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| 1 | 42,573 cases of hepatectomy in China: a multicenter retrospective investigation显示文摘Hepatectomy is currently routinely performed in most hospitals in China. China owns the largest population of liver diseases and the biggest number of liver resection cases. A nationwide multicenter retrospective investigation involving 112 hospitals was performed, and focused on liver resection for patients with hepatocellular carcinoma(HCC). 42,573 cases of hepatectomy were enrolled, and 18,275 valid cases of liver resection for HCC patients were selected for statistical analysis. The epidemiology of HCC, distribution of hepatectomy, postoperative complications and prognosis were finally analyzed. In the 18,275 HCC patients,81% had hepatitis B virus infection and 10% had hepatitis C virus infection. 38% of the HCC patients had normal Alphafetoprotein(AFP) level, and other 35% had an AFP level lower than 400 ng mL^(-1). In the study period, 97% of the hepatectomy for HCC were treated with open surgery, and 23.81% had vascular exclusion techniques. The operation time was(191.7±105.6) min,the blood loss was(546.0±562.8) m L, and blood transfusion was(543.0±1,035.2) m L. The median survival for HCC patients was 631 days, with 1-, 3-, and 5-year overall survival of 73.2%, 28.8% and 19.6%, respectively. Liver cirrhosis, multiple nodules,tumor thrombosis and high AFP level were risk factors that affect postoperative survival. | Binhao Zhang Bixiang Zhang Zhiwei Zhang Zhiyong Huang Yifa Chen Minshan Chen Ping Bie Baogang Peng Liqun Wu Zhiming Wang Bo Li Jia Fan Lunxiu Qin Ping Chen Jingfeng Liu Zhe Tang Jun Niu Xinmin Yin Deyu Li Songqing He Bin Jiang Yilei Mao Weiping Zhou Xiaoping Chen | 2018 | Science China(Life Sciences)2018，61，6： | 39 |
| 2 | The beneficial effects of intermittent fasting:an update on mechanism,and the role of circadian rhythm and gut microbiota显示文摘Importance:There is accumulating evidence that intermittent fasting(IF)is connected to improved health condition and longevity time-restricted feeding(TRF)is the most recognized and extensively studied model of IF.Objective:To investigate the underlying mechanism of pleiotropic benefits of IF and hint the most advantageous feeding pattern for humans.Evidence review:We searched MEDLINE,EMBASE,Cochrane Library and Google Scholar by 2020 April for publications on IF or TRF and their mechanisms.Studies include animal models and human cohorts.Findings:One important mechanism is that IF allows certain period of fasting time,in which our bodies activate pathways of repair and rejuvenation.Moreover,the advantages of IF,especially TRF over total caloric restriction(CR)provided bases for various animal and human studies which suggested that the feeding-fasting rhythm stimulates the fluctuation of our gut microbiota and a series of subsequent molecular alterations,which in turn restored a healthier circadian clock that resembled our inherent clock formed throughout millions of years of homo sapiens history.Conclusions and Relevance for Reviews:Complete understanding of the mechanism leading to the beneficial effects of IF paves the way for tailored dietary regimen to combat a wide range of diseases and ill health conditions. | Dandan Hu Zhibo Xie Yuqian Ye Suhad Bahijri Minshan Chen | 2020 | Hepatobiliary Surgery and Nutrition2020，9，5： | 5 |
| 3 | Nonlinear Optimization of Orthotropic Steel Deck System Based on Response Surface Methodology显示文摘The steel bridge deck system,directly subjected to the vehicle load,is an important component to be considered in the optimization design of the bridges.Due to its complex structure,the design parameters are coupled with each other,and many fatigue details in the system result in time-consuming calculation during structure optimization.In view of this,a nonlinear optimization method based on the response surface methodology(RSM)is proposed in this study to simplify the design process and to reduce the amount of calculations during optimization.The optimization design of the steel bridge deck system with two-layer pavement on the top of the steel deck plate is taken as an example,the influence of eight structural parameters is considered.The Box-Behnken design is used to construct a sample space in which the eight structural parameters can be distributed evenly to reduce the calculation workload.The finite element method is used to model the mechanical responses of the steel bridge deck system.From the regression analysis by the RSM,the explicit relationships between the fatigue details and the design parameters can be obtained,based on which the nonlinear optimization design of the bridge deck system is conducted.The influence of constraint functions,objective functions,and optimization algorithms is also analyzed.The method proposed in this study is capable of considering the influence of different structural parameters and different optimization objectives according to the actual needs,which will effectively simplify the optimization design of the steel bridge deck system. | Wei Huang Minshan Pei Xiaodong Liu Chuang Yan Ya Wei | 2020 | Research2020，，1： | 4 |
| 4 | General design of Sutong Bridge显示文摘The main span of Sutong Bridge is a double-pylon,double-plane cable-stayed bridge with steel box girder,which has the world's longest central span of 1 088 m within cable-stayed bridges.To overcome problems caused by severe meteorological conditions,perplexing hydrological conditions,deep buried bedrock and higher navigation level,many new technics and methods were created.Keys including structural system,steel box girder,stayed cable,tower,pier,tower foundation,collision avoidance system,wind-resistance,seismic-resistance,structural nonlinear response and structural static stability were presented individually in this paper. | Zhang Xigang Yuan Hong Pei Minshan Dai Jie Xu Lin | 2009 | Engineering Sciences2009，7，1： | 4 |
| 5 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 6 | Effects of antiviral therapy on hepatitis B virus reactivation and liver function after resection or chemoembolization for hepatocellular carcinoma显示文摘 | Xiang‐Ming Lao Guangyu Luo Liang‐Tao Ye Cheng Luo Ming Shi Dian Wang Rongping Guo Minshan Chen Shengping Li Xiaojun Lin Yunfei Yuan | 2013 | Liver Int2013，，4： | 3 |
| 7 | Global patterns of hepatocellular carcinoma management from diagnosis to death: the BRIDGE Study显示文摘 | Joong‐Won Park Minshan Chen Massimo Colombo Lewis R. Roberts Myron Schwartz Pei‐Jer Chen Masatoshi Kudo Philip Johnson Samuel Wagner Lucinda S. Orsini Morris Sherman | 2015 | Liver Int2015，，9： | 3 |
| 8 | Development of a rapid GC-FID method to simultaneously determine triethylamine, diisopropylamine, and 1,1,3,3-tetramethylguanidine residues in an active pharmaceutical ingredient显示文摘A rapid GC-FID method was developed to simultaneously determine residual levels of triethylamine(TEA), 1,1,3,3-tetramethylguanidine(TMG), and diisopropylamine(DIPA) in the synthetic route of an active pharmaceutical ingredient(API). Due to the severe absorption of amines on GC stationary phases,GC columns with various stationary phases were evaluated for optimal peak shape and reproducibility.The final conditions used the Agilent CP-Volamine column to resolve the three amines in 12 min. Various inlet liners were also screened to further improve the sensitivity of the analysis. The Restek Siltek~? liner was selected to achieve the desired detectability for the method. The quantitation limits were 4, 3, and 4 mg/mL for TEA, DIPA, and TMG in the presence of API, respectively. All three amines showed good linearity(r > 0.999) and recoveries(> 90%) over the concentration range of 3 to 16 mg/mL. The testing of residual amines was initially performed at the penultimate stage of the synthesis. However, this work demonstrates that TMG can act as a proton sponge to react with salicylic acid, the counter ion of the penultimate, to form a volatile component that elutes at a different retention time. Consequently, in the final method, these three amines were monitored in the final API to circumvent the matrix interference.Key parameters of the method were qualified per method validation requirements in ICH guidelines. The method was successfully applied for batch testing during development and implemented as an inprocess control procedure at manufacturing sites. | Minshan Shou Haixiao Qiu | 2021 | Journal of Pharmaceutical Analysis2021，11，2： | 2 |
| 9 | Design and construction of super-long span bridges in China: Review and future perspectives显示文摘Super-long span bridges demand high design requirements and involve many difficulties when constructed,which is an important indicator to reflect the bridge technical level of a country.Over the past three decades,a large percentage of the new long-span bridges around the world were built in China,and thus,abundant technological innovations and experience have been accumulated during the design and construction.This paper aims to review and summarize the design and construction practices of the superstructure,the substructure,and the steel deck paving of the long-span bridges during the past decades as well as the current operation status of the existing long-span bridges in China.A future perspective was given on the developing trend of high-speed railway bridge,bridge over deep-sea,health monitoring and maintenance,intellectualization,standard system,and information technology,which is expected to guide the development direction for the construction of future super long-span bridges and promote China to become a strong bridge construction country. | Wei HUANG Minshan PET Xiaodong LIU Ya WEI | 2020 | Frontiers of Structural and Civil Engineering2020，14，4： | 2 |
| 10 | Study on longitudinal wind load calculation method of cables for cable-stayed bridge显示文摘Along with the expanding of span of cable-stayed bridge,wind load becomes a more and more important controlling factor for bridge the design.A very large proportion of the wind load acting on cables has exceeded that acting on deck.There was not any detailed prescript in Chinese code for calculation of longitudinal wind load on cables due to lack of theoretical research and experiment,and conservative simplified calculation was adopted during design,which leads to conservative and uneconomical design of structures.To resolve this problem,cable force experiment was carried out during the design of Sutong Bridge.By comparing with international research results,the calculation formula of longitudinal wind drag coefficient for cables was advanced to fill the blank of bridge wind resistant code of China,and has already been adopted in the Highway Bridge Wind Resistant Design Code(JTG/T D60-01-2004)with great significance for bridge engineering. | Pei Minshan Zhang Xigang Zhu Bin Hou Bin Liu Changpeng | 2009 | Engineering Sciences2009，7，1： | 2 |
| 11 | Research on the characteristic of shell side support structures of heat exchanger with longitudinal flow of shell side fluid显示文摘 | DONG Qiwu LIU Minshan ZHAO Xudong | 2005 | IASME Trans2005，8，2： | 1 |
| 12 | Research on the characteristic of shellside support structures of heat exchanger with longitudinal flow of shellside fluid显示文摘 | DONG Qiwu LIU Minshan ZHAO Xiaodong | 2005 | IASME Trans2005，8，2： | 1 |
| 13 | Locality Preserving Genetic Algorithms for Spatial-spectral Hyperspectral Image Classification显示文摘 | CUI Minshan PRASAD S LI Wei | 2013 | IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing2013，6，3： | 1 |
| 14 | Numerical andexperimental investigation of shellside characteristics for ROD baffleheat exchanger 显示文摘 | Dong Qiwu Wang Yongqing Liu Minshan | 2008 | Applied Thermal Engineering2008，28，7： | 1 |
| 15 | Maternal high salt-diet increases offspring's blood pressure with dysfunction of NO/PKGI signaling pathway in heart tissue显示文摘Background:High salt-diets have become significant threats to human health,resulting in hypertension and cardiovascular diseases.Hypertensive disorders during pregnancy are complicated,since the maternal cardiovascular system undergoes extensive physiological changes during pregnancy.High-salt diets during pregnancy can disturb the intrauterine environment and negatively affect fetal development.Therefore,we explored how high-salt diets during pregnancy could affect the offspring.Methods:Rats were divided into three groups and fed with low,normal,and high salt diets.The offspring were separated into three groups after weaning based on dietary salt concentration.The blood pressure and urine protein content of both dams and offspring were measured.To evaluate cardiac function,we used Masson staining and immunodetection to confirm the fibrosis status.Finally,we extracted protein from cardiac tissue to test the expression levels of the Nitric Oxide(NO)/cGMP-dependent protein kinase I(PKGI)pathway and the angiotensin receptor.Results:High-salt diets increased blood pressure,and offspring previously exposed to high-salt environments were predisposed to hypertension.High-salt diets were also found to induce cardiac fibrosis and exacerbate fibrosis in offspring and alter the epithelial-mesenchymal transition(EMT).Under these conditions,the NO/PKGI pathway was activated in cardiac tissue and the type-1angiotensin II receptor(AT1R)was upregulated,though the type-2 angiotensin II receptor(AT2R)had the opposite effect.Conclusion:High-salt diets induce high blood pressure and increase predisposition to hypertension in offspring.They are accompanied by cardiac fibrosis,which could be caused by the activation of NO/PKGI and upregulation of AT1R. | Minshan Huang Xiuying Li Luwen Ren Lin Huang Jiahong Pan Jinlin Yao Lili Du Dunjin Chen Jingsi Chen | 2022 | Gynecology and Obstetrics Clinical Medicine2022，2，2： | 1 |
| 16 | Decision fusion of textural features derived from polarimetric data for levee assessment显示文摘 | CUI Minshan SAURABH P MAJID M | 2012 | IEEE Journal of Selected Topic in Applied Earth Observation and Remote Sensing2012，5，3： | 1 |
| 17 | Advances in the development of amorphous solid dispersions:The role of polymeric carriers显示文摘Amorphous solid dispersion(ASD)is one of the most effective approaches for delivering poorly soluble drugs.In ASDs,polymeric materials serve as the carriers in which the drugs are dispersed at the molecular level.To prepare the solid dispersions,there are many polymers with various physicochemical and thermochemical characteristics available for use in ASD formulations.Polymer selection is of great importance because it influences the stability,solubility and dissolution rates,manufacturing process,and bioavailability of the ASD.This review article provides a comprehensive overview of ASDs from the perspectives of physicochemical characteristics of polymers,formulation designs and preparation methods.Furthermore,considerations of safety and regulatory requirements along with the studies recommended for characterizing and evaluating polymeric carriers are briefly discussed. | Jie Zhang Minshan Guo Minqian Luo Ting Cai | 2023 | Asian Journal of Pharmaceutical Sciences2023，18，4： | 1 |
| 18 | Disulfiram enhances the antitumor activity of cisplatin by inhibiting the Fanconi anemia repair pathway显示文摘A series of chemotherapeutic drugs that induce DNA damage,such as cisplatin(DDP),are standard clinical treatments for ovarian cancer,testicular cancer,and other diseases that lack effective targeted drug therapy.Drug resistance is one of the main factors limiting their application.Sensitizers can overcome the drug resistance of tumor cells,thereby enhancing the antitumor activity of chemotherapeutic drugs.In this study,we aimed to identify marketable drugs that could be potential chemotherapy sensitizers and explore the underlying mechanisms.We found that the alcohol withdrawal drug disulfiram(DSF)could significantly enhance the antitumor activity of DDP.JC-1 staining,propidium iodide(PI)staining,and western blotting confirmed that the combination of DSF and DDP could enhance the apoptosis of tumor cells.Subsequent RNA sequencing combined with Gene Set Enrichment Analysis(GSEA)pathway enrichment analysis and cell biology studies such as immunofluorescence suggested an underlying mechanism:DSF makes cells more vulnerable to DNA damage by inhibiting the Fanconi anemia(FA)repair pathway,exerting a sensitizing effect to DNA damaging agents including platinum chemotherapy drugs.Thus,our study illustrated the potential mechanism of action of DSF in enhancing the antitumor effect of DDP.This might provide an effective and safe solution for combating DDP resistance in clinical treatment. | Meng YUAN Qian WU Mingyang ZHANG Minshan LAI Wenbo CHEN Jianfeng YANG Li JIANG Ji CAO | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，3： | 1 |
| 19 | Exergeeconomic analysis of heat exchanger networks for optimum minimum approach temperature 显示文摘 | JIN Zunlong DONG Qiwu LIU Minshan | 2008 | Chemical Engineering & Technology2008，31，2： | 1 |
| 20 | Heat exchanger network synthesis with detailed heat exchanger design 显示文摘 | JIN Zurdong DONG Qiwu LIU Minshan | 2008 | Chemical Engineering & Technology2008，31，7： | 1 |
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