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| 1 | Soil salinization research in China: Advances and prospects显示文摘与气候变化的进展引起的环境恶化,土壤 salinization 是一个严重、成长的全球问题。当前,大约 7% 世界陆地表面被 salinization 威胁。中国是其土壤被这个问题严重地影响的一个国家,它由于它的广泛的区域,并且宽分发形成严肃的威胁到地区性的农业开发。在这评论,我们在过去的 70 年在中国为土壤 salinization 研究总结框架,估计存在的软弱在两个研究国内、国际的上下文,加亮趋势并且给关于在过去的 30 年的盐的土壤的全球研究的调查结果调音,并且为关于盐的土壤的未来研究建议六个主要领域和方向。 | LI Jianguo PU Lijie HAN Mingfang ZHU Ming ZHANG Runsen XIANG Yangzhou | 2014 | Journal of Geographical Sciences2014，24，5： | 90 |
| 2 | Identification of Flowering Regulatory Genes in Allopolyploid Brassica juncea显示文摘Brassica juncea is an allopolyploid originating from the interspecific hybridization between Brassica rapa and Brassica nigra, which is of multiple usage as a vegetable, oilseed and condiment worldwide. Both vernalization and non-vernalization under long-day photoperiod can promote floral transition in B. juncea suggesting merged flowering pathways of its ancestors and better environmental adaptability. We identified genomewide flowering regulatory genes in B. juncea, which include 84 and 79 genes from A and B sub-genomes, respectively. Ka/Ks analysis revealed a purification effect on both photoperiod and vernalization flowering regulation pathways during evolution. Expression profile of those genes during long-day and vernalization treatments suggested Bju ACO4, Bju AFT1, Bju BFT4, Bju ASOC1 and Bju ASOC4 may be the major functional copies of B. juncea flowering regulation. Further functional studies about Bju COs showed three days delayed flowering time in Bju ACO4 or Bju BCO3 silenced plants. Increased transcription of all BjuFLCs in Bju ACO4 or Bju BCO3 silenced plants suggested interactions between photoperiod and vernalization pathways governing flowering time. Our findings provided flowering regulating networks in allopolyploid B. juncea. | Ning Zhao Chang Liu Yiqing Meng Zhongyuan Hu Mingfang Zhang Jinghua Yang | 2019 | Horticultural Plant Journal2019，5，3： | 6 |
| 3 | Performance of microbiological control by a point-of-use filter system for drinking water purification显示文摘Purification capacity of a faucet mounted type water filter for home use was evaluated,particularly with regard to microbiological performance under different running conditions.Biofilms were formed inside the filter,affecting the bacterial quality of the effuent water.Low flow rate,long stagnation period and high filter temperature were found favorable for bacterial growth inside.By commercial analytical profile index(API) kits,ten different bacterial species were identified in drinking water,four of which were probably contributed to the biofilm formation since they were also present in the biofilm.Fluorescence in situ hybridization(FISH) was used to confirm the API identification results,and direct viable count(DVC) method was employed to improve the sensitivity of FISH for the isolated Acinetobacter spp.and Pseudomonas putida as models.Relationship between the filter operating condition and the bacterial community alteration was partly revealed,which could provide the basic knowledge for the filter design and its practical use. | SU Fengyi LUO Mingfang ZHANG Fei LI Peng LOU Kai XING Xinhui | 2009 | Journal of Environmental Sciences2009，21，9： | 4 |
| 4 | The effect of forest harvesting and climatic variability on runoff in a large watershed: The case study in the Upper Minjiang River of Yangtze River basin显示文摘 | Mingfang Zhang Xiaohua Wei Pengsen Sun Shirong Liu | 2012 | Journal of Hydrology2012，，： | 4 |
| 5 | Association between essential hypertension and polymorphisms of beta 1 adrenergic receptor gene G1165C (Gly389Arg) in Chinese Mongolian population显示文摘BACKGROUND: The prevalences of hypertension, cerebrovascular diseases, etc. are higher in Mongolian population because of the influence of various factors including genetics, geography, diet, etc. Therefore, it is helpful to develop researches on the genetics of various diseases including hypertension in Mongolian population. OBJECTIVE: To analyze the association between the polymorphism of beta1 adrenergic receptor (β1-AR) gene G1165C (Arg389Gly), an important candidate gene for various diseases of cardiovascular system, and essential hypertension in Mongolian population. DESIGN: A cross-sectional study. SETTINGS: Department of Neurology, the First Affiliated Hospital of Inner Mongolia Medical College; Wulate Houqi Red Cross Society. PARTICIPANTS: The survey was carried out from February 2003 to March 2005. Totally 239 Mongolian residents, whose blood relations of 3 generations were all Mongolians, were selected from Wulate Houqi, Inner Mongolia, and they were all informed with the survey and detected items. Based on the diagnostic standard of hypertension set by WHO in 1999, the subjects were divided into two groups according to the level blood pressure: ① Normal blood pressure group (n=117): systolic blood pressure (SBP) < 140 mm Hg (1 mm Hg =0.133 kPa), diastolic blood pressure (DBP) < 90 mm Hg, and those having histories of cerebrovascular disease, heart disease, diseases of liver, kidney and tiroides, and diabetes mellitus were excluded. ② Essential hypertension group (n=122): including 51 patients with simple high SBP. All the enrolled subjects had no blood relationship with each other, and had no history of miscegenation. METHODS: The body height, body mass, waist circumference and blood lipids were measured routinely, and their habits of smoking and drinking were also investigated. Peripheral venous blood (5 mL) was drawn, the genome DNA was extracted, and the polymorphisms of the β1-AR G1165C (Gly389Arg) genotype were detected with the Sequenom system. Polymerase chain reaction (PCR) experiment and SNP detection were performed in Huada Gene Laboratory of Bejing, then the univariate analysis of variance was applied in the sample comparison among groups, and the chi-square test was used to compare the genotypes and allele frequencies. The odd ratio (OR) and 95% confidence interval (CI) were calculated. MAIN OUTCOME MEASURES: The distributions of β1-AR G1165C (Gly389Arg) genotypes and alleles were observed. RESULTS: All the 239 subjects were involved in the analysis of results, and no one missed. ①Comparison of β1-AR G1165C (Gly389Arg) genotypes and allele distributions: In Mongolian population, the frequencies of CC and GG+GC genotypes at β1-AR G1165C (Gly389Arg) site in the essential hypertension group (72%, 28%) were not significantly different from those in the normal blood pressure group (67%, 33%) (χ2=0.841, P=0.359; OR: 0.773, 95%CI: 0.445-1.342); The frequencies of C and G alleles also had no significant differences between the essential hypertension group (85%, 15%) and the normal blood pressure group (82%, 18%) (χ2=1.136, P=0.287; OR: 0.769, 95%CI: 0.747-1.248). ②The frequencies of CC and GG+GC genotypes at β1-AR G1165C (Gly389Arg) site had no significant differences between the patients with simple high SBP (71%, 29%) and the normal blood pressure group (χ2=0.250, P=0.617; OR: 0.833, 95%CI: 0.408-1.703); The frequencies of C and G alleles were not significantly different between the patients with simple high SBP (86%, 14%) and the normal blood pressure group (χ2=0.670, P=0.413; OR: 0.766, 95%CI: 0.404-1.453). CONCLUSION: In Mongolian population, the distributions of the genotypes and alleles of β1-AR G1165C (Gly389Arg) have no obvious differences between the subjects with normal blood pressure and the patients with essential hypertension (including simple SBP increase), which suggests that G1165C (Glu389Asp) site of β1-AR gene may be not a genetic mark of essential hypertension and simple high SBP in Mongolian population. | Rile Hu Rile Hu Shigang Zhao Guangming Niu Chunyu Zhang Zhiguang Wang Mingfang Jiang | 2006 | Neural Regeneration Research2006，1，3： | 2 |
| 6 | Mitochondrial retrograde regulation tuning fork in nuclear genes expressions of higher plants显示文摘In plant cells, there are three organelles: the nucleus, chloroplast, and mitochondria that store genetic information. The nucleus possesses the majority of genetic information and controls most aspects of organelles gene expression, growth, and development. In return, organelles also send signals back to regulate nuclear gene expression, a process defined as retrograde regulation. The best studies of organelles to nucleus retrograde regulation exist in plant chloroplast-to-nuclear regulation and yeast mitochondria-to-nuclear regulation. In this review, we summarize the recent understanding of mitochondrial retrograde regulation in higher plant, which involves multiple potential signaling pathway in relation to cytoplasmic male-sterility, biotic stress, and abiotic stress. With respect to mitochondrial retrograde regulation signal pathways involved in cytoplasmic male-sterility, we consider that nuclear transcriptional factor genes are the targeted genes regulated by mitochondria to determine the abnormal reproductive development, and the MAPK signaling pathway may be involved in this regulation in Brassica juncea. When plants suffer biotic and abiotic stress, plant cells will initiate cell death or other events directed toward recovering from stress. During this process, we propose that mitochondria may determine how plant cell responds to a given stress through retrograde regulation. Meanwhile, several transducer molecules have also been discussed here. In particular, the Paepe research group reported that leaf mitochondrial modulated whole cell redox homeostasis, set antioxidant capacity, and determined stress resistance through altered signaling and diurnal regulation, which is an indication of plant mitochondria with more active function than ever. | Jinghua Yang Mingfang Zhang Jingquan Yu | 2008 | Journal of Genetics and Genomics2008，35，2： | 2 |
| 7 | Study of the Toxicity of 1-Bromo-3-Chloro-5,5-Dimethylhydantoin to Zebrafish显示文摘Objective 1-Bromo-3-chloro-5,5-dimethylhydantoin (BCDMH) is a solid oxidizing biocide for water disinfection.The objective of this study was to investigate the toxic effect of BCDMH on zebrafish.Methods The developmental toxicity of BCDMH on zebrafish embryos and the dose-effect relationship was determined.The effect of BCDMH exposure on histopathology and tissue antioxidant activity of adult zebrafish were observed over time.Results Exposure to 4 mg/L BCDMH post-fertilization was sufficient to induce a number of developmental malformations,such as edema,axial malformations,and reductions in heart rate and hatching rate.The no observable effects concentration of BCDMH on zebrafish embryo was 0.5 mg/L.After 96 h exposure,the 50% lethal concentration (95% confidence interval (CI)) of BCDMH on zebrafish embryo was 8.10 mg/L (6.15-11.16 mg/L).The 50% inhibitory concentration (95% CI) of BCDMH on hatching rate was 7.37 mg/L (6.33-8.35 mg/L).Histopathology showed two types of responses induced by BCDMH,defensive and compensatory.The extreme responses were marked hyperplasia of the gill epithelium with lamellar fusion and epidermal peeling.The histopathologic changes in the gills after 10 days exposure were accompanied by significantly higher catalase activity and lipid peroxidation.Conclusion These results have important implications for studies on the toxicity and use of BCDMH and its analogs. | LI WanFang WEI JinFeng JIN HongTao HUANG MingFang ZHANG JingXuan LI ChengHe CHEN ChaoJie LIU Chang WANG AiPing | 2011 | Biomedical and Environmental Sciences2011，24，4： | 2 |
| 8 | Eukaryotic Translation Initiation Factors Shape RNA Viruses Resistance in Plants显示文摘Viruses are representative of a global threat to agricultural production. Genetic resistance is the preferred strategy for the control of viral infection and against loss of crop yield. Viral protein synthesis requires host cellular factors for translating their viral RNAs, and for regulating their replication and cell to cell systemic movement. Therefore, the viruses are dependent on cellular translation factors. Mutations in the gene encoding eIF4E and eIF4G or their isoforms, eIFiso4 E, eIFiso4 G and eIF2Bβ have been mapped as a source of plant potyvirus while other genus of plant virus recessive resistance genes in many species are originated from these loci. Some of other plant translation factors, such as eIF3,eIF4 A-like helicases, eEF1A and eEF1B, which are required in interacting with viral RNAs and regulating various aspects of the infection cycle,have also been identified. Here, we summarized the mechanisms utilized by RNA viruses of eukaryotic plants and the essential roles of e IFs in virus infection. Moreover, we discussed the potential of e IFs as a target gene in the development of genetic resistance to viruses for crop improvement. This review highlighted newly revealed examples of abnormal translational strategies and provided insights into natural host resistance mechanisms that have been linked to 3 cap-independent translational enhancer activity. | Jannat Shopan Xiaolong Lv Zhongyuan Hu Mingfang Zhang Jinghua Yang | 2020 | Horticultural Plant Journal2020，6，2： | 2 |
| 9 | Molecularphylogeny of Chinese vegetable mustard (Brassica juncea) basedon the internal transcribed spacers (ITS) of nuclear ribosomalDNA显示文摘 | Xiaoming Wu Xiaohua Qi Mingfang Zhang | 2007 | Genet Resour Crop Evol2007，54，： | 1 |
| 10 | RWO-Sampling: a random walk over-sampling approach to imbalanced data classification显示文摘 | ZHANG Huaxiang LI Mingfang | 2014 | Information fusion2014，20，： | 1 |
| 11 | Genetic predisposition to essential hypertension in a Mongolian population Detecting the C825T polymorphism of the G-protein beta 3 subunit gene显示文摘BACKGROUND: The prevalences of hypertension, cerebrovascular diseases, etc. are higher in Mongolian population because of the influence of various factors including genetics, geography, diet, etc. Therefore, it is helpful for prevention to develop researches on the genetics of various diseases including hypertension in Mongolian population. OBJECTIVE: To analyze the association between C825T polymorphisms of G-protein beta 3 subunit gene (GNB3), the important candidate gene of various disease of cardiovascular system, and Mongolian patients with essential hypertension. DESIGN: A comparative observation. SETTINGS: Department of Neurology, the First Affiliated Hospital of Inner Mongolia Medical College; Wulate Houqi Red Cross Society. PARTICIPANTS: Totally 267 Mongolian residents, whose blood relations of 3 generations were all Mongolians, were selected from Wulate Houqi, Inner Mongolia. The patients were screened based on the diagnostic standard of hypertension set by WHO in 1999, and the enrolled subjects were divided into two groups according to the level of blood pressure: ① Normal blood pressure group (n =124): 64 males and 60 females, systolic blood pressure (SBP) < 140 mm Hg (1 mm Hg=0.133 kPa), diastolic blood pressure (DBP) < 90 mm Hg; ② Essential hypertension group (n =143): 71 males and 72 females, including 60 patients with simple high SBP (SBP ranged 145 to 195 mm Hg, whereas DBP < 90 mm Hg). METHODS: Peripheral venous blood (5 mL) was drawn from all the subjects, the genome DNA was extracted, and the polymorphisms of the GNB3 C825T genotype were detected with the Sequenom system. Polymerase chain reaction (PCR) experiment and SNP detection were performed in Beijing Huada gene laboratory. Then the univariate analysis of variance was applied in the sample comparison among groups, and the chi-square test was used to compare the genotypes and allele frequencies. The odd ratio (OR) and 95% confidence interval (CI) were calculated. MAIN OUTCOME MEASURES: The distributions of GNB3 C825T genotypes and alleles were observed. RESULTS: All the 267 Mongolian subjects were involved in the analysis of results. ① GNB3 C825T genotypes: In Mongolian population, the frequencies of CC, CT and TT genotypes at GNB3 C825T site in the essential hypertension group (48%, 41%, 11%) were not obvious different from those in the normal blood pressure group (43%, 47%, 10%,χ2 =0.162, P =0.688; OR:1.176, 95%CI: 0.533–2.592), whereas there were also no obvious differences between the simple high SBP group (57%, 35%, 8%) and the normal blood pressure group (χ2 =0.733, P =0.392; OR:1.957, 95%CI: 0.623–6.143). ② GNB3 C825T alleles: In Mongolian population, The frequencies of C and T alleles in the essential hypertension group (69%, 31%) were not obviously different from those in the normal blood pressure group (67%, 33%, χ2 =0.094, P = 0.759; OR:0.945, 95%CI: 0.657–1.358), whereas there were also no obvious differences between the simple high SBP group (74%, 26%) and the normal blood pressure group (χ2 =2.133, P =0.144; OR:0.697, 95%CI: 0.428–1.133). CONCLUSION: GNB3 C825T site may be not a genetic marker of essential hypertension and simple highSBP in Mongolian population. | Chunyu Zhang Shigang Zhao Guangming Niu Rile Hu Zhiguang Wang Mingfang Jiang | 2007 | Neural Regeneration Research2007，2，3： | 1 |
| 12 | Synergistic antitumor effect of β-elemene and etoposide is mediatedvia induction of cell apoptosis and cell cycle arrest in non-small cell lung carcinomacells显示文摘 | Fan Zhang Ling Xu Xiujuan Qu Mingfang Zhao Bo Jin Jian Kang Yunpeng Liu Xuejun Hu | 2011 | Molecular Medicine Reports2011，，6： | 1 |
| 13 | Morphology analysis of tracks in the aerogels impacted by hypervelocity irregular particles显示文摘As an attractive collector medium for hypervelocity particles,combined with outstanding physical properties and suitable compositional characteristics,SiO2 aerogel has been deployed on outer space missions and laser shock-loaded collection experiments.In this paper,impact experiments were conducted to understand the penetration process of irregular grains,irregular Al_(2)O_(3) grains with two different sizes and speeds(~110μm@7 km/s,~251μm@2.3 km/s)at various density silica aerogels.By classifying the shapes of projectile residues and tracks,the morphology of tracks was analyzed.It was observed that there were several kinds of typical tracks in the penetration of irregular grains,accompanied by residues with the shapes of near-sphere,polyhedron,streamlined body wedge,and rotator.The rotational behavior was demonstrated by the final status of one flake projectile as direct evidence.In addition,there was no obvious relationship between the track length and experimental parameters,which may be caused by the uncertain interaction between aerogels and irregular particles.In addition,it confirmed the existence of fragmentation,melting situation by observing the shape of the impact entrance hole.At the same time,optical coherence tomography was used to observe the detail of tracks clearly,which provided a method to characterize the tracks nondestructively. | Ai Du Yi Ma Mingfang Liu Zhihua Zhang Guangwei Cao Hongwei Li Ling Wang Peijian Si Jun Shen Bin Zhou | 2021 | High Power Laser Science and Engineering2021，9，2： | 1 |
| 14 | Determination of phthalate esters in liquor samples by vortex‐assisted surfactant‐enhanced‐emulsification liquid–liquid microextraction followed by GC – MS显示文摘 | Geng Leng Wenjin Chen Mingfang Zhang Fang Huang Qiming Cao | 2014 | J Sep Science2014，，6： | 1 |
| 15 | Structural optimization and biological evaluation of 1,5-disubstituted pyrazole-3-carboxamines as potent inhibitors of human 5-lipoxygenase显示文摘Human 5-lipoxygenase(5-LOX)is a well-validated drug target and its inhibitors are potential drugs for treating leukotriene-related disorders.Our previous work on structural optimization of the hit compound 2 from our in-house collection identified two lead compounds,3a and 3b,exhibiting a potent inhibitory profile against 5-LOX with IC_(50) values less than 1 mmol/L in cell-based assays.Here,we further optimized these compounds to prepare a class of novel pyrazole derivatives by opening the fusedring system.Several new compounds exhibited more potent inhibitory activity than the lead compounds against 5-LOX.In particular,compound 4e not only suppressed lipopolysaccharide-induced inflammation in brain inflammatory cells and protected neurons from oxidative toxicity,but also significantly decreased infarct damage in a mouse model of cerebral ischemia.Molecular docking analysis further confirmed the consistency of our theoretical results and experimental data.In conclusion,the excellent in vitro andin vivo inhibitory activities of these compounds against 5-LOX suggested that these novel chemical structures have a promising therapeutic potential to treat leukotriene-related disorders. | Yu Zhou Jun Liu Mingyue Zheng Shuli Zheng Chunyi Jiang Xiaomei Zhou Dong Zhang Jihui Zhao Deju Ye Mingfang Zheng Hualiang Jiang Dongxiang Liu Jian Cheng Hong Liu | 2016 | Acta Pharmaceutica Sinica B2016，6，1： | 1 |
| 16 | Effects of root exudates and aqueous root extracts of cucumber ( Cucumis sati- vus) and allelochemicals, on photosynthesis and antioxidant en- zymes in cucumber 显示文摘 | Yu Jingquan Ye Sufeng Zhang Mingfang | 2003 | Biochemical Systematics and Ecology2003，31，2： | 1 |
| 17 | Akt-mTOR signaling is involved in Notch-1-mediated glioma cell survivaland proliferation显示文摘 | Nengjiang Zhao Ya Guo Mingfang Zhang Ling Lin Zhihong Zheng | 2010 | Oncology Reports2010，，5： | 1 |
| 18 | Electrosorptive photocatalytic degradation of highly concentrated p-nitroaniline with TiO 2 nanorod-clusters/carbon aerogel electrode under visible light显示文摘 | Yabo Wang Ya-nan Zhang Guohua Zhao Meifen Wu Mingfang Li Dongming Li Yonggang Zhang Yalei Zhang | 2013 | Separation and Purification Technology2013，，： | 1 |
| 19 | Ultra-high strength GNP/2024Al composite via thermomechanical treatment显示文摘The 5.0 vol.%GNP/2024Al composites were prepared by accumulated shear deformation combined with heat treatment,i.e.the thermomechanical treatment(TMT).The results showed that homogeneous distributed GNPs that aligned along the plastic deformation direction were obtained by six-pass drawing in the solution heat treatment state.The introducing of high-density dislocations in Al matrix by multiple drawing resulted in enhanced nucleation of precipitates and subsequent uniform growth during ageing.Consequently,ultra-strength GNP/2024Al composites,with yield and ultimate tensile strength 482 and571 MPa,respectively,were achieved.The high strength was attributed to homogeneous dispersion of undamaged GNPs,fine and dispersed precipitations and work-hardening effect.This work demonstrated that TMT could act as a feasible strategy for preparing high-performance GNP/Al composites. | Zhong Zheng Xuexi Zhang Mingfang Qian Jianchao Li Muhammad Imran Lin Geng | 2022 | Journal of Materials Science & Technology2022，，13： | 1 |
| 20 | De novo transcriptome characterization of Lilium ' Sorbonne' and key en- zymes related to the flavonoid biosynthesis显示文摘 | Zhang Mingfang Jiang Lingmin Zhang Dongmei | 2015 | Molecular Genetics and Genomics2015，290，： | 1 |
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