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| 1 | FXR: a metabolic regulator and cell protector显示文摘Farnesoid X 受体(FXR ) 是激活 ligand 的抄写因素的原子受体总科的一个成员。作为一个新陈代谢的管理者, FXR 戏在胆汁酸,胆固醇,类脂化合物,和葡萄糖新陈代谢给角色调音。因此, FXR 是为很多新陈代谢的混乱的一个潜在的药目标,特别那些与新陈代谢的症候群有关。更最近,我们的组和其它扩大了 FXR 的功能到非常新陈代谢的规定,它在肠,肝新生,和 hepatocarcinogenesis 包括抗菌剂生长。这些新调查结果比以前想建议 FXR 有宽广得多的角色,并且也为多重疾病作为一个药目标加亮 FXR。这评论总结 FXR 的基本信息,但是集中于它的新功能。 | Yan-Dong Wang Wei-Dong Chen David D Moore Wendong Huang | 2008 | Cell Research2008，18，11： | 33 |
| 2 | Consequences of bullying victimization in childhood and adolescence:A systematic review and meta-analysis显示文摘AIM To identify health and psychosocial problems associated with bullying victimization and conduct a meta-analysis summarizing the causal evidence.METHODS A systematic review was conducted using Pub Med, EMBASE, ERIC and Psyc INFO electronic databases up to 28 February 2015. The study included published longitudinal and cross-sectional articles that examined health and psychosocial consequences of bullying victimization. All meta-analyses were based on qualityeffects models. Evidence for causality was assessed using Bradford Hill criteria and the grading system developed by the World Cancer Research Fund.RESULTS Out of 317 articles assessed for eligibility, 165 satisfied the predetermined inclusion criteria for meta-analysis.Statistically significant associations were observed between bullying victimization and a wide range of adverse health and psychosocial problems. The evidence was strongest for causal associations between bullying victimization and mental health problems such as depression, anxiety, poor general health and suicidal ideation and behaviours. Probable causal associations existed between bullying victimization and tobacco and illicit drug use. CONCLUSION Strong evidence exists for a causal relationship between bullying victimization, mental health problems and substance use. Evidence also exists for associations between bullying victimization and other adverse health and psychosocial problems, however, there is insufficient evidence to conclude causality. The strong evidence that bullying victimization is causative of mental illness highlights the need for schools to implement effective interventions to address bullying behaviours. | Sophie E Moore Rosana E Norman Shuichi Suetani Hannah J Thomas Peter D Sly James G Scott | 2017 | World Journal of Psychiatry2017，7，1： | 12 |
| 3 | 静脉血栓栓塞症的抗血栓治疗:美国《胸科学》杂志指南显示文摘包括深静脉血栓和肺栓塞在内的静脉血栓栓塞症是癌症患者的主要并发症,发生率为4%~20%,并且是常见的潜在致命性急症。本文介绍了美国《胸科学》杂志指南中VET的抗血栓治疗的部分内容,其以第9版《美国胸内科医师学会循证临床实践指南》中的《静脉血栓栓塞症的抗血栓治疗:抗血栓治疗和阻止血栓形成》一文为参照,基于静脉血栓栓塞症治疗的Ⅲ期试验的发表年份,对口服抗凝剂(达比加群、利伐沙班、阿哌沙班、依度沙班)进行先后阐述(但是这一排序并不是指南专家组对药剂的优劣排序),以为临床医生提供参考。 | Kearon C Akl EA Ornelas J Blaivas A Jimenez D Bounameaux H Huisman M King CS MorrisT Sood N Stevens SM Vintch JRE Wells P Woller SC Moores CL 本刊编辑部 | 2016 | 中国全科医学2016，19，9： | 10 |
| 4 | Epigenetics of gastroenteropancreatic neuroendocrine tumors:A clinicopathologic perspective显示文摘Gastroenteropancreatic neuroendocrine tumors(GEP-NETs) are a heterogeneous group of rare tumors whose site-specific tumor incidence and clinical behavior vary widely. Genetic alterations associated with familial inherited syndromes have been well defined; however, the genetic profile of sporadic tumors is less clear as their tumorigenesis does not appear to be controlled by classic oncogenes such as P53, RB, or KRAS. Even within GEP-NETs, there are no common oncogenic drivers; for example, DAXX/ATRX mutations are strongly implicated in the tumorigenesis of pancreatic but not small bowel NETs. Accordingly, the dysregulation of epigenetic mechanisms has been hypothesized as a potential regulator of GEPNET tumorigenesis and has become a major focus of recent studies. Despite the heterogeneity of tumor cohorts evaluated in these studies, it is obvious that there are methylation patterns, chromatin remodeling alterations, and microR NA and long non-coding RNA(lncR NA) differential expression profiles that are distinctive of GEPNETs, some of which are correlated with significant differences in clinical outcomes. Several translational studies have provided convincing data identifying potential prognostic biomarkers, and some of these have demonstrated preliminary success as serum biomarkers that can be used clinically. Nevertheless, there are many opportunities to further define the mechanisms by which these epigenetic modifications influence tumorigenesis, and this will provide better insight into their prognostic and therapeutic utility. Furthermore, these findings form the foundation for future studies evaluating the clinical efficacy of epigenetic modifications as prognostic biomarkers, as well as potential therapeutic targets. | Brendan M Finnerty Katherine D Gray Maureen D Moore Rasa Zarnegar Thomas J FaheyⅢ | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 4 |
| 5 | Neuromuscular electrical stimulation and testosterone did not influence heterotopic ossification size after spinal cor injury: A case series显示文摘Neuromuscular electrical stimulation(NMES) and testosterone replacement therapy(TRT) are effective rehabilitation strategies to attenuate muscle atrophy and evoke hypertrophy in persons with spinal cord injury(SCI). However both interventions might increase heterotopic ossification(HO) size in SCI patients. We present the results of two men with chronic traumatic motor complete SCI who also had pre-existing HO and participated in a study investigating the effects of TRT or TRT plus NMES resistance training(RT) on body composition. The 49-year-old male, Subject A, has unilateral HO in his right thigh. The 31-year-old male, Subject B, has bilateral HO in both thighs. Both participants wore transdermal testosterone patches(4-6 mg/d) daily for 16 wk. Subject A also underwent progressive NMES-RT twice weekly for 16 wk. Magnetic resonance imaging scans were acquired prior to and post intervention. Cross-sectional areas(CSA) of thewhole thigh and knee extensor skeletal muscles, femoral bone, and HO were measured. In Subject A(NMES-RT + TRT), the whole thigh skeletal muscle CSA increased by 10%, the knee extensor CSA increased by 17%, and the HO + femoral bone CSA did not change. In Subject B(TRT), the whole thigh skeletal muscle CSA increased by 13% in the right thigh and 6% in the left thigh. The knee extensor CSA increased by 7% in the right thigh and did not change in the left thigh. The femoral bone and HO CSAs in both thighs did not change. Both the TRT and NMES-RT + TRT protocols evoked muscle hypertrophy without stimulating the growth of preexisting HO. | Pamela D Moore Ashraf S Gorgey Rodney C Wade Refka E Khalil Timothy D Lavis Rehan Khan Robert A Adler | 2016 | World Journal of Clinical Cases2016，4，7： | 3 |
| 6 | Bevacizumab plus oxaliplatin-based chemotherapy as adjuvant treatment for colon cancer (AVANT): a phase 3 randomised controlled trial显示文摘 | Aimery de Gramont Eric Van Cutsem Hans-Joachim Schmoll Josep Tabernero Stephen Clarke Malcolm J Moore David Cunningham Thomas H Cartwright J Randolph Hecht Fernando Rivera Seock-Ah Im Gy?rgy Bodoky Ramon Salazar Frédérique Maindrault-Goebel Einat Shacham- | 2012 | Lancet Oncology2012，，12： | 3 |
| 7 | High prevalence of antifungal resistance in Candida spp from patients with AIDS 显示文摘 | Law D Moore C B Wardle H M | 1994 | J Antimicrob Chemother1994，34，5： | 2 |
| 8 | Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis显示文摘 | Anakk Sayeepriyadarshini Watanabe Mitsuhiro Ochsner Scott A McKenna Neil J Finegold Milton J Moore David D | 2011 | Journal of Clinical Investigation2011，，1： | 2 |
| 9 | Fresh-water/See-water Relationship within a Groundwater Flow System, Northeastern Coast of the Yucatan Peninsula 显示文摘 | MOOR Y H STOESELL R K EASLEY D H | 1992 | Ground Water1992，30，3： | 1 |
| 10 | Abundance and partitioning of OH in a hlgh-pressure magmatic system: Megacrysts from the Monastery kimberlite, South Africa显示文摘 | Bell D B Rossman G R Moore R O | 2004 | J Petrol2004，45，： | 1 |
| 11 | 显示文摘 | GAYLOR D W MOORE J A | 2004 | Regulatory Toxicology and Pharmacology2004，39，： | 1 |
| 12 | Informal logic dialogue games in human-computer dialogue显示文摘 | Yuan T Moore D Reed C | 2009 | Knowledge Engineering Review2009，26，3： | 1 |
| 13 | Therapeutic use of etanercept in polyarticular course juvenile idiopathic arthritis over a two year period显示文摘 | Kietz D A Pepmueller P H Moore T L | 2002 | Ann Rheum Dis2002，61，2： | 1 |
| 14 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 15 | Assessing the quality of reports of randomized clinical trials:is blinding necessary?显示文摘 | Jadad AR Moore RA Carroll D | 1996 | Control Clin Trials1996，17，1： | 1 |
| 16 | Wavelet denoising techniques with applications to experimental geophysical data 显示文摘 | To A C Moore J R Glaser S D | 2009 | Signal Processing2009，89，2： | 1 |
| 17 | Experimental behavior of a steel structure under natural fire 显示文摘 | Wald F Sim?es da Silva L Moore D B | 2006 | Fire Safety Journal2006，41，7： | 1 |
| 18 | Recent advances in stream and river temperature research显示文摘 | WEBB B W HANNAH D M MOORE R D | 2008 | Hydrological Processes2008，22，7： | 1 |
| 19 | Postinjury multiple organ failure显示文摘 | Dewar D Moore FA Moore EE | 2009 | Injury2009，40，4： | 1 |
| 20 | Submanifolds of constant positive curvature I 显示文摘 | Moore J D | 1977 | Duke Math J1977，44，： | 1 |
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