4篇
您的检索式：作者名="LIN BingYing"
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| 1 | Molecular imaging of tumor angiogenesis using RGD-labeled iron oxide nanoparticles显示文摘Integrin is often significantly up-regulated in activated endothelial cells during tumor angiogenesis.The arginine-glycine-aspartic acid(RGD)peptide sequence is a specific recognition motif toανβ3 integrin.In this study,a RGD labeled,Poly lactic acid(PLA) coated ultrasmall paramagnetic iron oxide(USPIO)(referred to as RGD-PLA-USPIO)were developed and the ability to detect tumor angiogenesis was investigated in vitro and in vivo.Increased uptake of RGD-PLA-USPIO by human umbilical vein endothelial cells(HUVECs)was detected by Prussian blue stain and transmission electronic microscopy(TEM).Pronounced signal decrease in T2*-weighted magnetic resonance image(MRI)and heterogeneous arrangement of neovasculature of tumor tissue were clearly identified in Vx-2 tumor model.The MR signal of contralateral muscle only could be seen a slight background change after either RGD-PLA-USPIO or PLA-USPIO injection.These studies demonstrate the efficiency of RGD-PLA-USPIO to visualizeανβ3 integrin in activated tumor endothelial cells and its potential for detecting and monitoring tumor vasculature change after therapy. | WU XinYing ZHANG JingFeng LIN BingYing ZHANG MinMing | 2010 | Chinese Science Bulletin2010，55，24： | 3 |
| 2 | Postnatal state transition of cardiomyocyte as a primary step in heart maturation显示文摘Postnatal heart maturation Is the basis of normal cardiac function and provides critical insights into heart repair and regenerative medicine.While static snapshots of the maturing heart have provided much Insight into its molecular signatures,few key events during postnatal cardiomyocyte maturation have been uncovered.Here,we report that cardiomyocytes(CMs)experience epige-netic and transcriptional decline of cardiac gene expression immediately after birth,leading to a transi-tion state of CMs at postnatal day 7(P7)that was essential for CM subtype specification during heart maturation.Large-scale single-cell analysis and genetic lineage tracing confirm the presence of transition state CMs at P7 bridging immature state and mature states.Silencing of key transcription factor JUN In P1-hearts significantly repressed CM transition,resulting in per-turbed CM subtype proportions and reduced cardiac function in mature hearts.In addition,transplantation of P7-CMs into infarcted hearts exhibited cardiac repair potential superior to P1-CMs.Collectively,our data uncover CM state transition as a key event in postnatal heart maturation,which not only provides insights into molecular foundations of heart maturation,but also opens an avenue for manipulation of cardiomyocyte fate in disease and regenerative medicine. | Zheng Li Fang Yao Peng Yu Dandan Li Mingzhi Zhang Lin Mao Xiaomeng Shen Zongna Ren Li Wang Bingying Zhou | 2022 | Protein & Cell2022，13，11： | 2 |
| 3 | Modeling and simulation of electric power steering system based on AMESim显示文摘 | Jin Bingying Lin Yi Shi Guobiao | | 0，，05： | 1 |
| 4 | Profiling of immune features to predict immunotherapy efficacy显示文摘Immune checkpoint blockade(ICB)therapies exhibit substantial clinical benefit in different cancers,but relatively low response rates in the majority of patients highlight the need to understand mutual relationships among immune features.Here,we reveal overall positive correlations among immune checkpoints and immune cell populations.Clinically,patients benefiting from ICB exhibited increases for both immune stimulatory and inhibitory features after initiation of therapy,suggesting that the activation of the immune microenvironment might serve as the biomarker to predict immune response.As proof-of-concept,we demonstrated that the immune activation score(ISD)based on dynamic alteration of interleukins in patient plasma as early as two cycles(4-6 weeks)after starting immunotherapy can accurately predict immunotherapy efficacy.Our results reveal a systematic landscape of associations among immune features and provide a noninvasive,cost-effective,and time-efficient approach based on dynamic profiling of pre-and on-treatment plasma to predict immunotherapy efficacy. | Youqiong Ye Yongchang Zhang Nong Yang Qian Gao Xinyu Ding Xinwei Kuang Rujuan Bao Zhao Zhang Chaoyang Sun Bingying Zhou Li Wang Qingsong Hu Chunru Lin Jianjun Gao Yanyan Lou Steven HLin Lixia Diao Hong Liu Xiang Chen Gordon B.Mills Leng Han | 2022 | The Innovation2022，3，1： | 0 |
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