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| 1 | Xueshuantong improves cerebral blood perfusion in elderly patients with lacunar infarction显示文摘A total of 64 patients with acute lacunar infarction were enrolled within 24 hours of onset. The patients received conventional therapy (antiplatelet drugs and hypolipidemic drugs) alone or conventional therapy plus 450 mg Xueshuantong once a day. The main ingredient of the Xueshuantong lyophilized powder used for injection was Panax notoginseng saponins. Assessments were made at admission and at discharge using the National Institutes of Health Stroke Scale, the Activity of Daily Living and the Mini-Mental State Examination. Additionally, the relative cerebral blood flow, relative cerebral blood volume and relative mean transit time in the region of interest were calculated within 24 hours after the onset of lacunar infarction, using dynamic susceptibility contrast magnetic resonance perfusion imaging technology. Patients underwent a follow-up MRI scan after 4 weeks of treatment. There was an improvement in the Activity of Daily Living scores and a greater reduction in the scores on the National Institutes of Health Stroke Scale in the treatment group than in the control group. However, the Mini-Mental State Examination scores showed no significant differences after 4 weeks of treatment. Compared with the control group, the relative cerebral blood flow at discharge had increased and showed a greater improvement in the treatment group. Furthermore, there was a reduction in the relative mean transit time at discharge and the value was lower in the treatment group than in the control group. The experimental findings indicate that Xueshuantong treatment improves neurological deficits in elderly patients with lacunar infarction, and the mechanism may be related to increased cerebral perfusion. | Qifeng Gui Yunmei Yang Shihong Ying Minming Zhang | 2013 | Neural Regeneration Research2013，8，9： | 27 |
| 2 | Characteristics of acoustic emission signals in damp cracking coal rocks显示文摘A uniaxial load experiment on coal rocks at different stress rates was carried out, based on the characteristics of acoustic emission (AE) signals in cracking coal rocks, decomposition, de-noising and reconstruction for the AE signals through wavelet packet transform for solving the current problems created by the presence of noise in AE signals and the existing problems in AE signal processing. The results show that the various characteristics of AE signals in coal rocks cracking under different situations can be clearly reflected, after the AE signals are de-noised by the wavelet packet. Compared to dry coal rocks, the number of AE occurrences in damp coal rocks was significantly reduced, as well as the average amplitude. The number of AE occurrences in damp and dry coal rocks clearly increased with increases in the loading rate, but the largest amplitude of the AE signals in damp coal rocks has been reduced. There is no clear evidence of change in dry coal rocks. | TANG Shoufeng, TONG Minming, HU Junli, HE Xinmin School of Information and Electrical Engineering, China University of Mining & Technology, Xuzhou 221008, China | 2010 | Mining Science and Technology2010，20，1： | 17 |
| 3 | Region-Specific Iron Measured by MRI as a Biomarker for Parkinson's Disease显示文摘The identification of sensitive and specific biomarkers for Parkinson's disease(PD) poses an important clinical challenge. A potential biomarker for early diagnosis and disease monitoring of PD is region-specific iron. Iron accumulation in the substantia nigra pars compacta is considered a main characteristic of PD.However, questions remain, such as the relationship between nigral iron and clinical indices of PD(motor impairment or disease duration). Further, previous studies have suggested the influence of iron on other nuclei. Iron quantification using magnetic resonance imaging(MRI)allows for studies of the relationship between regional iron and clinical symptoms in vivo. Thus, in this review we discuss the following topics: the technological development of MRI in measuring brain iron, nigral iron as a potential marker for PD in both clinical and prodromal stages, other influences of regional iron on PD, and clinical translation and future perspectives. | Xiaojun Guan Xiaojun Xu Minming Zhang | 2017 | Neuroscience Bulletin2017，33，5： | 13 |
| 4 | Inverse design of digital nanophotonic devices using the adjoint method显示文摘A high-efficiency inverse design of'digital'subwavelength nanophotonic devices using the adjoint method is proposed.We design a single-mode 3dB power divider and a dual-mode demultiplexer to demonstrate the efficiency of the proposed inverse design approach,called the digitized adjoint method,for single-and dual-object optimization,respectively.The optimization comprises three stages:1)continuous variation for an'analog'pattern;2)forced permittivity biasing for a'quasi-digital'pattern;and 3)a multilevel digital pattern.Compared with the conventional brute-force method,the proposed method can improve design efficiency by about five times,and the performance optimization can reach approximately the same level.The method takes advantages of adjoint sensitivity analysis and digital subwavelength structure and creates a new way for the efficient and high-performance design of compact digital subwavelength nanophotonic devices,which could overcome the efficiency bottleneck of the brute-force method,which is restricted by the number of pixels of a digital pattern,and improve the device performance by extending a conventional binary pattern to a multilevel one. | KAIYUAN WANG XINSHU REN WEIJIE CHANG LONGHUI LU DEMING LIU MINMING ZHANG | 2020 | Photonics Research2020，8，4： | 7 |
| 5 | Optical meta-waveguides for integrated photonics and beyond显示文摘The growing maturity of nanofabrication has ushered massive sophisticated optical structures available on a photonic chip.The integration of subwavelength-structured metasurfaces and metamaterials on the canonical building block of optical waveguides is gradually reshaping the landscape of photonic integrated circuits,giving rise to numerous metawaveguides with unprecedented strength in controlling guided electromagnetic waves.Here,we review recent advances in meta-structured waveguides that synergize various functional subwavelength photonic architectures with diverse waveguide platforms,such as dielectric or plasmonic waveguides and optical fibers.Foundational results and representative applications are comprehensively summarized.Brief physical models with explicit design tutorials,either physical intuition-based design methods or computer algorithms-based inverse designs,are cataloged as well.We highlight how meta-optics can infuse new degrees of freedom to waveguide-based devices and systems,by enhancing light-matter interaction strength to drastically boost device performance,or offering a versatile designer media for manipulating light in nanoscale to enable novel functionalities.We further discuss current challenges and outline emerging opportunities of this vibrant field for various applications in photonic integrated circuits,biomedical sensing,artificial intelligence and beyond. | Yuan Meng Yizhen Chen Longhui Lu Yimin Ding Andrea Cusano Jonathan A.Fan Qiaomu Hu Kaiyuan Wang Zhenwei Xie Zhoutian Liu Yuanmu Yang Qiang Liu Mali Gong Qirong Xiao Shulin Sun Minming Zhang Xiaocong Yuan Xingjie Ni | 2021 | Light(Science & Applications)2021，10，12： | 6 |
| 6 | Simulation of bluff body stabilized flows with hybrid RANS and PDF method显示文摘这研究的动机是由使用概率调查骚乱化学相互作用密度功能(PDF ) 方法。历久不渝的混合雷纳兹平均 Navier 司烧(RANS )/PDF 方法被用来模仿狂暴的非反应、反应的流动。联合波动速度频率作文 PDF 方程结合了雷纳兹平均密度,动量和精力方程被与有限体积(FV ) 相结合的拉格兰加恩·蒙蒂·卡洛(MC ) 方法在未组织的网孔上解决方法。稳定的非反应的流动回答的 axisymmetric 绝壁身体的模拟在这篇论文被介绍。再通行地区的计算长度在对试验性的数据的好同意。而且,有 jet-to-coflow 动量流动比率的增加的流动模式的重要变化很好被预言。另外,比较在联合 PDF 模型和二个不同雷纳兹压力模型之间被做。 | Minming Zhu Xingsi Han Haiwen Ge Yiliang Chen | 2007 | Acta Mechanica Sinica2007，23，3： | 4 |
| 7 | Longitudinal Alterations of Local Spontaneous Brain Activity in Parkinson's Disease显示文摘We used resting-state fMRI to evaluate longitudinal alterations in local spontaneous brain activity in Parkinson's disease(PD) over a 2-year period. Data were acquired from 23 PD patients at baseline and follow-up,and 27 age-and sex-matched normal controls. Regional homogeneity(ReHo) and voxel-based-morphometry(VBM) were used to identify differences in local spontaneous brain activity and grey matter volume. With disease progression, we observed a progressive decrease in ReHo in the sensorimotor cortex, default-mode network, and left cerebellum, but increased ReHo in the supplementary motor area, bilateral temporal gyrus, and hippocampus.Moreover, there was a significant positive correlation between the rates of ReHo change in the left cerebellum and the rates of change in the Unified Parkinson's Disease Rating Scale-III scores. VBM revealed no significant differences in the grey matter volume among the three sets of acquisitions. We conclude that ReHo may be a suitable non-invasive marker of progression in PD. | Qiaoling Zeng Xiaojun Guan Jason C.F.Law Yan Lun Zhujing Shen Tao Guo Min Xuan Quanquan Gu Xiaojun Xu Min Chen Minming Zhang | 2017 | Neuroscience Bulletin2017，33，5： | 4 |
| 8 | Ultracompact dual-mode waveguide crossing based on subwavelength multimode-interference couplers显示文摘We propose and experimentally demonstrate a novel ultracompact dual-mode waveguide crossing based on subwavelength multimode-interference couplers for a densely integrated on-chip mode-division multiplexing system.By engineering the lateral-cladding material index and manipulating phase profiles of light at the nanoscale using an improved inverse design method, a subwavelength structure could theoretically realize the identical beat length for both TE_0 and TE1, which can reduce the scale of the device greatly. The fabricated device occupied a footprint of only 4.8 μm× 4.8 μm. The measured insertion losses and crosstalks were less than 0.6 d B and-24 d B from 1530 nm to 1590 nm for both TE0 and TE1 modes, respectively. Furthermore, our scheme could also be expandedto design waveguide crossings that support more modes. | WEIJIE CHANG LULUZI LU XINSHU REN DONGYU LI ZEPENG PAN MENGFAN CHENG DEMING LIU MINMING ZHANG | 2018 | Photonics Research2018，6，7： | 4 |
| 9 | Detection of coal dust in a mine using optical tomography显示文摘A dust concentration imaging system based on optical tomography is proposed to monitor concentration variations of coal dust in a mine.Concentration profiles,rather than just a point value,of coal dust concentrations are the goal of this method.An optical sensor array is employed to realize an optical sensing field of the coal dust concentration during on-line monitoring.A novel image reconstruction algorithm,called the simultaneous iterative reconstruction technique(SIRT),is compared to the well known linear,back projection algorithm(LBP).The SIRT was applied to the present problem and tested by modeling.The disadvantage of the SIRT is a slow speed but some improvements have been made by adding a weighting function that reduces the relative error to 1.7% from 3.1% for 50 iterations.The results of image reconstruction are presented for both simulated and real objects.They prove that the optical tomography technique,based on a multi-source fan projection scheme,can be an effective approach for estimating coal dust distribution.This system can be applied in real time for continuous measurements in a mine. | Wei Mingsheng Tong Minming Hao Jifei Cai Li Xu Jie | 2012 | International Journal of Mining Science and Technology2012，22，4： | 4 |
| 10 | Numerical investigation on hydrogen production by CH_4-Rich combustion in an alumina foam显示文摘The two-phase volume-averaged model with the detailed chemistry reaction mechanism GRI 3.0 was adopted in the quasi-steady-state simulation of hydrogen production by CH4-rich filtration combustion in an alumina foam under fully developed conditions. The relations among the combustion wave velocity, the inlet gas velocity and the equivalence ratio were discussed, and their influences on the distributions of temperature and species in the alumina foam and on H2 yield, CH4 conversion, H2 selectivity and CO selectivity were analyzed in detail. The results show that the combustion wave velocity increases with the increase of equivalence ratio or inlet gas velocity. The H2 yield exceeded 50% with equivalence ratio between 2.0 and 3.0 and combustion wave velocity larger than 0.4 mm/s. The H2 selectivity exceeded 50% with equivalence ratio larger than 2.0 and CO selectivity exceeded 80% with equivalence ratio between 1.8 and 2.0 and combustion wave velocity larger than 0.4 mm/s. | ZHAO PingHui, YE TaoHong, ZHU MinMing, JIANG Hai & CHEN YiLiang Thermal Science & Energy Engineering Department, University of Science & Technology of China, Hefei 230027, China | 2009 | Science China(Technological Sciences)2009，52，10： | 3 |
| 11 | Ataxia,acute mountain sickness,and high altitude cerebral edema显示文摘Previous investigations suggest that ataxia is common and often one of the most reliable warning signs of high altitude cerebral edema(HACE). The aim of this study was to investigate the diagnostic role of ataxia in acute mountain sickness(AMS)and HACE among mountain rescuers on the quake areas,and in approaching the relation between AMS and HACE. After the earthquake on April 14,2010,approximately 24 080 lowland rescuers were rapidly transported from sea level or lowlands to the mountainous rescue sites at 3 750 ~ 4 568 m,and extremely hardly worked for an emergency treatment after arrival. Assessments of acute altitude illness on the quake areas were using the Lake Louise Scoring System. 73 % of the rescuers were found to be developed AMS. The incidence of high altitude pulmonary edema(HAPE)and HACE was 0.73 % and 0.26 %,respectively,on the second to third day at altitude. Ataxia sign was measured by simple tests of coordination including a modified Romberg test. The clinical features of 62 patients with HACE were analyzed. It was found that the most frequent,serious neurological symptoms and signs were altered mental status(50/62,80.6 %)and truncal ataxia(47/62,75.8 %). Mental status change was rated slightly higher than ataxia,but ataxia occurred earlier than mental status change and other symptoms. The earliest sign of ataxia was a vague unsteadiness of gait,which may be present alone in association with or without AMS. Advanced ataxia was correlated with the AMS scores,but mild ataxia did not correlate with AMS scores at altitudes of 3 750~4 568 m. Of them,14 patients were further examined by computerized tomographic scanning of the brain and cerebral magnetic resonance imagines were examined in another 15 cases. These imaging studies indicated that the presence of the cerebral edema was in 97 % of cases who were clinically diagnosed as HACE(28/29). Ataxia seems to be a reliable sign of advanced AMS or HACE,so does altered mental status. | Wu Tianyi Ma Siqing Bian Huiping Zhang Minming | 2013 | Engineering Sciences2013，11，2： | 3 |
| 12 | Molecular imaging of tumor angiogenesis using RGD-labeled iron oxide nanoparticles显示文摘Integrin is often significantly up-regulated in activated endothelial cells during tumor angiogenesis.The arginine-glycine-aspartic acid(RGD)peptide sequence is a specific recognition motif toανβ3 integrin.In this study,a RGD labeled,Poly lactic acid(PLA) coated ultrasmall paramagnetic iron oxide(USPIO)(referred to as RGD-PLA-USPIO)were developed and the ability to detect tumor angiogenesis was investigated in vitro and in vivo.Increased uptake of RGD-PLA-USPIO by human umbilical vein endothelial cells(HUVECs)was detected by Prussian blue stain and transmission electronic microscopy(TEM).Pronounced signal decrease in T2*-weighted magnetic resonance image(MRI)and heterogeneous arrangement of neovasculature of tumor tissue were clearly identified in Vx-2 tumor model.The MR signal of contralateral muscle only could be seen a slight background change after either RGD-PLA-USPIO or PLA-USPIO injection.These studies demonstrate the efficiency of RGD-PLA-USPIO to visualizeανβ3 integrin in activated tumor endothelial cells and its potential for detecting and monitoring tumor vasculature change after therapy. | WU XinYing ZHANG JingFeng LIN BingYing ZHANG MinMing | 2010 | Chinese Science Bulletin2010，55，24： | 3 |
| 13 | Investigation of Swelling and Dissolution Process of Natural Rubber in Aromatic Oil显示文摘Aromatic oil has been used to promote the properties of crumb rubber modified asphalt which is an ideal method to deal with the resource utilization of waste rubber tires and by-product of refinery. Furfural extract oil(FEO) was separated into the light fraction and the heavy fraction. Swelling and dissolution process of natural rubber sheet in these three oil samples was investigated to shed light on the interaction mechanism. Crumb rubber also interacted on FEO and asphalt respectively. Energy dispersive spectrometer(EDS), thermo-gravimetric analysis(TGA) and scanning electron microscope(SEM) were used to characterize the chemical and structural properties of processed rubber. The chemical composition of processed oils and asphalt was investigated by using the hydrocarbon group analysis(SARA) and gel permeation chromatography. The results revealed that the swelling rate and mass loss of rubber in oils were much higher than those in asphalt and rose with an increasing processing temperature. The heavy fraction of FEO had more diffusion and dissolving capability than the light fraction, whilst compatibility was observed between the heavy fraction and the light fraction. Selective absorption was not observed in the study and detachment of dissolved rubber was disseminated from the outside to the inside. The cross-linking degree of the residue rubber was unchanged with the processing time, and sulfur predominantly remained in the undissolved rubber. Dissolution of crumbed rubber in oils was attributed to devulcanization, while that in the asphalt was mainly attributed to depolymerization. | Wang Feng Kuang Minming Li Guanlong Zhou Xiaolong Li Chenglie | 2015 | China Petroleum Processing & Petrochemical Technology2015，17，3： | 3 |
| 14 | Propeller cavitation viscous simulation and low-frequency noise prediction with non-uniform inflow显示文摘Aiming at predicting ship propeller’s cavitation low-frequency noise spectrum,a hybrid method combining the cavitation multi-phase flow unsteady simulation with the pulsating spherical bubble radiated noise theory was proposed.Then,both of the NSRDC4383 5-bladed propeller and a 7-bladed highly-skewed propeller’s cavitation low-frequency noise spectrum subjected to the full appended SUBOFF submarine’s nominal wake were investigated.The effects of thrust loading and cavity extension on the discrete line spectrum frequency and its spectrum source level were analyzed.The improved Sauer cavitation model and modified shear stress transport turbulence models were adopted to simulate the propeller sheet cavitation along with integrated verification.The cavity volume acceleration related to the characteristic length representing the unsteady sheet cavitation extension,which was more reasonable than the spherical cavity hypothesis,was used to the cavitation low-frequency noise spectrum prediction.Results show that the 7-bladed propeller truly appreciates the advantages of smaller loads,latter cavitation inception and lower cavitating tonal noise comparing to that of the 5 blades.Under the same cavitation index based on ship speed,the interaction of wake inflow and blades will induce significantly low frequency line spectrums and strengthen their source level.Given the submarine wake,cavitation index and rotating speed condition,the thrust,torque and cavity area of blades will decrease with the decreasing load,but the fluctuated acceleration amplitude of cavity volume and the tonal noise spectrum level increases,and the discrete line spectrum components shift mainly to the even times of the BPF harmonics from the odd.If the cavitation extension lightens,the BPF harmonics line spectrums will be depressed,and the spectrum level at 1 kHz reduces 2.54 dB.The numerical method above constructs a numerical system to measure the cavitating hydrodynamics and noise performances of ship propellers,which can be productive for the numerical design of wake adapted low noise submarine propeller. | YANG Qiongfang WANG Yongsheng ZHANG Minming | 2013 | Chinese Journal of Acoustics2013，32，2： | 2 |
| 15 | On-chip cyclic-AWG-based 12 × 12 silicon wavelength routing switches with minimized port-to-port insertion loss fluctuation显示文摘With the rapidly increasing bandwidth requirements of optical communication networks, compact and low-cost large-scale optical switches become necessary. Silicon photonics is a promising technology due to its small footprint, cost competitiveness, and high bandwidth density. In this paper, we demonstrate a 12 × 12 silicon wavelength routing switch employing cascaded arrayed waveguide gratings(AWGs) connected by a silicon waveguide interconnection network on a single chip. We optimize the connecting strategy of the crossing structure to reduce the switch's footprint. We develop an algorithm based on minimum standard deviation to minimize the port-toport insertion loss(IL) fluctuation of the switch globally. The simulated port-to-port IL fluctuation decreases by about 3 dB compared with that of the conventional one. The average measured port-to-port IL is 13.03 dB, with a standard deviation of 0.78 dB and a fluctuation of 2.39 dB. The device can be used for wide applications in core networks and data centers. | ZEPENG PAN SONGNIAN FU LULUZI LU DONGYU LI WEIJIE CHANG DEMING LIU MINMING ZHANG | 2018 | Photonics Research2018，6，5： | 2 |
| 16 | A new compressibility modification k-ε turbulence model with shock unsteadiness effect显示文摘A new compressibility modification k-ε model,including shock unsteadiness effect and the previous compressibility modification of pressure dilatation and dilatational dissipation rate,was developed with a simple formulation for numerical simulation in supersonic complex turbulent flows.The shock unsteadiness effect was modeled by inhibiting turbulent kinetic energy production in the governing equations of turbulent kinetic energy and the turbulent kinetic energy dissipation rate.Sarkar's correction models were employed accounting for the dilatational compressibility effects in the new model.Two types of flows,the free supersonic mixing layers and complex supersonic flow with transverse injection were simulated with different flow conditions.Comparisons with experimental data of the free supersonic mixing layers showed that the new compressibility modification k-ε model significantly inhibited the excessive growth of turbulent kinetic energy and improved predictions.On the supersonic mixing layer flows,prediction results with the new model were in close agreement with experimental data,accurately predicting the decreasing trend of the mixing layer spreading rate with the increase of the convective Mach number.Due to the complicated flow field with flow separation,shock unsteadiness modification inhibited excessive growth of the turbulent kinetic energy in shock regions and wider shock regions are predicted,thereby significantly improving results of the flow with a strong separation forecast.The flow separation was stronger,which was the primary modification effect of the new model.Predictions accord with experimental results even in strong separation flows. | HAN XingSi YE TaoHong ZHU MinMing CHEN YiLiang | 2008 | Chinese Science Bulletin2008，53，24： | 2 |
| 17 | Portable near-infrared diffusive light imager for breast cancer detection 显示文摘 | CHEN Nanguang HUANG Minming XIA Hongjun | 2004 | Journal of Biomedical Optics2004，9，3： | 1 |
| 18 | Barrier coverage by sensors with adjustable ranges显示文摘 | FAN Haosheng LI Minming SUN Xianwei | 2014 | ACM Transactions on Sensor Networks2014，11，1： | 1 |
| 19 | Cardiac protection: Evolving role of angiotensin receptor blockers 显示文摘 | CALIFF RM COHN JN MINM M | 2000 | Am Heart J2000，139，： | 1 |
| 20 | Nano-TiO 2 enhances the toxicity of copper in natural water to Daphnia magna显示文摘 | Wenhong Fan Minming Cui Hong Liu Chuan Wang Zhiwei Shi Cheng Tan Xiuping Yang | 2010 | Environmental Pollution2010，，3： | 1 |
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