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| 1 | Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor显示文摘T 房间 receptor-CD3 建筑群(TCR ) 是能基于 CD3 细胞质的领域的各种各样的生物化学的变化开始抗原特定的有免疫力的回答的一台万用的发信号机器,但是内在的结构的基础留下逃犯。这里,我们开发了生物物理的途径学习 CD3 细胞质的领域的 conformational 动力学(CD3 CD ) 。在单个分子的水平,我们发现那 CD3 CD 能与三个功能的主题的不同坦诚有多重 conformational 状态,即, ITAM, BRS 和 PRS。因为,这些符合构造被产生 CD3 CD 有异构的类脂化合物绑定性质因此有异构的动力学。实时房间的成像实验证明不同抗原刺激能稳定 CD3 在不同符合构造的 CD 。类脂化合物依赖者 conformational 动力学因此为 TCR 的万用的发信号性质提供结构的基础。 | Xingdong Guo Chengsong Yan Hua Li Wenmao Huan Xiaoshan Shi Min Huang Yingfang Wang Weiling Pan Mingjun Cai Lunyi Li Wei Wu Yibing Bai Chi Zhang Zhijun Liu Xinyan Wang Xiaohui F Zhang Chun Tang Hongda Wang Wanli Liu Bo Ouyang Catherine C Wong Yi Cao Chenqi Xu | 2017 | Cell Research2017，27，4： | 5 |
| 2 | Routing optimization for multi-type containerships in a hub-and-spoke network显示文摘This paper considers the ship routing optimization problem in a hub-and-spoke network.A routing optimization model for multi-type containerships with time deadlines is established,and the target is to minimize the total cost,which consists of the total travelling cost,total service cost and total waiting cost.The model is set up through an improved genetic algorithm.The study data are from the Pearl River Delta region of China,which include 1 hub port and 29 feeder ports and have a population of 30 million.Result shows that when the iteration time reaches 190,the total cost comes to 521 thousand yuan near the optimal value.There are 6 routes,including 3 containerships of 100 TEU,2 containerships of 150 TEU and 1 containership of 200 TEU.At the same time,in the single-type containerships case,there are 7 routes,and when the iteration time reaches 120,the total cost comes to 573 thousand yuan,which is close to the optimal value.Comparing the two cases,it shows that the model for multi-type containerships with time deadlines is reasonable,and the algorithm is practicable.In the last,three factors,which may affect the total cost to carry out sensitivity analysis are chosen.It shows that time deadline,containership capacity and cargo handling capacity of each port have significant influence on the total cost.It is also shown that the total cost for multi-type containerships is always less than that for the single-type containerships. | Mingjun Ji Lixin Shen Baishun Shi Yanyan Xue Fei Wang | 2015 | Journal of Traffic and Transportation Engineering(English Edition)2015，2，5： | 5 |
| 3 | Stable Isotope Signatures and Moisture Transport of a Typical Heavy Precipitation Case in the Southern Tianshan Mountains显示文摘Stable oxygen isotopes in precipitation contain meaningful environmental information on a synoptic scale and can be applied to diagnose hydrometeorological processes.A series of rainstorms occurred at the southern Tianshan Mountains during the period from May to June 2013,and the event-based precipitation was sampled along the mountain range from west to east.Based on δ18 O values in precipitation samples as well as the corresponding meteorological parameters,the moisture transport paths during the sampling period were identified.In late-May(stage 1),isotopes in precipitation collected generally showed a depleting trend.In mid-June(stage 2),there was no coherent trend of isotopes in precipitation for these stations,and only isotope values in Aksu showed a continually depleting trend.Checking other meteorological proxies during the sampling period,the event-based precipitation isotopes sensitively reflected the moisture process.In central Asia,both the westerly and monsoon moisture can be delivered to cause extreme precipitation events,and the isotopic information provides an alternative tool to investigate the atmospheric processes. | WANG Liwei ZHANG Mingjun WANG Shengjie Athanassios AARGIRIOU WANG Gaofei Vasileios SALAMALIKIS SHI Mengyu JIAO Rong | 2020 | Chinese Geographical Science2020，30，1： | 2 |
| 4 | Construction of WO_(3)/Ti-doped WO_(3)bi-layer nanopore arrays with superior electrochromic and capacitive performances显示文摘Crystalline WO_(3)/Ti-doped WO_(3)bi-layer nanopore arrays were constructed by the template synthesis of a WO_(3)nanopore layer modified by a magnetron sputtering of an amorphous Ti-doped/WO_(3)layer.The obtained bi-layer nanopore array shows a remarkable electrochromic performance with large dual-band optical modulation in both visible(VIS)and near infrared(NIR)regions(optical modulation of over 70%in the wavelength range from 600 to 1600 nm)and the fast response speed(coloring for 3.4 s and bleaching for 6.6 s).In addition,the bi-layer WO_(3)/Ti-doped WO_(3)nanopore array also present superior energy-storage properties(areal capacitance of 44.0 mF cm−2 and good rate capability),better than that of titanium-free thin films.The special bifunctional characteristics of electrochromism and pseudocapacitance can be ascribed to the large specific surface area provided by the architectural design,rich ion channels in the amorphous layer as well as proper titanium doping,which bestows the bi-layer nanopore array a great potential in clean energy applications. | Yingdi Shi Shujing Liu Yong Zhang Mingjun Sun Kai Tang Jiewu Cui Xia Shu Yan Wang Jiaqin Liu Yucheng Wu | 2019 | Tungsten2019，1，3： | 2 |
| 5 | Beneficiation of nickeliferous laterite by reduction roasting in the presence of sodium sulfate显示文摘 | Guanghui Li Tangming Shi Mingjun Rao Tao Jiang Yuanbo Zhang | 2012 | Minerals Engineering2012，，： | 1 |
| 6 | Klotho deficiency causes vascular calcification in chronic kidney disease显示文摘 | HU Ming - chang SHI Mingjun ZHANG Jianning | 2011 | J Am Soc Nephrol2011，22，1： | 1 |
| 7 | A modified optical flow algorithm based on bilateral-filter and multi-resolution analysis for PIV image processing显示文摘 | Baocheng Shi Jinjia Wei Mingjun Pang | 2014 | Flow Measurement and Instrumentation2014，38，8： | 1 |
| 8 | Klothodeficiency causes vascular calcification in chronickidney disease显示文摘 | Ming chang Hu Mingjun Shi Jianning Zhang | 2011 | J Am Soc Nephrol2011，22，： | 1 |
| 9 | Anti-infection effects of heparin on SARS-CoV-2 in a diabetic mouse model显示文摘Severe acute respiratory syndrome coronavirus 2(SARSCo V-2)infection can result in more severe syndromes and poorer outcomes in patients with diabetes and obesity.However,the precise mechanisms responsible for the combined impact of coronavirus disease 2019(COVID-19)and diabetes have not yet been elucidated,and effective treatment options for SARS-Co V-2-infected diabetic patients remain limited.To investigate the disease pathogenesis,K18-h ACE2 transgenic(h ACE2^(Tg))mice with a leptin receptor deficiency(h ACE2-Lepr^(-/-))and high-fat diet(h ACE2-HFD)background were generated.The two mouse models were intranasally infected with a 5×10^(5) median tissue culture infectious dose(TCID_(50))of SARSCo V-2,with serum and lung tissue samples collected at 3days post-infection.The h ACE2-Lepr^(-/-)mice were then administered a combination of low-molecular-weight heparin(LMWH)(1 mg/kg or 5 mg/kg)and insulin via subcutaneous injection prior to intranasal infection with1×10^(4) TCID_(50)of SARS-Co V-2.Daily drug administration continued until the euthanasia of the mice.Analyses of viral RNA loads,histopathological changes in lung tissue,and inflammation factors were conducted.Results demonstrated similar SARS-Co V-2 susceptibility in h ACE2^(Tg)mice under both lean(chow diet)and obese(HFD)conditions.However,compared to the h ACE2-Lepr^(+/+)mice,h ACE2-Lepr^(-/-)mice exhibited more severe lung injury,enhanced expression of inflammatory cytokines and hypoxia-inducible factor-1α(HIF-1α),and increased apoptosis.Moreover,combined LMWH and insulin treatment effectively reduced disease progression and severity,attenuated lung pathological changes,and mitigated inflammatory responses.In conclusion,preexisting diabetes can lead to more severe lung damage upon SARS-Co V-2 infection,and LMWH may be a valuable therapeutic approach for managing COVID-19patients with diabetes. | Zhongyun Zhang Ning Zhang Xuancheng Lu Min Zhou Xiaoxiang Yan Weiqiong Gu Jingru Yang Qin Zhang Cheng Zhang Yuhuan Gong Mingjun Jia Xiaoyu Zhang Peng Ning Mei Liu Xiaoyan Li Xiaomeng Shi Wenjun Liu George FGao Guang Ning Jiqiu Wang Yuhai Bi | 2023 | Zoological Research2023，44，6： | 1 |
| 10 | Klotho: a novel phosphaturic substance acting as anautocrine enzyme in the renal proximal tubule 显示文摘 | Ming chang Hu Mingjun Shi Jianning Zhang | 2010 | TheFASEB Journal2010，24，： | 1 |
| 11 | Association between epidermal growth factor gene rs4444903 polymorphism and risk of glioma显示文摘 | Mingjun Hu Hangyu Shi Zanfeng Xu Weiping Liu | 2013 | Tumor Biology2013，，3： | 1 |
| 12 | Beneficiation of nickeliferous laterite by reduction roasting in the presence of sodium sulfate显示文摘 | LI Guanghui SHI Tangming RAO Mingjun | 2012 | Minerals Engineering2012，32，： | 1 |
| 13 | New power generation technology options under the green house gases mitigation scenario in China显示文摘 | Liu Qiang Shi Mingjun Jiang Kejun | 2009 | Energy Policy2009，37，24： | 1 |
| 14 | A momentum exchange-based immersed boundary-lattice Boltzmann method for simulating a flexible filament in an incompressible flow显示文摘 | Hai-Zhuan Yuan Xiao-Dong Niu Shi Shu Mingjun Li Hiroshi Yamaguchi | 2014 | Computers and Mathematics with Applications2014，，： | 1 |
| 15 | A modified cross-correlation algorithm for PIV image processing of particle-fluid two-phase flow显示文摘 | Baocheng Shi Jinjia Wei Mingjun Pang | 2015 | Flow Measurement and Instrumentation2015，45，： | 1 |
| 16 | Beneficiation of nickeliferous laterite by reduction roasting in the presence of sodium sulfate显示文摘 | LI Guanghui SHI Tangming RAO Mingjun | 2012 | Minerals Engineering2012，32，： | 1 |
| 17 | Anomalous enhancement oxidation of few-layer MoS_(2)and MoS_(2)/h-BN heterostructure显示文摘Because of profound applications of two-dimensional molybdenum disulfide(MoS_(2))and its heterostructures in electronics,its thermal stability has been spurred substantial interest.We employ a precision muffle furnace at a series of increasing temperatures up to 340℃to study the oxidation behavior of continuous MoS_(2)films by either directly growing mono-and fewlayer MoS_(2)on SiO_(2)/Si substrate,or by mechanically transferring monolayer MoS_(2)or hexagonal boron nitride(h-BN)onto monolayer MoS_(2)substrate.Results show that monolayer MoS_(2)can withstand high temperature at 340℃with less oxidation while the few-layer MoS_(2)films are completely oxidized just at 280℃,resulting from the growth-induced tensile strain in few-layer MoS_(2).When the tensile strain of films is released by transfer method,the stacked few-layer MoS_(2)films exhibit superior thermal stability and typical layer-by-layer oxidation behavior at similarly high temperature.Counterintuitively,for the MoS_(2)/h-BN heterostructure,the h-BN film itself stacked on top is not damaged and forms many bubbles at 340℃,whereas the underlying monolayer MoS_(2)film is oxidized completely.By comprehensively using various experimental characterization and molecular dynamics calculations,such anomalous oxidation behavior of MoS_(2)/h-BN heterostructure is mainly due to the increased tensile strain in MoS_(2)film at elevated temperature. | Siming Ren Yanbin Shi Chaozhi Zhang Mingjun Cui Jibin Pu | 2022 | Nano Research2022，15，8： | 0 |
| 18 | Turning gas hydrate nucleation with oxygen-containing groups on size-selected graphene oxide flakes显示文摘Gas hydrate is a promising alternative for gas capture and storage due to its high gas storage capacity achieved with only structured water molecules.Nucleation is the critical controlling step in gas hydrate formation.Adding an alien solid surface is an effective approach to regulate gas hydrate nucleation.However,how the solid surface compositions control the gas hydrate nucleation remains unclear.Benefiting from the fact that the surface compositions of graphene oxide(GO)can be finely tuned,we report the effect of functional groups of size-selected GO flakes on methane hydrate nucleation.The carbonyl and carboxyl of GO flakes showed a more prominent promotion for methane hydrate nucleation than the hydroxyl of GO flakes.Surface energy,zeta potential,Raman spectra,and molecular dynamics simulation analysis were used to reveal the regulation mechanism of the functional groups of size-selected GO flakes on methane hydrate nucleation.The GO flakes with abundant carbonyl and carboxyl exhibited higher charge density than those enriched in hydroxyl.The negatively charged GO flakes can induce water molecules to form an ordered hydrogen-bonded arrangement via charge-dipole interactions.Therefore,the water molecules surrounding the carboxyl and carbonyl showed a more ordered hydrogen-bonded structure than those around the hydroxyl of GO flakes.The ordered water arrangement,similar to methane hydrate cages,significantly accelerated methane hydrate nucleation.Our study shows how the surface chemistry of solids control gas hydrate nucleation and sheds light on the design of effective heterogeneous nucleators for gas hydrate. | Huiquan Liu Changrui Shi Zherui Chen Shuai Wang Mingjun Yang Jiafei Zhao Cong Chen Yongchen Song Zheng Ling | 2023 | Journal of Energy Chemistry2023，，12： | 0 |
| 19 | Short-term serum deprivation causes no significant mitochondrial DNA mutation in vascular smooth muscle cells revealed by a new next generation sequencing technology显示文摘线粒体提供许多精力因为在线粒体的房间和混乱能几乎影响任何织物[1 ] 。mitochondrial DNA (mtDNA ) 盖住 16,569 bp,由在人的 37 基因和 1 个 D 环区域组成。线粒体在拥有他们被采用 multiprotein 机械组织成 mitochondrial nucleoids 的自己的染色体是唯一的,并且能执行基因复制,抄写,和修理的功能[2 ] 。尽管它让几乎所有已知的原子 DNA 修理小径,保护的 histones 的缺乏可以导致特别危险性到压力和 DNA 损坏事件[3 ] 。确实, mtDNA 让一个很高的变化评价[4 ] 。自从它的发现, mtDNA 变化被知道了普通并且包括糖尿病,心血管的疾病,癌症,神经与肌的混乱,和老化作为人的疾病的一个重要原因出现了,在 4300 人口影响 1 [5,6 ] 。因此,在压力和疾病识别 mtDNA 变化现在是一个热研究区域。 | Xiangqi Li Lianyong Liu Qian Xi Xuemei Zhao iingshuang Fang Junhua Ma ZhaohuiZhu Xing Wang Chao Shi Jingnan Wang Hongling Zhu Jichen Zhang Chaobao Zhang Shuanggang Hu Minjie Ni Mingjun Gu | 2016 | Acta Biochimica et Biophysica Sinica2016，48，9： | 0 |
| 20 | Satellite-measured water vapor isotopologues across the Tianshan Mountains,central Asia显示文摘The satellite-based water vapor stable isotope measurements have been widely used in modern hydrological and atmospheric studies.Their use is important for arid areas where the precipitation events are limited,and below-cloud evaporation is strong.This study presents the spatial and temporal characteristics of water vapor isotopologue across the Tianshan Mountains in arid central Asia using the NASAAura Tropospheric Emission Spectrometer(TES).The near-surface water vapor stable isotopes are enriched in summer and depleted in winter,consistent with the seasonality of precipitation isotopes.From the surface to 200 hPa,the isotope values in water vapor show a decreasing trend as the atmospheric pressure decreases and elevation rises.The vapor isotope values in the lower atmosphere in the southern basin of the Tianshan Mountains are usually higher than that in the northern basin,and the seasonal difference in vapor isotopes is slightly more significant in the southern basin.In addition,bottom vapor isotopologue in summer shows a depletion trend from west to east,consistent with the rainout effect of the westerly moisture path in central Asia.The isotopic signature provided by the TES is helpful to understand the moisture transport and below-cloud processes influencing stable water isotopes in meteoric water. | ShengJie Wang Yang Song MingJun Zhang Athanassios A.Argiriou YuDong Shi | 2021 | Research in Cold and Arid Regions2021，13，6： | 0 |
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