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| 1 | 循证指南:弥散和灌注MRI在急性缺血性卒中诊断中的作用美国神经病学学会治疗和技术评价委员会的报告显示文摘目的 评价弥散加权成像(diffusion-weighted imaging,DWI)和灌注加权成像(perfusionweighted imaging PWI)在急性缺血性卒中患者诊断中应用的证据.方法 对1966年至2008年1月期间有关DWI和PWI诊断和预后价值的文献进行系统分析.结果和推荐 对于发病12 h内的急性缺血性卒中的诊断,DWI已被确认为有效的评价手段,且其诊断价值应高于非增强CT.为了最准确地诊断急性缺血性卒中,应进行DWI(A级推荐);然而,在疑似急性卒中患者的总体样本中,DWI诊断缺血性卒中的敏感性并不完美.DWI诊断脑出血的准确性不在本指南的范围之内.根据Ⅱ级和Ⅲ级证据,基线DWI体积可预测前循环卒中的基线卒中严重程度(B级推荐),但不能预测椎基底动脉系统卒中的基线卒中严重程度(C级推荐).基线DWI病变体积可预测(最终)梗死体积(B级推荐),并且有可能预测早期和远期临床转归(C级推荐).与DWI相比,基线PWI体积预测基线卒中严重程度的价值较小(C级推荐).尚无足够的证据支持或反对PWI在急性缺血性卒中诊断中的价值(U级推荐). | P.D. Schellinger R.N. Bryan L.R. Caplan J.A. Detre R.R. Edelman C. Jaigobin C.S. Kidwell J.P. Mohr M. Sloan A.G. Sorensen S. Warach 章娟娟(译) 王国颖(译) 汪凯(译) | 2010 | 国际脑血管病杂志2010，18，11： | 38 |
| 2 | Flexible piezoelectric nanogenerators based on a fiber/ZnO nanowires/paper hybrid structure for energy harvesting显示文摘 | Qingliang Liao Zheng Zhang Xiaohui Zhang Markus Mohr Yue Zhang Hans-Jorg Fecht | 2014 | Nano Research2014，7，6： | 16 |
| 3 | Upper gastrointestinal sensory-motor dysfunction in diabetes mellitus显示文摘胃肠(官方补给) 感觉马达的畸形在有糖尿病的病人是普通的并且可以包含官方补给的道的任何部分。畸形经常是无临床症状的,并且幸好,严重、威胁生活的问题仅仅很少发生。在糖尿病的反常上面的官方补给的感觉马达的功能的致病不完全地被理解并且是最可能的起源多因素。糖尿病的自治神经病以及糖尿病的尖锐非最优的控制被显示了损害官方补给的马达和感觉功能。词法并且官方补给的墙的机械改变在糖尿病的持续时间期间开发的简历,并且可以贡献马达和感觉机能障碍。在感觉的这评论和活动性,在糖尿病的上面的官方补给的道的混乱被讨论;并且与感觉马达的机能障碍有关的机械改变也是的词法变化和简历探讨了。 | Jingbo Zhao Jens Brφndum Frφkjaer Asbjφrn Mohr Drewes Niels Ejskjaer | 2006 | World Journal of Gastroenterology2006，12，18： | 15 |
| 4 | 人肿瘤细胞核苷酸切除修复蛋白表达与抗癌药耐药的相关性(英文)显示文摘背景与目的:核苷酸切除修复(Nucleotideexcisionrepair,NER)是真核细胞中的DNA修复多酶系统,它可能与人肿瘤细胞对抗癌药的耐药有关。本实验将探讨NER蛋白(XPA,XPB,XPD和ERCC1)的表达与人肿瘤细胞耐药的关系。方法:采用westernblot检测美国国家癌症研究所(NationalCancerInstitute,NCI)用于抗癌药筛选的60株人肿瘤细胞的ERCC1,XPA,XPBXPD表达,并与170种抗癌药物的细胞毒试验结果进行相关性分析。结果:ERCC1,XPB和XPD的蛋白表达与抗癌药物敏感性呈负相关,在170种抗癌药物中分别有13,17和32种的耐药性与上述蛋白水平相关性显著或非常显著(P<0.05)。而XPA的表达与药物敏感性无明显正/负相关。根据已确定的6种药物作用机理分析,肿瘤细胞XPD表达与其对烷化剂类抗癌药耐药相关性显著。结论:本实验结果肿瘤细胞的XPD蛋白表达与烷化剂类抗癌药的耐药相关,提示XPD在肿瘤细胞耐药过程中起重要作用。 | 陈忠平 Areti MALAPETSA Anne MONKS Timothy G. MYERS Gérard MOHR Eaward A. SAUSVILLE Dominic A. SCUDIERO Lawrence C. PANASCI | 2002 | 癌症2002，21，3： | 12 |
| 5 | Pathophysiology of chronic pancreatitis显示文摘Chronic pancreatitis(CP)is an inflammatory disease of the pancreas characterized by progressive fibrotic destruction of the pancreatic secretory parenchyma.Despite the heterogeneity in pathogenesis and involved risk factors,processes such as necrosis/apoptosis,inflammation or duct obstruction are involved.This fibrosing process ultimately leads to progressive loss of the lobular morphology and structure of the pancreas,deformation of the large ducts and severe changes in the arrangement and composition of the islets.These conditions lead to irreversible morphological and structural changes resulting in impairment of both exocrine and endocrine functions.The prevalence of the disease is largely dependent on culture and geography.The etiological risk-factors associated with CP are multiple and involve both genetic and environmental factors.Throughout this review the M-ANNHEIM classification system will be used,comprising a detailed description of risk factors such as:alcohol-consumption,nicotineconsumption,nutritional factors,hereditary factors,efferent duct factors,immunological factors and miscellaneous and rare metabolic factors.Increased knowledge of the different etiological factors may encourage the use of further advanced diagnostic tools,which potentially will help clinicians to diagnose CP at an earlier stage.However,in view of the multi factorial disease and the complex clinical picture,it is not surprising that treatment of patients with CP is challenging and often unsuccessful. | Christina Brock Lecia Mφller Nielsen Dina Lelic Asbjφrn Mohr Drewes | 2013 | World Journal of Gastroenterology2013，19，42： | 11 |
| 6 | Impaired contractility and remodeling of the upper gastrointestinal tract in diabetes mellitus type-1显示文摘AIM: To investigate that both the neuronal function of the contractile system and structural apparatus of the gastrointestinal tract are affected in patients with longstanding diabetes and auto mic neuropathy. METHODS: The evoked esophageal and duodenal contractile activity to standardized bag distension was assessed using a specialized ultrasound-based probe. Twelve type-1 diabetic patients with autonomic neuropathy and severe gastrointestinal symptoms and 12 healthy controls were studied. The geometry and biomechanical parameters (strain, tension/stress, and stiffness) were assessed. RESULTS: The diabetic patients had increased frequency of distension-induced contractions (6.0 ± 0.6 vs 3.3 ± 0.5, P < 0.001). This increased reactivity was correlated with the duration of the disease (P = 0.009). Impaired coordination of the contractile activity in diabetic patients was demonstrated as imbalance between the time required to evoke the first contraction at the distension site and proximal to it (1.5 ± 0.6 vs 0.5 ± 0.1, P = 0.03). The esophageal wall and especially the mucosa-submucosa layer had increased thickness in the patients (P < 0.001), and the longitudinal and radial compressive stretch was less in diabetics (P <0.001). The esophageal and duodenal wall stiffness and circumferential deformation induced by the distensions were not affected in the patients (all P > 0.14). CONCLUSION: The impaired contractile activity with an imbalance in the distension-induced contractions likely reflects neuronal abnormalities due to autonomic neuropathy. However, structural changes and remodeling of the gastrointestinal tract are also evident and may add to the neuronal changes. This may contribute to the pathophysiology of diabetic gut dysfunction and impact on future management of diabetic patients with gastrointestinal symptoms. | Jens BrΦndum FrΦkjΦr SΦren Due Andersen Niels EjskjΦr Peter Funch-Jensen AsbjΦrn Mohr Drewes Hans Gregersen | 2007 | World Journal of Gastroenterology2007，13，36： | 8 |
| 7 | 竞技运动教育模式的教学赛季计划显示文摘竞技运动教育模式已经赢得业内文献的大量支持,成为美国学校身体教育环境中竞技运动教学的重要途径.随着竞技运动教育模式的日益风靡,身体教育领域中的理论学者应同实践教师协同建立合适的指导模式.介绍了美国中学身体教育实践中,一个帮助体育教师有效筹划竞技运动教育的教学赛季计划的体系,希望对中国的学校体育教育有所帮助. | Mohr D J Townsend J S Bulger S M 陈森林 | 2010 | 西南师范大学学报(自然科学版)2010，35，6： | 7 |
| 8 | 糖尿病性上消化道感觉和运动功能异常显示文摘糖尿病患者胃肠感觉运动功能异常非常常见,其可涉及胃肠道各个部位。糖尿病性胃肠异常经常是亚临床的,庆幸的是罕有严重和危及生命的问题发生。人们尚未完全了解糖尿病性上消化道感觉运动功能异常的发病机制,但是其机制似乎是多源性的。研究表明,糖尿病性自主神经病变和急性血糖异常可损伤感觉运动功能。糖尿病发展过程中胃肠道结构和生物力学特性的重构也可能与感觉运动功能异常有关。本综述只讨论糖尿病性上消化道感觉运动功能异常,同时结合讨论胃肠道结构和生物力学特性的重构在糖尿病性上消化道感觉运动功能异常发展中的作用。 | 赵静波 Jens Brφndum Frφkjr Asbjφrn Mohr Drewes Niels Ejskjaer | 2008 | 医学综述2008，14，23： | 6 |
| 9 | 六氧甲基鸟嘌呤DNA甲基转移酶基因表达与肿瘤耐药显示文摘目的:六氧甲基鸟嘌呤DNA甲基转移酶(MGMT)能阻止由氮芥类导致的DNA交连形成,因而降低其细胞毒性。本研究探讨肿瘤细胞对氯乙基亚硝脲(CENU)耐药与其MGMT基因表达之间的关系。方法:采用RNA印迹试验和蛋白印迹试验对13株人肿瘤细胞的MGMT基因表达进行了检测,并与采用改良的SulforhodaminaB(SRB)比色抗癌药筛选法测定的肿瘤细胞对CENU的耐药性进行比较。结果:肿瘤细胞MGMT的表达在mRNA水平和蛋白水平是一致的。MGMT阳性的肿瘤比MGMT阴性的肿瘤对BCNU(t=2.611,P=0.01)和SarCNU(t=2.558,P=0.01)明显耐药。可是,MGMT表达高低与肿瘤细胞耐药性程度之间无线性相关。结论:MGMT在肿瘤细胞对CENU耐药中起重要作用,但除了MGMT之外,还有其它机制参与肿瘤耐药。 | 陈忠平 Mohr G Panasci LC 黄强 | 1998 | 癌症1998，17，3： | 6 |
| 10 | Evaluation of the biliary tract in patients with functional biliary symptoms显示文摘这篇论文的目的是在这些病人为胆道的评估描述功能的胆汁的症候群和方法。没有可论证的器官的底层,功能的胆汁的症状能被定义为胆汁的症状。二主要症候群存在:胆囊机能障碍和 Oddi 机能障碍的括约肌。最重要的研究工具是 cholescintigraphy 和 Oddi 测压法的内视镜的括约肌。在胆囊机能障碍 scintigraphic 胆囊喷射部分在下面 35% 能选择将得益于胆囊炎的病人。Oddi 测压法的内视镜的括约肌在 Oddi 机能障碍的括约肌被认为标准答案,但是在 scintigraphic 方法的最近的开发就要改变这。因此, hilum-to-duodenum 运输时间的计算和 cholescintigraphy 上的十二指肠的外观时间在这些病人证明了有用。在结论,周围的方法能诊断功能的胆汁的症候群。然而,仍然有很多个问题,知识进一步被需要。可能,下一个向前走将在感觉测试和阻抗 planimetric 方法的区域。 | Peter Funch-Jensen Asbjφrn Mohr Drewes László Madácsy | 2006 | World Journal of Gastroenterology2006，12，18： | 6 |
| 11 | Pain and chronic pancreatitis: A complex interplay of multiple mechanisms显示文摘Despite multiple theories on the pathogenesis of pain in chronic pancreatitis,no uniform and consistently successful treatment strategy exists and abdominal pain still remains the dominating symptom for most patients and a major challenge for clinicians.Traditional theories focussed on a mechanical cause of pain related to anatomical changes and evidence of increased ductal and interstitial pressures.These observations form the basis for surgical and endoscopic drainage procedures,but the outcome is variable and often unsatisfactory.This underscores the fact that other factors must contribute to pathogenesis of pain,and has shifted the focus towards a more complex neurobiological understanding of pain generation.Amongst other explanations for pain,experimental and human studies have provided evidence that pain perception at the peripheral level and central pain processing of the nociceptive information is altered in patients with chronic pancreatitis,and resembles that seen in neuropathic and chronic pain disorders.However,pain due to e.g.,complications to the disease and adverse effects to treatment must not be overlooked as an additional source of pain.This review outlines the current theories on pain generation in chronic pancreatitis which is crucial in order to understand the complexity and limitations of current therapeutic approaches.Furthermore,it may also serve as an inspiration for further research and development of methods that can evaluate the relative contribution and interplay of different pain mechanisms in the individual patients,before they are subjected to more or less empirical treatment. | Jakob Lykke Poulsen Sφren Schou Olesen Lasse Paludan Malver Jens Brφndum Frφkjr Asbjφrn Mohr Drewes | 2013 | World Journal of Gastroenterology2013，19，42： | 5 |
| 12 | Experimental human pain models in gastro-esophageal reflux disease and unexplained chest pain显示文摘Methods related to experimental human pain research aim at activating different nociceptors, evoke pain from different organs and activate specific pathways and mechanisms. The different possibilities for using mechanical, electrical, thermal and chemical methods in visceral pain research are discussed with emphasis of combinations (e.g., the multimodal approach). The methods have been used widely in assessment of pain mechanisms in the esophagus and have contributed to our understanding of the symptoms reported in these patients. Hence abnormal activation and plastic changes of central pain pathways seem to play a major role in the symptoms in some patients with gastro-esophageal reflux disease and in patients with functional chest pain of esophageal origin. These findings may lead to an alternative approach for treatment in patients that does not respond to conventional medical or surgical therapy. | Asbjφrn Mohr Drewes Lars Arendt-Nielsen Peter Funch-Jensen Hans Gregersen | 2006 | World Journal of Gastroenterology2006，12，18： | 5 |
| 13 | Assessment of the cardiovascular and gastrointestinal autonomic complications of diabetes显示文摘The global prevalence of diabetes mellitus is increasing; arguably as a consequence of changes in diet, lifestyle and the trend towards urbanization. Unsurprisingly, the incidence of both micro and macrovascular complications of diabetes mirrors this increasing prevalence. Amongst the complications with the highest symptom burden, yet frequently under-diagnosed and sub-optimally treated, is diabetic autonomic neuropathy, itself potentially resulting in cardiovascular autonomic neuropathy and gastrointestinal(GI) tract dysmotility. The aims of this review are fourfold. Firstly to provide an overview of the pathophysiological processes that cause diabetic autonomic neuropathy. Secondly, to discuss both the established and emerging cardiometric methods for evaluating autonomic nervous system function in vivo. Thirdly, to examine the tools for assessing pan-GI and segmental motility and finally, we will provide the reader with a summary of putative non-invasive biomarkers that provide a pathophysiological link between lowgrade neuro inflammation and diabetes, which may allow earlier diagnosis and intervention, which in future may improve patient outcomes. | Christina Brock Birgitte Brock Anne Grave Pedersen Asbjorn Mohr Drewes Niels Jessen Adam D Farmer | 2016 | World Journal of Diabetes2016，7，16： | 5 |
| 14 | Understanding and treatment of chronic pancreatitis显示文摘Chronic pancreatitis is characterized by an inflammatory process of the pancreas,which is replaced by fibrosis and progressive destruction.The three major clinical features of chronic pancreatitis are pain,maldigestion,and diabetes.Chronic pancreatitis has a profound impact on social life and employment patterns.In the current issue,different topics highlight experimental models of chronic pancreatitis and bridge findings from recent research to bedside.Although the disease is still difficult to treat the current papers represent useful guidelines on how to approach chronic pancreatitis in the clinical settings with the major aim to improve the patient’s suffering and quality of life. | Asbjφrn Mohr Drewes | 2013 | World Journal of Gastroenterology2013，19，42： | 5 |
| 15 | ERCC2诱导表达在人脑胶质瘤细胞对BCNU耐药中的作用显示文摘目的 探讨BCNU诱导ERCC2表达在胶质瘤细胞耐药中的作用。方法 选用ERCC2基础表达在蛋白水平相同 ,而mRNA水平不同的 2株人脑胶质瘤细胞T98 G和SK MG 4(在mRNA水平 ,T98 G比SK MG 4高 2 5倍 ) ,在体外培养时用BCNU处理 ,随后采用WesternBlot测定肿瘤细胞的ERCC2蛋白水平变化。结果 对BCNU耐药的T98 G在BCNU处理后 6h ,ERCC2蛋白水平上升 6倍 ,随后逐渐下降 ,48h回复到基础水平。而对BCNU敏感的SK MG 4,BCNU处理后ERCC2蛋白水平没有增加。结论 本研究提示 ,mRNA基础水平与胶质瘤耐药密切相关 ,在mRNA基础水平较高的肿瘤细胞 ,BCNU能诱导ERCC2蛋白表达 ,并直接与肿瘤耐药相关。 | 陈忠平 Grard Mohr Lawrence C Panasci | 2003 | 中华神经外科杂志2003，19，1： | 5 |
| 16 | 面向未来的双燃料发动机技术进展显示文摘当前双燃料发动机正在大缸径发动机市场逐步觉醒。长期以来双燃料技术仅应用于电站发电领域,然而近十年来,由于纯天然气发动机性能的大幅度提高,以及采用大型中速发动机实现功率等级的延伸,电站市场显著萎缩。除了先前大量的陆用外,移动式应用也为大缸径双燃料发动机提供了更广阔的市场。上述应用包括船用主推进(例如液化天然气运输船,豪华游轮)和辅机应用(例如集装箱船)以及铁路牵引(例如,长途机车)。促使业界关注双燃料发动机的主要动力是,与使用昂贵的重油或柴油相比较低的燃料成本,以及降低以NOx为主的排放污染物进而满足未来的排放法规。另外,对于大量的移动式发动机的应用,天然气将很快成为一种潜在的低硫燃料。除天然气之外的典型液态替代燃料通常不利于在电站双燃料发动机的应用,然而对于移动式应用却是一种可靠的备用燃料。对于船舶应用可以在ECA(排放控制区)区域内外通过天然气和柴油模式切换,从而使双燃料发动机更容易满足IMO(国际海事组织)的排放法规。移动式应用的难点在于,频繁的转速工况变化、快速的负荷响应要求、天然气品质变化和复杂工况下,对发动机运转可靠性的考验。由于双燃料发动机具有两种典型运转模式(天然气工况和柴油工况),在发动机设计时必须进行折中考虑(例如压缩比、活塞碗形状、气门正时等),这就导致了目前效率和功率密度方面的缺陷。关于上述问题,奥地利AVL公司通过单缸中速发动机测试研究了双燃料发动机相关技术问题。对大量参数进行了评估并对工况边界条件进行了研究。基于获得的数据,将给出当前双燃料发动机技术的短期预测。AVL公司关于双燃料发动机技术的展望也将促进中期开发需求。 | Hinrich Mohr Torsten Baufeld 管明华 | 2013 | 国外铁道机车与动车2013，，6： | 5 |
| 17 | Nutrition in chronic pancreatitis显示文摘The pancreas is a major player in nutrient digestion.In chronic pancreatitis both exocrine and endocrine insufficiency may develop leading to malnutrition over time.Maldigestion is often a late complication of chronic pancreatic and depends on the severity of the underlying disease.The severity of malnutrition is correlated with two major factors:(1)malabsorption and depletion of nutrients(e.g.,alcoholism and pain)causes impaired nutritional status;and(2)increased metabolic activity due to the severity of the disease.Nutritional deficiencies negatively affect outcome if they are not treated.Nutritional assessment and the clinical severity of the disease are important for planning any nutritional intervention.Good nutritional practice includes screening to identify patients at risk,followed by a thoroughly nutritional assessment and nutrition plan for risk patients.Treatment should be multidisciplinary and the mainstay of treatment is abstinence from alcohol,pain treatment,dietary modifications and pancreatic enzyme supplementation.To achieve energy-end protein requirements,oral supplementation might be beneficial.Enteral nutrition may be used when patients do not have sufficient calorie intake as in pylero-duodenalstenosis,inflammation or prior to surgery and can be necessary if weight loss continues.Parenteral nutrition is very seldom used in patients with chronic pancreatitis and should only be used in case of GI-tract obstruction or as a supplement to enteral nutrition. | Henrik Hφjgaard Rasmussen φivind Irtun Sφren Schou Olesen Asbjφrn Mohr Drewes Mette Holst | 2013 | World Journal of Gastroenterology2013，19，42： | 4 |
| 18 | Multimodal pain stimulation of the gastrointestinal tract显示文摘疼痛和另外的感觉症状的理解和描述在在有胃肠的混乱的病人的诊断和评价的最重要的问题之中。唤起并且估计试验性的疼痛的方法最近为多模式的刺激与可能性发展成一个新区域(例如,电、机械、热、化学的刺激) 不同神经和疼痛,在人的小径毁坏。如此的方法模仿在诊所经验丰富的疼痛到高度。多模式的疼痛方法处于健康和疾病在内脏增加了我们不同外部受体的基本理解。和先进肌肉分析,方法增加了我们对敏感的受体的理解机械,在疾病的化学药品和温度刺激,例如全身的硬化和糖尿病。方法能也被用来解开中枢性痛机制例如涉及 allodynia 的那些,痛觉过敏和提交的疼痛。在中枢性痛机制的畸形经常依靠刺激可以帮助在这些病人理解症状的多模式的疼痛的长期的内脏疼痛和因此方法地在病人被看见。性差别在内脏的几疾病被观察了,并且在中枢性痛在男性和女性之间处理的差别用多模式的疼痛刺激被假设了。最后,多模式的方法最近被用来在官方补给的道对疼痛获得更多的卓见进药的效果。因此,多模式的方法无疑表示一个学生与内脏的各种各样的疾病在未来描述和病人的治疗向前走。 | Asbjφrn Mohr Drewes Hans Gregersen | 2006 | World Journal of Gastroenterology2006，12，16： | 4 |
| 19 | 心脏瓣膜病10年进展显示文摘对10年来结构性心脏瓣膜病的了解和治疗有了巨大的进展,包括微创手术的广泛应用和许多介入技术的发展和改进,这些创新将成为将来瓣膜治疗的常态。结构性瓣膜病的修复和置换仍然认为优于原有的保守治疗。过去10年在这方面有了很大的进步,尤其是微创外科和介入技术。这些发展使专家们能够治疗更多的病人,特别是一些以前认为无法处理的患者。 | Mohr FW 余国膺 | 2015 | 中国心脏起搏与心电生理杂志2015，0，2： | 4 |
| 20 | The effects of corporate social responsibility and price on consumer responses显示文摘 | LoisA. Mohr DeborahJ. Webb | 2005 | Journal of Consumer Affairs2005，，1： | 3 |
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