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| 1 | Emerging roles for PlWl proteins in cancer显示文摘 | Yi Tan Lianyong Liu Mingan Liao Chaobao Zhang Shuanggang Hu Mei Zou Mingjun Gu Xiangqi Li | 2015 | Acta Biochimica et Biophysica Sinica2015，47，5： | 4 |
| 2 | Why choose 3D bioprinting?Part II:methods and bioprinters显示文摘Classification of 3D bioprinting As we mentioned in the last editorial,3D printing,also known as additive manufacturing,could be considered as the reverse process of potato cutting,automatically assembling sliced potato,shredded potato,diced potato to integrity[1].Generally speaking,cell-laden 3D bioprinting can be classified into three types:extrusion-based,droplet-based and photocuring-based bioprinting according to different printing principles.Extrusion-based bioprinting squeezes out continuous hydrogel fibers to set up structures;dropletbased bioprinting generates droplets as the basic unit for biofabrication;and photocuring-based bioprinting utilizes the characteristics of light-sensitive materials,to stack 3D models layer-by-layer.Different bioprinting approaches own diverse characteristics facing various scenarios and have specific requirements for bioinks. | Yong He Zeming Gu Mingjun Xie Jianzhong Fu Hui Lin | 2020 | Bio-Design and Manufacturing2020，3，1： | 2 |
| 3 | Characterization of three H5N5 and one H5N8 highly pathogenic avian influenza viruses in China显示文摘 | Kunkun Zhao Min Gu Lei Zhong Zhiqiang Duan Yan Zhang Yanmei Zhu Guo Zhao Mingjun Zhao Zhaoyang Chen Shunlin Hu Wenbo Liu Xiaowen Liu Daxin Peng Xiufan Liu | 2013 | Veterinary Microbiology (-)2013，，3： | 1 |
| 4 | Aerodynamic levitated laser annealing method to defective titanium dioxide with enhanced photocatalytic performance显示文摘因为它的缩小的乐队差距,有缺点的 TiO 2 在 photocatalytic 和电气化学的材料为使用吸引了增加的注意并且改进了可见光的 photocatalytic 活动。然而,为获得充满缺点的 TiO 2 的一条灵巧、有效的途径仍然是挑战。此处,我们表明如此的一条途径缩小它的 bandgap 并且通过由空气动力学的升在空中的激光退火植入丰富的缺点改进可见光的吸收(ALLA ) 处理。笔记 ALLA 方法不仅提供快速的退火,团结并且使过程凉下来,而且为同类、有缺点的 TiO 2 nanoparticles 展出高效率。退火激光的 TiO 2 完成 8.54 mmol 愠楮湯捩戠潬正挠灯汯浹牥洠捩汥敬瀠汯? 整瑲戭瑵汹愠牣汹瑡 ? 潣攭桴汹愠牣汹瑡 ? 潣洭瑥慨牣汹捩愠楣 ? 的高氢进化率 ? 呐 ?? 椠 ? 档獯湥愠 ?? 潭敬畣慬? 慣牲敩 ? 潦 ? 桴 ? 湩潣灲牯瑡潩 ? 景戠獩 ? 栭摹潲祸畱湩汯瑡 ? 稠湩 ? 娨煮猼'T 资 ? ??? 湡 ? 灯湥爭湩 ? 敭潲祣湡湩 ???? 敤潮整 ? 獡 ? 湚 ? ??? 猯'T??? 呐吗?? | Hehe Wei Xiaoguang Ma Liu Gu Jianqiang Li Wenjie Si Gang OU Wen Yu Chunsong Zhao Jiaying Li Mingjun Song Zhijian Peng Hui Wu | 2016 | Nano Research2016，9，12： | 1 |
| 5 | Anti-infection effects of heparin on SARS-CoV-2 in a diabetic mouse model显示文摘Severe acute respiratory syndrome coronavirus 2(SARSCo V-2)infection can result in more severe syndromes and poorer outcomes in patients with diabetes and obesity.However,the precise mechanisms responsible for the combined impact of coronavirus disease 2019(COVID-19)and diabetes have not yet been elucidated,and effective treatment options for SARS-Co V-2-infected diabetic patients remain limited.To investigate the disease pathogenesis,K18-h ACE2 transgenic(h ACE2^(Tg))mice with a leptin receptor deficiency(h ACE2-Lepr^(-/-))and high-fat diet(h ACE2-HFD)background were generated.The two mouse models were intranasally infected with a 5×10^(5) median tissue culture infectious dose(TCID_(50))of SARSCo V-2,with serum and lung tissue samples collected at 3days post-infection.The h ACE2-Lepr^(-/-)mice were then administered a combination of low-molecular-weight heparin(LMWH)(1 mg/kg or 5 mg/kg)and insulin via subcutaneous injection prior to intranasal infection with1×10^(4) TCID_(50)of SARS-Co V-2.Daily drug administration continued until the euthanasia of the mice.Analyses of viral RNA loads,histopathological changes in lung tissue,and inflammation factors were conducted.Results demonstrated similar SARS-Co V-2 susceptibility in h ACE2^(Tg)mice under both lean(chow diet)and obese(HFD)conditions.However,compared to the h ACE2-Lepr^(+/+)mice,h ACE2-Lepr^(-/-)mice exhibited more severe lung injury,enhanced expression of inflammatory cytokines and hypoxia-inducible factor-1α(HIF-1α),and increased apoptosis.Moreover,combined LMWH and insulin treatment effectively reduced disease progression and severity,attenuated lung pathological changes,and mitigated inflammatory responses.In conclusion,preexisting diabetes can lead to more severe lung damage upon SARS-Co V-2 infection,and LMWH may be a valuable therapeutic approach for managing COVID-19patients with diabetes. | Zhongyun Zhang Ning Zhang Xuancheng Lu Min Zhou Xiaoxiang Yan Weiqiong Gu Jingru Yang Qin Zhang Cheng Zhang Yuhuan Gong Mingjun Jia Xiaoyu Zhang Peng Ning Mei Liu Xiaoyan Li Xiaomeng Shi Wenjun Liu George FGao Guang Ning Jiqiu Wang Yuhai Bi | 2023 | Zoological Research2023，44，6： | 1 |
| 6 | Aldosterone may induce visfatin expression via the GR-ERK1/2 signal pathway in 3T3-L1 adipocytes显示文摘The main function of aldosterone is to regulate blood pressure and electrolytic balance;however,recent studies have also focused on the effect of aldosterone on glucose metabolism especially in adipose tissue.Aldosterone was found to inhibit insulin-induced glucose uptake in 3T3-L1 adipocytes [1] and aldosterone deficiency was found to prevent high-fat-feeding-induced hyperglycemia and adipocyte dysfunction in mice [2].Visfatin,an adipokine discovered by the team of Fukuhara,is mainly released by adipose tissue [3].Treatment of 3T3-L1 adipocytes and L6 myocytes with visfatin increased basal glucose uptake,and glucose release was suppressed in H4IIEC3 hepatocytes after visfatin treatment [3].It has also been suggested that visfatin may act as a proinflammatory cytokine [4] and produce chronic inflammation in adipocytes [5].Eyileten et al.[6] reported that treatment with angiotensin-converting enzyme inhibitor,which can reduce plasma aldosterone concentration,decreased circulating visfatin level in diabetic nephropathy patients.These findings suggest a possible interaction between the renin–angiotensin–aldosterone system(RAAS)and visfatin.Considering the important roles of aldosterone and visfatin and the association between RAAS and visfatin,we hypothesize that there may be a direct regulatory interaction between aldosterone and visfatin.To test this hypothesis,3T3-L1 adipocytes were used as the cell model and the expression of visfatin was measured by qRT-PCR and western blot analysis. | Junhua Ma Xuemei Zhao Jichen Zhang Fei Sun Jiancan Lu Hongling Zhu Mingjun Gu Jingnan Wang Xiangqi Li | 2019 | Acta Biochimica et Biophysica Sinica2019，51，3： | 1 |
| 7 | Short-term serum deprivation causes no significant mitochondrial DNA mutation in vascular smooth muscle cells revealed by a new next generation sequencing technology显示文摘线粒体提供许多精力因为在线粒体的房间和混乱能几乎影响任何织物[1 ] 。mitochondrial DNA (mtDNA ) 盖住 16,569 bp,由在人的 37 基因和 1 个 D 环区域组成。线粒体在拥有他们被采用 multiprotein 机械组织成 mitochondrial nucleoids 的自己的染色体是唯一的,并且能执行基因复制,抄写,和修理的功能[2 ] 。尽管它让几乎所有已知的原子 DNA 修理小径,保护的 histones 的缺乏可以导致特别危险性到压力和 DNA 损坏事件[3 ] 。确实, mtDNA 让一个很高的变化评价[4 ] 。自从它的发现, mtDNA 变化被知道了普通并且包括糖尿病,心血管的疾病,癌症,神经与肌的混乱,和老化作为人的疾病的一个重要原因出现了,在 4300 人口影响 1 [5,6 ] 。因此,在压力和疾病识别 mtDNA 变化现在是一个热研究区域。 | Xiangqi Li Lianyong Liu Qian Xi Xuemei Zhao iingshuang Fang Junhua Ma ZhaohuiZhu Xing Wang Chao Shi Jingnan Wang Hongling Zhu Jichen Zhang Chaobao Zhang Shuanggang Hu Minjie Ni Mingjun Gu | 2016 | Acta Biochimica et Biophysica Sinica2016，48，9： | 0 |
| 8 | Artificial intelligence modeling of vascular calcification显示文摘Vascular calcification is a pathological process during which deposits of calcium mineral in vessel walls are progressively formed,leading to tissue stiffening,plaque rupture,and heart failure[1].The mortality rate is 3%among non-calcification individuals,while it reaches 28%in patients with high levels of vascular calcification[2].Despite rapid advances in the understanding of this health problem,medical treatments targeting vascular calcification are still lacking.There are no approved therapeutic drugs available except the costly invasive transcatheter procedures and surgeries that do not fully address the wide spectrum of these conditions[3].Unfortunately,current studies of vascular calcification are far behind the actual needs,probably because vascular calcification,especially microcalcification,is difficult to diagnose and treat. | Mingjun Gu Lin zhou Xing Wang Chao Shi Xiangqi Li | 2020 | Acta Biochimica et Biophysica Sinica2020，52，11： | 0 |
| 9 | Bitter receptor member TAS2R4 may have neurobiological function beyond acting as a bitter receptor显示文摘Among the five basic taste receptors of sweet,bitter,sour,salty,and umami,bitter receptors(TAS2Rs)are particularly important for animal survival because they have evolved as a central warning system to help avoid ingesting potentially toxic substances[1].TAS2R,belonging to G protein-coupled receptors(GPCRs)superfamily,can recognize varieties of bitter substances as ligands.TAS2Rs are different from many other GPCRs in that they are promiscuous and capable of binding with a wide range of compounds with relatively low specificity and affinity[2].TAS2Rs are expressed in many tissues,including respiratory tract,bladder,pancreas,testes,central nervous system,and the gastrointestinal tract in addition to the tongue[3,4]. | Hongling Zhu Lianyong Liu Li Ren Juan Chen Li Peng Chao Shi Xing Wang Shuanggang Hu Chaobao Zhang Mingjun Gu Xiangqi Li | 2020 | Acta Biochimica et Biophysica Sinica2020，52，4： | 0 |
| 10 | Decreased expression of piR-35413 in human papillary thyroid cancer显示文摘The piRNAs(PIWI-interacting RNAs)are?26-31 nt in length and are very similar to but little longer than the microRNAs(miRNAs)in size[1].Since the discovery of the first piRNA in 2006,the number of piRNA sequences has now reached 173 million from 264 datasets in 21 organisms[2].And,there are 8,438,265 piRNAs identified in the human genome,which far exceeds the total number of miRNAs(~2000)[2],suggesting that piRNAs may play a wide variety of roles in biological activities that remain to be explored.Primarily,piRNAs have been suggested to have functions in transposon silencing by DNA methylation[3].Following that,many functions of piRNAs were reported[1].Of note,early reports claimed the specific expression of piRNAs in the reproduction system[4].However,in recent studies,the expressions of piRNAs in other normal tissues or cancer tissues,such as breast cancer,gastric cancer,colorectal cancer,lung cancer,and liver cancer,have been reported[1].But to date,there is no report demonstrating the expression of piRNA in thyroid and/or in thyroid cancer. | Lianyong Liu Li Ren Li Shen Chaobao Zhang Hongling Zhu Mingjun Gu Xiangqi Li | 2019 | Acta Biochimica et Biophysica Sinica2019，51，12： | 0 |
| 11 | A bionic controllable strain membrane for cell stretching at air–liquid interface inspired by papercutting显示文摘Lung diseases associated with alveoli,such as acute respiratory distress syndrome,have posed a long-term threat to human health.However,an in vitro model capable of simulating different deformations of the alveoli and a suitable material for mimicking basement membrane are currently lacking.Here,we present an innovative biomimetic controllable strain membrane(BCSM)at an air–liquid interface(ALI)to reconstruct alveolar respiration.The BCSM consists of a high-precision three-dimensional printing melt-electrowritten polycaprolactone(PCL)mesh,coated with a hydrogel substrate—to simulate the important functions(such as stiffness,porosity,wettability,and ALI)of alveolar microenvironments,and seeded pulmonary epithelial cells and vascular endothelial cells on either side,respectively.Inspired by papercutting,the BCSM was fabricated in the plane while it operated in three dimensions.A series of the topological structure of the BCSM was designed to control various local-area strain,mimicking alveolar varied deformation.Lopinavir/ritonavir could reduce Lamin A expression under over-stretch condition,which might be effective in preventing ventilator-induced lung injury.The biomimetic lung-unit model with BCSM has broader application prospects in alveoli-related research in the future,such as in drug toxicology and metabolism. | Yuanrong Li Mingjun Xie Shang Lv Yuan Sun Zhuang Li Zeming Gu Yong He | 2023 | International Journal of Extreme Manufacturing2023，5，4： | 0 |
| 12 | Improved dot blotting for small RNA detection显示文摘Non-coding small RNAs,such as small interfering RNA (siRNA), microRNA (miRNA),and piwi-interacting RNA (piRNA),have a common feature that their sizes always fall within a narrow,defined range of between 18 and 32nt [1,2].These tiny RNAs have revolutionized our comprehension of gene expression as key post-transcriptional regulators.Compared with long RNA,small RNA has a low abundance with very small size,making it difficult to be detected using traditional methods[3]. | Li Ren Lianyong Liu Shuanggang Hu Zhaohui Zhu Hongling Zhu Junhua Ma Xuemei Zhao Xing Wang Chaobao Zhang Mingjun Gu Xiangqi Li | 2018 | Acta Biochimica et Biophysica Sinica2018，50，12： | 0 |
| 13 | A simple and rapid model of vascular calcification显示文摘Vascular calcification is the aggregation and deposition of hydroxyapatite crystals within arterial wall cells,which can lead to increased vascular wall hardness,decreased compliance,thrombosis,and plaque rupture,and is an important factor for the high incidence and mortality of vascular diseases[1].Arterial calcification was discovered 5000 years ago in the Iceman[2].Nowadays,vascular calcification has become a very common adverse phenotype of vascular lesions,a common phenotypic feature of diabetes,atherosclerosis,chronic kidney disease,hypertension,and other diseases,as well as an independent risk factor for its occurrence,development,and death[3].Vascular calcification is also an independent risk factor and a sign of disease worsening.For example,in patients with diabetes and chronic kidney disease,accelerated calcification occurs in the vascular intima,media,and heart valves[4].The incidence of vascular calcification increases with age,however even young people have a significant proportion of vascular calcification[5].However,there is no effective clinical response to this,especially no specific drugs to treat it.Therefore,the study of vascular calcification will not only improve our understanding of the pathogenesis of diseases and the aging mechanism but also help to develop new treatment strategies and drugs for these diseases. | Mingjun Gu Lianyong Liu Chaobao Zhang Juan Chen Xiangqi Li | 2021 | Acta Biochimica et Biophysica Sinica2021，53，5： | 0 |
| 14 | New values of a type 2 taste receptor TAS2R14 in thyroid cancer显示文摘Recognition of bitter substances is mediated by type 2 taste receptors(TAS2Rs)family which consists of over 20 members.Traditionally,TAS2Rs are thought to be specifically expressed in the tongue.Recent studies on TAS2R member TAS2R14 in non-gustatory tissues supported its new functions beyond the perception of bitter taste.TAS2R14 regulates resveratrol transport across the human blood-cerebrospinal fluid barrier[1],which renders hope for resveratrol to be used in the treatment of brain diseases.TAS2R14 also mediates the relaxation of smooth muscle[2],indicating its value for the development of effective tocolytics for preterm birth management.TAS2R14 also has an anti-inflammatory property.TAS2R14 can inhibit IgE-induced mast cell degranulation with anti-asthma activity when activated directly by Saikosaponin b[3],and prevent LPS-induced cytokine production in human lung macrophages[4].Of note,TAS2R14 also has endocrine regulatory effect.It stimulates glucagon-like peptide 1 secretion in rat gastrointestinal tract[5],and may also have appetite-suppressant effects by inducing cholecystokinin secretion[6].Of greater interest is that we found that TAS2R14 might be a receptor for bitter medicines to fight COVID-19[7,8].Meanwhile,TAS2R14 has recently been linked to oncology.Agonists of TAS2R14,including quercetin and naringenin,exhibit anti-cancer activities in numerous cancer types[9].Noscapine stimulation of TAS2R14 increases apoptosis in ovarian cancer cells[10].However,the involvement of TAS2R14 in the risk and development of cancers including thyroid cancer(THCA)has yet to be clarified. | Lianyong Liu Qingyun Zhu Hong Du Chao Shi Mingjun Gu Xiangqi Li | 2022 | Acta Biochimica et Biophysica Sinica2022，54，4： | 0 |
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