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| 1 | Xueshuantong improves cerebral blood perfusion in elderly patients with lacunar infarction显示文摘A total of 64 patients with acute lacunar infarction were enrolled within 24 hours of onset. The patients received conventional therapy (antiplatelet drugs and hypolipidemic drugs) alone or conventional therapy plus 450 mg Xueshuantong once a day. The main ingredient of the Xueshuantong lyophilized powder used for injection was Panax notoginseng saponins. Assessments were made at admission and at discharge using the National Institutes of Health Stroke Scale, the Activity of Daily Living and the Mini-Mental State Examination. Additionally, the relative cerebral blood flow, relative cerebral blood volume and relative mean transit time in the region of interest were calculated within 24 hours after the onset of lacunar infarction, using dynamic susceptibility contrast magnetic resonance perfusion imaging technology. Patients underwent a follow-up MRI scan after 4 weeks of treatment. There was an improvement in the Activity of Daily Living scores and a greater reduction in the scores on the National Institutes of Health Stroke Scale in the treatment group than in the control group. However, the Mini-Mental State Examination scores showed no significant differences after 4 weeks of treatment. Compared with the control group, the relative cerebral blood flow at discharge had increased and showed a greater improvement in the treatment group. Furthermore, there was a reduction in the relative mean transit time at discharge and the value was lower in the treatment group than in the control group. The experimental findings indicate that Xueshuantong treatment improves neurological deficits in elderly patients with lacunar infarction, and the mechanism may be related to increased cerebral perfusion. | Qifeng Gui Yunmei Yang Shihong Ying Minming Zhang | 2013 | Neural Regeneration Research2013，8，9： | 27 |
| 2 | Region-Specific Iron Measured by MRI as a Biomarker for Parkinson's Disease显示文摘The identification of sensitive and specific biomarkers for Parkinson's disease(PD) poses an important clinical challenge. A potential biomarker for early diagnosis and disease monitoring of PD is region-specific iron. Iron accumulation in the substantia nigra pars compacta is considered a main characteristic of PD.However, questions remain, such as the relationship between nigral iron and clinical indices of PD(motor impairment or disease duration). Further, previous studies have suggested the influence of iron on other nuclei. Iron quantification using magnetic resonance imaging(MRI)allows for studies of the relationship between regional iron and clinical symptoms in vivo. Thus, in this review we discuss the following topics: the technological development of MRI in measuring brain iron, nigral iron as a potential marker for PD in both clinical and prodromal stages, other influences of regional iron on PD, and clinical translation and future perspectives. | Xiaojun Guan Xiaojun Xu Minming Zhang | 2017 | Neuroscience Bulletin2017，33，5： | 13 |
| 3 | Inverse design of digital nanophotonic devices using the adjoint method显示文摘A high-efficiency inverse design of'digital'subwavelength nanophotonic devices using the adjoint method is proposed.We design a single-mode 3dB power divider and a dual-mode demultiplexer to demonstrate the efficiency of the proposed inverse design approach,called the digitized adjoint method,for single-and dual-object optimization,respectively.The optimization comprises three stages:1)continuous variation for an'analog'pattern;2)forced permittivity biasing for a'quasi-digital'pattern;and 3)a multilevel digital pattern.Compared with the conventional brute-force method,the proposed method can improve design efficiency by about five times,and the performance optimization can reach approximately the same level.The method takes advantages of adjoint sensitivity analysis and digital subwavelength structure and creates a new way for the efficient and high-performance design of compact digital subwavelength nanophotonic devices,which could overcome the efficiency bottleneck of the brute-force method,which is restricted by the number of pixels of a digital pattern,and improve the device performance by extending a conventional binary pattern to a multilevel one. | KAIYUAN WANG XINSHU REN WEIJIE CHANG LONGHUI LU DEMING LIU MINMING ZHANG | 2020 | Photonics Research2020，8，4： | 7 |
| 4 | Optical meta-waveguides for integrated photonics and beyond显示文摘The growing maturity of nanofabrication has ushered massive sophisticated optical structures available on a photonic chip.The integration of subwavelength-structured metasurfaces and metamaterials on the canonical building block of optical waveguides is gradually reshaping the landscape of photonic integrated circuits,giving rise to numerous metawaveguides with unprecedented strength in controlling guided electromagnetic waves.Here,we review recent advances in meta-structured waveguides that synergize various functional subwavelength photonic architectures with diverse waveguide platforms,such as dielectric or plasmonic waveguides and optical fibers.Foundational results and representative applications are comprehensively summarized.Brief physical models with explicit design tutorials,either physical intuition-based design methods or computer algorithms-based inverse designs,are cataloged as well.We highlight how meta-optics can infuse new degrees of freedom to waveguide-based devices and systems,by enhancing light-matter interaction strength to drastically boost device performance,or offering a versatile designer media for manipulating light in nanoscale to enable novel functionalities.We further discuss current challenges and outline emerging opportunities of this vibrant field for various applications in photonic integrated circuits,biomedical sensing,artificial intelligence and beyond. | Yuan Meng Yizhen Chen Longhui Lu Yimin Ding Andrea Cusano Jonathan A.Fan Qiaomu Hu Kaiyuan Wang Zhenwei Xie Zhoutian Liu Yuanmu Yang Qiang Liu Mali Gong Qirong Xiao Shulin Sun Minming Zhang Xiaocong Yuan Xingjie Ni | 2021 | Light(Science & Applications)2021，10，12： | 6 |
| 5 | Longitudinal Alterations of Local Spontaneous Brain Activity in Parkinson's Disease显示文摘We used resting-state fMRI to evaluate longitudinal alterations in local spontaneous brain activity in Parkinson's disease(PD) over a 2-year period. Data were acquired from 23 PD patients at baseline and follow-up,and 27 age-and sex-matched normal controls. Regional homogeneity(ReHo) and voxel-based-morphometry(VBM) were used to identify differences in local spontaneous brain activity and grey matter volume. With disease progression, we observed a progressive decrease in ReHo in the sensorimotor cortex, default-mode network, and left cerebellum, but increased ReHo in the supplementary motor area, bilateral temporal gyrus, and hippocampus.Moreover, there was a significant positive correlation between the rates of ReHo change in the left cerebellum and the rates of change in the Unified Parkinson's Disease Rating Scale-III scores. VBM revealed no significant differences in the grey matter volume among the three sets of acquisitions. We conclude that ReHo may be a suitable non-invasive marker of progression in PD. | Qiaoling Zeng Xiaojun Guan Jason C.F.Law Yan Lun Zhujing Shen Tao Guo Min Xuan Quanquan Gu Xiaojun Xu Min Chen Minming Zhang | 2017 | Neuroscience Bulletin2017，33，5： | 4 |
| 6 | Ultracompact dual-mode waveguide crossing based on subwavelength multimode-interference couplers显示文摘We propose and experimentally demonstrate a novel ultracompact dual-mode waveguide crossing based on subwavelength multimode-interference couplers for a densely integrated on-chip mode-division multiplexing system.By engineering the lateral-cladding material index and manipulating phase profiles of light at the nanoscale using an improved inverse design method, a subwavelength structure could theoretically realize the identical beat length for both TE_0 and TE1, which can reduce the scale of the device greatly. The fabricated device occupied a footprint of only 4.8 μm× 4.8 μm. The measured insertion losses and crosstalks were less than 0.6 d B and-24 d B from 1530 nm to 1590 nm for both TE0 and TE1 modes, respectively. Furthermore, our scheme could also be expandedto design waveguide crossings that support more modes. | WEIJIE CHANG LULUZI LU XINSHU REN DONGYU LI ZEPENG PAN MENGFAN CHENG DEMING LIU MINMING ZHANG | 2018 | Photonics Research2018，6，7： | 4 |
| 7 | Ataxia,acute mountain sickness,and high altitude cerebral edema显示文摘Previous investigations suggest that ataxia is common and often one of the most reliable warning signs of high altitude cerebral edema(HACE). The aim of this study was to investigate the diagnostic role of ataxia in acute mountain sickness(AMS)and HACE among mountain rescuers on the quake areas,and in approaching the relation between AMS and HACE. After the earthquake on April 14,2010,approximately 24 080 lowland rescuers were rapidly transported from sea level or lowlands to the mountainous rescue sites at 3 750 ~ 4 568 m,and extremely hardly worked for an emergency treatment after arrival. Assessments of acute altitude illness on the quake areas were using the Lake Louise Scoring System. 73 % of the rescuers were found to be developed AMS. The incidence of high altitude pulmonary edema(HAPE)and HACE was 0.73 % and 0.26 %,respectively,on the second to third day at altitude. Ataxia sign was measured by simple tests of coordination including a modified Romberg test. The clinical features of 62 patients with HACE were analyzed. It was found that the most frequent,serious neurological symptoms and signs were altered mental status(50/62,80.6 %)and truncal ataxia(47/62,75.8 %). Mental status change was rated slightly higher than ataxia,but ataxia occurred earlier than mental status change and other symptoms. The earliest sign of ataxia was a vague unsteadiness of gait,which may be present alone in association with or without AMS. Advanced ataxia was correlated with the AMS scores,but mild ataxia did not correlate with AMS scores at altitudes of 3 750~4 568 m. Of them,14 patients were further examined by computerized tomographic scanning of the brain and cerebral magnetic resonance imagines were examined in another 15 cases. These imaging studies indicated that the presence of the cerebral edema was in 97 % of cases who were clinically diagnosed as HACE(28/29). Ataxia seems to be a reliable sign of advanced AMS or HACE,so does altered mental status. | Wu Tianyi Ma Siqing Bian Huiping Zhang Minming | 2013 | Engineering Sciences2013，11，2： | 3 |
| 8 | Molecular imaging of tumor angiogenesis using RGD-labeled iron oxide nanoparticles显示文摘Integrin is often significantly up-regulated in activated endothelial cells during tumor angiogenesis.The arginine-glycine-aspartic acid(RGD)peptide sequence is a specific recognition motif toανβ3 integrin.In this study,a RGD labeled,Poly lactic acid(PLA) coated ultrasmall paramagnetic iron oxide(USPIO)(referred to as RGD-PLA-USPIO)were developed and the ability to detect tumor angiogenesis was investigated in vitro and in vivo.Increased uptake of RGD-PLA-USPIO by human umbilical vein endothelial cells(HUVECs)was detected by Prussian blue stain and transmission electronic microscopy(TEM).Pronounced signal decrease in T2*-weighted magnetic resonance image(MRI)and heterogeneous arrangement of neovasculature of tumor tissue were clearly identified in Vx-2 tumor model.The MR signal of contralateral muscle only could be seen a slight background change after either RGD-PLA-USPIO or PLA-USPIO injection.These studies demonstrate the efficiency of RGD-PLA-USPIO to visualizeανβ3 integrin in activated tumor endothelial cells and its potential for detecting and monitoring tumor vasculature change after therapy. | WU XinYing ZHANG JingFeng LIN BingYing ZHANG MinMing | 2010 | Chinese Science Bulletin2010，55，24： | 3 |
| 9 | Propeller cavitation viscous simulation and low-frequency noise prediction with non-uniform inflow显示文摘Aiming at predicting ship propeller’s cavitation low-frequency noise spectrum,a hybrid method combining the cavitation multi-phase flow unsteady simulation with the pulsating spherical bubble radiated noise theory was proposed.Then,both of the NSRDC4383 5-bladed propeller and a 7-bladed highly-skewed propeller’s cavitation low-frequency noise spectrum subjected to the full appended SUBOFF submarine’s nominal wake were investigated.The effects of thrust loading and cavity extension on the discrete line spectrum frequency and its spectrum source level were analyzed.The improved Sauer cavitation model and modified shear stress transport turbulence models were adopted to simulate the propeller sheet cavitation along with integrated verification.The cavity volume acceleration related to the characteristic length representing the unsteady sheet cavitation extension,which was more reasonable than the spherical cavity hypothesis,was used to the cavitation low-frequency noise spectrum prediction.Results show that the 7-bladed propeller truly appreciates the advantages of smaller loads,latter cavitation inception and lower cavitating tonal noise comparing to that of the 5 blades.Under the same cavitation index based on ship speed,the interaction of wake inflow and blades will induce significantly low frequency line spectrums and strengthen their source level.Given the submarine wake,cavitation index and rotating speed condition,the thrust,torque and cavity area of blades will decrease with the decreasing load,but the fluctuated acceleration amplitude of cavity volume and the tonal noise spectrum level increases,and the discrete line spectrum components shift mainly to the even times of the BPF harmonics from the odd.If the cavitation extension lightens,the BPF harmonics line spectrums will be depressed,and the spectrum level at 1 kHz reduces 2.54 dB.The numerical method above constructs a numerical system to measure the cavitating hydrodynamics and noise performances of ship propellers,which can be productive for the numerical design of wake adapted low noise submarine propeller. | YANG Qiongfang WANG Yongsheng ZHANG Minming | 2013 | Chinese Journal of Acoustics2013，32，2： | 2 |
| 10 | On-chip cyclic-AWG-based 12 × 12 silicon wavelength routing switches with minimized port-to-port insertion loss fluctuation显示文摘With the rapidly increasing bandwidth requirements of optical communication networks, compact and low-cost large-scale optical switches become necessary. Silicon photonics is a promising technology due to its small footprint, cost competitiveness, and high bandwidth density. In this paper, we demonstrate a 12 × 12 silicon wavelength routing switch employing cascaded arrayed waveguide gratings(AWGs) connected by a silicon waveguide interconnection network on a single chip. We optimize the connecting strategy of the crossing structure to reduce the switch's footprint. We develop an algorithm based on minimum standard deviation to minimize the port-toport insertion loss(IL) fluctuation of the switch globally. The simulated port-to-port IL fluctuation decreases by about 3 dB compared with that of the conventional one. The average measured port-to-port IL is 13.03 dB, with a standard deviation of 0.78 dB and a fluctuation of 2.39 dB. The device can be used for wide applications in core networks and data centers. | ZEPENG PAN SONGNIAN FU LULUZI LU DONGYU LI WEIJIE CHANG DEMING LIU MINMING ZHANG | 2018 | Photonics Research2018，6，5： | 2 |
| 11 | Diffusion-Weighted Imaging in Assessing Renal Pathology of Chronic Kidney Disease: A Preliminary Clinical Study显示文摘 | Qinghai Li Jinning Li Lan Zhang Ying Chen Minming Zhang Fuhua Yan | 2014 | European Journal of Radiology2014，，： | 1 |
| 12 | Large eddy simulation of turbulent premixed piloted flame using artificial thickened flame model coupled with tabulated chemistry显示文摘A sub-grid scale(SGS) combustion model, which combines the artificial thickened flame(ATF) model with the flamelet generated manifold(FGM) tabulation method, is proposed. Based on the analysis of laminar flame structures, two self-contained flame sensors are used to track the diffusion and reaction processes with different spatial scales in the flame front, respectively. The dynamic formulation for the proposed SGS combustion model is also performed. Large eddy simulations(LESs) of Bunsen flame F3 are used to evaluate the different SGS combustion models. The results show that the proposed SGS model has the ability in predicting the distributions of temperature and velocity reasonably, while the predictions for the distributions of some species need further improvement. The snapshots of instantaneous normalized progress variables reveal that the flame is more remarkably and severely wrinkled at the flame tip for flame F3.More satisfactory results obtained by the dynamic model indicate that it can preserve the premixed flame propagation characteristics better. | Zhou YU Hongda ZHANG Taohong YE Minming ZHU | 2018 | Applied Mathematics and Mechanics(English Edition)2018，39，9： | 1 |
| 13 | Hemodynamic characterization of hepatic angiomyolipoma with least amount of fat evaluated by contrast-enhanced magnetic resonance angiography显示文摘 | Wenbo Xiao Min Zhou Haiyan Lou Zhaoming Wang Minming Zhang | 2010 | Abdominal Imaging2010，，2： | 1 |
| 14 | Virtual presentation and customization for products based on Internet显示文摘 | Pan Zhigeng Chen Tian Zhang Minming | | 0，，01： | 1 |
| 15 | Large eddy simulation of turbulent premixed and stratified combustion using flame surface density model coupled with tabulation method显示文摘Large eddy simulations(LESs) are performed to investigate the Cambridge premixed and stratified flames, SwB1 and SwB5, respectively. The flame surface density(FSD) model incorporated with two different wrinkling factor models, i.e., the Muppala and Charlette2 wrinkling factor models, is used to describe combustion/turbulence interaction, and the flamelet generated manifolds(FGM) method is employed to determine major scalars. This coupled sub-grid scale(SGS) combustion model is named as the FSD-FGM model. The FGM method can provide the detailed species in the flame which cannot be obtained from the origin FSD model. The LES results show that the FSD-FGM model has the ability of describing flame propagation, especially for stratified flames. The Charlette2 wrinkling factor model performs better than the Muppala wrinkling factor model in predicting the flame surface area change by the turbulence.The combustion characteristics are analyzed in detail by the flame index and probability distributions of the equivalence ratio and the orientation angle, which confirms that for the investigated stratified flame, the dominant combustion modes in the upstream and downstream regions are the premixed mode and the back-supported mode, respectively. | Zhou YU Hongda ZHANG Taohong YE Minming ZHU | 2018 | Applied Mathematics and Mechanics(English Edition)2018，39，12： | 1 |
| 16 | Practical decoy-state quantum secure direct communication显示文摘Quantum secure direct communication(QSDC) has been demonstrated in both fiber-based and free-space channels using attenuated lasers. Decoy-state QSDC by exploiting four decoy states has been proposed to address the problem of photon-numbersplitting attacks caused by the use of attenuated lasers. In this study, we present an analysis of the practical aspects of decoy-state QSDC. First, we design a two-decoy-state protocol that only requires two decoy states, thereby significantly reducing experimental complexity. Second, we successfully perform full parameter optimization for a real-life QSDC system by introducing a genetic algorithm. Our simulation results show that the two-decoy-state protocol could be the best choice for developing a practical QSDC system. Furthermore, full optimization is crucial for a high-performance QSDC system. Our work serves as a major step toward the further development of practical decoy-state QSDC systems. | Xin Liu Zijian Li Di Luo Chunfeng Huang Di Ma Minming Geng Junwei Wang Zhenrong Zhang Kejin Wei | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，12： | 1 |
| 17 | 4×4 MIMO fiber-wireless transmission based on an integrated four-channel directly modulated optical transceiver显示文摘In this paper, an integrated compact four-channel directly modulated analog optical transceiver is proposed and fabricated. The 3 d B bandwidth of this optical transceiver exceeds 20 GHz, and the measured spurious-free dynamic range is up to 91.2 d B · Hz^2∕3. The optical coupling efficiency(CE) is improved by using a precise submicron alignment technique for lens coupling in a transmitter optical subassembly, and the highest CE is achieved when the oblique angle of the arrayed waveguide grating using a silica-based planar lightwave circuit(AWG-PLC) in receiver optical sub assembly is set to 42°. Based on the proposed optical transceiver, we have experimentally demonstrated a 6.624 Gbit/s 4 × 4 multi-input multioutput(MIMO) 16-quadrature amplitude modulation orthogonal frequency division multiplexing(16 QAM-OFDM) radio signal over 15.5 km standard single mode fiber, together with 1.2 m wireless transmission in both an uplink and a downlink. To cope with the channel interference and noise of the fiber-wireless transmission system, a low-complexity MIMO demodulation algorithm based on lattice reduction zero-forcing(LR-ZF) is designed. In our experiment, 1.6 d B power penalty is achieved by using the proposed LR-ZF algorithm, compared to the commonly used zero-forcing algorithm.Moreover, this LR-ZF algorithm has much less complexity than the optimal maximum-likelihood sequence estimation(MLSE) at a given transmission performance. These results not only demonstrate the feasibility of the integrated optical transceiver for MIMO fiber-wireless application but also validate that the proposed LR-ZF algorithm is effective to eliminate the interference for hybrid fiber-wireless transmission. | DI ZHANG YAO YE LEI DENG DI LI HAIPING SONG YUCHENG ZHANG MINMING ZHANG SHU WANG DEMING LIU | 2019 | Photonics Research2019，7，12： | 1 |
| 18 | Improving anti-sulfur performance of methane sensors by new vectors and active components显示文摘Conventional Pd/?-Al2O3 methane sensors are easily poisoned in a sulfur-containing atmosphere, with a subsequent de-crease in sensitivity and the working life of methane sensors. We mainly investigated the effect of nanotechnology and a cerium co-catalyst on the stability and anti-sulfur performance of methane sensors. In our experiment, an anti-sulfur methane sensor was prepared by immersing cerium-containing ?-alumina nanometer elements into a Pt-Pd bimetallic nanometer catalyst. The experi-ment about the sensitivity and stability performance of different catalytic methane sensors indicate that sensitivity, decreased by catalyst sulfur poisoning, is improved significantly by adding cerium to the vector. As well, the long-term operational stability of methane sensors increased significantly. | WANG Ying, TONG Minming, ZHANG Tao School of Information and Electrical Engineering, China University of Mining & Technology, Xuzhou 221008, China | 2010 | Mining Science and Technology2010，20，6： | 0 |
| 19 | Magnetic Resonance Imaging Studies of Neurodegenerative Disease:From Methods to Translational Research显示文摘Neurodegenerative diseases(NDs)have become a significant threat to an aging human society.Numerous studies have been conducted in the past decades to clarify their pathologic mechanisms and search for reliable biomarkers.Magnetic resonance imaging(MRI)is a powerful tool for investigating structural and functional brain alterations in NDs.With the advantages of being non-invasive and non-radioactive,it has been frequently used in both animal research and large-scale clinical investigations.MRI may serve as a bridge connecting micro-and macro-level analysis and promoting bench-to-bed translational research.Nevertheless,due to the abundance and complexity of MRI techniques,exploiting their potential is not always straightforward.This review aims to briefly introduce research progress in clinical imaging studies and discuss possible strategies for applying MRI in translational ND research. | Peiyu Huang Minming Zhang | 2023 | Neuroscience Bulletin2023，39，1： | 0 |
| 20 | Is ecstasy-induced protracted symptom of motion perception associated with altered regional homogeneity of brain?显示文摘The synthetic hallucinogen 3,4-methylenedioxymet hamphetamine (MDMA) is the main psychoactive constituent of the popular recreational drug 'ecstasy.' Whether its neurotoxic effects are fully reversible is unknown.Here we report a patient with protracted syndrome induced by ecstasy. A 31-year-old female came to the psychiatric clinic and complained of a more than 7-year abnormality of motion perception.She described the symptom to be similar to 'head-shaking.' The symptom was described as a status of being on a swinging boat.The abilities of occupation and social interaction of the patient were all impaired.Her mood was depressed because of the abnormal motion perception. | Wei Ning Lai Jianbo Xu Dongrong Qi Hongli Wang Qidong Zhang Minming Huang Manli Xu Yi Hu Shaohua | 2014 | Chinese Medical Journal2014，，17： | 0 |
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