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| 1 | Identification of Flowering Regulatory Genes in Allopolyploid Brassica juncea显示文摘Brassica juncea is an allopolyploid originating from the interspecific hybridization between Brassica rapa and Brassica nigra, which is of multiple usage as a vegetable, oilseed and condiment worldwide. Both vernalization and non-vernalization under long-day photoperiod can promote floral transition in B. juncea suggesting merged flowering pathways of its ancestors and better environmental adaptability. We identified genomewide flowering regulatory genes in B. juncea, which include 84 and 79 genes from A and B sub-genomes, respectively. Ka/Ks analysis revealed a purification effect on both photoperiod and vernalization flowering regulation pathways during evolution. Expression profile of those genes during long-day and vernalization treatments suggested Bju ACO4, Bju AFT1, Bju BFT4, Bju ASOC1 and Bju ASOC4 may be the major functional copies of B. juncea flowering regulation. Further functional studies about Bju COs showed three days delayed flowering time in Bju ACO4 or Bju BCO3 silenced plants. Increased transcription of all BjuFLCs in Bju ACO4 or Bju BCO3 silenced plants suggested interactions between photoperiod and vernalization pathways governing flowering time. Our findings provided flowering regulating networks in allopolyploid B. juncea. | Ning Zhao Chang Liu Yiqing Meng Zhongyuan Hu Mingfang Zhang Jinghua Yang | 2019 | Horticultural Plant Journal2019，5，3： | 6 |
| 2 | Desulfurization metabolite of Rhodococcus erythropolis LSSE8-1 and its related desulfurizational gene fragments显示文摘Rhodococcus erythropolis LSSE8-1 is a newly isolated biodesulfurizaion strain from the soil of Chishui gas field, Guizhou Province, China. The analysis of its metabo-lism product shows that the strain is a kind of biocatalyst able to oxidize dibenzothiophene (DBT) to 2-hydroxydi- phenyl (HBP), and therefore the sulfur in DBT is selectively removed. By using DBTO2 (dibenzothiophene 5,5-dioxide) as substrate, both DBT and HBP are found in the culture, which shows that the reaction from DBT to DBTO2 is re-versible in the cell. While using 0.5 mmol/L DBT as control, 0.01—0.4 mmol/L DBTO2 shows poisonous effect to the cell, which will explain why there is no DBTO2 accumulation in the process of biodesulfurization. After treatment by lysozme, the plasmid DNA of the strain is isolated by alkaline method to be used as the template of PCR reaction. Three dsz gene fragments of 1.3, 1.0 and 1.2 kb respectively were amplified. Each fragment is ligate with PGEM-T vector, and cloned into E. coli. DH5. The clone DNA is sequenced and the result shows that dsz related genes are highly conservative. The identities of dszA and dszB with respect to IGTS8 are 100%, and the identity of dszC with that of IGTS8 is 99%. | GOU Zhongxuan, LUO Mingfang, LI Xin, XING Jianmin & LIU Huizhou Laboratory of Separation Science and Engineering, State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100080, China Correspondence should be addressed to Liu Huizhou (e-mail: hzliu@ home.ipe.ac.cn) | 2003 | Chinese Science Bulletin2003，48，24： | 5 |
| 3 | Effect of burden and origin sites of premature ventricular contractions on left ventricular function by 7-day Holter monitor显示文摘Recent studies have shown that premature ventricular contractions(PVCs) could enlarge the heart,but its risk factors are incompletely understood as a single 24-hour recording cannot reflect the true PVC burden due to day-to-day variability.Our purpose was to investigate the effect of burden and origin sites on left ventricular(LV) function in patients with PVCs by 7-day Holter electrocardiography(ECG).From May 2012 to August2013,112 consecutive patients with PVCs were recruited from the authors' affiliated hospital.All patients received2-dimensional transthoracic echocardiography,12-lead routing ECG and 7-days Holter ECG.Serum N-terminal probrain natriuretic peptide(NT-proBNP) levels were measured.A total of 102 participants with PVCs were included in the final analysis.Origin of PVCs from the tricuspid annulus had the highest burden and NT-proBNP level.LV papillary muscle had a higher LV ejection fraction(EF) level and a lower LV end-systolic dimension(ESD) than other PVC foci(P<0.05).The high burden group had a higher LV end-diastolic dimension(EDD) and LVESD but lower LVEF than the other two groups(P<0.05).Female,older age,physical work,and history of PVCs had a significantly positive correlation with symptoms.Male,older age,physical work,and high burden were positive predictors of enlarged LVEDD,LVESD and higher serum NT-proBNP level,but lower LVEF.Seven-day dynamic ECG Holter monitor showed the true PVC burden on patients with PVCs.PVCs with a lower burden or origin from the LV papillary muscle and the fascicle were relatively benign,while PVCs with a higher burden or origin from the tricuspid annulus may lead to cardiac dysfunction. | Wenhua Xu Mingfang Li Minglong Chen Bing Yang Daowu Wang Xiangqing Kong Hongwu Chen Weizhu Ju Kai Gu Kejiang Cao Hailei Liu Qi Jiang Jiaojiao Shi Yan Cui Hong Wang | 2015 | The Journal of Biomedical Research2015，29，6： | 4 |
| 4 | Preparation and Microstructure of Green Ceramsite Made from Sewage Sludge显示文摘A pilot study was conducted to produce high performance green ceramsite by using sewage sludge, fly ash and silt. According to the theory of Riley, the proportions of raw materials were chosen to perform the sintering experiments. Thereby, the optimum proportion of sludge, fly ash and silt and sintering parameters were determined. The microstructure of the optimized mixture and the leaching of heavy metal elements were also analyzed. The lab testing results show that sintering parameters have significant impact on the performance of ceramsite. For solid waste ceramsite with high loss of ignition, inadequate pre-burning process lowers the strength and increases the water absorption. Low water absorption can be achieved by the enameled surface and closed pore structure. The high performance green ceramsite has the density grade of 700, water absorption of 6% and compressive strength of 6.6 MPa. The ceramsite is mainly composed of cristobalite and mullite. The leaching of heavy metal elements from the solid waste ceramsite are lower than the limits required by the national standard. This study shows that the utilization of solid waste ceramsite as the light weight aggregate is feasible and safe. | 柳俊哲 LIU Rui HE Zhimin BA Mingfang 李玉顺 | 2012 | Journal of Wuhan University of Technology(Materials Science)2012，27，1： | 4 |
| 5 | The effect of forest harvesting and climatic variability on runoff in a large watershed: The case study in the Upper Minjiang River of Yangtze River basin显示文摘 | Mingfang Zhang Xiaohua Wei Pengsen Sun Shirong Liu | 2012 | Journal of Hydrology2012，，： | 4 |
| 6 | Epidemiological characteristics and temporal-spatial analysis of overseas imported dengue fever cases in outbreak provinces of China, 2005–2019显示文摘Background Overseas imported dengue fever is an important factor in local outbreaks of this disease in the mainland of China.To better prevent and control such local outbreaks,the epidemiological characteristics and temporal-spatial distribution of overseas imported dengue fever cases in provincial-level administrative divisions(PLADs)where dengue fever is outbreak in the mainland of China were explored.Methods Using the Chinese National Notifiable Infectious Disease Reporting Information System(CNNDS),we identified overseas imported dengue fever cases in dengue fever outbreak areas in the mainland of China from 2005 to 2019 to draw the epidemic curve and population characteristic distribution of overseas imported cases in each PLAD.Based on spatial autocorrelation analysis of ArcGIS 10.5 and temporal-spatial scanning analysis of SaTScan 9.5,we analyzed the temporal-spatial distribution of overseas imported dengue fever in dengue fever outbreak areas in the mainland of China.Results A total of 11,407 imported cases,mainly from Southeast Asia,were recorded from 2005 to 2019 in these 13 PLADs.Of which 62.1%were imported into Yunnan and Guangdong Provinces.Among the imported cases,there were more males than females,mainly from the 21–50 age group.The hot spots were concentrated in parts of Yunnan,Guangdong and Fujian Provinces.We found the cluster of infected areas were expanding northward.Conclusions Based on the analysis of overseas imported dengue cases in 13 PLADs of the mainland of China from 2005 to 2019,we obtained the epidemiological characteristics and spatial distribution of imported dengue cases.Border controls need to pay attention to key population sectors,such as 21–50 years old men and education of key populations on dengue prevention.There is a need to improve the awareness of the prevention and control of imported cases in border areas.At the same time,northern regions cannot relax their vigilance. | Xinchang Lun Yiguan Wang Chunchun Zhao Haixia Wu Caiying Zhu Delong Ma Mingfang Xu Jun Wang Qiyong Liu Lei Xu Fengxia Meng | 2022 | Infectious Diseases of Poverty2022，11，1： | 3 |
| 7 | Gaussian process regression-based quaternion unscented Kalman robust filter for integrated SINS/GNSS显示文摘High-precision filtering estimation is one of the key techniques for strapdown inertial navigation system/global navigation satellite system(SINS/GNSS)integrated navigation system,and its estimation plays an important role in the performance evaluation of the navigation system.Traditional filter estimation methods usually assume that the measurement noise conforms to the Gaussian distribution,without considering the influence of the pollution introduced by the GNSS signal,which is susceptible to external interference.To address this problem,a high-precision filter estimation method using Gaussian process regression(GPR)is proposed to enhance the prediction and estimation capability of the unscented quaternion estimator(USQUE)to improve the navigation accuracy.Based on the advantage of the GPR machine learning function,the estimation performance of the sliding window for model training is measured.This method estimates the output of the observation information source through the measurement window and realizes the robust measurement update of the filter.The combination of GPR and the USQUE algorithm establishes a robust mechanism framework,which enhances the robustness and stability of traditional methods.The results of the trajectory simulation experiment and SINS/GNSS car-mounted tests indicate that the strategy has strong robustness and high estimation accuracy,which demonstrates the effectiveness of the proposed method. | LYU Xu HU Baiqing DAI Yongbin SUN Mingfang LIU Yi GAO Duanyang | 2022 | Journal of Systems Engineering and Electronics2022，33，5： | 2 |
| 8 | Study of the Toxicity of 1-Bromo-3-Chloro-5,5-Dimethylhydantoin to Zebrafish显示文摘Objective 1-Bromo-3-chloro-5,5-dimethylhydantoin (BCDMH) is a solid oxidizing biocide for water disinfection.The objective of this study was to investigate the toxic effect of BCDMH on zebrafish.Methods The developmental toxicity of BCDMH on zebrafish embryos and the dose-effect relationship was determined.The effect of BCDMH exposure on histopathology and tissue antioxidant activity of adult zebrafish were observed over time.Results Exposure to 4 mg/L BCDMH post-fertilization was sufficient to induce a number of developmental malformations,such as edema,axial malformations,and reductions in heart rate and hatching rate.The no observable effects concentration of BCDMH on zebrafish embryo was 0.5 mg/L.After 96 h exposure,the 50% lethal concentration (95% confidence interval (CI)) of BCDMH on zebrafish embryo was 8.10 mg/L (6.15-11.16 mg/L).The 50% inhibitory concentration (95% CI) of BCDMH on hatching rate was 7.37 mg/L (6.33-8.35 mg/L).Histopathology showed two types of responses induced by BCDMH,defensive and compensatory.The extreme responses were marked hyperplasia of the gill epithelium with lamellar fusion and epidermal peeling.The histopathologic changes in the gills after 10 days exposure were accompanied by significantly higher catalase activity and lipid peroxidation.Conclusion These results have important implications for studies on the toxicity and use of BCDMH and its analogs. | LI WanFang WEI JinFeng JIN HongTao HUANG MingFang ZHANG JingXuan LI ChengHe CHEN ChaoJie LIU Chang WANG AiPing | 2011 | Biomedical and Environmental Sciences2011，24，4： | 2 |
| 9 | Synergistic antitumor effect of β-elemene and etoposide is mediatedvia induction of cell apoptosis and cell cycle arrest in non-small cell lung carcinomacells显示文摘 | Fan Zhang Ling Xu Xiujuan Qu Mingfang Zhao Bo Jin Jian Kang Yunpeng Liu Xuejun Hu | 2011 | Molecular Medicine Reports2011，，6： | 1 |
| 10 | Morphology analysis of tracks in the aerogels impacted by hypervelocity irregular particles显示文摘As an attractive collector medium for hypervelocity particles,combined with outstanding physical properties and suitable compositional characteristics,SiO2 aerogel has been deployed on outer space missions and laser shock-loaded collection experiments.In this paper,impact experiments were conducted to understand the penetration process of irregular grains,irregular Al_(2)O_(3) grains with two different sizes and speeds(~110μm@7 km/s,~251μm@2.3 km/s)at various density silica aerogels.By classifying the shapes of projectile residues and tracks,the morphology of tracks was analyzed.It was observed that there were several kinds of typical tracks in the penetration of irregular grains,accompanied by residues with the shapes of near-sphere,polyhedron,streamlined body wedge,and rotator.The rotational behavior was demonstrated by the final status of one flake projectile as direct evidence.In addition,there was no obvious relationship between the track length and experimental parameters,which may be caused by the uncertain interaction between aerogels and irregular particles.In addition,it confirmed the existence of fragmentation,melting situation by observing the shape of the impact entrance hole.At the same time,optical coherence tomography was used to observe the detail of tracks clearly,which provided a method to characterize the tracks nondestructively. | Ai Du Yi Ma Mingfang Liu Zhihua Zhang Guangwei Cao Hongwei Li Ling Wang Peijian Si Jun Shen Bin Zhou | 2021 | High Power Laser Science and Engineering2021，9，2： | 1 |
| 11 | Thermally crosslinkable poly ( phenylene sulfide)/poly ( ether sulfone) polymerization of monomer reactant--polyimide blends 显示文摘 | LAI Mingfang YANG Yuming LIU Jingjiang | 2002 | Appl Polym Sci2002，83，： | 1 |
| 12 | Temporal and Spatial Distribution of Auxin Response Factor Genes During Tomato Flower Abscission显示文摘 | Xiaoxi Guan Tao Xu Song Gao Mingfang Qi Yanling Wang Xin Liu Tianlai Li | 2014 | Journal of Plant Growth Regulation2014，，2： | 1 |
| 13 | Thermally crosslinkable poly (phenylene sulfide)/poly (ether sulfone)/polymerization of monomer reactant-polyimide blends显示文摘 | Mingfang Lai Yuming Yang Jingjiang Liu | 2002 | Journal of Applied Polymer Science2002，83，4： | 1 |
| 14 | Transformational offshore outsourcing: Empirical evidence from alliances in China 显示文摘 | Yuan Li Yi Liu Mingfang Li | 2008 | Journal of Operations Management2008，26，2： | 1 |
| 15 | Structural optimization and biological evaluation of 1,5-disubstituted pyrazole-3-carboxamines as potent inhibitors of human 5-lipoxygenase显示文摘Human 5-lipoxygenase(5-LOX)is a well-validated drug target and its inhibitors are potential drugs for treating leukotriene-related disorders.Our previous work on structural optimization of the hit compound 2 from our in-house collection identified two lead compounds,3a and 3b,exhibiting a potent inhibitory profile against 5-LOX with IC_(50) values less than 1 mmol/L in cell-based assays.Here,we further optimized these compounds to prepare a class of novel pyrazole derivatives by opening the fusedring system.Several new compounds exhibited more potent inhibitory activity than the lead compounds against 5-LOX.In particular,compound 4e not only suppressed lipopolysaccharide-induced inflammation in brain inflammatory cells and protected neurons from oxidative toxicity,but also significantly decreased infarct damage in a mouse model of cerebral ischemia.Molecular docking analysis further confirmed the consistency of our theoretical results and experimental data.In conclusion,the excellent in vitro andin vivo inhibitory activities of these compounds against 5-LOX suggested that these novel chemical structures have a promising therapeutic potential to treat leukotriene-related disorders. | Yu Zhou Jun Liu Mingyue Zheng Shuli Zheng Chunyi Jiang Xiaomei Zhou Dong Zhang Jihui Zhao Deju Ye Mingfang Zheng Hualiang Jiang Dongxiang Liu Jian Cheng Hong Liu | 2016 | Acta Pharmaceutica Sinica B2016，6，1： | 1 |
| 16 | Performance of combined process of anoxic baffled reactor-biological contact oxidation treating printing and dyeing wastewater显示文摘 | Huifang Wu Shihe Wang Huoliang Kong Tiantian Liu Mingfang Xia | 2006 | Bioresource Technology2006，，7： | 1 |
| 17 | Fabrication of biodegradable nano-sized β-TCP/Mg composite by a novel melt shearing technology显示文摘 | Debao Liu Yubo Zuo Wanyu Meng Mingfang Chen Z. Fan | 2012 | Materials Science & Engineering C2012，，5： | 1 |
| 18 | Microstructure and performance of sludge-ceramisite concrete显示文摘 | Liu Junzhe Ba Mingfang He Zhimin | 2013 | Constr Build Mater2013，39，： | 1 |
| 19 | Microbial desulfurization of dibenzothiophene and 4,6-dimethyldibenzothiophene in dodecane and straight-run diesel oil显示文摘 | Luo Mingfang Xing Jianmin Gou Zhongxuan Liu Huizhou Chen Jiayong | 2003 | Korean Journal of Chemical Engineering2003，，4： | 1 |
| 20 | Adsorption equilibria and kinetics for phenol and cresol onto polymeric adsorbents: effects of adsorbents/adsorbates structure and interface显示文摘 | LIU Fuqiang XIA Mingfang YAO Sanli | 2008 | Journal of Hazardous Materials2008，152，2： | 1 |
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