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| 1 | Impact of changing our cannulation method on the incidenceof post-endoscopic retrograde cholangiopancreatography pancreatitis after pancreatic guidewire placement显示文摘AIM: To clarify whether the incidence of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) after pancreatic guidewire placement (PGW) can be reduced by using a different cannulation method. METHODS: Between April 2001 and October 2009, PGW was performed in 142 patients with native papilla to overcome difficult biliary cannulation. Our cannulation method for ERCP was changed from contrast injection (CI) using a single-lumen catheter (April 2001-May 2008) to wire-guided cannulation (WGC) using a double-lumen catheter (June 2008-October 2009). The CI protocol was also changed during the study period: in the first period it was used for routine pancreatography for detecting small pancreatic cancer (April 2001-November 2002), whereas in the second period it was not (December 2002-May 2008). In PGW with CI using a singlelumen catheter, the contrast medium in the catheter lumen was injected into the pancreatic duct. The success rate of biliary cannulation, the incidence of PEP according to the cannulation method, and the impact of CI using a single-lumen catheter on PEP in comparison with WGC using a double-lumen catheter were investigated.RESULTS: CI with routine pancreatography, CI without routine pancreatography, and WGC were performed in 27 patients, 77 patients and 38 patients, respectively. Routine pancreatography did not contribute to the early diagnosis of pancreatic cancer in our study period. In CI without routine pancreatography and WGC, diagnostic pancreatography was performed in 17 patients and no patients, respectively. The success rate of biliary cannulation by PGW alone was 69%, and the final success rate was increased to 80.3% by the addition of consecutive maneuvers or a second ERCP. PEP occurred in 22 patients (15.5%), and the severity was mild in all cases. When analyzed according to cannulation method, the incidence of PEP was 37.0% (10/27) in the patients who underwent CI with routine pancreatography, 14.3% (11/77) in those who underwent CI without routine pancreatography, and 2.6% (1/38) in those who underwent WGC. In all patients who underwent CI using a singlelumen catheter, the incidence of PEP was 20% (21/104), which was significantly higher than that in WGC using a double-lumen catheter. In univariate and multivariate analysis, CI using a single-lumen catheter showed a high, statistically significant, odds ratio for PEP after PGW. CONCLUSION: The practice of a cannulation method involving the use of a double-lumen catheter minimizes the CI dose administered to the pancreatic duct and reduces the incidence of PEP after PGW. | Takeshi Hisa Ryusuke Matsumoto Masato Takamatsu Masayuki Furutake | 2011 | World Journal of Gastroenterology2011，17，48： | 7 |
| 2 | Facile and Scalable Synthesis of a Highly Hydroxylated Water-Soluble Fullerenol as a Single Nanoparticle显示文摘水溶性的 polyhydroxylated fullerene,即 fullerenol 与 44 个氢氧根组和 8 个第二等的界限水分子一起, C60 (哦) | Ken Kokubo Shogo Shirakawa Naoki Kobayashi Hisae Aoshima Takumi Oshima | 2011 | Nano Research2011，4，2： | 5 |
| 3 | Tangnaikang improves insulin resistance and β-cell apoptosis by ameliorating metabolic inflammation in SHR.Cg-Lepr^(cp)/NDmcr rats显示文摘OBJECTIVE: To investigate the effects of Tangnaikang(TNK), a mixture of five herbal plant extracts,on inflammation-mediated insulin resistance andβ-cell apoptosis in SHR.Cg-Leprcp/NDmcr(SHR-cp)rats.METHODS: Seven-week-old SHR-cp rats were randomly divided into a control(CON) group and a TNK(3.24 g/kg) group. Wistar-Kyoto rats at the same age were used as the normal control group.After 7 weeks of continuous intragastric administration of TNK, the glucose metabolic status and insulin sensitivity of the rats were evaluated by assessing fasting serum glucose(FBG), the oral glucose tolerance test(OGTT), fasting serum insulin(FINS),and the insulin sensitivity index(ISI). Serum tumor necrosis factor-α(TNF-α), interleukin-6(IL-6), C-reactive protein(CRP) and adiponectin were measured via enzyme-linked immunosorbent assays.Macrophage infiltration and apoptosis in adipose tissues were detected through F4/80 immunohistochemistry and the terminal deoxynucleotidyl transferase d UTP nick end labeling(TUNEL) assay. Islet morphology and β-cell apoptosis were investigated using double immunofluorescence staining and the TUNEL assay. The expression of cytokine genes in adipose tissue, the liver, and the pancreas was detected in real-time polymerase chain reaction assays. The expression and phosphorylation levels of insulin signaling-, inflammation-, and β-cell survival-related proteins in the liver and pancreas of SHR-cp rats were detected by western blotting.RESULTS: TNK(3.24 g/kg) treatment significantly decreased body weight, FBG and FINS; improved impaired glucose tolerance; increased the ISI; reduced serum levels of TNF-α, CRP and IL-6; and increased serum adiponectin. The m RNA expression of inflammatory markers was markedly reduced in the liver, pancreas, and adipose tissue. F4/80-and TUNEL-positive cells in adipose tissues were decreased, as was the number of TUNEL-positiveβ-cells. The phosphorylation of c-Jun N-terminal kinase and that of insulin receptor substrate-1 at serines 307 and 1101 was significantly decreased.In the pancreas, the expression of nuclear factor kappa-light chain-enhancer of activated B cells-p65 was significantly decreased, and phosphoinositide3-kinase and IRS-2 were significantly increased.CONCLUSION: TNK was able to improve insulin resistance and β-cell apoptosis in SHR-cp rats, which might be associated with its ability to relieve the overall and local metabolic inflammatory responses observed in SHR-cp rats. | Li Linyi Hisae Yoshitomi Qin Lingling Wu Xinli Zhou Tian Wang Haiyan Jiang Yueying Wei Ying Xu Tunhai Liu Tonghua Gao Ming | 2017 | Journal of Traditional Chinese Medicine2017，37，3： | 3 |
| 4 | Coincidence between malignant perivascular epithelioid cell tumor arising in the gastric serosa and lung adenocarcinoma显示文摘A 4-mo history of both epigastralgia and back pain was presented in a 39-year-old male. Computed tomography showed right lung nodule and abdominal mass attached to the gastric wall, measuring approximately 30 mm and 70 mm in diameter. Since biopsy samples from the lung and abdomen revealed poorly differentiated adenocarcinoma and malignant tumor, clinicians first interpreted the abdominal mass as metastatic carcinoma, and a right lower lobectomy with following resection of the mass was performed. Gross examination of both lesions displayed gray-whitish to yellow-whitish cut surfaces with hemorrhagic and necrotic foci, and the mass attached to the serosa of the lesser curvature on the gastric body. On microscopic examination, the lung tumor was composed of a proliferation of highly atypical epithelial cells having abundant eosinophilic cytoplasm, predominantly arranged in an acinar or solid growth pattern with vessel permeation, while the abdominal tumor consisted of sheets or nests with markedly atypical epithelioid cells having pleomorphic nuclei and abundant eosinophilic to clear cytoplasm focally in a radial perivascular or infiltrative growth pattern. Immunohistochemically, the latter cells were positive for HMB45 or α-smooth muscle actin, but the former ones not. Therefore, we finally made a diagnosis of malignant perivascular epithelioid cell tumor(PEComa) arising in the gastric serosa, combined with primary lung adenocarcinoma. Furthermore, small papillary car-cinoma of the thyroid gland was identified. The current case describes the coincidence of malignant PEComa with other carcinomas, posing a challenge in distinction from metastatic tumor disease. | Sohsuke Yamada Atsunori Nabeshima Hirotsugu Noguchi Aya Nawata Hisae Nishii Xin Guo Ke-Yong Wang Masanori Hisaoka Toshiyuki Nakayama | 2015 | World Journal of Gastroenterology2015，21，4： | 2 |
| 5 | Growth process of small pancreatic carcinoma: A case report with imaging observation for 22 months显示文摘This report describes serial observations of the growth process of a small invasive ductal carcinoma (IDC) of the pancreas from imaging studies. Histopathological studies showed IDC with macroscopic retention cysts proximal to an intraductal papillary-mucinous adenoma with mild atypia of the branch duct type in the pancreatic body, with no relation between the two lesions. IDC was demonstrated as an extremely low-echoic mass resembling a cyst with an unclear margin on the initial endoscopic ultrasonography. We misinterpreted the low-echoic mass as a benign intraductal mucinous-papillary neoplasm (IPMN) based on findings of other imaging studies, and the patient was followed-up. The mass increased from 7 mm to 13 mm in diameter over 22 mo, and remained smaller than 10 mm in diameter for about 420 d. The tumor volume doubling time was 252 d. The Ki67 labeling index was 15.9%, similar to that described in previous reports. Hence, IDC may grow slowly while remaining small. | Takeshi Hisa Hiroki Ohkubo Satoshi Shiozawa Hiroki Ishigame Masato Takamatsu Masayuki Furutake Bunsei Nobukawa Koichi Suda | 2008 | World Journal of Gastroenterology2008，14，12： | 2 |
| 6 | Screening of agonistic activities against four nuclear receptors in wastewater treatment plants in Japan using a yeast two-hybrid assay显示文摘To assess the potential endocrine disruptive effects through multiple nuclear receptors(NRs),especially non-steroidal NRs,in municipal wastewater,we examined the agonistic activities on four NRs(estrogen receptor α,thyroid hormone receptor α,retinoic acid receptor α and retinoid X receptor α) of untreated and treated wastewater from municipal wastewater treatment plants(WWTPs) in Japan using a yeast two-hybrid assay.Investigation of the influent and effluent of seven WWTPs revealed that agonistic activities against steroidal and non-steroidal NRs were always detected in the influents and partially remained in the effuents.Further investigation of four WWTPs employing conventional activated sludge,pseudo-anoxic-oxic,anoxic-oxic and anaerobic-anoxic-oxic processes revealed that the ability to reduce the agonistic activity against each of the four NRs varies depending on the treatment process.These results indicated that municipal wastewater in Japan commonly contains endocrine disrupting chemicals that exert agonistic activities on steroidal and non-steroidal NRs,and that some of these chemicals are released into the natural aquatic environment.Although the results obtained in yeast assays suggested that measured levels of non-steroidal NR agonists in the effluent of WWTPs were not likely to cause any biological effect,further study is required to assess their possible risks in detail. | Daisuke Inoue Koki Nakama Kazuko Sawada Taro Watanabe Hisae Matsui Kazunari Sei Tsuyoshi Nakanishi Michihiko Ike | 2011 | Journal of Environmental Sciences2011，23，1： | 2 |
| 7 | Acceleration of Cell Growth by Xyloglucan Oligosaccharides in Suspension-Cultured Tobacco Cells显示文摘进暂停有教养的烟草房间的墙的 xyloglucan oligosaccharide (XXXG ) 的加入加速了房间分割跟随的房间扩大,改变的房间形状从对球形的、减少的房间尺寸,和引起的房间聚集圆柱。荧光灯在强壮的加入发生在表面上的地方,加到文化媒介的 XXXG 被发现被合并到全部墙的表面不仅,而且在在房间之间的接口墙中在房间分割期间。房间扩大比在纵的方向在横向的方向总是是更大的然后立即,扩大面对 XXXG 导致了房间分割;这个过程可能导致在有教养的烟草房间看见的房间聚集的高水平。我们断定进墙的这 oligosaccharide 的集成能在有教养的房间加速不仅房间扩大,而且房间分割。 | Rumi Kaid Satoko Sugawara Kanako Negoro Hisae Maki Takahisa Hayashi Takako S. Kaneko | 2010 | Molecular Plant2010，3，3： | 2 |
| 8 | Clinicopathological and prognostic significance of microRNA-107 andits relationship to DICER1 mRNA expression in gastric cancer显示文摘 | Taisuke Inoue Hisae Iinuma Etsushi Ogawa Tsuyoshi Inaba Ryoji Fukushima | 2012 | Oncology Reports2012，，6： | 2 |
| 9 | Trans-cinnamaldehyde promotes nitric oxide release via the protein kinase-B/v-Akt murine thymoma viral oncogene-endothelial nitric oxide synthase pathway to alleviate hypertension in SHR.Cg-Lepr^(cp)/NDmcr rats显示文摘OBJECTIVE:To evaluate whether endothelial dysfunction and hypertension are prevented by trans-cinnamaldehyde(t CA) through the activation of endothelial nitric oxide synthase(e NOS).METHODS:Human umbilical vein endothelial cells(HUVECs) were cultured in vitro and stimulated with t CA to determine cell viability using the methyl thiazolyl tetrazolium assay.The effect of t CA on nitric oxide(NO) production was determined by diaminofluorescein-dyes in the absence or presence of inhibitors of e NOS,AMPK,PKA,and AKT.The effect of t CA on blood pressure was determined by the tail-cuff method in obesity spontaneous hypertension(SHR.Cg-Leprcp/NDmcr) rats.The phosphorylation of e NOS and protein expression of the insulin-signaling pathway(Ins R-IRS1-PI3 K-AKT)were measured by western blot.RESULTS:t CA at concentrations less than 100 μM did not affect cell viability in cultured HUVECs.Stimulation with t CA promoted NO release in a time-dependent manner compared with the control group.t CA-treated HUVECs also significantly increased AKT-Ser473 and e NOS-Ser1177 phosphorylation.In SHR-CP rats,treatment with t CA at a dose of 40 mg/kg/day for 6 weeks markedly reduced the systolic blood pressure and diastolic blood pressure,increased the phosphorylation of AKT and e NOS,and increased urinary nitric oxidation.CONCLUSION:t CA attenuated endothelial dysfunction and reduced blood pressure in SHR-CP rats.The underlying mechanisms may involve the increase in AKT and e NOS phosphorylation and the release of e NOS-derived NO. | Zhang Lu Wu Lili Liu Ximing Yoshitomi Hisae Ikeda Katsumi Negishi Hiroko Pan Yajing Sun Wen Qin Lingling Li Juan-E Xu Tunhai Liu Tonghua Gao Ming | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 2 |
| 10 | A Flavanonol Rhamnoside from Hypericum japonicum显示文摘 | Kyoko I Satoko N Hisae F | 1991 | Phytochemistry1991，30，9： | 1 |
| 11 | Differentiation of Benign and Malignant Breast Tumors Using Doppler Spectral Parameters Including Acceleration Time Index显示文摘 | Mesaki K Hisa N Kubota K | 2003 | Oncol Rep2003，10，4： | 1 |
| 12 | Effects of blockades of alpha and beta adrenoceptors and dopamine receptors on renal nerve stimulation-induced prostaglandin E2 and renin release in anesthetized dogs显示文摘 | Hisa H Hayashi Y Satoh S | 1985 | J Pharmacol Exp Ther1985，235，2： | 1 |
| 13 | Hydrogen production from waste aluminum at different temperatures with LCA显示文摘 | Hiraki T Takeuchi M Hisa M | 2005 | Materials Transactions2005，46，5： | 1 |
| 14 | A Dipeptide Derivative from Hypericum japonicum 显示文摘 | Kyoko I Satoko N Hisae F | 1991 | Phytochemistry1991，30，11： | 1 |
| 15 | Evaluation of hepatocellular carcinoma after treatment with transcatheter arterial chemoembolization: comparison of Lipiodol-CT, power Doppler sonography, and dynamic MRI显示文摘 | K. Kubota N. Hisa T. Nishikawa Y. Fujiwara Y. Murata S. Itoh D. Yoshida S. Yoshida | 2001 | Abdominal Imaging2001，，2： | 1 |
| 16 | Differentiation of benign and malignant breast tunmors using Doppler spectral parameters including acceleration time index显示文摘 | Hisa N Kubota K | 2003 | Oncology Reports2003，10，4： | 1 |
| 17 | Hydrogen production from waste aluminum at different temperatures with LCA显示文摘 | HIRAKI T TAKEUCHI M HISA M | 2005 | Mater Trans2005，46，5： | 1 |
| 18 | Effect of M-A constituent on fracture behavior of 780 and 980MPa class HSLA steel subjected to weld HAZ thermal cycle 显示文摘 | FU KU Hisa Matsuda Kenji lkeuchi Hitoshiok Ada | 1994 | Trans JWRI1994，23，2： | 1 |
| 19 | Evaluation of hepatocel- lular carcinoma after treatment with transcatheter arterial che moembolization: comparison of Lipiodol-CT, power doppler sonography, and dynamic MRI显示文摘 | Kubota K Hisa N Nishikawa T | 2001 | Abdom Imaging2001，26，2： | 1 |
| 20 | Hydrogen production from waste aluminum at different tcrnperaturcs with LCA显示文摘 | HIRAKI T TAKEUCHI M HISA M ctal | 2005 | Mater Trans2005，46，： | 1 |
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