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| 1 | Does Helicobacter pylori infection eradication modify peptic ulcer prevalence? A 10 years' endoscopical survey显示文摘瞄准:为了在病人比较消化性溃疡流行,在根除治疗的进步散开以后在 pre-Helicobacter 时代和十年在二所意大利的医院里为上面的胃肠的内视镜检查法参考了。方法:我们检查了连续地在 1992 和 2002 期间在 1986-1987 和 1995-1996 期间在 Padova 的肠胃病学单位,并且在 Parma 的肠胃病学单位执行的所有内视镜的考试。迟平方测试被用于统计分析。结果:从两个的数据内视镜的中心在溃疡的流行显示出统计上重要的减少:从 12.7% ~ 6.3%(P<0.001 ) 在 Padova 并且从 15.6% ~ 12%(P<0.001 ) 在 Parma。减少两个都是重要的为十二指肠(从 8.8% ~ 4.8% , P<0.001 ) 并且胃溃疡(3.9% ~ 1.5% , P<0.001 ) 在 Padova,并且仅仅为在 Parma 的十二指肠溃疡(9.2% ~ 6.1% , P<0.001;胃溃疡:6.3% ~ 5.8% , NS ) 。结论:在征兆的病人的根除在消化性溃疡流行导致了重要减小的广泛的 Helicobacter pylori (H pylori ) 的十年。这减小在 Padova 是特别地明显的,在为在一般 practioners 之中的 H pylori 根除的致敏的一个工程在 1990 和 1992 之间被执行的地方。假如我们的假设应该是真的, H pylori 根除可能在未来导致是的消化性溃疡一稀罕内视镜的发现。 | Giorgio Nervi Stefania Liatopoulou Lucas Giovanni Cavallaro Alessandro Gnocchi Nadia Dal Bò Massimo Rugge Veronica Iori Giulia Martina Cavestro Marta Maino Giancarlo Colla Angelo Franzè Francesco Di Mario | 2006 | World Journal of Gastroenterology2006，12，15： | 5 |
| 2 | Constipation,deficit in colon contractions and alpha-synuclein inclusions within the colon precede motor abnormalities and neurodegeneration in the central nervous system in a mouse model of alphasynucleinopathy显示文摘Background:Gastrointestinal dysfunction can affect Parkinson’s disease(PD)patients long before the onset of motor symptoms.However,little is known about the relationship between gastrointestinal abnormalities and the development of PD.Contrary to other animal models,the human A53T alpha-synuclein(αS)transgenic mice,Line G2–3,developsαS-driven neurological and motor impairments after 9 months of age,displaying a long presymptomatic phase free of central nervous system(CNS)dysfunction.Methods:To determine whether this line can be suitable to study constipation as it occurs in prodromal PD,gastrointestinal functionality was assessed in young mice through a multidisciplinary approach,based on behavioral and biochemical analysis combined with electrophysiological recordings of mouse intestinal preparations.Results:We found that the A53TαS mice display remarkable signs of gastrointestinal dysfunction that precede motor abnormalities andαS pathology in the CNS by at least 6 months.YoungαS mice show a drastic delay in food transit along the gastrointestinal tract,of almost 2 h in 3 months old mice that increased to more than 3 h at 6 months.Such impairment was associated with abnormal formation of stools that resulted in less abundant but longer pellets excreted,suggesting a deficit in the intestinal peristalsis.In agreement with this,electrically evoked contractions of the colon,but not of the ileum,showed a reduced motor response in both longitudinal and circular muscle layers inαS mice already at 3 months of age,that was mainly due to an impaired cholinergic transmission of the underlying enteric nervous system.Interestingly,the presence of insoluble and aggregatedαS was found in enteric neurons in both myenteric and submucosal plexi only in the colon of 3 months oldαS mice,but not in the small intestine,and exacerbated with age,mimicking the increase in transit delay and the contraction deficit showed by behavioral and electrical recordings data.Conclusions:Gastrointestinal dysfunction in A53TαS mice represents an early sign ofαS-driven pathology without concomitant CNS involvement.We believe that this model can be very useful to study disease-modifying strategies that could extend the prodromal phase of PD and haltαS pathology from reaching the brain. | Lucia Rota Carolina Pellegrini Laura Benvenuti Luca Antonioli Matteo Fornai Corrado Blandizzi Antonino Cattaneo Emanuela Colla | 2019 | Translational Neurodegeneration2019，8，1： | 5 |
| 3 | Subcellular localization of alpha-synuclein aggregates and their interaction with membranes显示文摘For more than a decade numerous evidence has been reported on the mechanisms of toxicity of α-synuclein(αS) oligomers and aggregates in α-synucleinopathies.These species were thought to form freely in the cytoplasm but recent reports of αS multimer conformations when bound to synaptic vesicles in physiological conditions,have raised the question about where αS aggregation initiates.In this review we focus on recent literature regarding the impact on membrane binding and subcellular localization of αS toxic species to understand how regular cellular function of αS contributes to pathology.Notably αS has been reported to mainly associate with specific membranes in neurons such as those of synaptic vesicles,ER/Golgi and the mitochondria,while toxic species of αS have been shown to inhibit,among others,neurotransmission,protein trafficking and mitochondrial function.Strategies interfering with αS membrane binding have shown to improve αS-driven toxicity in worms and in mice.Thus,a selective membrane binding that would result in a specific subcellular localization could be the key to understand how aggregation and pathology evolves,pointing out to αS functions that are primarily affected before onset of irreversible damage. | Fabiana Miraglia Alessio Ricci Lucia Rota Emanuela Colla | 2018 | Neural Regeneration Research2018，13，7： | 4 |
| 4 | Design and optimization of a semi-active suspension system for railway applications显示文摘The present work focused on the application of innovative damping technologies in order to improve rail-way vehicle performances in terms of dynamic stability and comfort.As a benchmark case-study,the secondary sus-pension stage was selected and different control techniques were investigated,such as skyhook,dynamic compensation,and sliding mode control.The ?nal aim was to investigate which control schemes are suitable for optimal exploitation of the non-linear behavior of the actuators.The performance improvement achieved by adoption of the semi-active dampers on a standard high-speed train was evaluated in terms of passenger comfort.Different control strategies have been investigated by comparing a simple SISO(single input single output) regulator based on the skyhook damper ap-proach with a centralized regulator.The centralized regulator allows for the estimation of a near optimal set of control forces that minimize car-body accelerations with respect to constraints imposed by limited performance of semi-active actuators.Simulation results show that best results is obtained using a mixed approach that considers the simultaneous applications of model based and feedback compensation control terms. | Benedetto ALLOTTA Luca PUGI Valentina COLLA Fabio BARTOLINI Francesco CANGIOLI | 2011 | Journal of Modern Transportation2011，19，4： | 2 |
| 5 | Nature:研究鉴定出侵袭性胰腺癌细胞及其弱点显示文摘在一项新的研究中,来自美国德州大学MD安德森癌症中心的研究人员利用患者源性肿瘤异种移植(patient—derived tumorxenograft,PDx)和模式小鼠开展一系列临床前实验,鉴定出一种门卫蛋白(gatekee Perprotein)阻止胰腺癌细胞转化为一种极具侵袭性的细胞类型,并且也发现剔除这种门卫蛋白的疗法能够阻止这些癌细胞。这些发现有助为携带这种进展迅速的治疗抵抗性的胰腺癌细胞亚群的患者开发出潜在的疗法。 | Genovese, Giannicola Carugo, Alessandro Tepper, James Robinson, Frederick Scott Li, Liren Svelto, Maria Nezi, Luigi Corti, Denise Minelli, Rosalba Pettazzoni, Piergiorgio Gutschner, Tony Wu, Chia-Chin Seth, Sahil Akdemir, Kadir Caner Leo, Elisabetta Amin, Samirkumar Dal Molin, Marco Ying, Haoqiang Kwong, Lawrence N. Colla, Simona Takahashi, Koichi Ghosh, Papia Giuliani, Virginia Muller, Florian Dey, Prasenjit Jiang, Shan Garvey, Jill Liu, Chang-Gong Zhang, Jianhua Heffernan, Timothy P. Toniatti, Carlo Fleming, Jason B. Goggins, Michael G. Wood, Laura D. Sgambato, Alessandro Agaimy, Abbas Maitra, Anirban Roberts, Charles W. M. Wang, Huamin Viale, Andrea DePinho, Ronald A. Draetta, Giulio F. Chin, Lynda | 2017 | 现代生物医学进展2017，17，14： | 2 |
| 6 | Is Renal Warm Ischemia over 30 Minutes during Laparoscopic Partial Nephrectomy Possible? One-Year Results of a Prospective Study显示文摘 | Francesco Porpiglia Julien Renard Michele Billia Francesca Musso Alessandro Volpe Rodolfo Burruni Carlo Terrone Loredana Colla Giorgina Piccoli Valerio Podio Roberto Mario Scarpa | 2007 | European Urology2007，，4： | 2 |
| 7 | An Approach of the Fuzzy Weighted Inputs to the Generalized Predictive Control | LIU Xiao\|hua\+1,\ FANG Xiao\|juan\+2,\ SUN Xiao\|lin\+3 1.Dept. of Math.& Computer Science, Yantai Teachers University Yantai 264025, China 2.Dept. of Mathematics, Yantai University, Yantai 264001, China 3.Dept. of Mathematics, Yantai Education Colla | 2000 | Systems Science and Systems Engineering2000，10，1： | 2 |
| 8 | Human myeloma cells stimulate the receptor activator of nuclear factor-kappa B ligand (RANKL) in T lymphocytes: a potential role in multiple myeloma bone disease显示文摘 | Giuliani N Colla S Sala R | 2002 | Blood2002，100，13： | 1 |
| 9 | Preparation of nuclear transplant embryos by electroporation显示文摘 | Fissore R Robl J M | 1993 | Anal Biochemistry1993，208，1： | 1 |
| 10 | Measuring patient safety cli- mate : A review of Surveys 显示文摘 | Colla JB Bracken AC Kinney LM | 2005 | Qual Saf Health Care2005，14，5： | 1 |
| 11 | Influence of recipient oocyte cell cycle stage on DNA synthesis,nuclear envelope breakdown, chromosome constitution, and development in nuclear transplant bovine embryos显示文摘 | Barnes FL Collas P PowelI P | 1993 | Mol Reprod1993，36，： | 1 |
| 12 | Three-dimensional Ferroelectric Domain Imaging of Bulk Pb ( Zr, Ti) 03 by Atomic Force Microscopy显示文摘 | Hong S Ecabart B Colla E | 2004 | Appl Phys Lett2004，84，13： | 1 |
| 13 | Relationship between nuclear remodeling and development in nuclear transplant rabbit embryos显示文摘 | Collas P Robl J M | 1991 | Biol Reprod1991，45，： | 1 |
| 14 | Synthe-sis and antiviral activity of water-soluble esters of acyclovir guanine ] 显示文摘 | Colla L De C E Busson R | 1983 | Journal of Medical Chemistry1983，，26： | 1 |
| 15 | Yield,mineral composition,water relations,and water use efficiency of grafted mini-watermelon plants under deficit irrigation显示文摘 | Rouphael Y Cardarelli M Colla q Rea E | 2008 | Hort Science2008，43，3： | 1 |
| 16 | A way to reduce environmen- tal impact of ladle furnace slag显示文摘 | Branca T A Colla V Valentini R | 2009 | Ironmaking and Steelmaking2009，36，8： | 1 |
| 17 | Ultrahigh Strain Hardening in Thin Palladium Films with Nanoscale Twins显示文摘 | Ldrissi H Wang B Colla M S | 2011 | Advanced Materials2011，23，18： | 1 |
| 18 | Effect of salinity on yield, fruit quality, leaf gas exchange, and mineral composition cf grafted watermelon plants显示文摘 | Colla G Rnupahel Y Cardarelli M | 2006 | Hortscience2006，41，3： | 1 |
| 19 | Electrically induced calcium elevation activation and parthenogenetic development of bovine oocytes 显示文摘 | COLLAS P FISSORE R ROBL J M | 1993 | Mol Reprod Dev1993，34，： | 1 |
| 20 | Changes in antioxidant content of tomato fruits in response to cultivar and nutrient solution composition显示文摘 | Fanasca S Colla G Maiani G | 2006 | Journal of Agricultural and Food Chemistry2006，54，： | 1 |
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