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| 1 | Short-chain fatty acids act as antiinflammatory mediators by regulating prostaglandin E_2 and cytokines显示文摘AIM:To investigate the effect of short-chain fatty ac-ids (SCFAs) on production of prostaglandin E2 (PGE2),cytokines and chemokines in human monocytes.METHODS:Human neutrophils and monocytes were isolated from human whole blood by using 1-Step Polymorph and RosetteSep Human Monocyte Enrich-ment Cocktail,respectively. Human GPR41 and GPR43 mRNA expression was examined by quantitative real-time polymerase chain reaction. The calcium flux assay was used to examine the biological activities of SCFAs in human neutrophils and monocytes. The effect ofSCFAs on human monocytes and peripheral blood mononuclear cells (PBMC) was studied by measuring PGE2,cytokines and chemokines in the supernatant. The effect of SCFAs in vivo was examined by intraplantar injection into rat paws.RESULTS:Human GPR43 is highly expressed in human neutrophils and monocytes. SCFAs induce robust calcium flux in human neutrophils,but not in human monocytes. In this study,we show that SCFAs can in-duce human monocyte release of PGE2 and that this effect can be enhanced in the presence of lipopolysac-charide (LPS). In addition,we demonstrate that PGE2 production induced by SCFA was inhibited by pertussis toxin,suggesting the involvement of a receptor-mediated mechanism. Furthermore,SCFAs can specifi cally inhibit constitutive monocyte chemotactic protein-1 (MCP-1) production and LPS-induced interleukin-10 (IL-10) production in human monocytes without affecting the secretion of other cytokines and chemokines examined. Similar activities were observed in human PBMC for the release of PGE2,MCP-1 and IL-10 after SCFA treatment. In addition,SCFAs inhibit LPS-induced production of tumor necrosis factor-α and interferon-γ in human PBMC. Finally,we show that SCFAs and LPS can induce PGE2 production in vivo by intraplantar injection into rat paws (P < 0.01). CONCLUSION:SCFAs can have distinct antiinflammatory activities due to their regulation of PGE2,cytokine and chemokine release from human immune cells. | Mary Ann Cox James Jackson Michaela Stanton Alberto Rojas-Triana Loretta Bober Maureen Laverty Xiaoxin Yang Feng Zhu Jianjun Liu Suke Wang Frederick Monsma Galya Vassileva Maureen Maguire Eric Gustafson Marvin Bayne Chuan-Chu Chou Daniel Lundell Chung-Her Jenh | 2009 | World Journal of Gastroenterology2009，15，44： | 30 |
| 2 | Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Eric Van Cutsem Andrea Feyereislova Hyun C Chung Lin Shen Akira Sawaki Florian Lordick Atsushi Ohtsu Yasushi Omuro Taroh Satoh Giuseppe Aprile Evgeny Kulikov Julie Hill Michaela Lehle Josef Rüschoff Yoon-Koo Kang | 2010 | The Lancet2010，，9742： | 20 |
| 3 | Blocking the Metabolism of Starch Breakdown Products in Arabidopsis Leaves Triggers Chloroplast Degradation显示文摘在大多数植物,吸收相片的碳的大部分作为淀粉在日子期间在叶绿体被存储并且在随后的夜里期间重新动员支持新陈代谢。在 Arabidopsis thaliana 堵住淀粉合成或淀粉故障的变化减少植物生长。麦芽糖是在夜里从叶绿体出口的淀粉故障的主要产品。麦芽糖过量 1 异种(mex1 ) 缺乏叶绿体信封麦芽糖 transporter,在叶绿体积累麦芽糖和淀粉的高水平并且发展一特殊但是以前叶子成熟的 unexplained 萎黄病显型。阻止淀粉合成的另外的变化的介绍,或从淀粉的那块麦芽糖生产,也阻止 mex1 的褪绿。相反,在 disproportionating 酶(DPE1 ) 的变化的介绍除了麦芽糖导致 maltotriose 的累积,并且极大地增加褪绿。这些数据建议在麦芽糖累积和叶绿体动态平衡之间的一个连接。显微镜的分析证明在萎黄病 mex1 叶子的叶肉房间比野类型的房间比叶绿体的半数字有少数。传播电子显微镜学在 mex1 和 dpe1/mex1 揭示象 autophagy 一样叶绿体降级两倍异种。Microarray 分析揭示新陈代谢、细胞的过程的实质的 reprogramming,建议那 organellar 蛋白质周转在 mex1 被增加,尽管叶老朽和老朽相关的叶绿素分解代谢没被导致。我们建议麦芽糖和 malto-oligosaccharides 的累积引起叶绿体机能障碍,它可以由经由一种形式发信号后退发信号并且被触发叶绿体降级。 | Michaela Stettler Simona Eicke Tabea Mettler Gaelle Messerli Stefan Hortensteiner Samuel C. Zeeman | 2009 | Molecular Plant2009，2，6： | 9 |
| 4 | Preemptive mechanical ventilation can block progressive acute lung injury显示文摘Mortality from acute respiratory distress syndrome(ARDS) remains unacceptable, approaching 45% in certain high-risk patient populations. Treating fulminant ARDS is currently relegated to supportive care measures only. Thus, the best treatment for ARDS may lie with preventing this syndrome from ever occurring. Clinical studies were examined to determine why ARDS has remained resistant to treatment over the past several decades. In addition, both basic science and clinical studies were examined to determine the impact that early, protective mechanical ventilation may have on preventing the development of ARDS in at-risk patients. Fulminant ARDS is highly resistant to both pharmacologic treatment and methods of mechanical ventilation. However, ARDS is a progressive disease with an early treatment window that can be exploited. In particular, protective mechanical ventilation initiated before the onset of lung injury can prevent the progression to ARDS. Airway pressure release ventilation(APRV) is a novel mechanical ventilation strategy for delivering a protective breath that has been shown to block progressive acute lung injury(ALI) and prevent ALI from progressing to ARDS. ARDS mortality currently remains as high as 45% in some studies. As ARDS is a progressive disease, the key to treatment lies with preventing the disease from ever occurring while it remains subclinical. Early protective mechanical ventilation with APRV appears to offer substantial benefit in this regard and may be the prophylactic treatment of choice for preventing ARDS. | Benjamin Sadowitz Sumeet Jain Michaela Kollisch-Singule Joshua Satalin Penny Andrews Nader Habashi Louis A Gatto Gary Nieman | 2016 | World Journal of Critical Care Medicine2016，5，1： | 9 |
| 5 | Dental and periodontal phenotype in sclerostin knockout mice显示文摘Sclerostin is a Wnt signalling antagonist that controls bone metabolism.Sclerostin is expressed by osteocytes and cementocytes;however,its role in the formation of dental structures remains unclear.Here,we analysed the mandibles of sclerostin knockout mice to determine the influence of sclerostin on dental structures and dimensions using histomorphometry and micro-computed tomography(mCT)imaging.mCT and histomorphometric analyses were performed on the first lower molar and its surrounding structures in mice lacking a functional sclerostin gene and in wild-type controls.mCT on six animals in each group revealed that the dimension of the basal bone as well as the coronal and apical part of alveolar part increased in the sclerostin knockout mice.No significant differences were observed for the tooth and pulp chamber volume.Descriptive histomorphometric analyses of four wild-type and three sclerostin knockout mice demonstrated an increased width of the cementum and a concomitant moderate decrease in the periodontal space width.Taken together,these results suggest that the lack of sclerostin mainly alters the bone and cementum phenotypes rather than producing abnormalities in tooth structures such as dentin. | Ulrike Kuchler Uwe Y Schwarze Toni Dobsak Patrick Heimel Dieter D Bosshardt Michaela Kneissel Reinhard Gruber | 2014 | International Journal of Oral Science2014，6，2： | 7 |
| 6 | 烧结矿竖冷窑——烧结厂能量回收的新标准显示文摘针对国内基于横向流动原理的烧结矿环形冷却机传热效率低、污染环境问题,普锐特冶金技术开发了一种新型烧结矿竖冷窑。竖冷窑的设计采用逆向流动原理,能够有效地利用高温烧结矿的全部显热,使热量传递给竖炉内逆向流经烧结料床的冷却空气。与传统的环形烧结矿冷却机相比,竖冷窑所需冷却空气少,灰尘排放少,热回收率提高70%。普锐特竖冷窑的一个独特优点是装料系统的设计能够保证烧结矿均匀分布,消除了偏析现象。特殊设计的出料系统能够有效地控制竖冷窑的冷却效果。普锐特冶金技术和鞍钢集团工程技术公司合作为鞍钢265 m2烧结机安装了首台竖冷窑。该项目回收的余热将被用来产生蒸汽,蒸汽通过汽轮机驱动系统带动烧结主抽风机,无需使用外部能源,大幅度降低运行成本。 | Michaela Boeberl 屈鹏飞 Peter Puschitz 李益民 于丽娟 | 2018 | 河北冶金2018，，11： | 7 |
| 7 | Management of Hyperglycemia in Type 2 Diabetes: A Patient-Centered Approach: Position Statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)显示文摘 | Inzucchi Silvio E Bergenstal Richard M Buse John B Diamant Michaela Ferrannini Ele Nauck Michael Peters Anne L Tsapas Apostolos Wender Richard Matthews David R | 2012 | EN2012，，3： | 6 |
| 8 | Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Eric Van Cutsem Andrea Feyereislova Hyun C Chung Lin Shen Akira Sawaki Florian Lordick Atsushi Ohtsu Yasushi Omuro Taroh Satoh Giuseppe Aprile Evgeny Kulikov Julie Hill Michaela Lehle Josef Rüschoff Yoon-Koo Kang | 2010 | The Lancet . 2010 (9742)2010，，9742： | 6 |
| 9 | Drug-induced liver injury in inflammatory bowel disease: 1-year prospective observational study显示文摘AIM To analyze 1-year liver injury burden in inflammatory bowel disease(IBD) patients. METHODS During a 6-mo inclusion period, consecutive IBD cases having a control visit at IBD center were included. Basic demographics, IBD phenotype and IBD treatment were recorded on entry. Aminotransferase(AT) activities of ALT, AST, ALP and gamma-glutamyl transpeptidase(GGT) were measured at baseline, 3 mo prior to study entry and prospectively every 3 mo for 1 year. Liver injury patterns were predefined as: Grade 1 in ALT 1-3 × upper limit of normal(ULN), grade 2 in ALT > 3 × ULN, hepatocellular injury in ALT > 2 × ULN, cholestatic injury in simultaneous GGT and ALP elevation > ULN.Persisting injury was reported when AT elevations were found on > 1 measurement. Risk factors for the patterns of liver injury were identified among demographic parameters, disease phenotype and IBD treatment in univariate and multivariate analysis. Finally, implications for the change in IBD management were evaluated in cases with persisting hepatocellular or cholestatic injury.RESULTS Two hundred and fifty-one patients were included having 917 ALT and 895 ALP and GGT measurements. Over one year, grade 1 injury was found in 66(26.3%), grade 2 in 5(2%) and hepatocellular injury in 16 patients(6.4%). Persisting hepatocellular injury was found in 4 cases. Cholestasis appeared in 11 cases(4.4%) and persisted throughout the entire study period in 1 case. In multivariate analysis, hepatocellular injury was associated with BMI(OR = 1.13, 1.02-1.26), liver steatosis(OR = 10.61, 2.22-50.7), IBD duration(1.07, 1.00-1.15) and solo infliximab(OR = 4.57, 1.33-15.7). Cholestatic liver injury was associated with prior intestinal resection(OR = 32.7, 3.18-335), higher CRP(OR = 1.04, 1.00-1.08) and solo azathioprine(OR = 10.27, 1.46-72.3). In one case with transient hepatocellular injury azathioprine dose was decreased. In 4 cases with persisting hepatocellular injury, fatty liver or alcohol were most likely causes and IBD treatment was pursued without change. In the case with persisting cholestatic injury, no signs of portal hypertension were identified and treatment with infliximab continued.CONCLUSION Liver injury was frequent, mostly transient and rarely changed management. Infliximab or azathioprine were confirmed as its risk factors indicating the need for regular AT monitoring. | tomas koller martina galambosova simona filakovska michaela kubincova tibor hlavaty jozef toth anna krajcovicova juraj payer | 2017 | World Journal of Gastroenterology2017，23，22： | 5 |
| 10 | Bone marrow-derived mesenchymal stem cells migrate to healthy and damaged salivary glands following stem cell infusion显示文摘Xerostomia is a severe side effect of radiation therapy in head and neck cancer patients. To date, no satisfactory treatment option has been established. Because mesenchymal stem cells(MSCs) have been identified as a potential treatment modality, we aimed to evaluate stem cell distribution following intravenous and intraglandular injections using a surgical model of salivary gland damage and to analyse the effects of MSC injections on the recruitment of immune cells. The submandibular gland ducts of rats were surgically ligated. Syngeneic adult MSCs were isolated, immortalised by simian virus 40(SV40) large T antigen and characterized by flow cytometry. MSCs were injected intravenously and intraglandularly. After 1, 3 and 7 days, the organs of interest were analysed for stem cell recruitment. Inflammation was analysed by immunohistochemical staining. We were able to demonstrate that, after intravenous injection, MSCs were recruited to normal and damaged submandibular glands on days 1, 3 and 7. Unexpectedly, stem cells were recruited to ligated and non-ligated glands in a comparable manner. After intraglandular injection of MSCs into ligated glands, the presence of MSCs, leucocytes and macrophages was enhanced, compared to intravenous injection of stem cells. Our data suggest that injected MSCs were retained within the inflamed glands, could become activated and subsequently recruited leucocytes to the sites of tissue damage. | Silke Schwarz Ralf Huss Michaela Schulz-Siegmund Breda Vogel Sven Brandau Stephan Lang Nicole Rotter | 2014 | International Journal of Oral Science2014，6，3： | 5 |
| 11 | Ternary Ni-Co-Fe oxyhydroxide oxygen evolution catalysts:Intrinsic activity trends,electrical conductivity,and electronic band structure显示文摘Nickel-,cobalt-,and iron-based(oxy)hydroxides comprise the most-commonly studied electrocatalysts for the oxygen-evolution reaction(OER)in alkaline solution.A fundamental understanding of composition-structure-activity relationships for mixed-metal Ni-Co and Ni-Co-Fe(oxy)hydroxides is important to guide the design of advanced OER catalysts.Here we use cyclic voltammetry,chronopotentiometry,inductively-coupled plasma-optical emission spectroscopy,and in situ electrical conductivity measurements to characterize the properties and activity of various compositions of Ni-Co-Fe(oxy)hydroxides prepared by cathodic co-electrodeposition.Consistent with previous studies,we find Fe is essential for the mixed-metal(oxy)hydroxides to achieve high OER activity.In the rigorous absence of Fe(achieved by using specially cleaned electrolytes),the most-active Ni-Co(oxy)hydroxide composition has an OER turn-over frequency only twice that ofpure Co(oxy)hydroxide,suggesting minimal synergism between the two metals.The addition of Co to Ni-Fe(oxy)hydroxides shifts the onset of electrical conductivity to lower potentials,but has little effect on the intrinsic OER activity,with the most-active Ni-Co-Fe(oxy)hydroxide having an OER turn-over frequency only -1.5 times that of the Ni-Fe(oxy)hydroxides.The magnitudes of the electrical conductivities are similar for all the compositions measured.Density-functional-theory-calculated projected density of states show a significant contribution of all chemical elements at the valence band edge of the mixed-metal oxyhydroxide electronic structure,demonstrating significant electronic hybridization between the elements.The calculations suggest the involvement of all the elements in modulating the electronic structure at putative Fe-based active sites that are probably located at edges or defects in the two-dimensional oxyhydroxide sheets. | Michaela Burke Stevens Lisa J. Enman Ester Hamal Korkus Jeremie Zaffran Christina D. M. Trang James Asbury Matthew G. Kast Maytal Caspary Toroker Shannon W. Boettcher | 2019 | Nano Research2019，12，9： | 5 |
| 12 | Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies显示文摘在地岬基因的 Oncogenic 变化在人的癌症是很普通的,导致有描绘得好的选择优点,而且不太听说得好的危险的房间。我们执行了一幅大规模 loss-of-function 屏幕识别被转变 KRAS 的结肠癌房间,然而并非由缺乏这 oncogene 的衍生物要求的基因。最高得分的基因然后在 KRAS 变异、野类型的癌症房间的一块更大的面板被测试。表示 oncogenic KRAS 的癌症房间被发现高度依赖于抄写因素 GATA2 和 DNA 复制开始管理者 CDC6。与已知的目标用许多药扩大这分析,我们发现有变异的 KRAS 的癌症房间与 topoisomerase 抑制显示出选择嗜好到 proteasome 功能,以及合成致命性。联合指向引起的这些功能改善了相对野类型的房间 KRAS 变异的房间杀死。这些观察建议新奇目标和在地岬变异的癌症为最佳的效果联合存在治疗的新方法,它传统地被看作对治疗高度倔强。 | Michael Steckel Miriam Molina-Arcas Britta Weigelt Michaela Marani Patricia H Warne Hanna Kuznetsov Gavin Kelly Becky Saunders Michael Howell Julian Downward David C Hancock | 2012 | Cell Research2012，22，8： | 5 |
| 13 | Urban Park Soil and Vegetation: Effects of Natural and Anthropogenic Factors显示文摘Various soil surface components, such as trees, shrubs and biological crusts, and human recreational activities, e.g., barbecues and trampling by visitors, may divide the area of the urban park into smaller fragments/microenvironments, differentiated by their microenvironmental conditions, which may differ in soil and vegetation characteristics. The spatial changes in the soil and vegetation characteristics and their causes were investigated in an urban park located south of Tel Aviv-Jaffa, Israel. The area of the park is 0.5km2, including groves, a lake, lawns, and rest areas. Soil was sampled in nine microenvironments, of which seven were within the park:under Ceratonia siliqua trees(Cs U), under Ficus sycomorus trees(Fi U), rest area between tables under F. sycomorus(Fi B), rest area under tables under F. sycomorus(Fi T), open area with bare soil(Oa S), open area with biological crust cover(Oa C), and open area covered by herbaceous vegetation(Oa V). Two more microenvironments, planar and sloping open areas(Co P and Co S, respectively) in the vicinity of the park, were used as the controls. Electrical conductivity, concentrations of soluble ions(Mg2+, Ca2+, Na+, K+and HCO-3), p H, contents of organic carbon, calcium carbonate and moisture, and grain size distribution were determined. In addition,herbaceous vegetation cover, number and diversity of herbaceous vegetation species were measured. It was found that soil properties and herbaceous vegetation characteristics varied within the park. Soil organic carbon, electrical conductivity, soluble salts, penetration depth, and vegetation characteristics were affected by human activities, mainly in the rest area between the tables. In contrast, the above characteristics were affected by natural factors mainly in the rest of the microenvironments, which were subjected to low levels of anthropogenic intervention. The heterogeneous structure of the park, as represented by the various microenvironments, offered new habitats and promoted the preservation of natural vegetation. | Pariente SARAH Helena Michaela ZHEVELEV Atar OZ | 2015 | Pedosphere2015，25，3： | 4 |
| 14 | Phase II Study of Everolimus in Patients with Metastatic Colorectal Adenocarcinoma Previously Treated with Bevacizumab-, Fluoropyrimidine-, Oxaliplatin-, and Irinotecan-Based Regimens显示文摘 | Kimmie Ng Josep Tabernero Jimmy Hwang Emilio Bajetta Sunil Sharma Salvatore A. Del Prete Edward R. Arrowsmith David P. Ryan Michaela Sedova Jin Jin Kamel Malek Charles S. Fuchs | 2013 | Clinical Cancer Research2013，，14： | 4 |
| 15 | Superior Properties of Mg–4Y–3RE–Zr Alloy Prepared by Powder Metallurgy显示文摘Magnesium alloys are important materials for application in the automotive and aviation industries. During the last few years, the number of possible applications as biodegradable implants in medicine has grown. Mg–RE(rare earth) alloys belong to the most advanced group of products, offering the best combination of mechanical properties and corrosion resistance. Among these materials, WE43(Mg–Y–Nd)is a very well-known commercial alloy that has been extensively studied for applications at increased temperatures and also in organisms. Although this material has been described, there are still possibilities to improve its properties and subsequently expand its applicability. Powder metallurgy has already been used for the preparation of magnesium alloys with superior mechanical properties and occasionally superior corrosion properties. Therefore, the present paper is oriented toward the preparation of Mg–4Y–3RE–Zr(WE43) alloy by the powder metallurgy technique(WE43-PM) and comparison of the final properties with the product of extrusion of as-cast ingot(WE43-IM). Our processing leads to a partial improvement in the mechanical properties and superior corrosion resistance of WE43-PM. The texture strength of WE43-PM was low, and therefore, anisotropy of mechanical properties was suppressed. | Jirí Kubásek Drahomír Dvorsky Miroslav Cavojsky Dalibor Vojtěch Nad'a Beronská Michaela Fousová | 2017 | Journal of Materials Science & Technology2017，33，7： | 4 |
| 16 | Tenascin C upregulates interleukin-6 expression in human cardiac myofibroblasts via toll-like receptor 4显示文摘AIM:To investigate the effect of Tenascin C(TNC)on the expression of pro-inflammatory cytokines and matrixmetalloproteinases in human cardiac myofibroblasts(CMF).METHODS:CMF were isolated and cultured from patients undergoing coronary artery bypass grafting.Cultured cells were treated with either TNC(0.1μmol/L,24 h)or a recombinant protein corresponding to different domains of the TNC protein;fibrinogen-like globe(FBG)and fibronectin typeⅢ-like repeats(TNⅢ5-7)(both 1μmol/L,24 h).The expression of the proinflammatory cytokines;interleukin(IL)-6,IL-1β,TNFαand the matrix metalloproteinases;MMPs(MMP1,2,3,9,10,MT1-MMP)was assessed using real time RT-PCR and western blot analysis.RESULTS:TNC increased both IL-6 and MMP3(P<0.01)mR NA levels in cultured human CMF but had no significant effect on the other markers studied.The increase in IL-6 mR NA expression was mirrored by an increase in protein secretion as assessed by enzymelinked immunosorbant assay(P<0.01).Treating CMF with the recombinant protein FBG increased IL-6mR NA and protein(P<0.01)whereas the recombinant protein TNⅢ5-7 had no effect.Neither FBG nor TNⅢ5-7 had any significant effect on MMP3 expression.The expression of toll-like receptor 4(TLR4)in human CMF was confirmed by real time RT-PCR,western blot and immunohistochemistry.Pre-incubation of cells with TLR4neutralising antisera attenuated the effect of both TNC and FBG on IL-6 mR NA and protein expression.CONCLUSION:TNC up-regulates IL-6 expression in human CMF,an effect mediated through the FBG domain of TNC and via the TLR4 receptor. | Azhar Maqbool Emma J Spary Iain W Manfield Michaela Ruhmann Lorena Zuliani-Alvarez Filomena O Gamboa-Esteves Karen E Porter Mark J Drinkhill Kim S Midwood Neil A Turner | 2016 | World Journal of Cardiology2016，8，5： | 4 |
| 17 | 基于系统动力学的青少年吸烟成瘾健康教育模型探索显示文摘目的建立一种针对青少年的、基于计算机交互的、动态且可视化的吸烟成瘾健康教育模型,使青少年在操作模型的过程中了解吸烟成瘾的机制,对吸烟的危害获得进一步的认识。方法应用系统动力学方法,根据吸烟成瘾生理学机制,构造动态教育模型,通过模型检测和初步仿真,以验证该模型的正确性、有效性和教育作用。结果该模型结构可以正确演示吸烟成瘾的机制,且在极端赋值的情况下仍能正常运作。通过在计算机上进行该模型的仿真演练,证明了青少年在实验前后对自己是否能控制吸烟的认识有明显差异。结论该模型能帮助青少年认识到自己很难将吸烟数量长期维持在较低水平,所以不可能仅通过自控方法避免吸烟成瘾,对青少年具有一定的警示和教育作用。 | 施莉莉 蔡雨阳 Tabacaru Michaela Erling Moxnes | 2015 | 上海交通大学学报(医学版)2015，35，2： | 4 |
| 18 | The barren stalk2 Gene Is Required for Axillary Meristem Development in Maize显示文摘The diversity of plant architecture is determined by axillary meristems (AMs). AMs are produced from small groups of stem cells in the axils of leaf primordia and generate vegetative branches and reproductive inflorescences . Previous studies identified genes critical for AM development that function in auxin biosynthesis, transport, and signaling. barren stalkl (ba1), a basic helix-loop-helix transcription factor, acts downstream of auxin to control AM formation. Here, we report the cloning and characterization of barren stalk2 (ba2), a mutant that fails to produce ears and has fewer branches and spikelets in the tassel, indicating that ba2 functions in reproductive AM development. Furthermore, the ba2 mutation suppresses tiller growth in the teosinte branchedl mutant, indicating that ba2 also plays an essential role in vegetative AM development. The ba2 gene encodes a protein that co-localizes and heterodimerizes with BA1 in the nucleus . Characterization of the genetic interaction between ba2 and ba1 demonstrates that ba1 shows a gene dosage effect in ba2 mutants, providing further evidence that BA1 and BA2 act together in the same pathway. Characterization of the molecular and genetic interaction between ba2 and additional genes required for the regulation of ba1 further supports this finding. The ba1 and ba2 genes are orthologs of rice genes, LAX PANICLE1 (LAX1) and LAX2, respectively, hence providing insights into pathways controlling AMs development in grasses. | Hong Yao Andrea Skirpan Brian Wardell Michaela S.Matthes Norman B.Best Tyler McCubbin Amanda Durbak Taylor Smith Simon Malcomber Paula McSteen | 2019 | Molecular Plant2019，12，3： | 4 |
| 19 | Efficacy and tolerability of a single-pill combination of telmisartan/ hydrochlorothiazide 80/25 mg in Chinese and Korean patients with moderate to severe hypertension: a subgroup analysis of a randomized, double-blind, active-controlled trial显示文摘 | Zhu Ding-liang Gao Ping-jin Liu Shao-wen Jeong, Myung Ho Mattheus, Michaela Voelker, Birgit | 2013 | Chinese Medical Journal2013，，21： | 4 |
| 20 | Alanine aminotransferase predicts coronary heart disease events: A 10-year follow-up of the Hoorn Study显示文摘 | Roger K. Schindhelm Jacqueline M. Dekker Giel Nijpels Lex M. Bouter Coen D.A. Stehouwer Robert J. Heine Michaela Diamant | 2006 | Atherosclerosis2006，，2： | 3 |
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