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| 1 | Influence of ellagic acid on prostate cancer cell proliferation:A caspase-dependent pathway显示文摘Objective:To evaluate the effect of allagic acid treatment on the cell viability of human prostate cancer cells.Methods:Ellagic acid(10-100 mol/L) treatment(48 h) of human prostate carcinoma PC3 cells was found to result in a dose-dependent inhibition of cell growth and apoptosis of PC3 cells as assessed by MTT assay,western blotting.flow cytometry and confocal microscopy.Results:We observed that ellagic acid treatment of PC3 cells resulted in a dose dependent inhibition of cell growth/cell viability.This ellagic acid caused cell growth inhibition was found to be accompanied by induction of apoptosis,as assessed by the cleavage of poly (ADP-ribose) polymerase(PARP) and morphological changes.Further,induction of apoptosis accompanied a decrease in the levels of antiapoptotic protein Bcl-2 and increase in proapoptotic protein Bax.thus shifting the Bax:Bcl-2 ratio in favor of apoptosis.Ellagic acid treatment of PC3 cells was also found to result in significant activation of caspases,as shown by the dose dependent decrease in the protein expression of procaspase-3,-6.-8 and -9.This ellagic acid-mediated induction of apoptosis was significantly(80%-90%) inhibited by the caspase inhibitor N-benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone(Z-VAD-FMK).Thus these data suggested an essential role of caspases in ellagic acid-mediated apoptosis of PC3 cells.Conclusions:It is tempting to suggest that consumption of tropical pigmented fruits and vegetables could be an effective strategy to combat prostate cancer. | Arshi Malik Sarah Afaq Mohammad Shahid Kafil Akhtar Abdullah Assiri | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，7： | 18 |
| 2 | 泰国热带典型岩溶峰丛谷地区不同土地利用土下的溶蚀速率显示文摘岩溶作用对气候、水文与土地利用等环境因子变化十分敏感。对比不同气候区岩溶作用的空间(土地利用的影响)及季节变化,有助于进一步揭示岩溶作用的短时间尺度效应。本文以泰国北碧赛要县普特热带岩溶峰丛谷地小流域为背景,利用标准溶蚀试片法研究不同土地利用区土下溶蚀量,分析了溶蚀速率的差异程度与影响因素,并与中国西南亚热带典型峰丛洼地区进行了对比。结果表明,空中(离地面1.5m高)年平均溶蚀量为27.2~31.7mg,变化较小;土下不同深度年平均溶蚀量为29.2~266.6mg。旱季与雨季土下平均溶蚀量分别为12.1~37.4mg和71.6~173.0mg,雨季最大溶蚀量发生在竹林地土下20cm处(213.6mg),而旱季最大溶蚀量则发生在稀疏乔木林地土下50cm处(57.7mg)。不同土地利用区试片土下平均溶蚀量为83.8~210.4mg/a,雨季土下溶蚀量占全年溶蚀量的57.2%~87.9%,平均为76.5%。年平均溶蚀量从大到小依次发生在竹林地、稀疏乔木林地、荒草地、人工林地与灌木林地。土下溶蚀速率为29.0~72.8t/km2·a,远高于中国西南亚热带典型峰丛洼地岩溶区,与灌木和乔木林地对比,普特热带峰丛洼地区土下溶蚀速率是我国西南亚热带的1.5~2.5倍,说明热带高温与均一化降雨过程配置以土壤有机碳快速分解产生的高CO2浓度是导致强烈岩溶作用发生的重要控制因素。土壤的演化总体上可促进岩溶作用,但过高的土壤无机碳含量和异源母质混入可能对土下溶蚀产生不利影响。 | 章程 Mahippong Worakul 汪进良 Patsakron Assiri 黄奇波 张强 肖琼 苗迎 | 2016 | 第四纪研究2016，36，6： | 8 |
| 3 | Drainage vs. non-drainage after cholecystectomy for acute cholecystitis:a retrospective study显示文摘Many surgeons practice prophylactic drainage after cholecystectomy without reliable evidence,this study was conducted to answer the question whether to drain or not to drain after cholecystectomy for acute calculous cholecystitis.A retrospective review of all patients who had cholecystectomy for acute cholecystitis in Aseer Central Hospital,Abha,Saudi Arabia,was conducted from April 2010 to April 2012.Data were extracted from hospital case files.Preoperative data included clinical presentation,routine investigations and liver function tests.Operative data included excessive adhesions,bleeding,bile leak,and drain insertion.Complicated cases such as pericholecystic collections,mucocele and empyema were also reported.Patients who needed therapeutic drainage were excluded.Postoperative data included hospital stay,volume of drained fluid,time of drain removal,and drain site problems.The study included 103 patients allocated into two groups;group A(n = 38) for patients with operative drain insertion and group B(n = 65) for patients without drain insertion.The number of patients with preoperative diagnosis of acute non-complicated cholecystitis was significantly greater in group B(80%) than group A(36.8%)(P < 0.001).Operative time was significantly longer in group A.All patients who were converted from laparoscopic to open cholecystectomy were in group A.Multivariate analysis revealed that hospital stay was significantly(P < 0.001) longer in patients with preoperative complications.There was no added benefit for prophylactic drain insertion after cholecystectomy for acute calculous cholecystitis in non-complicated or in complicated cases. | Mohammed A Bawahab Walid M Abd El Maksoud Saeed A Alsareii Fahad S Al Amri Hala F Ali Abdul Rahman Nimeri Abdul Rahman M Al Amri Adel A Assiri Mohammed I Abdul Aziz | 2014 | The Journal of Biomedical Research2014，28，3： | 3 |
| 4 | Impacts of center pivot irrigation system uniformity on growth of potato crop and residual soil nitrogen显示文摘Maintaining the homogeneity of soil nitrogen(N)and plant vigor across agricultural fields is a major concern for farmers and agricultural scheme planners,particularly fields that are irrigated through pressurized systems,such as center pivots.Therefore,this study was carried out on a 30 hm2 potato field located 650 km south of Riyadh,the capital city of the Kingdom of Saudi Arabia,to investigate the impacts of the center pivot irrigation distribution uniformity on the crop development and the spatial distribution of residual soil N.Irrigation performance test was designed to investigate water application rate and distribution uniformities.The overall water application uniformity coefficients(Cu),determined through Christiansen(Cud)and Heerman(CuH)methods,were determined at 81.29%and 80.64%,respectively.However,the overall water distribution uniformity(Du)was determined at 70%.A considerable variability in the distribution uniformity of irrigation water was observed across the experimental field(a Du value of 67%over the medium spans compared to a Du value of 88%over the inner spans).Results of this study showed a linear correlation between the irrigation water distribution uniformity and the soil N(R^(2)=0.88).On the other hand,the vegetation cover distribution,indicated by the Cumulative Normalized Difference Vegetation Index(CNDVI),was not found to be much responsive to the irrigation distribution uniformity(R^(2)=0.11).A time series of successive NDVI maps extracted throughout the potato crop growth stages showed a consistent trend in the distribution of NDVI across the field,with R2 values that ranged between 0.25-0.73. | Khalid A.Al-Gaadi Abdalhaleem A.Hassaballa ElKamil Tola Ahmed G.Kayad Rangaswamy Madugundu Fahad Assiri Mohamed Edrris Ahmed Alameen Haroon Edrees | 2019 | International Journal of Agricultural and Biological Engineering2019，12，1： | 2 |
| 5 | Prevalence of MERS- CoV nasal carriage and compliance with the Saudi health recommendations among pilgrims attending the 2013 Hajj 显示文摘 | Memish ZA Assiri A Almasri M | 2014 | J Infect Dis2014，210，7： | 1 |
| 6 | Atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion:cytohistologic correlation study with diagnostic pitfalls显示文摘 | Mokhtar GAiDelatour NL Assiri AH | 2008 | Acta Cytol2008，52，： | 1 |
| 7 | Middle East respiratory syndrome coronavirus disease in children显示文摘 | Ziad A Memish Jaffar A A1-Tawfiq Abdullah Assiri | 2014 | Pedi- atr Infect Dis J2014，，33： | 1 |
| 8 | Middle East respiratory syn- drome coronavirus disease in children 显示文摘 | Memish ZA AI-Tawfiq JA Assiri A | 2014 | Pediatr Infect Dis J2014，33，9： | 1 |
| 9 | Occupational exposure to blood-borne pathogens in a tertiary hospital:benchmarking using patient days显示文摘 | MAZI W SENOK A C ASSIRI A M | 2015 | Asia Pac J Public Health2015，27，2： | 1 |
| 10 | Middle East respiratory syndrome coronavirus ( MERS-CoV ) viral shedding in the respiratory tract: an observational analysis with infection control implications 显示文摘 | Memish ZA Assiri AM AI-Tawfiq JA | 2014 | Int J Infect Dis2014，29，： | 1 |
| 11 | Prevalence of MERS- CoV Nasal Carriage and Compliance with the Saudi Health Recommendations Among Pilgrims Attending the 2013 Hajj显示文摘 | Memish ZA Assiri A Almasri M | 2014 | J Infect Dis2014，210，： | 1 |
| 12 | Corticoste- roid administration and outcome of adolescents and adults with acute bacterial meningitis: a meta-analysis显示文摘 | Assiri AM Alasmari FA Zimmerman VA | 2012 | Mayo Clin Proc2012，8，4： | 1 |
| 13 | Heart failure models: traditional and novel therapy 显示文摘 | Haidara M A Assiri A S Yassin H Z | 2015 | Curr Vase Pharmacol2015，13，1： | 1 |
| 14 | Mixed treatment comparison meta-analysis of aspirin,warfarin,and new anticoagulants for stroke prevention in patients with nonvalvular atrial fibrillation显示文摘 | Assiri A A1-Majzoub 0 Kanaan A 0 | | 0，，7： | 1 |
| 15 | Anomaly Classification Using Genetic Algorithm-Based Random Forest Modelfor Network Attack Detection显示文摘Anomaly classification based on network traffic features is an important task to monitor and detect network intrusion attacks.Network-based intrusion detection systems(NIDSs)using machine learning(ML)methods are effective tools for protecting network infrastructures and services from unpredictable and unseen attacks.Among several ML methods,random forest(RF)is a robust method that can be used in ML-based network intrusion detection solutions.However,the minimum number of instances for each split and the number of trees in the forest are two key parameters of RF that can affect classification accuracy.Therefore,optimal parameter selection is a real problem in RF-based anomaly classification of intrusion detection systems.In this paper,we propose to use the genetic algorithm(GA)for selecting the appropriate values of these two parameters,optimizing the RF classifier and improving the classification accuracy of normal and abnormal network traffics.To validate the proposed GA-based RF model,a number of experiments is conducted on two public datasets and evaluated using a set of performance evaluation measures.In these experiments,the accuracy result is compared with the accuracies of baseline ML classifiers in the recent works.Experimental results reveal that the proposed model can avert the uncertainty in selection the values of RF’s parameters,improving the accuracy of anomaly classification in NIDSs without incurring excessive time. | Adel Assiri | 2021 | Computers, Materials & Continua2021，，1： | 1 |
| 16 | Epidemiologi- eal, demographic, and clinical characteristics of 47 cases of Mid- dle East respiratory syndrome eoronavirus disease from Saudi Ara- bia : a descriptive study 显示文摘 | Assiri A A1-Tawfiq JA A1-Rabeeab AA | 2013 | Lancet Infect Dis2013，13，9： | 1 |
| 17 | Candida and other yeasts of clinical importance in Aseer region, southern Saudi Arabia显示文摘 | Hamid ME Assiry MM Joseph MR | 2014 | Saudi Med J2014，35，10： | 1 |
| 18 | Gingival en- largement in different age groups during fixed orthodontic treatment显示文摘 | Hossam A Eid Hassan Ahmed M Assiri | 2014 | Int Oral Health2014，6，1： | 1 |
| 19 | An infant with biliary aseites 显示文摘 | Saeed A Mouzan ME Assiri A | 2014 | J Coil Physieians Surg Pak2014，24，11： | 1 |
| 20 | Hospital outbreak of Mid- dle East respiratory syndrome coronavirus显示文摘 | Assiri A McGeer A Perl TM | 2013 | N Engl J Med2013，369，5： | 1 |
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