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| 1 | Cultured meat from muscle stem cells: A review of challenges and prospects显示文摘Growing muscle tissue in culture from animal stem cells to produce meat theoretically eliminates the need to sacrifice animals. So-called 'cultured' or 'synthetic' or 'in vitro' meat could in theory be constructed with different characteristics and be produced faster and more efficiently than traditional meat. The technique to generate cultured muscle tissues from stem cells was described long ago, but has not yet been developed for the commercial production of cultured meat products. The technology is at an early stage and prerequisites of implementation include a reasonably high level of consumer acceptance, and the development of commercially-viable means of large scale production. Recent advancements in tissue culture techniques suggest that production may be economically feasible, provided it has physical properties in terms of colour, flavour, aroma, texture and palatability that are comparable to conventional meat. Although considerable progress has been made during recent years, important issues remain to be resolved, including the characterization of social and ethical constraints, the fine-tuning of culture conditions, and the development of culture media that are cost-effective and free of animal products. Consumer acceptance and confidence in in vitro produced cultured meat might be a significant impediment that hinders the marketing process. | Isam T Kadim Osman Mahgoub Senan Baqir Bernard Faye Roger Purchas | 2015 | Journal of Integrative Agriculture2015，14，2： | 20 |
| 2 | Selection of glass, compatibility anodic bonding conditions for silicon-glass capacitive and material sensors显示文摘 | Rogers T Kowal J | 1995 | Sensors and Actuators A1995，47，： | 2 |
| 3 | Dissociated overexpression of cathepsin D and estrogen receptor alpha in preinvasive mammary tumors显示文摘 | Roger P Daures JP Maudelonde T | 2000 | Hum Pathol2000，31，5： | 2 |
| 4 | Mutifactorial analysis of risk factors for reduced bone mineral density in patients with Crohn’s disease显示文摘AIM: To determine the prevalence of osteoporosis in a cohort of patients with Crohn’s disease (CD) and to identify the relative significance of risk factors for osteoporosis. METHODS: Two hundred and fifty-eight unselected patients (92 M, 166 F) with CD were studied. Bone mineral density (BMD) was measured at the lumbar spine and hip by dual X-ray absorptiometry. Bone formation was assessed by measuring bone specific alkaline phosphatase (BSAP) and bone resorption by measuring urinary excretion of deoxypyridinoline (DPD) and N-telopeptide (NTX). RESULTS: Between 11.6%-13.6% patients were osteoporotic (T score < -2.5) at the lumbar spine and/or hip. NTX levels were significantly higher in the patients with osteoporosis (P < 0.05) but BSAP and DPD levels were not significantly different. Independent risk factors for osteoporosis at either the lumbar spine or hip were a low body mass index (P < 0.001), increasing corticosteroid use (P < 0.005), and male sex (P < 0.01). These factors combined accounted for 23% and 37% of the reduction in BMD at the lumbar spine and hip respectively. CONCLUSION: Our results confirm that osteoporosis is common in patients with CD and suggest that increased bone resorption is the mechanism responsible for thebone loss. However, less than half of the reduction in BMD can be attributed to risk factors such as corticosteroid use and low BMI and therefore remains unexplained. | Sarah A Bartram Robert T Peaston David J Rawlings David Walshaw Roger M Francis Nick P Thompson | 2006 | World Journal of Gastroenterology2006，12，35： | 2 |
| 5 | Modeling cardiac arrest and resuscitation in the domestic pig显示文摘Cardiac arrest remains a leading cause of death and permanent disability worldwide. Although many victims are initially resuscitated, they often succumb to the extensive ischemia-reperfusion injury inflicted on the internal organs, especially the brain. Cardiac arrest initiates a complex cellular injury cascade encompassing reactive oxygen and nitrogen species, Ca2+ overload, ATP depletion, pro- and anti-apoptotic proteins, mitochondrial dysfunction, and neuronal glutamate excitotoxity, which injures and kills cells, compromises function of internal organs and ignites a destructive systemic inflammatory response. The sheer complexity and scope of this cascade challenges the development of experimental models of and effective treatments for cardiac arrest. Many experimental animal preparations have been developed to decipher the mechanisms of damage to vital internal organs following cardiac arrest and cardiopulmonary resuscitation(CPR), and to develop treatments to interrupt the lethal injury cascades. Porcine models of cardiac arrest and resuscitation offer several important advantages over other species, and outcomes in this large animal are readily translated to the clinical setting. This review summarizes porcine cardiac arrest-CPR models reported in the literature, describes clinically relevant phenomena observed during cardiac arrest and resuscitation in pigs, and discusses numerous methodological considerations in modeling cardiac arrest/CPR. Collectively, published reports show the domestic pig to be a suitable large animal model of cardiac arrest which is responsive to CPR, defibrillatory countershocks and medications, and yields extensive information to foster advances in clinical treatment of cardiac arrest. | Brandon H Cherry Anh Q Nguyen Roger A Hollrah Albert H Olivencia-Yurvati Robert T Mallet | 2015 | World Journal of Critical Care Medicine2015，4，1： | 2 |
| 6 | Mineralization and biodegradability enhancement of low level p-nitrophenol in water using Fenton's reagent显示文摘 | Eakalak K Roger B W Hsu T M | 2005 | Journal of Environmental Engineering2005，131，2： | 1 |
| 7 | Experimental laminar failing film heat transfer coefficients on large diameter horizontal tubes显示文摘 | ROGERS J T GOINDP S S | 1989 | Canadian Journal of Chemical Engineering1989，67，4： | 1 |
| 8 | A versatile camera calibration technique for high-accuracy 3D machine vision metrology using off-the- shelf TV cameras and lenses显示文摘 | Roger Y T | 1987 | Robotics and Automa- tion1987，3，4： | 1 |
| 9 | Sensitive questions in surveys显示文摘 | Roger T Ting Y | 2007 | Psy-chol Bull2007，133，5： | 1 |
| 10 | Pseudohypo parathyroidism with hypercalcemia 显示文摘 | Renuka RB Roger T Robert R | 2001 | Endocr2001，10，： | 1 |
| 11 | High speed tapping mode atomic force microscopy in liquid using an insulated piezoelectric cantilever显示文摘 | Rogers B Sulchek T Murray K | 2003 | Rev Sci Instrum2003，74，11： | 1 |
| 12 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 13 | Particle packing in loess deposits and the problem of structure collapse and hydroconsolidation 显示文摘 | DIJKSTRA T A SMALLEY I J ROGERS E D F | 1995 | Engi- neering Geology1995，40，： | 1 |
| 14 | Translation of the Alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5'-untrsnated region sequences 显示文摘 | Rogers J T Leiter L M Mcphee J | 1999 | J Biol chem1999，294，： | 1 |
| 15 | Macrophage migration inhibitory factor:a regulator of innate immunity显示文摘 | Calandra T Roger T | 2003 | Nat Rev Immunol2003，13，10： | 1 |
| 16 | Mechanistic approach to predict real machining time for milling free- form geometries applying high feed rate显示文摘 | COELHO R T SOUZA A F ROGER A R | 2010 | International Journal of Advanced Manufacturing Technology2010，46，9101112： | 1 |
| 17 | Macrophage migration in- hibitory factor and innate immune responses to bacterial infections 显示文摘 | Froidevaux C Roger T Martin C | 2001 | Crit Care Med2001，29，7： | 1 |
| 18 | Functional equivalence between radial basis function networks and fuzzy inference systems显示文摘 | Roger J S Sun S T | 1995 | IEEE Transactions on Neural Networks1995，4，1： | 1 |
| 19 | Improving biological indicators to better assess the condition of streams显示文摘 | SOUTHERLAND M T ROGERS G M KLINE M J | 2007 | Ecological Indicators2007，7，4： | 1 |
| 20 | ESL/EFL instructors' classroom assessment practices: Purposes, methods, and procedures 显示文摘 | Cheng L Rogers T Hu H | 2004 | Language Testing2004，21，3： | 1 |
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