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1篇 您的检索式：作者名="Simrit Reyar"

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		题名	作者	年代	出处	被引量
	1	Quantitative estimation of irbesartan in two different matrices and its application to human and dog bioavailability studies using LCeMS/MS显示文摘A simple,rapid and robust high-throughput assay for the quantitative analysis of irbesartan in plasma from two species using liquid chromatography tandem mass spectrometric method was developed and validated.Solid phase extraction was used and quantification was achieved using a positive electrospray ionization interface under multiple reactions monitoring condition.Complete validation(as per recent regulatory requirements)was done using human plasma.The same method was validated using dog plasma and the validation parameters met respective acceptance criteria.The method has shorter run time of 3 min.This will help in high throughput.The low aliquot volume in the method helped us to take enough sampling time points for better pharmacokinetic profiles.The calibration curve was shown to be linear from 12.1 to 6018.7 ng/ml in human plasma and 12.1 to 5987.2 ng/ml in dog plasma.This method was successfully applied to samples collected during bioavailability studies of irbesartan in humans and dogs.	Hari Krishan Tiwari Tausif Monif Priya Ranjan Prasad Verma Simrit Reyar Arshad Hussain Khuroo Sanjeev Mishra	2013	Asian Journal of Pharmaceutical Sciences2013，8，6：	0

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