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| 1 | Factors correlating with acoustic radiation force impulse elastography in chronic hepatitis C显示文摘AIM: To investigate the factors other than fibrosis stage correlating with acoustic radiation force impulse(ARFI) elastograpy in chronic hepatitis C. METHODS: ARFI elastograpy was performed in 108 consecutive patients with chronic hepatitis C who underwent a liver biopsy. The proportion of fibrosis area in the biopsy specimens was measured by computerassisted morphometric image analysis. RESULTS: ARFI correlated significantly with fibrosis stage(β = 0.1865, P < 0.0001) and hyaluronic acid levels(β = 0.0008, P = 0.0039) in all patients by multiple regression analysis. Fibrosis area correlated significantly with ARFI by Spearman's rank correlation test but not by multiple regression analysis. ARFI correlated significantly with body mass index(BMI)(β =-0.0334, P = 0.0001) in F 0 or F 1, with γ-glutamyltranspeptidase levels(β = 0.0048, P = 0.0012) in F 2, and with fibrosis stage(β = 0.2921, P = 0.0044) and hyaluronic acid levels(β = 0.0012, P = 0.0025) in F 3 or F 4. The ARFI cutoff value was 1.28 m/s for F ≥ 2, 1.44 m/s for F ≥ 3, and 1.73 m/s for F 4. CONCLUSION: ARFI correlated with fibrosis stage and hyaluronic acid but not with inflammation. ARFI was affected by BMI, γ-glutamyltranspeptidase, and hyaluronic acid in each fibrosis stage. | Toru Nishikawa Senju Hashimoto Naoto Kawabe Masao Harata Yoshifumi Nitta Michihito Murao Takuji Nakano Yuko Mizuno Hiroaki Shimazaki Toshiki Kan Kazunori Nakaoka Yuka Takagawa Masashi Ohki Naohiro Ichino Keisuke Osakabe Kentaro Yoshioka | 2014 | World Journal of Gastroenterology2014，20，5： | 7 |
| 2 | A new index for non-invasive assessment of liver fibrosis显示文摘AIM:To construct and evaluate a new non-invasive fibrosis index for assessment of the stage of liver f ibrosis. METHODS:A new f ibrosis index (Fibro-Stiffness index) was developed in 165 of 285 patients with chronic hepatitis C, and was validated in the other 120 patients where liver biopsy was performed. Its usefulness was compared with liver stiffness (LS) measured by FibroScan, the aminotransferase-to-platelet ratio index, the Forns index and the FibroIndex. RESULTS: The Fibro-Stiffness index consists of LS,platelet count and prothrombin time. The values of the Fibro-Stiffness index differed signif icantly between neighboring f ibrosis stages except F0-F1. The area under the receiver operating characteristics curves of the Fibro-Stiffness index for prediction of F≥2 (0.90), F≥ 3 (0.90) and F= 4(0.92) in the estimation group and those for F≥ 3 (0.93) and F =4 (0.97) in the validation group were the highest among the 5 methods examined. The accuracy of the Fibro-Stiffness index had highest values for F≥2, F≥3 and F=4 in both the estimation and validation groups. The diagnostic performance for F= 4 was improved by a combination of the Fibro-Stiffness index with serum hyaluronic acid level. CONCLUSION: The Fibro-Stiffness index was constructed and validated. It showed superior diagnostic performance to other indices for F ≥ 2,3 and 4. | Naohiro Ichino Keisuke Osakabe Toru Nishikawa Hiroko Sugiyama Miho Kato Shiho Kitahara Senju Hashimoto Naoto Kawabe Masao Harata Yoshifumi Nitta Michihito Murao Takuji Nakano Yuko Arima Hiroaki Shimazaki Koji Suzuki Kentaro Yoshioka | 2010 | World Journal of Gastroenterology2010，16，38： | 7 |
| 3 | Recent trends in diverticulosis of the right colon in Japan显示文摘 | Dr. Seiji Miura M.D. Susumu Kodaira M.D. Tomoo Shatari M.D. Michihito Nishioka M.D. Yoichiro Hosoda M.D. Kosei Hisa M.D | 2000 | Diseases of the Colon & Rectum2000，，10： | 1 |
| 4 | Recent trends in diverticulosis of the right colon in Japan显示文摘 | Dr. Seiji Miura M.D. Susumu Kodaira M.D. Tomoo Shatari M.D. Michihito Nishioka M.D. Yoichiro Hosoda M.D. Kosei Hisa M.D | 2000 | Diseases of the Colon & Rectum2000，，10： | 1 |
| 5 | The loss of HBeAg without precore mutation results in lower HBV DNA levels and ALT levels in chronic hepatitis B virus infection显示文摘 | Naoto Kawabe Senju Hashimoto Masao Harata Yoshifumi Nitta Michihito Murao Takuji Nakano Hiroaki Shimazaki Yuko Arima Naruomi Komura Kyoko Kobayashi Kentaro Yoshioka | 2009 | Journal of Gastroenterology2009，，7： | 1 |
| 6 | The loss of HBeAg without precore mutation results in lower HBV DNA levels and ALT levels in chronic hepatitis?B virus infection显示文摘 | Naoto Kawabe Senju Hashimoto Masao Harata Yoshifumi Nitta Michihito Murao Takuji Nakano Hiroaki Shimazaki Yuko Arima Naruomi Komura Kyoko Kobayashi Kentaro Yoshioka | 2009 | Journal of Gastroenterology2009，，7： | 1 |
| 7 | Recent trends in diverticulosis of the right colon in Japan显示文摘 | Dr. Seiji Miura M.D. Susumu Kodaira M.D. Tomoo Shatari M.D. Michihito Nishioka M.D. Yoichiro Hosoda M.D. Kosei Hisa M.D | 2000 | Diseases of the Colon & Rectum2000，，10： | 1 |
| 8 | Peripheral Nerve Sheath Tumors from Patients with Neurofibromatosis Type 1 Do Not Have the Chromosomal Translocation t(X;18)显示文摘 | Michael A. Liew Cheryl M. Coffin Jonathan A. Fletcher Minh-Thu N. Hang Katsumi Tanito Michihito Niimura David Viskochil | 2002 | Pediatric and Developmental Pathology2002，，2： | 1 |
| 9 | Recent trends in diverticulosis of the right colon in Japan显示文摘 | Dr. Seiji Miura M.D. Susumu Kodaira M.D. Tomoo Shatari M.D. Michihito Nishioka M.D. Yoichiro Hosoda M.D. Kosei Hisa M.D | 2000 | Diseases of the Colon & Rectum2000，，10： | 1 |
| 10 | Development of Vehicle Dynamics Management System for Hybrid Vehicles: ECB System for /reproved Environmental and Vehicle Dynamic Performance显示文摘 | Masayuki Soga Michihito Shirnada Jyun-lchi Sakamoto | 2002 | JSAE Review2002，，23： | 1 |
| 11 | The deacetylase SIRT2 contributes to autoimmune disease pathogenesis by modulating IL-17A and IL-2 transcription显示文摘Aberrant IL-17A expression together with reduced IL-2 production by effector CD4^(+)T cells contributes to the pathogenesis of systemic lupus erythematosus(SLE).Here,we report that Sirtuin 2(SIRT2),a member of the family of NAD^(+)-dependent histone deacetylases,suppresses IL-2 production by CD4^(+)T cells while promoting their differentiation into Th17 cells.Mechanistically,we show that SIRT2 is responsible for the deacetylation of p70S6K,activation of the mTORC1/HIF-1α/RORγt pathway and induction of Th17-cell differentiation.Additionally,SIRT2 was shown to be responsible for the deacetylation of c-Jun and histones at the Il-2 gene,resulting in decreased IL-2 production.We found that the transcription factor inducible cAMP early repressor(ICER),which is overexpressed in T cells from people with SLE and lupus-prone mice,bound directly to the Sirt2 promoter and promoted its transcription.AK-7,a SIRT2 inhibitor,limited the ability of adoptively transferred antigen-specific CD4^(+)T cells to cause autoimmune encephalomyelitis in mice and limited disease in lupus-prone MRL/lpr mice.Finally,CD4^(+)T cells from SLE patients exhibited increased expression of SIRT2,and pharmacological inhibition of SIRT2 in primary CD4^(+)T cells from patients with SLE attenuated the ability of these cells to differentiate into Th17 cells and promoted the generation of IL-2–producing T cells.Collectively,these results suggest that SIRT2-mediated deacetylation is essential in the aberrant expression of IL-17A and IL-2 and that SIRT2 may be a promising molecular target for new SLE therapies. | Ryo Hisada Nobuya Yoshida Masataka Umeda Catalina Burbano Rhea Bhargava Marc Scherlinger Michihito Kono Vasileios C.Kyttaris Suzanne Krishfield George C.Tsokos | 2022 | Cellular & Molecular Immunology2022，19，6： | 1 |
| 12 | Polypoid endobronchial extension from invasive thymoma显示文摘 | Koichi Honma Michihito Mishina Yoshiichi Watanabe | 1988 | Virchows Archiv A Pathological Anatomy and Histopathology1988，，5： | 1 |
| 13 | Changes of shear-wave velocity by interferon-based therapy in chronic hepatitis C显示文摘AIM: To evaluate the changes of shear-wave velocity(Vs) by acoustic radiation force impulse after treatment in chronic hepatitis C.METHODS: Eighty-seven patients with chronic hepatitis C were consecutively treated with combinations of interferon(IFN) plus ribavirin(RBV). Vs value(m/s) was measured with acoustic radiation force impulse before treatment, at end of treatment(EOT), 1 year after EOT, and 2 years after EOT.RESULTS: In patients with a sustained virological response(SVR)(n = 41), Vs significantly decreased at EOT [1.19(1.07-1.37), P = 0.0004], 1 year after EOT [1.10(1.00-1.22), P = 0.0001], and 2 years after EOT [1.05(0.95-1.16), P < 0.0001] compared with baseline [1.27(1.11-1.49)]. In patients with a relapse(n = 26), Vs did not significantly decrease at EOT [1.23(1.12-1.55)], 1 year after EOT [1.20(1.12-1.80)], and 2 years after EOT [1.41(1.08-2.01)] compared with baseline [1.39(1.15-1.57)]. In patients with a nonvirological response(n = 20), Vs did not significantly decrease at EOT [1.64(1.43-2.06)], 1 year after EOT [1.66(1.30-1.95)], and 2 years after EOT [1.61(1.36-2.37)] compared with baseline [1.80(1.54-2.01)]. Among genotype 1 patients, baseline Vs was significantly lower in SVR patients [1.28(1.04-1.40)] than in non-SVR patients [1.56(1.20-1.83)](P = 0.0142).CONCLUSION: Reduction of Vs values was shown in SVR patients after IFN-plus-RBV therapy by acoustic radiation force impulse. | Keisuke Osakabe Naohiro Ichino Toru Nishikawa Hiroko Sugiyama Miho Kato Ai Shibata Wakana Asada Naoto Kawabe Senju Hashimoto Michihito Murao Takuji Nakano Hiroaki Shimazaki Toshiki Kan Kazunori Nakaoka Yuka Takagawa Masashi Ohki Takamitsu Kurashita Tomoki Takamura Kentaro Yoshioka | 2015 | World Journal of Gastroenterology2015，21，35： | 0 |
| 14 | Vitamin E reduces liver stiffness in nonalcoholic fatty liver disease显示文摘AIM: To evaluate the efficacy of vitamin E treatment on liver stiffness in nonalcoholic fatty liver disease(NAFLD).METHODS: Thirty-eight NAFLD patients were administered vitamin E for > 1 year. The doses of vitamin E were 150, 300, or 600 mg; three times per day after each meal. Responses were assessed by liver enzyme levels [aspartate aminotransferase(AST), alanine aminotranferease(ALT), and γ-glutamyl transpeptidase(γ-GTP)], noninvasive scoring systems of hepatic fibrosis-4 [FIB-4 index and aspartate aminotransferaseto-platelet index(APRI)], and liver stiffness [velocity of shear wave(Vs)] measured by acoustic radiation force impulse elastography. Vs measurements were performed at baseline and 12 mo after baseline. The patients were genotyped for the patatin-like phospholipase domain containing 3(PNPLA3) polymorphisms and then divided into either the CC/CG or GG group to examine each group's responses to vitamin E treatment. RESULTS: We found marked differences in the platelet count, serum albumin levels, alkaline phosphatase levels, FIB-4 index, APRI, and Vs at baseline depending on the PNPLA3 polymorphism. AST, ALT, and γ-GTP levels(all P < 0.001); FIB-4 index(P = 0.035); APRI(P < 0.001); and Vs(P < 0.001) significantly decreased from baseline to 12 mo in the analysis of all patients. In the subset analyses of PNPLA3 genotypes, AST levels(P = 0.011), ALT levels(P < 0.001), γ-GTP levels(P = 0.005), APRI(P = 0.036), and Vs(P = 0.029) in genotype GG patients significantly improved, and AST and ALT levels(both P < 0.001), γ-GTP levels(P = 0.003), FIB-4 index(P = 0.017), and APRI(P < 0.001) in genotype CC/CG patients. CONCLUSION: One year of vitamin E treatment improved noninvasive fibrosis scores and liver stiffness in NAFLD patients. The responses were similar between different PNPLA3 genotypes. | Aiko Fukui Naoto Kawabe Senju Hashimoto Michihito Murao Takuji Nakano Hiroaki Shimazaki Toshiki Kan Kazunori Nakaoka Masashi Ohki Yuka Takagawa Tomoki Takamura Hiroyuki Kamei Kentaro Yoshioka | 2015 | World Journal of Hepatology2015，7，27： | 0 |
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