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	题名	作者	年代	出处	被引量
1	Hepatitis C virus enhances incidence of idiopathic pulmonary fibrosis显示文摘AIM: To investigate the cumulative development incidence and predictive factors for idiopathic pulmonary fibrosis in hepatitis C virus (HCV) positive patients. METHODS: We studied 6150 HCV infected patients who were between 40-70 years old (HCV-group). Another 2050 patients with hepatitis B virus (HBV) were selected as control (HBV-group). The mean observation period was 8.0 ± 5.9 years in HCV-group and 6.3 ± 5.5 years in HBV-group. The primary goal is the development of idiopathic pulmonary fibrosis (IPF) in both groups. The cumulative appearance rate of IPF and independent factors associated with the incidence rate of IPF were calculated using the Kaplan- Meier method and the Cox proportional hazard model. All of the studies were performed retrospectively by collecting and analyzing data from the patient records in our hospital. RESULTS: Fifteen patients in HCV-group developedIPF. On the other hand, none of the patients developed IPF in HBV-group. In HCV-group, the cumulative rates of IPF development were 0.3% at 10th year and 0.9% at 20th year. The IPF development rate in HCV-group was higher than that in HBV-group (P = 0.021). The IPF development rate in patients with HCV or HBV was high with statistical significance in the following cases: (1) patients ≥ 55 years (P < 0.001); (2) patients who had smoking index (package per day × year) of ≥ 20 (P = 0.002); (3) patients with liver cirrhosis (P = 0.042). CONCLUSION: Our results indicate that age, smoking and liver cirrhosis enhance the development of IPF in HCV positive patients.	Yasuji Arase Fumitaka Suzuki Yoshiyuki Suzuki Norio Akuta Masahiro Kobayashi Yusuke Kawamura Hiromi Yatsuji Hitomi Sezaki Tetsuya Hosaka Miharu Hirakawa Satoshi Saito Kenji Ikeda Hiromitsu Kumada	2008	World Journal of Gastroenterology2008，14，38：	8
2	Long‐term entecavir treatment reduces hepatocellular carcinoma incidence in patients with hepatitis B virus infection显示文摘	Tetsuya Hosaka Fumitaka Suzuki Masahiro Kobayashi Yuya Seko Yusuke Kawamura Hitomi Sezaki Norio Akuta Yoshiyuki Suzuki Satoshi Saitoh Yasuji Arase Kenji Ikeda Mariko Kobayashi Hiromitsu Kumada	2013	Hepatology2013，，：	5
3	Long-term continuous entecavir therapy in nucleos(t)ide-na?ve chronic hepatitis B patients显示文摘	Atsushi Ono Fumitaka Suzuki Yusuke Kawamura Hitomi Sezaki Tetsuya Hosaka Norio Akuta Masahiro Kobayashi Yoshiyuki Suzuki Satoshi Saitou Yasuji Arase Kenji Ikeda Mariko Kobayashi Sachiyo Watahiki Rie Mineta Hiromitsu Kumada	2012	Journal of Hepatology2012，，3：	3
4	Effect of type 2 diabetes on risk for malignancies includes hepatocellular carcinoma in chronic hepatitis C显示文摘	Yasuji Arase Mariko Kobayashi Fumitaka Suzuki Yoshiyuki Suzuki Yusuke Kawamura Norio Akuta Masahiro Kobayashi Hitomi Sezaki Satoshi Saito Tetsuya Hosaka Kenji Ikeda Hiromitsu Kumada Tetsuro Kobayashi	2013	Hepatology2013，，3：	2
5	Poor Response to Pegylated Interferon and Ribavirin in Older Women Infected with Hepatitis C Virus of Genotype 1b in High Viral Loads显示文摘	Hitomi Sezaki Fumitaka Suzuki Yusuke Kawamura Hiromi Yatsuji Tetsuya Hosaka Norio Akuta Masahiro Kobayashi Yoshiyuki Suzuki Satoshi Saitoh Yasuji Arase Kenji Ikeda Yuzo Miyakawa Hiromitsu Kumada	2009	Digestive Diseases and Sciences2009，，6：	2
6	Association of two polymorphisms of the IL28B gene with viral factors and treatment response in 1,518 patients infected with hepatitis C virus显示文摘	Mariko Kobayashi Fumitaka Suzuki Norio Akuta Hitomi Sezaki Yoshiyuki Suzuki Tetsuya Hosaka Yusuke Kawamura Masahiro Kobayashi Satoshi Saitoh Yasuji Arase Kenji Ikeda Kazuaki Chayama Yuzo Miyakawa Hiromitsu Kumada	2012	Journal of Gastroenterology2012，，5：	2
7	Selection of a virus strain resistant to entecavir in a nucleoside-naive patient with hepatitis B of genotype H显示文摘	Fumitaka Suzuki Norio Akuta Yoshiyuki Suzuki Hiromi Yatsuji Hitomi Sezaki Yasuji Arase Yusuke Kawamura Tetsuya Hosaka Masahiro Kobayashi Kenji Ikeda Mariko Kobayashi Sachiyo Watahiki Hiromitsu Kumada	2007	Journal of Clinical Virology2007，，2：	2
8	Predictive values of amino acid sequences of the core and NS5A regions in antiviral therapy for hepatitis C: a Japanese multi-center study显示文摘	Takeshi Okanoue Yoshito Itoh Hiroaki Hashimoto Kohichiroh Yasui Masahito Minami Tetsuo Takehara Eiji Tanaka Morikazu Onji Joji Toyota Kazuaki Chayama Kentaro Yoshioka Namiki Izumi Norio Akuta Hiromitsu Kumada	2009	Journal of Gastroenterology2009，，9：	2
9	Prevalence of hepatitis C virus variants resistant to NS3 protease inhibitors or the NS5A inhibitor (BMS-790052) in hepatitis patients with genotype 1b显示文摘	Fumitaka Suzuki Hitomi Sezaki Norio Akuta Yoshiyuki Suzuki Yuya Seko Yusuke Kawamura Tetsuya Hosaka Masahiro Kobayashi Satoshi Saito Yasuji Arase Kenji Ikeda Mariko Kobayashi Rie Mineta Sachiyo Watahiki Yuzo Miyakawa Hiromitsu Kumada	2012	Journal of Clinical Virology2012，，4：	2
10	Viral Elimination Reduces Incidence of Malignant Lymphoma in Patients with Hepatitis C显示文摘	Yusuke Kawamura Kenji Ikeda Yasuji Arase Hiromi Yatsuji Hitomi Sezaki Tetsuya Hosaka Norio Akuta Masahiro Kobayashi Fumitaka Suzuki Yoshiyuki Suzuki Hiromitsu Kumada	2007	The American Journal of Medicine2007，，12：	2
11	Response to long-term lamivudine treatment in patients infected with hepatitis B virus genotypes A,B,and C显示文摘	Kobayashi M Suzuki F Akuta N	2006	J Med Virol2006，78，10：	1
12	An open pilot study exploring the efficacy of fluvastatin, pegylated interferon and ribavirin in patients with hepatitis C virus genotype lb in high viral loads 显示文摘	Sezaki H Suzuki F Akuta N	2009	Intervirology2009，52，1：	1
13	Efficacy oflamivudine therapy in elderly patients with chronic hepatitis B infection 显示文摘	Kawaoka T Suzuki F Akuta N etal	2007	J Gastroenterol2007，42，5：	1
14	Loss of hepatitis B surface antigen from he serum of patients with chronic hep- atitis treated with lamivudine 显示文摘	Kobayashi M Suzuki F Akuta N	2007	J Med Virol2007，79，10：	1
15	Protein transduction domain of HIV-1 Tat protein promotes efficient delivery of DNA into mammalian cells显示文摘	Eguchi A Akuta T Okuyama H	2001	J Biol Chem2001，276，26：	1
16	Guanine nitration in idiopathic pulmonary fibrosis and its implication for carcinogenesis 显示文摘	Terasaki Y Akuta T Terasaki M	2006	Am J Respir Crit Care Med2006，174，6：	1
17	Randomized, controlled trial of natural interferon-α therapy for e-antigen-positive chronic hepatitis B patients显示文摘	Yasuji Arase Akihito Tsubota Satoshi Saitoh Yoshiyuki Suzuki Masahiro Kobayashi Fumitaka Suzuki Takashi Someya Norio Akuta Kenji Ikeda Mariko Kobayashi Hiromitsu Kumada	2002	Hepatology Research2002，，2：	1
18	Nitric oxide-induced downregulation of leptin production by 3T3-L1 adipocytes 显示文摘	Unno Y Akuta T Yu-ichiro S	2006	Nitric Oxide2006，15，2：	1
19	Development of an automatic 3-D shape me asuring system using a new auto-focusing method显示文摘		1991	Measurement1991，9，3：	1
20	Protein transduction domain of HIV21 tat protein promotes efficient delivery of DNA into mammalian cells显示文摘	AKUTA T OKUYAMA H	2001	J Biol Chem2001，276，26：	1

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