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| 1 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 2 | Neolignans from arum italicum显示文摘 | Greca M D Molinaro A Monaco P | 1994 | Phytochemistry1994，35，3： | 1 |
| 3 | Aerospace communications for emergency applications显示文摘 | Berioli M Molinaro A Morosi S | | 0，，11： | 1 |
| 4 | Priming,Induction and Modulation of Plant Defence Responses by Bacterial Lipopolysaccharides显示文摘 | NEWMAN M A DOW J M MOLINARO A | 2007 | J Endotoxin Res2007，13，2： | 1 |
| 5 | Inhaled foreign bodies in pediatric patients:review of personal experience显示文摘 | PINZONI F BONIOTTI C MOLINARO S M | 2007 | Int J Pediatr Otorhinolaryngol2007，71，12： | 1 |
| 6 | Local expression of mlgf-1 modulates ubiquitin, caspase and CDK5 expression in skeletal muscle of an ALS mouse model显示文摘 | DOBROWOLNY G AUCELLO M MOLINARO M | 2008 | Neurol Res2008，30，2： | 1 |
| 7 | Enhancing multi-hop communication over multi-radio multi-channel wireless Mesh net- works: a cross-layer approach 显示文摘 | BONONI L Di FELICE M MOLINARO A | 2011 | Computer Communications2011，34，13： | 1 |
| 8 | Aerospace communica tions for emergency applications显示文摘 | Berioli M Molinaro A Morosi S | 2011 | Proceedings of the IEEE2011，99，11： | 1 |
| 9 | Lignans from Arum italicum显示文摘 | Greca M D Molinaro A Monaco P | 1994 | Phytochemistry1994，35，3： | 1 |
| 10 | Clinical pharmacokinetics of tacrolimus in heart transplant recipients 显示文摘 | REGAZZI M B RENALDI M MOLINARO M | 1999 | Ther Drug Monit1999，21，1： | 1 |
| 11 | R e c o m b i n a n t h u m a n t h y r o t r o p i n - s t i m u l a t e d s e r u mthyroglobulin combined with neck ultrasonography hasthe highest sensitivity in monitoring differentiated thyroidcarcinoma 显示文摘 | PACINI F MOLINARO E CASTAGNA M G | 2003 | J Clin Endocrinol Metab2003，88，8： | 1 |
| 12 | Dietary intakeexposure to sulfites in Italy-analytical determination of sulfite-containingfoods and their combination into standard meals for adults and children显示文摘 | LECLERCQ C MOLINARO M G PICCINELLI R | 2000 | Food Additives and Contaminants2000，17，12： | 1 |
| 13 | Spontaneous idiopathic intestinal perforation (SIPI):a distinct clinical entity in the preterm infant:242显示文摘 | Messina M Amato G Molinaro F | 2005 | Pediatr Res2005，58，2： | 1 |
| 14 | Changes in mGlu5 receptor-dependent synaptic plasticity and coupling to homer proteins in the hippocampus of Ube3A hemizy- gous mice modeling angelman syndrome 显示文摘 | Pignatelli M Piccinin S Molinaro G | 2014 | J Neurosci2014，34，： | 1 |
| 15 | Genome-wide screen of promoter methylation identifies novel markers in melanoma显示文摘 | Koga Y Pelizzola M Cheng E Krauthammer M Sznol M Ariyan S Narayan D Molinaro A M Halaban R Weissman S M | | 0，，08： | 1 |
| 16 | Glioma groups based on lp/19q, IDH, and TERT promoter mutations in tumors显示文摘 | Eckel-Passow J E Lachance D H Molinaro A M | 2015 | N Engl J Med2015，372，26： | 1 |
| 17 | Neolignans from Arum italicaum显示文摘 | Molinaro A Monaco P | 1994 | Phytochemisty1994，35，： | 1 |
| 18 | Phenalene metabolites from Eichhornia crassipes显示文摘 | GRECA M D LANZETTA R MOLINARO A | 1992 | Bioorganic & Medicinal Chemistry Letters1992，2，： | 1 |
| 19 | Mental imagery combined with physical practice of approach shots for golf beginners 显示文摘 | Brouziyne M Molinaro C | 2005 | Per- cept Mot Skills2005，101，1： | 1 |
| 20 | Clinical pharmacokinetics of tacrolimus in heart transplant recipients 显示文摘 | Rinaldi M Molinaro M Pellegrini C Calvi M Arbustini E Bellotti E Bascape V Martinelli L Vigano M | 1999 | Ther Drug Monit1999，21，1： | 1 |
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