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| 1 | Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis显示文摘AIM:To investigate whether butyrate or glutamine enemas could diminish inflammation in experimental diversion colitis.METHODS:Wistar specific pathogen-free rats were submitted to a Hartmann's end colostomy and treated with enemas containing glutamine,butyrate,or saline.Enemas were administered twice a week in the excluded segment of the colon from 4 to 12 wk after the surgical procedure.Follow-up colonoscopy was performed every 4 wk for 12 wk.The effect of treatment was evaluated using video-endoscopic and histologic scores and measuring interleukin-1β,tumor necrosis factor-alpha,and transforming growth factor beta production in organ cultures by enzyme linked immunosorbent assay.RESULTS:Colonoscopies of the diverted segment showed mucosa with hyperemia,increased number of vessels,bleeding and mucus discharge.Treatment with either glutamine or butyrate induced significant reductions in both colonoscopic(P < 0.02) and histological scores(P < 0.01) and restored the densities of collagen fibers in tissue(P = 0.015;P = 0.001),the number of goblet cells(P = 0.021;P = 0.029),and the rate of apoptosis within the epithelium(P = 0.043;P = 0.011) to normal values.The high levels of cytokines in colon explants from rats with diversion colitis significantly decreased to normal values after treatment with butyrate or glutamine.CONCLUSION:The improvement of experimental diversion colitis following glutamine or butyrate enemas highlights the importance of specific luminal nutrients in the homeostasis of the colonic mucosa and supports their utilization for the treatment of human diversion colitis. | Rodrigo Goulart Pacheco Christiano Costa Esposito Lucas CM Müller Morgana TL Castelo-Branco Leonardo Pereira Quintella Vera Lucia A Chagas Heitor Siffert P de Souza Alberto Schanaider | 2012 | World Journal of Gastroenterology2012，18，32： | 9 |
| 2 | On the complexity of recognizing tough graphs显示文摘 | Bauer D Morgana A Schmeichel E | 1994 | Discrete Math1994，124，： | 1 |
| 3 | On the complexity of recognizing tough graphs显示文摘 | Bauer D Morgana A Schmeichel E | 1994 | Discrete Mathematics1994，124，13： | 1 |
| 4 | Long Cycles in Graphs with Large Degree Sums显示文摘 | Bauer D Veldman H J Morgana A | 1989 | Discrete Math1989，79，： | 1 |
| 5 | On the complexity of recognizing tough graphs显示文摘 | Bauer D Morgana A Schmeichel E F | 1994 | Discrete Math1994，124，： | 1 |
| 6 | Tutte Sets in Graphs Ⅰ:maximal Tutte sets and D-graphs显示文摘 | Bauer D Broersma H J Morgana A | | 0，，04： | 1 |
| 7 | Tutte sets in graphs I: maximal Tutte sets and D-graphs显示文摘 | Bauer D Broersma H J Morgana A Schmeichel E Surowiec T | 2007 | J Grpah Theory2007，，55： | 1 |
| 8 | Tutte sets in graphs II: the complexity of finding maximum Tutte sets显示文摘 | Bauer D Broersma H J Kahl N Morgana A Schmeichel E Surowiec T | 2007 | Discrete Appl Math2007，，155： | 1 |
| 9 | Distinct patterns of mucosal apoptosis in H pylori-associated gastric ulcer are associated with altered FasL and perforin cytotoxic pathways显示文摘AIM: To analyze the level of apoptosis in different mucosal compartments and the differential expression of Fas/Fas-ligand and perforin in H pylori-associated gastric ulcer. METHODS: Antral specimens from patients with H pylori-related active gastric ulcer (GU), H pylori-related gastritis, and non-infected controls were analysed for densities and distribution of apoptotic cells determined by the TdT-mediated dUDP-biotin nick-end-labelling method. GU patients were submitted to eradication therapy with follow-up biopsy after 60 d. Fas, FasL, and perforin-expressing cells were assessed by immunoper- oxidase, and with anti-CD3, anti-CD20 and anti-CD68 by double immunofluorescence and confocal microscopy. Quantitative analysis was performed using a computer- assisted image analyser. RESULTS: H pylori-infected antrum showed greater surface epithelial apoptosis which decreased after eradi- cation therapy. In the lamina propria, higher rates of mononuclear cell apoptosis were observed in H pylori- gastritis. Co-expression of Fas with T-cell and macro- phage markers was reduced in GU. FasL- and perforin-expressing cells were increased in H pylori-infection and correlated with epithelial apoptosis. Perforin-expressing cells were also increased in GU compared with H pylori- gastritis. CONCLUSION: Epithelial apoptosis is increased in H pylori-infection and correlates to FasL- and perforin- expression by T cells. Expression of perforin is correlated with the tissue damage, and may represent the enhance- ment of a distinct cytotoxic pathway in GU. Increased expression of FasL not paralleled by Fas on T-cells and macrophages may indicate a reduced susceptibility to the Fas/FasL-mediated apoptosis of lymphoid cells in H pylori-infection. | Heitor SP Souza Marcelo S Neves Celeste CS Elia Claudio JA Tortori Ilana Dines Cesonia A Martinusso Kalil Madi Leonardo Andrade Morgana TL Castelo-Branco | 2006 | World Journal of Gastroenterology2006，12，38： | 1 |
| 10 | Species richness and similarity of the flora on four lajedos in Boa Nova, Bahia, Brazil显示文摘The municipality of Boa Nova,in northeastern Brazil,is in an ecotone zone between the Caatinga and Atlantic Forest phytogeographic domains.The transition phytophysiognomy is seasonal forest and known locally as mata de cipó.In these phytophysiognomies there are lajedos,which are rock outcrops colonized by vegetation welladapted to extreme microclimatic variation and vegetation diversity is affected by the vegetation types of the surrounding areas.Due to the singularity of these environments and the relevance of floristic studies for conservation,this work aimed to identify the species richness and compare the similarity of the flora on four rock outcrops in Boa Nova.The flora was surveyed during exploratory walks along lajedos between 2016 and 2019.In total,162 species were identified on the Boa Nova outcrops.The flora has a composition and structure similar to semiarid outcrops,as well as endemic species that also occur in surrounding phytophysiomies.Despite the proximity,a similarity index revealed there is floristic dissimilarity between the areas.Nine new occurrences were recorded for the region,five species are threatened with extinction(Aosa gilgiana,Ficus cyclophylla,Hippeastrum stigmovittatum,Pleroma caatingae and Trixis pruskii),and 43 species are common in anthropogenic areas.This reinforces the importance of actions to conserve these areas. | Morgana Maria DO CARMO BARBOSA Anderson FERREIRA PINTO MACHADO Andrea Karla ALMEIDA DOS SANTOS Raymundo JoséDE Sá-NETO Michele MARTINS CORRêA | 2023 | Journal of Mountain Science2023，20，6： | 0 |
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