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26篇 您的检索式：作者名="Mirando"

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	题名	作者	年代	出处	被引量
1	Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9显示文摘RBPjk-dependent Notch signaling regulates both the onset of chondrocyte hypertrophy and the progression to terminal chondrocyte maturation during endochondral ossification. It has been suggested that Notch signaling can regulate Sox9 transcription, although how this occurs at the molecular level in chondrocytes and whether this transcriptional regulation mediates Notch control of chondrocyte hypertrophy and cartilage development is unknown or controversial. Here we have provided conclusive genetic evidence linking RBPjk-dependent Notch signaling to the regulation of Sox9 expression and chondrocyte hypertrophy by examining tissuespecific Rbpjk mutant(Prx1Cre;Rbpjkf/f), Rbpjk mutant/Sox9 haploinsufficient(Prx1Cre;Rbpjkf/f;Sox9f/1),and control embryos for alterations in SOX9 expression and chondrocyte hypertrophy during cartilage development. These studies demonstrate that Notch signaling regulates the onset of chondrocyte maturation in a SOX9-dependent manner, while Notch-mediated regulation of terminal chondrocyte maturation likely functions independently of SOX9. Furthermore, our in vitro molecular analyses of the Sox9 promoter and Notch-mediated regulation of Sox9 gene expression in chondrogenic cells identified the ability of Notch to induce Sox9 expression directly in the acute setting, but suppresses Sox9 transcription with prolonged Notch signaling that requires protein synthesis of secondary effectors.	Anat Kohn Timothy P Rutkowski Zhaoyang Liu Anthony J Mirando Michael J Zuscik Regis J O'Keefe Matthew J Hilton	2015	Bone Research2015，3，3：	8
2	Secreted Threonyl-tRNA synthetase stimulates endothelial cell mi-gration and angiogenesis显示文摘	Williams TF Mirando AC Wilkinson B		0，，：	1
3	RBP-Jkappa-de- pendent Notch signaling is required for murine articular cartilage and joint maintenance 显示文摘	MIRANDO A J LIU Z MOORE T	2013	Arthritis Rheum2013，65，10：	1
4	The role of essential trace elements in embryonic and fetal development in livestock显示文摘	HOSTETLER C E KINCAID R L MIRANDO M A	2003	Vet J2003，166，2：	1
5	Expression of the uterine Mx protein in cyclic and pregnant cows,gilts,and mares显示文摘	Hicks BA Etter SJ Carnahan KG Joyce MM Assiri AA Carling SJ Kodali K Johnson GA Hansen TR Mirando MA Woods GL Vandervall DK Ott TL		0，，06：	1
6	An inflammatory eruption associated with recombinant human IL-6显示文摘	Fleming TE Mirando WS Soohoo LF	1994	Br J Dermatol1994，130，4：	1
7	Retinol binding protein:a major secretory product of the pig conceptus显示文摘	Jacob P Harney M A Mirando L C	1990	Bio Reprod1990，42，：	1
8	Structure of the metabolism LL-S490 beta from an unidentified Aspersillus species显示文摘	ELLESTAD G A MIRANDO P KUNSTMANN M P	1973	Journal of Organic Chemistry1973，38，24：	1
9	Retinol- binding protein: A major secretory product of the pig conceptus显示文摘	Harney J P Mirando M A Smith L C	1990	Biol Reprod1990，42，：	1
10	Cartilage-specific RBPj- dependent and -independent Notch signals regulate cartilage and bone development 显示文摘	Kohn A Dong Y Mirando AJ	2012	Development2012，139，6：	1
11	Genetic Algorithms in Optimal Multistage Distribution Network Planning显示文摘	Vladimiro Mirando	1994	IEEE Transaction on Power System1994，9，4：	1
12	Cartilage- specific RBPjk- dependent and - independent Notch signals regulate cartilage and bone develop- ment显示文摘	Kohn A Dong Y Mirando A J	2012	Development2012，139，：	1
13	Retinol binding pro- tein:a major secretory product of the pig conceptus显示文摘	Jacob P Harney M A Mirando L C	1990	Bio Re- prod1990，，42：	1
14	beta-catenin/cyclin D1 mediated development of suture mesenchyme in calvarial morphogenesis显示文摘	Mirando AJ Maruyama T Fu J	2010	BMC Dev Biol2010，10，：	1
15	Exogenous oxytocin stimulates uterine secretion of prostaglandin F2 alpha in cyclic and early pregnant swine显示文摘	Prince BC Mirando MA	1996	Biol Reprod1996，55，4：	1
16	Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation显示文摘	Fu J Jiang M Mirando A J	2009	Proc Natl Acad Sci U S A2009，106，18：	1
17	Introducing an integrated care pathway for the last days of life显示文摘	Mirando S Davies PD	2005	Palliative Medicine2005，19，：	1
18	Induction of partruition: a comparison of the effects of lutalyse and estrumate in sows显示文摘	Conover ML Mirando M Newberry R	2001	Washington State University the McNair Journal2001，，1：	1
19	Dietary sup-plementation of proteinated trace minerals influences reproduc-tive performance of sows 显示文摘	Mirando M A Peters D N Hostetler C E	1993	Journal of Animal Science1993，71，1：	1
20	Retionl binding pmtein:a major decretory product of the pig conceptus 显示文摘	HARNEY J P MIRANDO M A SMITH L C	1990	Biol Re- prod1990，42，3：	1

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