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| 1 | Metabolic syndrome as a risk factor for gallstone disease显示文摘AIM: To establish an association between the presence of metabolic syndrome and the development of gallstone disease.METHOIDS: We carried out a cross-sectional study in a check-up unit in a university hospital in Mexico City. We enrolled 245 subjects, comprising 65 subjects with gallstones (36 women, 29 men) and 180 controls (79women and 101 men without gallstones). Body mass index, waist circumference, blood pressure, plasma insulin, and serum lipids and lipoproteins levels were measured. Insulin resistance was calculated by homeostasis model assessment. Unconditional logistic regressionanalysis (univariate and multivariate) was used to calculate the risk of gallstone disease associated with the presence of at least three of the criteria (Adult Treatment Panel Ⅲ). Analyses were adjusted for age and sex.RESULTS: Among 245 subjects, metabolic syndrome was present in 40% of gallstone disease subjects, compared with 17.2% of the controls, adjusted by age and gender (odds ratio (OR) = 2.79; 95%CI, 1.46-5.33; P = 0.002),a dose-dependent effect was observed with each component of metabolic syndrome (OR = 2.36, 95%CI, 0.72-7.71;P = 0.16 with one component and OR = 5.54, 95%CI,1.35-22.74; P = 0.02 with four components of metabolic syndrome). Homeostasis model assessment was significantly associated with gallstone disease (adjusted OR = 2.25;95%CI, 1.08-4.69; P = 0.03).CONCLUSION: We conclude that as for cardiovascular disease and diabetes mellitus, gallstone disease appears to be strongly associated with metabolic syndrome. | Nahum Méndez-Sánchez Norberto C. Chavez-Tapia Daniel Motola-Kuba Karla Sanchez-Lara Guadalupe Ponciano-Rodríguez Héctor Baptista Martha H. Ramos Misael Uribe | 2005 | World Journal of Gastroenterology2005，11，11： | 32 |
| 2 | Adiponectin as a protective factor in hepatic steatosis显示文摘AIM: Obesityand insulin resistance (IR) are closely related to hepatic steatosis (HS), and adiponectin is a hepatic insulin sensitizer that has important effects in liver function.This study aims at investigating the relationship between serum adiponectin concentration and the presence of HS.METHODS: We carried out a cross-sectional study in a check-up unit of a University Hospital in Mexico City. We enrolled 196 subjects, comprising 98 subjects with HS (27 women, 71 men) and 98 controls (37 women and 61men). Anthropometric, metabolic and biochemical variables were measured in the two groups. Serum adiponectin and leptin concentrations were determined,their association with grade of HS tested, and concentrations,according to quartiles, compared between cases and controls. χ2 analysis for linear trends was used to test for a dose-response relationship and logistic regression analysis was conducted to test for a protective effect of adiponectin.RESULTS: The HS subjects were older and more obese than controls, with a central obesity pattern. In the fourth quartile of adiponectin concentrations, HS was less common and severe. In a multivariate model of the fourth quartile of the adiponectin concentrations, we observed a protective effect (OR = 0.17, 95%CI: 0.04-0.67, P= 0.01).In subjects with more severe HS, we observed higher leptin concentrations, and caloric intakes, total fat and iron consumption were higher than in controls.CONCLUSION: The results of the present study suggest that a high serum concentration of adiponectin is associated with a protective effect against HS. | Nahum Méndez-Sánchez Norberto C.Chávez-Tapia Antonio R.Villa Karla Sánchez-Lara Daniel Zamora-Valdés Martha H.Ramos Misael Uribe | 2005 | World Journal of Gastroenterology2005，11，12： | 12 |
| 3 | Serum leptin levels and insulin resistance are associated with gallstone disease in overweight subjects显示文摘AIM: To establish an association between the serum leptin levels and the development of gallstone disease (GD).METHODS: We carried out a non-matched case-controlled study in a university hospital in Mexico City. Two hundred and eighty-seven subjects were included: 97 cases with gallstones and 190 controls. Body mass index (BMI), fasting plasma leptin, insulin, serum lipid, and lipoprotein levels were measured. Insulin resistance was calculated by homeostasis model assessment (HOMA-IR). Unconditional logistic regression analysis (univariate and multivariate)stratified by BMI was used to calculate the risk of GD.RESULTS: The multivariate conditional regression analysis revealed a model for those patients with BMI <30. The selected variables in the model were HOMA-IR index with OR = 1.31, P= 0.02 and leptin higher than median with OR = 2.11, P= 0.05. In the stratum of BMI ≥30, we did not find a useful model.CONCLUSION: We concluded that insulin resistance and the development of GD appears to be associated with serum leptin levels in subjects with overweight, but not in obese subjects with similar metabolic profiles. | Nahum Méndez-Sánchez Luisa B Bermejo-Martínez Yolanda Vi(n|~)als Norberto C Chavez-Tapia Irina Vander Graff Guadalupe Ponciano-Rodríguez Martha H Ramos Misael Uribe | 2005 | World Journal of Gastroenterology2005，11，39： | 11 |
| 4 | Insulin sensitizers in treatment of nonalcoholic fatty liver disease:Systematic review显示文摘AIM: To summarize the evidence available for the clinical effectiveness of insulin sensitizers in the treatment of nonalcoholic fatty liver disease (NAFLD) systematically. METHODS: Relevant articles were located using computer-assisted searches of Medline (1966-March 2006), EMBASE (1988-March 2006), CINAHL (1982-March 2003), Educational Resource Information Center (1966-March 2006), Library, Information Science & Technology Abstracts (1967-March 2006), Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effects (1994-2006), dissertations in ProQuest and FirstSearch databases. Manual searches were made in the abstracts from meetings of the American Gastroenterological Association (1999-2006), and the American Association for the Study of Liver Diseases (2003-2005). Studies were retrieved using the following selection criteria: (1) clinical trials using insulin sensitizers in subjects with NAFLD, (2) adult patients, (3) published as full manuscripts or abstracts, and (4) English, Spanish, German, and French languages only. Data were abstracted independently by two reviewers following standardized procedures. A face-to- face comparison of data was conducted to ensure the completeness and reliability of the abstraction process. RESULTS: Nine studies were included, six using metformin and three using thiazolidinediones. Only two studies were placebo-controlled trials. The mediansample size for all studies was 18 subjects. In the placebo-controlled trials, metformin improved insulin resistance markers and liver function tests, but not histological scores. In the single-arm trials, metformin and thiazolidinediones improved insulin resistance markers and liver function tests, and beneficial histological changes were reported. There is limited high-quality information available from which to draw categorical conclusions about the clinical use of insulin sensitizers in NAFLD.CONCLUSION: Current information indicates that the use of insulin sensitizers in NAFLD improves insulin resistance and liver function. Histological changes must be corroborated in randomized controlled trials. | Norberto C Chavez-Tapia Tonatiuh Barrientos-Gutierrez Felix I Tellez-ávila Francisco Sánchez-ávila Maria Antonieta Montao-Reyes Misael Uribe | 2006 | World Journal of Gastroenterology2006，12，48： | 11 |
| 5 | Endoscopic submucosal dissection in dogs in a World Gastroenterology Organisation training center显示文摘AIM: To evaluate if canine models are appropriate for teaching endoscopy fellows the techniques of endoscopic submucosal dissection (ESD). METHODS: ESD was performed in 10 canine models under general anesthesia, on artificial lesions of the esophagus or stomach marked with coagulation points. After ESD, each canine model was euthanized and surgical resection of the esophagus or stomach was carried out according to 'The Principles of Humane Experimental Technique, Russel and Burch'. The ESD specimens were fixed with needles on cork submerged in a formol solution with the esophagus or stomach, and delivered to the pathology department to be analyzed. RESULTS: ESD was completed without complications using the Hook-knife in five esophageal areas, with a procedural duration of 124 ± 19 min, a length of 27.4 ± 2.6 mm and a width of 21 ± 2.4 mm. ESD was also completed without complications using the IT-knife2 in five gastric areas, with a procedural duration of 92.6 ± 19 min, a length of 32 ± 2.5 mm and a width of 18 ± 3.7 mm. CONCLUSION: ESD is feasible in the normal esopha- gus and stomach of canine models, which are appropriate for teaching this technique. | Miguel A Tanimoto Gonzalo Torres-Villalobos Rikiya Fujita Patricio Santillan-Doherty Jorge Albores-Saavedra German Gutierrez Luis A Martin-del-Campo Carlos Bravo-Reyna Octavio Villanueva Jose J Villalobos Misael Uribe Miguel A Valdovinos | 2010 | World Journal of Gastroenterology2010，16，14： | 7 |
| 6 | Prevalence of metabolic syndrome, obesity and diabetes type 2 in cryptogenic cirrhosis显示文摘AIM: To evaluate the prevalence of metabolic syndrome (MS), obesity and type 2 diabetes mellitus (T2DM) in a group of Mexican Mestizo patients with cryptogenic cirrhosis (CC) and to compare this group with patients with cirrhosis secondary to other causes (disease controls). METHODS: Patients with CC, diagnosed between January, 1990 and April, 2005, were included in a retrospective study. Patients with cirrhosis caused by chronic hepatitis C, alcohol abuse or autoimmune hepatitis (AIH) served as disease controls. RESULTS: A total of 134 patients with CC were analyzed. Disease controls consisted of 81 patients with chronic hepatitis C, 33 with alcohol abuse and 20 with AIH. The median age of patients with CC was 57 years (range, 16-87); 83 (61.9%) patients were female; 53 (39.6%) were Child A, 65 (48.5%) Child B, and 16 (11.9%) were Child C cirrhosis. The prevalence of MS (29.1% vs 6%; P < 0.001), obesity (16.4% vs 8.2%; P = 0.04) and T2DM (40% vs 22.4%; P = 0.013) was higher in CC patients than in disease controls. There were no differences in sex, age or liver function tests between the two groups. CONCLUSION: The prevalence of MS, obesityand T2DM were higher in patients with CC than in patients with cirrhosis secondary to others causes. Our findings support the hypothesis that non-alcoholic steatohepatitis (NASH) plays an under-recognized role in CC. | Felix I Tellez-Avila Francisco Sanchez-Avila Mauricio García-Saenz-de-Sicilia Norberto C Chavez-Tapia Ada M Franco-Guzman Gustavo Lopez-Arce Eduardo Cerda-Contreras Misael Uribe | 2008 | World Journal of Gastroenterology2008，14，30： | 6 |
| 7 | Factors that influence outcome in non-invasive and invasive treatment in polycystic liver disease patients显示文摘AIM: To evaluate the factors that influence outcome of both non-invasive and invasive treatment of polycystic liver disease. METHODS: Analysis of clinical files of patients with complete follow-up from July 1986 to June 2006. RESULTS: Forty-one patients (male, 7; female, 34), 47.8 ± 11.9 years age, and 5.7 ± 6.7 years follow-up, were studied. Alkaline phosphatase (AP) elevation (15% of patients) was associated with the requirement of invasive treatment (IT, P = 0.005). IT rate was higher in symptomatic than non-symptomatic patients (65.4% vs 14.3%, P = 0.002), and in women taking hormonal replacement therapy (HRT) (P = 0.001). Cysts complications (CC) were more frequent (22%) in the symptomatic patients group (P = 0.023). Patients with body mass index (BMI) > 25 (59%) had a trend to complications after IT (P = 0.075). Abdominal pain was the most common symptom (56%) and indication for IT (78%). Nineteen patients (46%) required a first IT: 12 open fenestration (OF), 4 laparoscopic fenestration (LF) and 3 fenestration with hepatic resection (FHR). Three required a second IT, and one required a third procedure. Complications due to first IT were found in 32% (OF 16.7%, LF 25%, FHR 66.7%), and in thesecond IT in 66.7% (OF 100%). Follow-up mortality rate was 0. CONCLUSION: Presence of symptoms, elevated AP, and CC are associated with IT requirement. HRT is associated with presence of symptoms and IT requirement. Patients with BMI > 25 have a trend be susceptible to IT complications. The proportions of complications are higher in FHR and second IT groups. RS is more frequent after OF. | Josué Barahona-Garrido Jesús Camacho-Escobedo Eduardo Cerda-Contreras Jorge Hernández-Calleros Jesús K Yamamoto-Furusho Aldo Torre Misael Uribe | 2008 | World Journal of Gastroenterology2008，14，20： | 4 |
| 8 | Mitochondrial DNA from hepatocytes as a ligand for TLR9: Drivers of nonalcoholic steatohepatitis?显示文摘Nonalcoholic fatty liver disease(NAFLD) is the most common liver disease worldwide, affecting approximately one third of the Western world. It consists of a wide spectrum of liver disorders, ranging from fatty liver to nonalcoholic steatohepatitis(NASH), which consists of steatosis, ballooning injury and inflammation. Despite an alarming growth in the statistics surrounding NAFLD, there are as yet no effective therapies for its treatment. Innate immune signaling has been thought to play a significant role in initiating and augmenting hepatic inflammation, contributing to the transition from nonalcoholic fatty liver to NASH. An immune response is triggered by countless signals called damage-associated molecular patterns(DAMPs) elicited by lipid-laden and damaged hepatocytes, which are recognized by pattern recognition receptors(PRRs) on hepatic immune cells to initiate inflammatory signaling. In this editorial, in addition to summarizing innate immune signaling in NAFLD and discussing potential therapies that target innate immune pathways, we have described a recent study that demonstrated that mitochondrial DNA serves as a DAMP activating a hepatic PRR, TLR9, in mice and in the plasma of NASH patients. In addition to identifying a new ligand for TLR9 during NASH progression, the study shows that blocking TLR9 reverses NASH, paving the way for the development of future NASH therapy. | Priya Handa Akhila Vemulakonda Kris V Kowdley Misael Uribe Nahum Méndez-Sánchez | 2016 | World Journal of Gastroenterology2016，22，31： | 3 |
| 9 | Smoking is not associated with nonalcoholic fatty liver disease显示文摘瞄准:分析在吸烟和不含酒精的脂肝疾病(NAFLD ) 之间的关系。方法:这是一张健康人口的代表性的研究,在墨西哥在一所大学医院的一个检查单位执行了城市。我们注册了 933 个题目, 368 个当前的吸烟者(盒子) 和从来没吸过的 565 个人(控制) 。人口统计、新陈代谢、生物化学的变量在二个组被测量。NAFLD 被超声和新陈代谢的症候群根据 ATPIII 决定。结果:548 个男人(205 个盒子和 343 控制) 和 337 个女人(114 个盒子和 223 控制) 的一个总数在分析被包括。盒子和控制之间的统计差别仅仅在高血压流行被观察(6.6% 对 11.3% , P <
0.05;盒子和控制分别地),高密度的脂蛋白( 1.00 +/- 0.26 对 1.06 +/- 0.28 mmol/L , P <
0.005 ), triglycerides ( 2.18 +/- 1.49 对 1.84 +/- 1.1 mmol/L , P <
0.001 ),并且红细胞沉降率( 11.3 +/- 9.3 对 13.5 +/- 11.9 mm/h , P <
0.001 )。没有差别在 NAFLD 的流行被观察(22.27% 对 29.68% , P = NS ) 并且新陈代谢的症候群(41.69% 对 36.74% , P = NS ) 。Univariate 分析证明吸烟不是为 NAFLD 的一个风险因素(或 = 0.89, 95% CI 0.65-1.21 ) 。结论:在 NAFLD 流行的差别都没在当前的吸烟者和不抽烟的人之间被观察,并且而且,没有差别在重吸烟者(超过 20 包装 / 年) 被观察,显示在吸烟和 NAFLD 之间没有关系。 | Norberto C Chavez-Tapia Javier Lizardi-Cervera Oliver Perez-Bautista Martha H Ramos-Ostos Misael Uribe | 2006 | World Journal of Gastroenterology2006，12，32： | 2 |
| 10 | Clinical heterogeneity in autoimmune acute liver failure显示文摘AIM: To describe the outcome and prognosis in a cohort of patients with acute liver failure due to autoimmune hepatitis without liver transplantation. METHODS: A retrospective trial was conducted in 11 patients with acute liver failure due to autoimmune hepatitis who attended the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran. Demographic, biochemical and severity indexes, and treatment and outcome were assessed. RESULTS: Among the 11 patients, with a median age of 31 years, 72% had inflammatory response syndrome, and six patients received corticosteroids. The mortality rate within four weeks was 56%, and the one-year survival was 27%. In the survivors, severity indexes were lower and 83% received corticosteroids. CONCLUSION: We observed a relatively high survival rate in patients with acute liver failure due to autoimmune hepatitis. This survival rate could be influenced by severity of the disease and/or use of corticosteroids. | Norberto C Chavez-Tapia Julio Martinez-Salgado Julio Granados Misael Uribe Felix I Tellez-Avila | 2007 | World Journal of Gastroenterology2007，13，12： | 1 |
| 11 | Learning Curve in a Western Training Center of the Circumferential En Bloc Esophageal Endoscopic Submucosal Dissection in an In Vivo Animal Model显示文摘 | Miguel A. Tanimoto Gonzalo Torres-Villalobos Rikiya Fujita Patricio Santillan-Doherty Jorge Albores-Saavedra Fredy Chable-Montero Luis A. Martin-del-Campo Lucia Vasquez Carlos Bravo-Reyna Octavio Villanueva Jose J. Villalobos Misael Uribe Miguel A. Valdov | 2011 | Diagnostic and Therapeutic Endoscopy2011，，： | 1 |
| 12 | Eosinophilic Gastroenteritis: A Review显示文摘 | Nahum Méndez-Sánchez Norberto C. Chávez-Tapia Genaro Vazquez-Elizondo Misael Uribe | 2007 | Digestive Diseases and Sciences2007，，11： | 1 |
| 13 | Invitro study of a ferromagnetic stent for implant assisted - magnetic drug targeting显示文摘 | Misael O Aviles Chen Haitao Armin D Ebner | 2007 | Condensed Matter2007，388，1： | 1 |
| 14 | In vitro study of a ferromagnetic stent for implant assisted-magnetic drug targeting显示文摘 | Misael O Aviles Chen Haitao Armin D Ebner | 2007 | Condensed Matter2007，311，1： | 1 |
| 15 | Theoretical analysis of a transdermal ferromagnetic implant for retention of magnetic drug carrier particles 显示文摘 | Misael O Aviles Armin D Ebner | 2005 | J Mag Mag Mat2005，293，1： | 1 |
| 16 | Ferromagnetic seeding for the magnetic targeting of drugs and radiation in capillary beds 显示文摘 | Misael O Aviles Armin D Ebner James A Ritter | 2007 | J Mag Mag Mat2007，310，1： | 1 |
| 17 | Role of diet in cholesterol gallstone formation显示文摘 | Nahum Méndez-Sánchez Daniel Zamora-Valdés Norberto C. Chávez-Tapia Misael Uribe | 2006 | Clinica Chimica Acta2006，，1： | 1 |
| 18 | 显示文摘 | Misael O A Chen H T Armin D E | 2007 | Journal of Magnetism and Magnetic Materials2007，311，1： | 1 |
| 19 | Multifunctional, multichannel bridges that deliver neurotrophin encoding lentivirus for regeneration following spinal cord injury显示文摘 | Hannah M. Tuinstra Misael O. Aviles Seungjin Shin Samantha J. Holland Marina L. Zelivyanskaya Alan G. Fast Sarah Y. Ko Daniel J. Margul Anne K. Bartels Ryan M. Boehler Brian J. Cummings Aileen J. Anderson Lonnie D. Shea | 2011 | Biomaterials2011，，5： | 1 |
| 20 | Influence of S. babylonica extract on feed intake, growth performance and diet in vitro gas production profile in young lambs显示文摘 | Abdelfattah Z.M. Salem Ahmed E. Kholif Misael Olivares Mona M.Y. Elghandour Miguel Mellado Javier Arece | 2014 | Tropical Animal Health and Production2014，，1： | 1 |
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