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| 1 | On-road pollutant emission and fuel consumption characteristics of buses in Beijing显示文摘On-road emission and fuel consumption (FC) levels for Euro III and IV buses fueled on diesel and compressed natural gas (CNG) were compared,and emission and FC characteristics of buses were analyzed based on approximately 28,700 groups of instantaneous data obtained in Beijing using a portable emissions measurement system (PEMS).The experimental results revealed that NOx and PM emissions from CNG buses were decreased by 72.0% and 82.3% respectively,compared with Euro IV diesel buses.Similarly,these emissions were reduced by 75.2% and 96.3% respectively,compared with Euro III diesel buses.In addition,CO 2,CO,HC,NOx,PM emissions and FC of Euro IV diesel buses were reduced by 26.4%,75.2%,73.6%,11.4%,79.1%,and 26.0%,respectively,relative to Euro III diesel buses.The CO 2,CO,HC,NOx,PM emissions and FC factors all decreased with bus speed increased,while increased as bus acceleration increased.At the same time,the emission/FC rates as well as the emission/FC factors exhibited a strong positive correlation with the vehicle specific power (VSP).They all were the lowest when VSP < 0,and then rapidly increased as VSP increased.Furthermore,both the emission/FC rates and emission/FC factors were the highest at accelerations,higher at cruise speeds,and the lowest at decelerations for non-idling buses.These results can provide a base reference to further estimate bus emission and FC inventories in Beijing. | Aijuan Wang Yunshan Ge Jianwei Tan Mingliang Fu Asad Naeem Shah Yan Ding Hong Zhao Bin Liang | 2011 | Journal of Environmental Sciences2011，23，3： | 19 |
| 2 | Vehicular volatile organic compounds losses due to refueling and diurnal process in China: 2010–2050显示文摘Volatile organic compounds(VOCs) are crucial to control air pollution in major Chinese cities since VOCs are the dominant factor influencing ambient ozone level, and also an important precursor of secondary organic aerosols. Vehicular evaporative emissions have become a major and growing source of VOC emissions in China. This study consists of lab tests, technology evaluation, emissions modeling, policy projections and cost-benefit analysis to draw a roadmap for China for controlling vehicular evaporative emissions. The analysis suggests that evaporative VOC emissions from China's light-duty gasoline vehicles were approximately 185,000 ton in 2010 and would peak at 1,200,000 ton in 2040 without control. The current control strategy implemented in China, as shown in business as usual(BAU) scenario, will barely reduce the long-term growth in emissions. Even if Stage II gasoline station vapor control policies were extended national wide(BAU + extended Stage II), there would still be over 400,000 ton fuel loss in 2050. In contrast, the implementation of on-board refueling vapor recovery(ORVR) on new cars could reduce 97.5% of evaporative VOCs by 2050(BAU + ORVR/BAU + delayed ORVR). According to the results, a combined Stage II and ORVR program is a comprehensive solution that provides both short-term and long-term benefits. The net cost to achieve the optimal total evaporative VOC control is approximately 62 billion CNY in 2025 and 149 billion CNY in 2050. | Xiaofan Yang Huan Liu Hongyang Cui Hanyang Man Mingliang Fu Jiming Hao Kebin He | 2015 | Journal of Environmental Sciences2015，27，7： | 19 |
| 3 | Overall assessment of antibiotic substitutes for pigs:a set of meta-analyses显示文摘Background:Antibiotic growth promoters are widely used to improve weight gain.However,the abuse of antibiotics can have many negative effects on people.Developing alternatives to antibiotics is an urgent need in livestock production.We aimed to perform a meta-analysis and network meta-analysis(NMA)to investigate the effects of feed additives as potential antibiotic substitutes(ASs)on bacteriostasis,growth performance,intestinal morphology and immunity.Furthermore,the primary,secondary,and tertiary ASs were defined by comparing their results with the results of antibiotics.Results:Among 16,309 identified studies,37 were summarized to study the bacteriostasis effects of feed additives,and 89 were included in the meta-analysis and NMA(10,228 pigs).We summarized 268 associations of 57 interventions with 32 bacteria.The order of bacteriostasis effects was as follows:antimicrobial peptides(AMPs)≈antibiotics>organic acids>plant extracts>oligosaccharides.We detected associations of 11 feed additives and 11 outcomes.Compared with a basal diet,plant extract,AMPs,probiotics,microelements,organic acids,bacteriophages,lysozyme,zymin,and oligosaccharides significantly improved growth performance(P<0.05);organic acids,probiotics,microelements,lysozyme,and AMPs remarkably increased the villus height:crypt depth ratio(V/C)(P<0.05);and plant extracts,zymin,microelements,probiotics,and organic acids notably improved immunity(P<0.05).The optimal AMP,bacteriophage,lysozyme,microelements,oligosaccharides,organic acids,plants,plant extracts,probiotics,and zymin doses were 0.100%,0.150%,0.012%,0.010%,0.050%,0.750%,0.20%,0.040%,0.180%,and 0.100%,respectively.Compared with antibiotics,all investigated feed additives exhibited no significant difference in effects on growth performance,IgG,and diarrhoea index/rate(P>0.05);AMPs and microelements significantly increased V/C(P<0.05);and zymin significantly improved lymphocyte levels(P<0.05).Furthermore,linear weighting sum models were used to comprehensively estimate the overall impact of each feed additive on pig growth and health.Conclusions:Our findings suggest that AMPs and plant extracts can be used as primary ASs for weaned piglets and growing pigs,respectively.Bacteriophages,zymin,plants,probiotics,oligosaccharides,lysozyme,and microelements can be regarded as secondary ASs.Nucleotides and organic acids can be considered as tertiary ASs.Future studies should further assess the alternative effects of combinational feed additives. | Bocheng Xu Jie Fu Luoyi Zhu Zhi Li Mingliang Jin Yizhen Wang | 2021 | Journal of Animal Science and Biotechnology2021，12，2： | 9 |
| 4 | Emission characteristics of offshore fishing ships in the Yellow Bo Sea, China显示文摘Maritime transport has been playing a decisive role in global trade. Its contribution to the air pollution of the sea and coastal areas has been widely recognized. The air pollutant emission inventories of several harbors in China have already been established. However,the emission factors of local ships have not been addressed comprehensively, and thus are lacking from the emission inventories. In this study, on-board emission tests of eight diesel-powered offshore fishing ships were conducted near the coastal region of the northern Yellow Bo Sea fishing ground of Dalian, China. Results show that large amounts of fine particles(< 0.5 μm, 90%) were found in maneuvering mode, which were about five times higher than those during cruise mode. Emission rates as well as emission factors based on both distance and fuel were determined during the cruise and maneuvering modes(including departure and arrival). Average emission rates and distance-based emission factors of CO, HC and PM were much higher during the maneuvering mode as compared with the cruise mode. However, the average emission rate of Nitrous Oxide(NOx) was higher during the cruise mode as compared with the maneuvering modes. On the contrary, the average distance-based emission factors of NOxwere lower during the cruise mode relative to the maneuvering mode due to the low sailing speed of the latter. | Yingshuai Liu Yunshan Ge Jianwei Tan Mingliang Fu Asad Naeem Shah Luqiang Li Zhe Ji Yan Ding | 2018 | Journal of Environmental Sciences2018，30，3： | 5 |
| 5 | Digital Twin for Integration of Design-Manufacturing-Maintenance:An Overview显示文摘Traditional design,manufacturing and maintenance are run and managed independently under their own rules and regulations in an increasingly time-and-cost inefective manner.A unifed platform for efcient and intelligent designmanufacturing-maintenance of mechanical equipment and systems is highly needed in this rapidly digitized world.In this work,the defnition of digital twin and its research progress and associated challenges in the design,manufacturing and maintenance of engineering components and equipment were thoroughly reviewed.It is indicated that digital twin concept and associated technology provide a feasible solution for the integration of design-manufacturingmaintenance as it has behaved in the entire lifecycle of products.For this aim,a framework for information-physical combination,in which a more accurate design,a defect-free manufacturing,a more intelligent maintenance,and a more advanced sensing technology,is prospected. | Yang Fu Gang Zhu Mingliang Zhu Fuzhen Xuan | 2022 | Chinese Journal of Mechanical Engineering2022，35，4： | 4 |
| 6 | Dietary fatty acids in gut health: Absorption, metabolism and function显示文摘In biological responses,fatty acids(FA)are absorbed and metabolized in the form of substrates for energy production.The molecular structures(number of double bonds and chain length)and composition of dietary FA impact digestion,absorption and metabolism,and the biological roles of FA.Recently,increasing evidence indicates that FA are essentially utilized as an energy source and are signaling molecules that exert physiological activity of gut microbiota and immune responses.In addition,FA could serve as natural ligands for orphan G protein-coupled receptors(GPCR),also called free fatty acid receptors(FFAR),which intertwine metabolic and immune systems via multiple mechanisms.The present review explores the recent findings on FA absorption and its impact on gut health,particularly addressing the mechanism by which dietary FA potentially influences intestinal microbiota and epithelial functions.Also,this work attempts to uncover research ideas for devising future strategies for manipulating the composition of dietary FA to regulate gut health and support a normal immune system for metabolic and immune disorders. | E.Xu Chao Chen Jie Fu Luoyi Zhu Junlan Shu Mingliang Jin Yizhen Wang Xin Zong | 2021 | Animal Nutrition2021，，4： | 4 |
| 7 | YTHDF1 promotes NLRP3 translation to induce intestinal epithelial cell inflammatory injury during endotoxic shock显示文摘Dear editor,Endotoxic shock usually results from infection-induced physiologic, pathologic, and biologic abnormalities(Singer et al., 2016). Undeniably, it is still a profoundly damaging and life-threatening condition for many individuals(Guan et al., 2019;Ding et al., 2021). Studies have shown that it is associated with the accumulation of apoptotic markers(Kayagaki et al., 2015;Zong et al., 2019). | Xin Zong Xiao Xiao Fu Jie Yuanzhi Cheng Mingliang Jin Yulong Yin Yizhen Wang | 2021 | Science China(Life Sciences)2021，64，11： | 3 |
| 8 | Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury显示文摘Compelling evidence has revealed that biased activation of G protein-coupled receptor(GPCR)signaling,including angiotensin II(AngII)receptor type 1(AT1)signaling,plays pivotal roles in vascular homeostasis and injury,but whether a clinically relevant endogenous biased antagonism of AT1 signaling exists under physiological and pathophysiological conditions has not been clearly elucidated.Here,we show that an extracellular matrix protein,cartilage oligomeric matrix protein(COMP),acts as an endogenous allosteric biased modulator of the AT1 receptor and its deficiency is clinically associated with abdominal aortic aneurysm(AAA)development.COMP directly interacts with the extracellular N-terminus of the AT1 via its EGF domain and inhibits AT1-β-arrestin-2 signaling,but not Gq or Gi signaling,in a selective manner through allosteric regulation of AT1 intracellular conformational states.COMP deficiency results in activation of AT1a-β-arrestin-2 signaling and subsequent exclusive AAA formation in response to AngII infusion.AAAs in COMP–/–or ApoE–/–mice are rescued by AT1a orβ-arrestin-2 deficiency,or the application of a peptidomimetic mimicking the AT1-binding motif of COMP.Explorations of the endogenous biased antagonism of AT1 receptor or other GPCRs may reveal novel therapeutic strategies for cardiovascular diseases. | Yi Fu Yaqian Huang Zhao Yang Yufei Chen Jingang Zheng Chenfeng Mao Zhiqing Li Zhixin Liu Bing Yu Tuoyi Li Meili Wang Chanjuan Xu Yiwei Zhou Guizhen Zhao Yiting Jia Wei Guo Xin Jia Tao Zhang Li Li Ziyi Liu Shengchao Guo Mingliang Ma Heng Zhang Bo Liu Junbao Du Wengong Wang Chaoshu Tang Pei Gao Qingbo Xu Xian Wang Jianfeng Liu Jinpeng Sun Wei Kong | 2021 | Cell Research2021，31，7： | 2 |
| 9 | Pharmacological inhibition of SRC-1 phase separation suppresses YAP oncogenic transcription activity显示文摘Dear Editor,Yes-associated protein(YAP)is a transcriptional coactivator that plays an essential role in promoting cell proliferation,development and stem cell fate.1 Aberrant YAP activation is prevalent in diverse types of human solid cancers. | Guangya Zhu Jingjinq Xie Zhenzhen Fu Mingliang Wang Qichen Zhang Hao He Zijun Chen Xin Guo Jidong Zhu | 2021 | Cell Research2021，31，9： | 2 |
| 10 | Maximum likelihood estimation of nonlinear mixed-effects models with crossed random effects by combining first-order conditional linearization and sequential quadratic programming显示文摘Nonlinear mixed-eirects (NLME) modek have become popular in various disciplines over the past several decades.However,the existing methods for parameter estimation imple-mented in standard statistical packages such as SAS and R/S-Plus are generally limited k) single-or multi-level NLME models that only allow nested random effects and are unable to cope with crossed random effects within the framework of NLME modeling.In t his study,wc propose a general formulation of NLME models that can accommodate both nested and crassed random effects,and then develop a computational algorit hm for parameter estimation based on normal assumptions.The maximum likelihood estimation is carried out using the first-order conditional expansion (FOCE) for NLME model linearization and sequential quadratic programming (SCJP) for computational optimization while ensuring positive-definiteness of the estimated variance-covariance matrices of both random effects and error terms.The FOCE-SQP algorithm is evaluated using the height and diameter data measured on trees from Korean larch (L.olgeiisis var,Chang-paienA.b) experimental plots aa well as simulation studies.We show that the FOCE-SQP method converges fast with high accuracy.Applications of the general formulation of NLME models are illustrated with an analysis of the Korean larch data. | Liyong Fu Mingliang Wang Zuoheng Wang Xinyu Song Shouzheng Tang | 2019 | International Journal of Biomathematics2019，12，5： | 1 |
| 11 | Characteristics of typical non-road machinery emissions in China by using portable emission measurement system 显示文摘 | FU Mingliang GE Yunshan TAN Jianwei | 2012 | Science of the Total Environment2012，437，： | 1 |
| 12 | Effect of angiotensin I-converting enzyme inhibitory peptide from rice dregs protein on antihypertensive activity in spontaneously hypertensive rats显示文摘 | CHEN Qihe XUAN Guodong FU Mingliang | 2009 | Asian Pacific Journal of Clinical Nutrition2009，16，： | 1 |
| 13 | Preparation and properties of octenyl succinic anhydride modified potato starch显示文摘 | RUAN Hui CHEN Qihe FU Mingliang | | 0，，01： | 1 |
| 14 | Magnetoresistance Oscillations of Ultrathin Pb Bridges显示文摘Pb nanobridges with a thickness of less than 10 nm and a width of several hundred nm have been fabricated from single-crystalline Pb fi lms using low-temperature molecular beam epitaxy and focus ion beam microfabrication techniques.We observed novel magnetoresistance oscillations below the superconducting transition temperature(TC)of the bridges.The oscillations which were not seen in the crystalline Pb fi lmsmay originate from the inhomogeneity of superconductivity induced by the applied magnetic fi elds on approaching the normal state,or the degradation of fi lm quality by thermal evolution. | Jian Wang Xucun Ma Shuaihua Ji Yun Qi Yingshuang Fu Aizi Jin Li Lu Changzhi Gu X.C.Xie Mingliang Tian Jinfeng Jia Qikun Xue | 2009 | Nano Research2009，2，9： | 1 |
| 15 | Optimization ofultrasonic-assisted extraction (UAE) of betulin from white birch barkusing response surface methodology 显示文摘 | CHEN Qihe FU Mingliang LIU Jing | 2009 | Ultrasonics Sonochemistry2009，16，5： | 1 |
| 16 | Carbonyl compound emissions from passenger cars fueled with methanol/gasoline blends显示文摘 | Hong Zhao Yunshan Ge Chunxiao Hao Xiukun Han Mingliang Fu Linxiao Yu Asad Naeem Shah | 2010 | Science of the Total Environment2010，，17： | 1 |
| 17 | Preparation and propertics of octvnyl succinic anhydride modified potato starch显示文摘 | RUAN Hui CHEN Qihe FU Mingliang | 2009 | Food Chemistry2009，114，1： | 1 |
| 18 | Self-assembly of various Au nanocrystals on functionalized water-stable PVA/PEI nanofibers: A highly efficient surface-enhanced Raman scattering substrates with high density of “hot” spots显示文摘 | Han Zhu MingLiang Du Ming Zhang Pan Wang ShiYong Bao Meiling Zou YaQin Fu JuMing Yao | 2014 | Biosensors and Bioelectronics2014，，： | 1 |
| 19 | Mechanisms and regulation of defensins in host defense显示文摘As a family of cationic host defense peptides,defensins are mainly synthesized by Paneth cells,neutrophils,and epithelial cells,contributing to host defense.Their biological functions in innate immunity,as well as their structure and activity relationships,along with their mechanisms of action and therapeutic potential,have been of great interest in recent years.To highlight the key research into the role of defensins in human and animal health,we first describe their research history,structural features,evolution,and antimicrobial mechanisms.Next,we cover the role of defensins in immune homeostasis,chemotaxis,mucosal barrier function,gut microbiota regulation,intestinal development and regulation of cell death.Further,we discuss their clinical relevance and therapeutic potential in various diseases,including infectious disease,inflammatory bowel disease,diabetes and obesity,chronic inflammatory lung disease,periodontitis and cancer.Finally,we summarize the current knowledge regarding the nutrient-dependent regulation of defensins,including fatty acids,amino acids,microelements,plant extracts,and probiotics,while considering the clinical application of such regulation.Together,the review summarizes the various biological functions,mechanism of actions and potential clinical significance of defensins,along with the challenges in developing defensins-based therapy,thus providing crucial insights into their biology and potential clinical utility. | Jie Fu Xin Zong Mingliang Jin Junxia Min Fudi Wang Yizhen Wang | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 1 |
| 20 | Effect of angiotensin I-converting enzyme inhibitory peptide from rice dregs protein on antihypertensive activity in spontaneously hypertensive rats显示文摘 | Qihe Chen Guodong Xuan Mingliang Fu | 2007 | Asia Pac J Clin Nurtr2007，16，1： | 1 |
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