol A-and octylphenol-induced oxidative stress in male albino rats显示文摘 | Ashraf M Morgana Salsh S | 2014 | Toxicology Reports2014，1，： | 1 |
| 14 | On the complexity of recognizing tough graphs显示文摘 | Bauer D Morgana A Schmeichel E | 1994 | Discrete Mathematics1994，124，13： | 1 |
| 15 | Visiting the Trenches:Exploring Meanings and Motivations in Battlefield Tourism显示文摘 | DUNKLEYA R MORGANA N WESTWOOD S | 2011 | Tourism Management2011，，4： | 1 |
| 16 | Ionomycin enhances Ca^2+ influx by stimulating store-regulated cation entry and not by a direct actionat the plasma membrane显示文摘 | MorganA JacobR | 1994 | BiochemJ1994，300，： | 1 |
| 17 | Application of biotic and taxonomic distinctness indices in assessing the ecological quality status of two coastal lakes:Caprolace and Fogliano lakes (Central Italy)显示文摘 | PRATO S MORGANA J G LA VALLE P | 2009 | Ecological Indicators2009，9，3： | 1 |
| 18 | Long Cycles in Graphs with Large Degree Sums显示文摘 | Bauer D Veldman H J Morgana A | 1989 | Discrete Math1989，79，： | 1 |
| 19 | Exfoliated polystyrene-clay nanocomposites synthesized by solvent blending with sonication 显示文摘 | ALEXANDER B MORGANA J D H | 2004 | Polymer2004，45，26： | 1 |
| 20 | On the complexity of recognizing tough graphs显示文摘 | Bauer D Morgana A Schmeichel E F | 1994 | Discrete Math1994，124，： | 1 |
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