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| 1 | Efficacy and safety of metformin and sitagliptin based triple antihyperglycemic therapy(STRATEGY):a multicenter,randomized,controlled,non-inferiority clinical trial显示文摘Despite the current guideline's recommendation of a timely stepwise intensification therapy,the 'clinical inertia',termed as the delayed treatment intensification,commonly exists in the real world,which may be partly due to the relatively little substantial evidence and no clear consensus regarding the efficacy and safety of triple oral agents in patients inadequately controlled with dual therapy.In this clinical trial performed in 237 centers in China,5,535 type 2 diabetic patients inadequately controlled by previous therapies were treated with a stable metformin/sitagliptin dual therapy for 20 weeks.The patients who did not reach the glycated hemoglobin A1c(HbA1c) goal were then further randomized into glimepiride,gliclazide,repaglinide,or acarbose group for an additional 24-week triple therapy.A mean HbAlc reduction of 0.85%was observed when sitagliptin was added to the patients inadequately controlled with metformin in 16 weeks.Further HbAlc reductions in the 24-week triple therapy stage were 0.65%in glimepiride group,0.70%in gliclazide group,0.61%in repaglinide group,and 0.45%in acarbose group.The non-inferiority criterion for primary hypotheses was met for gliclazide and repaglinide,but not for acarbose,compared with glimepiride,when added to metformin/sitagliptin dual therapy.The incidences of adverse events(AEs) were 29.2%in the dual therapy stage and30.3%in the triple therapy stage.Metformin/sitagliptin as baseline therapy,with the addition of a third oral antihyperglycemic agent,including glimepiride,gliclazide,repaglinide,or acarbose,was effective,safe and well-tolerated for achieving an HbAlc<7.0%goal in type 2 diabetic patients inadequately controlled with previous therapies.The timely augmentation of up to three oral antihyperglycemic agents is valid and of important clinical benefit to prevent patients from exposure to unnecessarily prolonged hyperglycemia. | Wen Xu Yiming Mu Jiajun Zhao Dalong Zhu Qiuhe Ji Zhiguang Zhou Bin Yao Anhua Mao Samuel S.Engel Bin Zhao Yan Bi Longyi Zeng Xingwu Ran Juming Lu Linong Ji Wenying Yang Weiping Jia Jianping Weng | 2017 | Science China(Life Sciences)2017，60，3： | 19 |
| 2 | 澳洲坚果果壳解吸等温线与吸附等温线拟合模型显示文摘采用非线性回归方法,分析评价了6种模型与试验得到的澳洲坚果果壳在25℃下的解吸等温线与吸附等温线的拟合程度,以确定最佳拟合模型及其参数。结果表明,根据国际理论和应用化学联合会(IUPAC)的分类,解吸等温线与吸附等温线都属于第Ⅰ种类型。解吸吸附滞后现象属于H3型。GAB模型是最佳的解吸等温线和吸附等温线拟合方程。GAB模型拟合解吸等温线的参数A、B、C分别为9.693、0.605、8.378,拟合吸附等温线的参数分别为9.695、0.635、3.268。 | 王云阳 张丽 王绍金 Tang Juming 李元瑞1 | 2012 | 农业机械学报2012，43，5： | 11 |
| 3 | A new free-hand pedicle screw placement technique with reference to the supraspinal ligament显示文摘We sought to compare the safety and accuracy of a new free-hand pedicle screw placement technique to that of the conventional technique.One hundred fifty-three consecutive adult patients with simple fracture in the thoracic or/and lumbar spine were alternately assigned to either the new free-hand or the conventional group.In the new free-hand technique group,preoperative computerized tomography(CT) images were used to calculate the targeted medial-lateral angle of each pedicle trajectory and the pedicle screw was inserted perpendicular to the corresponding supraspinal ligament.In the conventional technique group,the medial-lateral and cranial-caudal angle of each pedicle trajectory was determined by intraoperatively under fluoroscopic guidance.The accuracy rate of pedicle screw placement,the time of intraoperative fluoroscopy,the operating time and the amount of blood loss during operation were respectively compared.All screws were analyzed by using intraoperative radiographs,intraoperative triggered electromyography(EMG) monitoring data,postoperative CT data and clinical outcomes.The accuracy rate of pedicle screw placement in the new free-hand technique group and the conventional technique group was 96.3% and 94.2%(P < 0.05),respectively.The intraoperative fluoroscopy time of the new technique group was less than that of the conventional technique group(5.37 seconds vs.8.79 seconds,P < 0.05).However,there was no statistical difference in the operating time and the amount of blood loss during operation(P > 0.05).Pedicle screw placement with the free-hand technique which keeps the screw perpendicular to the supraspinal ligament is an accurate,reliable and safe technique to treat simple fracture in the thoracic or lumbar spine. | Juming Li Hong Zhao Hao Xie Lipeng Yu Jifu Wei Min Zong Feng Chen Ziqiang Zhu Ning Zhang Xiaojian Cao | 2014 | The Journal of Biomedical Research2014，28，1： | 7 |
| 4 | Template-free synthesis of carbon doped TiO2 mesoporous microplates for enhanced visible light photodegradation显示文摘钛二氧化物(TiO 2) 广泛地为太阳能变换和环境补习作为稳固的光催化剂被采用。与控制粒子尺寸和缩小的 bandgap 构造多孔的 TiO 2 的能力是为设计的一个必要要求高度有效并且 recyclable 光催化剂。这里,我们报导没有模板的醋酸与高 crystallinity 和 mesoporous 结构为可见光的应答的做碳的 TiO 2 microplates 的合成导致了方法。从醋酸导出的撤退电子的有二齿的羧化物 ligands 能缩小 TiO 2 的 bandgap,这被显示出(1.84 ? eV ) 实质地。而且,结果的 microplate 光催化剂展出优秀 photocatalytic 效率和稳固液体的分离性能,它将为未来是有益的工业应用。 | Juming Liu Lu Han Huiyan Ma Hao Tian Jucai Yang Qiancheng Zhang Benjamin J. Seligmann Shaobin Wang Jian Liu | 2016 | Science Bulletin2016，61，19： | 4 |
| 5 | Review of dielectric drying of foods and agricultural products显示文摘Dielectric drying methods with microwave(MW)and radio frequency(RF)energy as emerging drying technologies have drawn much attention from both research community and industry over the past decades.When properly applied,MW and RF drying can be energy efficient and of great potential to be used for a wide range of materials.However there are few reviews that cover both MW and RF drying technologies.Such a review is timely considering the ever increasing interest of the food industry in adapting energy efficient new drying technologies.This paper attends to provide a comprehensive review on uses of MW and RF energy in drying of foods and agricultural products.It provides a brief discussion on the fundamental theory of MW and RF heating and gives a general overview of the works of the most active research groups on modeling of drying kinetic,energy control strategy and the influence of MW and RF drying conditions on quality and structural changes of the final products.Finally,it proposes possible solutions to main challenges facing the industrial adaptation of the technologies and makes suggestions on further research directions to improve the dielectric drying. | Yunyang Wang Yuanrui Li Shaojin Wang Li Zhang Mengxiang Gao Juming Tang | 2011 | International Journal of Agricultural and Biological Engineering2011，4，1： | 4 |
| 6 | Effects of antioxidants on homocysteine thiolactone-induced apoptosis in human umbilical vein endothelial cells显示文摘Background and objectives Hyperhomocysteinemia is an independent risk factor for cardiovascular disease. Homocysteine thiolactone (HcyT), one of the homocysteine metabolites in vivo, is toxic both in vivo and in vitro. The aim of this study was to investigate the effect of HcyT on apoptotic damage in human umbilical vein endothelial cells (HUVECs) and the role of antioxidants in the reduction of HcyT-induced apoptosis. Methods HUVECs were cultured in DMEM supplemented with 20% heat inactivated fetal bovine serum cell cultures were maintained in a humidified 5% CO2 atmosphere at 37 ℃. Cytotoxicity was determined by MTT assay,which consists of hypodiploid cells with propidium iodide labeling and intracellular reactive oxygen species levels using 2',7'-dichlorofluorescein diacetate as the probe by flow cytometry. Results HcyT (250-2000μM) induced HUVECs apoptosis in a time- and concentration-dependent manner. Reactive oxygen species levels rose in response to increasing HcyT concentrations at 24-h incubation.The reduction of cell apoptosis by N-acetylcysteine, vitamin E, or pyrrolidine dithiocarbamate, occurred simultaneously with a significant decrease in intracellular reactive oxygen species levels. Conclusion HcyT exerts its cytotoxic effects on endothelial cells through an apoptotic mechanism involving cellular reactive oxygen species production. The capacity of N-acetylcysteine, vitamin E, and pyrrolidine dithiocarbamate to scavenge HcyT-induced cellular reactive oxygen species correlates well with their efficiency to protect against HcyT-promoted apoptotic damage. The protective effect of pyrrolidine dithiocarbamate on cell apoptosis indicates HcyT-generated hydrogen peroxide may provoke cell apoptosis via activating nuclear factor-kappa binding protein. | Weijun GU Juming LU Guoqing YANG Qinghua GUO Baoan WANG Yiming MU Changyu PAN | 2006 | Journal of Geriatric Cardiology2006，3，2： | 3 |
| 7 | Empirical formulae for electric double-layer repulsion between two arbitrarily inclined clay particles显示文摘To understand the mesoscopic mechanism of clayey soil in view of macroscopic behavior, it is essential to quantitatively calculate the electric double-layer repulsion between arbitrarily inclined clay particles.However, suitable calculation methods with high efficiency and accuracy are still rare at present in literature. Based on a great number of numerical calculations of the repulsion between two inclined platy clay particles, explicit empirical formulae for estimating electric double-layer repulsion between clay particles are put forward. Comparison between the empirical solutions and corresponding numerical results shows that the proposed formulae have a reasonable accuracy, and application of the presented formula is easy and efficient. | Xiangyu Shang Juming Lu Lianfei Kuang Chen Yang Guoqing Zhou | 2018 | Journal of Rock Mechanics and Geotechnical Engineering2018，10，6： | 3 |
| 8 | Electrospun Polyethylene Glycol/Polyvinyl Alcohol Composite Nanofibrous Membranes as Shape-Stabilized Solid-Solid Phase Change Materials显示文摘In this work,shape-stabilized solid-solid phase change materials(PCMs)were fabricated by simply electrospinning polyethylene glycol(PEG)and polyvinyl alcohol(PVA).Owing to the strong hydrogen bonds and entanglement between those molecular chains of PEG and PVA,PEG was packaged by PVA.The morphological structures,thermal stability and thermal energy storage properties of those fibers were investigated.SEM results showed that those electrospun PVA/PEG composite membranes hold a three-dimensional nonwoven web structure even the content of PEG as high as 70%.The thermal energy storage ability of those composite fibers increased with the increase of the content of PEG.The heat enthalpies of PEG/PVA=7/3 were as high as 78.806 J/g.Moreover,those composite fibers had excellent thermal stability.After 100 heating and cooling cycles,there was almost no obvious change in the melting enthalpy and crystallization enthalpy.Those fibers still maintained good thermal regulation.The simple preparation process,low cost of raw materials and excellent stability endow the PCMs great utilization potentiality in smart textile and energy storage systems. | Junwen Huang Houyong Yu Somia Yassin Hussain Abdalkarim Jaromir Marek Jiri Militky Yingzhan Li Juming Yao | 2020 | Advanced Fiber Materials2020，2，3： | 2 |
| 9 | Robust Segmentation Method for Noisy Images Based on an Unsupervised Denosing Filter显示文摘Level-set-based image segmentation has been widely used in unsupervised segmentation tasks.Researchers have recently alleviated the influence of image noise on segmentation results by introducing global or local statistics into existing models.Most existing methods are based on the assumption that the distribution of image noise is known or observable.However,real-time images do not meet this assumption.To bridge this gap,we propose a novel level-set-based segmentation method with an unsupervised denoising mechanism.First,a denoising filter is acquired under the unsupervised learning paradigm.Second,the denoising filter is integrated into the level-set framework to separate noise from the noisy image input.Finally,the level-set energy function is minimized to acquire segmentation contours.Extensive experiments demonstrate the robustness and effectiveness of the proposed method when applied to noisy images. | Ling Zhang Jianchao Liu Fangxing Shang Gang Li Juming Zhao Yueqin Zhang | 2021 | Tsinghua Science and Technology2021，26，5： | 2 |
| 10 | Shelf life and sales concerns of bakery products- a review显示文摘 | Jumes P Smith | 2004 | Boca Raton2004，44，： | 1 |
| 11 | Artificial spinning and characterization of silk fiber from Bombyx mori silk fibroin in hexafluoroacetone hydrate 显示文摘 | Yao Juming Masuda H Zhao Chenhua | 2002 | Macromolecules2002，35，1： | 1 |
| 12 | Prevalence offJiabe, tes among Men and Women in China 显示文摘 | Wenying Yang Juming Liu Jianping Wen | 2010 | N Engl J Med2010，362，12： | 1 |
| 13 | Prevalence of diabetes a- mong men and women in China 显示文摘 | Wengying Y Juming L Jianping W | 2010 | N Engl J Med2010，362，： | 1 |
| 14 | Prevalence of diabetes among men and women in China显示文摘 | Yang Wenying Lu Juming Weng Jianping | 2010 | N Engl J Med2010，362，： | 1 |
| 15 | Dielectric properties of dehydrated apples as affected by moisture and temperature显示文摘 | FENG Hao TANG Juming CAVALIERI R P | 2002 | Transactions of the ASAE2002，45，1： | 1 |
| 16 | Prevalence of diabetes among men and women in China 显示文摘 | Yang Wenying Lu Juming Weng Jianping | | N Engl J Med0，362，19： | 1 |
| 17 | Preva-lence of diabetes among men and women in China显示文摘 | YANG WENYIN LU JUMING WENG JIANPING | 2010 | N Engl JMed2010，362，12： | 1 |
| 18 | Prevalence of Diabetes among Men and Women in China 显示文摘 | Wenying Yang Juming Lu Jianping Weng | 2010 | The New England Journal of Medicine2010，，3： | 1 |
| 19 | Powers antioxidant activity andquality of asparagus affected by microwave circulated water combination and conventional sterilization显示文摘 | Ting Sun Juming Tang | | 0，，： | 1 |
| 20 | Prevalence of Diabetes among Men And Women in China显示文摘 | Wenying Yang Juming Lu Jianping Weng | 2010 | NEngl JMed2010，362，12： | 1 |
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