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| 1 | Liquid chromatography tandem mass spectrometry method for the estimation of lamotrigine in human plasma:Application to a pharmacokinetic study显示文摘A reliable,selective and sensitive liquid chromatography tandem mass spectrometry method was developed and validated for the quantification of lamotrigine in human plasma using lamotrigine13C3,d3 as an internal standard.Analyte and internal standard were extracted from human plasma by solid-phase extraction and detected in positive ion mode by tandem mass spectrometry with electrospray ionization(ESI) interface.Chromatographic separation was performed on a Chromolith s SpeedROD;RP-18e column(50-4.6 mm i.d.) using acetonitrile:570.1 mM ammonium formate solution(90:10,v/v) as the mobile phase at a flow rate of 0.500 mL/min.The calibration curves were linear over the range of 5.02-1226.47 ng/mL with the lower limit of quantitation validated at 5.02 ng/mL.The analytes were found stable in human plasma through three freeze(-20℃)-thaw(ice-cold water bath) cycles and under storage on bench-top in ice-cold water bath for at least 6.8 h,and also in the mobile phase at 10℃ for at least 57h.The method has shown good reproducibility,as the intra-and inter-day precisions were within 3.0%,while the accuracies were within 76.0% of nominal values.The validated LC-MS/MS method was applied for the evaluation of pharmacokinetic and bioequivalence parameters of lamotrigine after an oral administration of 50mg lamotrigine tablet to thirty-two healthy adult male volunteers. | Santosh Ghatol Vatsal Vithlani Sanjay Gurule Arshad Khuroo Tausif Monif Pankaj Partani | 2013 | Journal of Pharmaceutical Analysis2013，3，2： | 4 |
| 2 | Simultaneous quantitation of atorvastatin and its two active metabolites in human plasma by liquid chromatography/(–) electrospray tandem mass spectrometry显示文摘A sensitive, accurate and selective liquid chromatography–tandem mass spectrometry method(LC–MS/MS) was developed and validated for the simultaneous quantitation of atorvastatin(AT) and its equipotent hydroxyl metabolites, 2-hydroxy atorvastatin(2-AT) and 4-hydroxy atorvastatin(4-AT), in human plasma. Electrospray ionization(ESI) interface in negative ion mode was selected to improve the selectivity and the sensitivity required for this application. Additionally, a solid phase extraction(SPE)step was performed to reduce any ion-suppression and/or enhancement effects. The separation of all compounds was achieved in less than 6 min using a C18reverse-phase fused-corescolumn and a mobile phase, composed of a mixture of 0.005% formic acid in water:acetonitrile:methanol(35:25:40, v/v/v), in isocratic mode at a flow rate of 0.6 mL/min. The method has lower limit of quantitation(LLOQ) of0.050 ng/mL for all analytes. The method has shown tremendous reproducibility, with intra- and inter-day precision less than 6.6%, and intra- and inter-day accuracy within 74.3% of nominal values, for all analytes, and has proved to be highly reliable for the analysis of clinical samples. | Pankaj Partani S.Manaswita Verma Sanjay Gurule Arshad Khuroo Tausif Monif | 2014 | Journal of Pharmaceutical Analysis2014，4，1： | 3 |
| 3 | 炎症、癫痫发作和癫痫发生:对人类疾病的探索显示文摘癫痫在历史上被认为是一种神经元信号异常传导的疾病,表现为癫痫发作。随着大量自身抗体的发现和对自身免疫性脑炎认识的不断加深,人们越来越重视先天性和适应性免疫系统在癫痫发作和癫痫发生中的作用。在不同的癫痫发作相关的神经炎症和自身免疫疾病中,不同程度观察到了致病性抗体、补体激活、CD8+细胞毒性T细胞和小胶质细胞激活。这些异常的免疫反应被认为会导致神经元信号传导破坏,产生急性症状性癫痫发作,并且在某些情况下,还会发展为长期的自身免疫性癫痫。虽然早期使用免疫调节疗法可以改善自身免疫性脑炎和自身免疫性癫痫的预后,但患者的识别和治疗方法的选择并不总是明确。本篇综述讨论了免疫系统的不同成分在各种形式的癫痫发作中的作用,包括自身免疫性脑炎、自身免疫性癫痫、Rasmussen脑炎、热性感染相关性癫痫综合征和新发难治性癫痫持续状态。尤其是讨论了在这些疾病中观察到的病理生理学和独特的细胞因子谱,及其与诊断、预后和治疗决策的联系。 | Tan TH Perucca P O'Brien TJ Kwan P 高凡凯(译) 李硕(译) 薛国芳(审) Mastura Monif | 2022 | 癫痫杂志2022，8，4： | 2 |
| 4 | Female genital tract bacterial coisolates withCandida albicans in patients without clinical vaginitis显示文摘 | Monif GR Carson HJ | 1998 | InfectDis Obstet Gynecol1998，6，2： | 1 |
| 5 | Comparative Bioavailability Study with Two Pantoprazole Delayed-released Tablet Formulations Administered with and without Food in Healthy Subjects显示文摘 | Mendes Fabiana Patni Anil Reyer Simrit Monif Tausif Moreira Leonard Ilha Jaime Mendes Gustavo Nucci Gilberto | 2008 | Arzneimittelforschung2008，，03： | 1 |
| 6 | Cesarean section and genital herpesvirus infection显示文摘 | Amstey MS Monif GR Nahmias AJ | 1979 | Obstet Gynecol1979，53，5： | 1 |
| 7 | In vitro ability of the group B Streptococci to inhibit gram2positive and gram - variable constituent s of t he bacterial flora of the female genital tract 显示文摘 | Chaisilwattana P Monif G R | 1995 | Infect Dis Obstet Gynecol1995，3，1： | 1 |
| 8 | Pharmacokinetic and bioequivalence study of endogenous compound tretinoin 10 mg capsules in healthy volunteers by base line correction approach显示文摘 | Thudi NR Shrivastav VK Monif T | | 0，，03： | 1 |
| 9 | The P2X7 receptor drives microglial activation and proliferation: atrophic role for P2X7R pore显示文摘 | Monif M Reid CA Powell KL | 2009 | J Neurosci2009，29，12： | 1 |
| 10 | The P2X7 receptor drives microglial activation and proliferation: atrophic role for P2XTR pore显示文摘 | Monif M Reid CA Powell KL | 2009 | J Neurosci2009，29，： | 1 |
| 11 | The significance of a negative map ELISA test for Mycobacterium avium subspecies para- tuberculosis 显示文摘 | Monif G R G Williams J E | 2013 | Int J Appl Res Vet Med2013，11，2： | 1 |
| 12 | In vitro ability of the group B strepococi to inhibit gram-positive and gram-variable constituents of the bacterial flora of the female genital tract显示文摘 | Chaisilwattnan P Monif GR | 1995 | Infect Dis Obstet Gynecol1995，79，3： | 1 |
| 13 | Ruptured tubo-ovarian abscess in pregnancy:recovery of a penicillinase-producing strain of Neisseria gonorrhoeae显示文摘 | Stubbs RE Monif GR | 1985 | Sex Transm Dis1985，12，4： | 1 |
| 14 | The P2X7 receptor drives microglial activation and proliferation:a trophic role for P2X7R pore显示文摘 | Monif M Reid C A Powell K L | 2009 | J Neurosci2009，29，12： | 1 |
| 15 | Cesarean section and genital herpes virus infection显示文摘 | AMstey MS Monif GR Nahlnias AJ | 1979 | Obstet Gynecol1979，53，： | 1 |
| 16 | Quantitative and qualitative effects of povidone-iodine liquid and gel on the aerobic and anaerobic flora of the female genital tract显示文摘 | Monif G R Thompson J L Stephens H D Baer H | 1980 | Am J Obstet Gynecol1980，137，： | 1 |
| 17 | The P2X7 receptor drives mi- croglial activation and proliferation: atrophic role for P2XTR pore,显示文摘 | Monif M Reid C A Powell K L | 2009 | J Neurosci2009，29，12： | 1 |
| 18 | Cesarean section and genitul herpes virus infection显示文摘 | Amstey MS Monif GR Pahmias AJ | 1979 | J Obstet Gynecol1979，53，5： | 1 |
| 19 | In vitro ability of the group B streptococci to inhibit gram-positive and gram-variable constituents of the bacterial flora of the female genital tact 显示文摘 | Chaisilwattana P Monif G R | 1995 | Infect Dis Obstet Gynecol1995，3，3： | 1 |
| 20 | Quantitative estimation of irbesartan in two different matrices and its application to human and dog bioavailability studies using LCeMS/MS显示文摘A simple,rapid and robust high-throughput assay for the quantitative analysis of irbesartan in plasma from two species using liquid chromatography tandem mass spectrometric method was developed and validated.Solid phase extraction was used and quantification was achieved using a positive electrospray ionization interface under multiple reactions monitoring condition.Complete validation(as per recent regulatory requirements)was done using human plasma.The same method was validated using dog plasma and the validation parameters met respective acceptance criteria.The method has shorter run time of 3 min.This will help in high throughput.The low aliquot volume in the method helped us to take enough sampling time points for better pharmacokinetic profiles.The calibration curve was shown to be linear from 12.1 to 6018.7 ng/ml in human plasma and 12.1 to 5987.2 ng/ml in dog plasma.This method was successfully applied to samples collected during bioavailability studies of irbesartan in humans and dogs. | Hari Krishan Tiwari Tausif Monif Priya Ranjan Prasad Verma Simrit Reyar Arshad Hussain Khuroo Sanjeev Mishra | 2013 | Asian Journal of Pharmaceutical Sciences2013，8，6： | 0 |
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