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| 1 | PTEN encoding product:a marker for tumorigenesis and progression of gastric carcinoma显示文摘AIM: To detect the expression of PTEN encoding productin normal mucosa, intestinal metaplasia (IM), dysplasia andcarcinoma of the stomach, and to investigate its clinicalimplication in tumorigenesis and progression of gastriccarcinoma.METHODS: Formalin-fixed paraffin embedded specimens from184 cases of gastric carcinoma, their adjacent normal mucosa,IM and dysplasia were evaluated for PTEN protein expressionby SABC immunohistochemistry. PTEN expression wascompared with tumor stage, lymph node metastasis, Lauren'sand WHO's histological classification of gastric carcinoma.Expression of VEGF was also detected in 60 cases of gastriccarcinoma and its correlation with PTEN was concerned.RESULTS: The positive rates of PTEN protein were 100 %(102/102), 98.5 %(65/66), 66.7 % (4/6) and 47.8 %(88/184)in normal mucosa, IM, dysplasia and carcinoma of the stomach,respectively. The positive rates in dysplasia and carcinomawere lower than in normal mucosa and IM (P<0.01).Advanced gastric cancers expressed less frequent PTEN thanearly gastric cancer (42.9 % v567.6 %, P<0.01). The positiverate of PTEN protein was lower in gastric cancer with thanwithout lymph node metastasis (40.3 % v563.3 %, P<0.01).PTEN was less expressed in diffuse-type than in intestinal-type gastric cancer (41.5 % v557.8 %,P<0.05). Signet ringcell carcinoma showed the expression of PTEN at the lowestlevel (25.0 %, 7/28); less than well and moderatelydifferentiated ones (P<0.01). Expression of PTEN was notcorrelated with expression of VEGF (P>0.05).CONCLUSION: Loss or reduced expression of PTEN proteinoccures commonly in tumorigenesis and progression of gastriccarcinoma. It is suggested that PTEN can be an objective markerfor pathologically biological behaviors of gastric carcinoma. | Lin Yang Li-Ge Kuang Hua-Chuan Zheng Jin-Yi Li Dong-Ying Wu Su-Min Zhang Yan Xin No.4 Lab,Cancer Institute,The First Affiliated Hospital,China Medical University,Shenyang 110001,China Ying Chen Shen Yang Gynecology & Obstetrics Hospital,Shenyang 110014,China | 2003 | World Journal of Gastroenterology2003，9，1： | 127 |
| 2 | Mobius Isoparametric Hypersurfaces in S^(n+1) with Two Distinct Principal Curvatures | Hai Zhong LI Department of Mathematics, Tsinghua University. Beijing 100084. P. R. China Hui Li LIU Department of Mathematics, Northeastern University. Shenyang 110000. P. R. China Chang Ping WANG Key Laboratory of Pure and Applied Mathematics, School of Mathematical Sciences. Peking University, Beijing 100871, P. R. China Guo Song ZHAO Department of Mathematics, Sichuan University, Chengdu 610064. P. R. China | 2002 | Acta Mathematica Sinica,English Series2002，18，3： | 53 |
| 3 | Apoptosis,proliferation and p53 gene expression of H.pylori associated gastric epithelial lesions显示文摘AIM: To study the relationship between Helicobacter pylori (H. Pylori) and gastric carcinoma and its possible pathogenesis by H. Pylori.METHODS: DNEL technique and immunohistochemical technique were used to study the state of apoptosis,proliferation and p53 gene expression. A total of 100 gastric mucosal biopsy specimens, including 20 normal mucosa, 30H. Pylori-negative and 30 H. Pylorf-positive gastric precancerous lesions along with 20 gastric carcinomas were studied.RESULTS: There were several apoptotic cells in the superficial epithelium and a few proliferative cells within the neck of gastric glands, and no p53 protein expression in normal mucosa. In gastric carcinoma, there were few apoptotic cells, while there were a large number of proliferative cells, and expression of p53 protein significantly was increased. In the phase of metaplasia, the apoptotic index (Al, 4.36% ± 1.95%), proliferative index (PI, 19.11% ± 6.79%) and positivity of p53 expression (46.7%) in H. Pylori-positive group were higher than those in normal mucosa (P< 0.01). Al in H. Pylori-positive group was higher than that in H. Pylori-negative group (3.81% ±1.76%), PI in H. Pylori-positive group was higher than that in H. Pylori-negative group (12.25% ±5.63%, P<0.01 ). In the phase of dysplasia, Al (2.31% ± 1.10%) in H. Pylori-positive group was lower (3.05% ± 1.29%) than that in H. Pylori-negative group, but PI (33.89% ± 11.65%)wassignificantly higher(22.09± 8018%, P< 0.01). In phases of metaplasia, dysplasia and gastric cancer in the H. Pylori-positive group, Als had an evidently graduall decreasing trend (P < 0.01 ), while Pis had an evidently gradual increasing trend (P< 0.05 or P< 0.01), and there was also a trend of gradual increase in the expression of p53 gene.CONCLUSION: In the course of the formation of gastric carcinoma, proliferation of gastric mucosa can be greatly increased by H. Pylori, and H. Pylori can induce apoptosis in the phase of metaplasia but in the phase of dysplasia H.pylori can inhibit cellular apoptosis. And H. Pylori infection can strengthen the expression of mutated p53 gene. | Zhong Zhang~1 Yuan Yuan Hua Gao Ming Dong Lan Wang Yue-Hua Gong 1 Department of Pathology,Shenyang Medical College,Shenyang 110031 Liaoning Province,China | 2001 | World Journal of Gastroenterology2001，7，6： | 46 |
| 4 | Relationship between phenotypes of cell-function differentiation and pathobiological behavior of gastric carcinomas显示文摘AIM To reveal the correlation between thefunctional differentiation phenotypes of gastriccarcinoma cells and the invasion and metastasisby a new way of cell-function classification.METHODS Surgically resected specimens of361 gastric carcinomas (GC) were investigatedwith enzyme-, mucin-, and tumor-related markerimmunohistochemist ry. According to thedirection of cell-function differentiation,stomach carcinomas were divided into fivefunctionally differentiated types.iation type (AFDT): there were 82 (22.7%)patients including 76 (92.7%) aged 45 years.Sixty-nine (84.1%) cases belonged to theintestinal type. Thirty-eight (46.3%) expressedCD44v6 and 9 (13.6%) of 66 male patientsdeveloped liver metastasis. The 5-year survivalrate of patients in this group (58.5%) was higherMucin secreting function differentiation type(MSFDT): 54 (15%) cases. Fifty-three (98.1%)tumors had penetrated the serosa, 12 (22.2%)expressed ER and 22 (40.7%) expressedCD44v6. The postoperative 5-year survival ratefunction differentiation type (AMPFDT): therewere 180 (49.9%) cases, including 31 (17.2%)aged yanger than 45 years. The tumor was morecommon in women (62, 34.4%,) and expressedmore frequently estrogen receptors (ER) ( 129,81.7%) than other types (P<0.01). Ovarymetastasis was found in 12 (19.4%) out of 62female subjects. The patients with this type GChad the lowest 5-year survival rate (24.7%)differentiation type (SFDT): 13 (3.6%) cases.Nine (69.2%) tumors of this type derived fromAPUD system, the other 4 (30.7%) were ofdifferent histological differentiation. Sixty percent of the patients survived at least five years.(8.9%) cases. Nineteen (59.4%) cases hadlymph node metastases but no one with liver orovary metastasis. The 5-year survival rate was28.1%.CONCLUSION This new cell-functionclassification of GC is helpful in indicating thecharacteristics of invasion and metastasis of GCwith different cell-function differentiationphenotypes. Further study is needed to disclosethe correlation between the cell-functionaldifferentiation phenotypes and the relevantgenotypes and the biological behavior of gastriccarcinoma. | Yan Xin Xiao Ling Li Yan Ping Wang Su Min Zhang Hua Chuan Zheng Dong Ying Wu Yin Chang Zhang The Fourth Laboratory of Cancer Institute, China Medical University, Shenyang 110001, Liaoning Province, China | 2001 | World Journal of Gastroenterology2001，7，1： | 38 |
| 5 | 沈阳郑家洼子的两座青铜时代墓葬显示文摘郑家洼子位于沈阳西南,东距沈阳站约5公里,南距浑河3公里,地势低洼,多沼泽,故名'洼子'。1958年春,曾在洼子北边发现一组青铜器,包括短剑等共二十七件。 | The Former Palace Museum of Shenyang and CPAM, City of Shenyang | 1975 | 考古学报1975，，1： | 40 |
| 6 | Expression of gastric cancer-associated MG7 antigen in gastric cancer,precancerous lesions and H.pylori-associated gastric diseases显示文摘AIM: To investigate the relationship between the antigen MG7 antigen expression and gastric cancer as well as precancerous condition; to study the relationship between the MG7 antigen expression and H. pyloriinfection in benign gastric lesions in order to find out the effect of H. pylori infection on the process of gastric cancer development.METHODS: The level of MG7 antigen expression was determined by immunohistochemical method in 383 gastric biopsied materials. The intestinal metaplasia was determined by histochemistry method. The H. pyloriinfection was determined by HE stain, PCR and ELISA in 291 specimens, among which only 34 cases of H. pylori-associated gastric lesions were followed up.RESULTS: The positive rate of MG7 expression in normal gastric mucosa, intestinal metaplasia, dysplasia and gastric cancer increased gradually in ascending order (P<0.01). The positive rate of MG7 antigen expression in type Ⅲ intestinal metaplasia of gastric mucosa was higher than that of type Ⅰand Ⅱ intestinal metaplasia, being highly significant (P<0.05).The positive rate of MG7 antigen expression in superficial gastritis, atrophic gastritis and gastric cancer increased gradually (11.9 %, 64.8 %, 91.2 %, P<0.01). There was no significant difference between H.pylori-negative and H. pyloripositive intestinal metaplasia, atrophic gastritis and dysplasia of gastric epithelium in the positive rate of MG7 antigen expression. There was no expression of MG7 antigen in H. pylori-negative superficial gastritis. The positive rate of MG7 expression in H. pylori-positive superficial gastritis was 20.5 %, and the difference between them was significant (P<0.05). During following up, one of the three H. pylori negative cases turned positive again, and its MG7 antigen expression turned to be stronger correspondingly. 3 of 31 H. pyloripositive cases were detected as early gastric cancer, among which one with '+++' MG7 antigen expression was diminished after H. pylori eradication.CONCLUSION: MG7 antigen expression is highly specific in gastric cancer and can be used as a good marker for screening of gastric cancer; type Ⅲ intestinal metaplasia, atrophic gastritis and dysplasia should be followed up and MG7 antigen expression has high clinical value in the dynamic follow-up study; although the positive -MG7 in positiveH. pylorisuperficial gastritis show benign morphology in features, there is still the potential risk of developing into gastric cancer, hence special attention should be paid to those showing increasing MG7 antigen expression. | Dong-Li Guo Ming Dong Lan Wang Li-Ping Sun Yuan Yuan,Cancer Institute,First Affiliated Hospital,China Medical University,Shenyang,110001,Liaoning Province,China | 2002 | World Journal of Gastroenterology2002，8，6： | 37 |
| 7 | Abnormal immunity and gene mutation in patients with severe hepatitis-B显示文摘AIM: To evaluate the abnormal immunity and gene mutation at precore 1896 site in patients with severe hepatitis-B.METHODS: This study included 23 patients with severe hepatitis-B, 22 patients with acute hepatitis-B and 20 controls.Mutation at precore 1896 site of HBV gene was confirmed with restriction fragment length polymorphism (RFLP) analysis.Cytokines including TNF-α, IFN-y, IL-6, and IL-8 were measured with ELISA, and T subgroups were detected with alkaline phosphatase anti alkaline phosphatase (APAAP) technique.RESULTS: In patients with severe hepatitis-B, the infective rate of HBV mutant strain was 52.5% (12/23), and only one patient with acute hepatitis-B was infected with the mutant strain. The percentage of CD8+ T lymphocyte was obviously lower (0.16±0.02%) and the ratio of CD4+/CD8+ was obviously higher (2.35±0.89) in mutant group than in wildtype group (0.28±0.05% and 1.31±0.18%, respectively,P<0.01 or P<0.05). The levels of cytokines in patients with severe hepatitis-B were higher (TNF-α 359.0±17.2 ng/L, IFNγ 234.7±16.5 ng/L, IL-6 347.5±31.3 ng/L, IL-8 181.1±19.6ng/L) than those in acute hepatitis-B (TNF-α 220.6±8.9ng/L, IFN-γ 174.9±12.0 ng/L, IL-6 285.8±16.5 ng/L, IL-8118.4±5.1 ng/L, P<0.01 or 0.05). In patients with severe hepatitis-B, the levels of IFN-γ and IL-6 were higher in mutant group (273.4±26.6 ng/L, 387.7±32.5 ng/L) than in wild-type group (207.8±12.8 ng/L, 300.9±16.3 ng/L). The mortality of patients infected with HBV mutant strain was higher (100%)than that with wild-type (0.9%).CONCLUSION: In severe hepatitis-B, the infective rate of HBV mutant strain was high. The mutant strain induces more severe immune disorders in host, resulting in the activation of lymphocyte and release of cytokines. HBV DNA mutates easily in response to the altered immunity. Ultimately liver damage is more prominent. | Jing-Yan Wang Pei Liu Department of Infectious Diseases,the Second Hospital,China Medical University,Shenyang 110004,Liaoning Province,China | 2003 | World Journal of Gastroenterology2003，9，9： | 39 |
| 8 | New development thoughts on the bio-inspired intelligence based control for unmanned combat aerial vehicle显示文摘Bio-inspired intelligence is in the spotlight in the field of international artificial intelligence,and unmanned combat aerial vehicle(UCAV),owing to its potential to perform dangerous,repetitive tasks in remote and hazardous,is very promising for the technological leadership of the nation and essential for improving the security of society.On the basis of introduction of bioinspired intelligence and UCAV,a series of new development thoughts on UCAV control are proposed,including artificial brain based high-level autonomous control for UCAV,swarm intelligence based cooperative control for multiple UCAVs,hy-brid swarm intelligence and Bayesian network based situation assessment under complicated combating environments, bio-inspired hardware based high-level autonomous control for UCAV,and meta-heuristic intelligence based heterogeneous cooperative control for multiple UCAVs and unmanned combat ground vehicles(UCGVs).The exact realization of the proposed new development thoughts can enhance the effectiveness of combat,while provide a series of novel breakthroughs for the intelligence,integration and advancement of future UCAV systems. | DUAN HaiBin 1 ,SHAO Shan 2 ,SU BingWei 3 &ZHANG Lei 41 State Key Laboratory of Science and Technology on Holistic Flight Control,School of Automation Science and Electrical Engineering, Beijing University of Aeronautics and Astronautics,Beijing 100191,China 2 Flight Control Department,Shenyang Aircraft Design and Research Institute,Shenyang 110035,China 3 Beijing Institute of Near Space Vehicle’s System Engineering,Beijing 100076,China 4Integration and Project Section,Air Force Equipment Academy,Beijing 100085,China | 2010 | Science China(Technological Sciences)2010，53，8： | 32 |
| 9 | Effect of bax,bcl-2 and bcl-xL on regulating apoptosis in tissues of normal liver and hepatocellular carcinoma显示文摘AIM: To investigate the expression of bax, bcl-2 and bcl-xL mRNA in the tissues of normal liver and hepatocellular carcinoma (HCC), and analyze the relationship between the expression of bax, bcl-2 and bcl-xL mRNA and clinical parameters of HCC patients.METHODS: The expression of bax, bcl-2 and bcl-xL mRNA of normal liver and HCC was measured by Northern blot. Statistical analyses were made by t test and correlation analysis.RESULTS: A very low mRNA level was indicated at bax,bcl-2 and bcl-xL in the HCC tissues in contrast to the tissues of normal liver by Northern blot analysis. The analyses of mRNA level revealed that HCC tissues exhibited a mean 7.6-fold decrease in bax, 4.2-fold in bcl-2 and 3.5-fold in bcl-xL in comparison with normal control tissues, respectively. Positive correlation was found between bax and bcl-xL (r=0.7061,P<0.01). There was no significance between the mRNA expression of these three genes and age, gender, tumor differentiation and tumor stage of HCC patients. CONCLUSION: The results are consistent with the fact that apoptosis rarely occurs in normal livers but increases in HCC, indicating that bcl-2 and bcl-xL may play a very important role in regulating the apoptosis of normal liver and HCC. | Xiao-Zhong Guo Xiao-Dong Shao Min-Pei Liu Jian-Hua Xu Li-Nan Ren Jia-Jun Zhao Hong-Yu Li Di Wang,Department of Gastroenterology,General Hospital of Shenyang Military Region,Shenyang 110016,Liaoning Province,China | 2002 | World Journal of Gastroenterology2002，8，6： | 34 |
| 10 | Effect of Cultivation on Spatial Distribution of Nematode Trophic Groups in Black Soil显示文摘Geostatistics combined with GIS was applied to assess the spatial distribution of nematode trophic groups following two contrasting soil uses in the black soil region of Northeast China. Two plots, one with fallow for 12 years and the other cultivated, were marked on regular square grids with 2-m spacing. Soil samples were collected from each sampling point, nematodes were extracted from these samples and classified into four trophic groups: bacterivores, fungivores, plant parasites, and omnivores/predators. The numbers of total nematodes and trophic groups analyzed had normal distributions on both fallow and cultivated plots. The absolute abundances of total nematodes and trophic groups were observed to be much more homogeneous on cultivated plot than on fallow one. Geostatistical analysis showed that the densities of total nematodes and trophic groups on both fallow and cultivated plots exhibited spatial dependence at the sampled scale and their experimental semivariograms were adjusted to a spherical or exponential model, except those of bacterivores and fungivores on cultivated plot. The spatial distribution of nematode trophic groups was found to be different for the two land uses, indicating that cultivation changed the native condition for soil nematode activities. | LIANG WENJU, LI QI, JIANG YONG, CHEN WENBO and WEN DAZHONGShenyang Experimental Station of Ecology, Institute of Applied Ecology, the Chinese Academy of Sciences, Shenyang 110016 (China) | 2003 | Pedosphere2003，13，2： | 29 |
| 11 | The Simulation of Grinding Wheels and Ground Surface Roughness Based on Virtual Reality Technology显示文摘The paper describes the feasibility and method of the application of virtual reality technology to grinding process, and introduces the modeling method of object entity in the environment of virtual reality. The simulation process of grinding wheels and ground surface roughness is discussed, and the computation program system of numerical simulation is compiled with Visual C++ programming language. At the same time, the three-dimensional simulation models of grinding wheels and ground surface roughness are made with OpenGL tool. The choice of grinding wheels, the forecast of ground surface quality and some simulation results can be realized by interactively inputting grinding parameters. The paper applies virtual reality technology to grinding process,makes the model of virtual grinding wheel and simulates the grinding process. The roughness of ground surface is showed in three-dimensional images, and therefore the grinding technology is studied. Computer simulation can not only be used as a shortcut to analyze and research the grinding process, but also increase the research scope and content. The virtual reality technology used in the paper is an advanced visualized simulation with interaction. The surface roughness Ra on simulated ground workpiece can be calculated by the arithmetic average of contour warp absolute value in sampling length of simulated ground workpiece. The parameters of virtual wheel and simulated grinding process can be changed by interaction input, so the simulated results in the desired grinding condition are gained. The effect of each parameter to ground surface can be analyzed by comparing the grinding results in different condition. | GONG Ya-dong, WANG Bin, WANG Wan-Shan (School of Mechanical Engineering & Automation, Northeastern University, Shenyang 110004, China) | 2002 | 厦门大学学报(自然科学版)2002，41，S1： | 25 |
| 12 | Fe-Mo-B-CSINTERED STE ELS PRODUCED BY ADDITI ON OF MASTER ALLOY POWDERS显示文摘Addition of Fe B C and Fe Mo B C m aster alloy pow ders to Fe Mo B Csintered steels can ac tivate the sintering process by liquid phase sintering . The for m ation of liquid ( α- Fe + ( Fe , Mo) 2 B+ Fe3( B, C) → L) i m proves m echanical properties of the steels , and ultim ate tensilestrengths of 684 774 M Pa , i m pact energy of 47 ±7 Jand elongation of 2 5 ±0 9 were ob tained . Optim u m a mount of liquid phase exists , and alarge a mount of liquid phase will re sult in the form ation of continuous netw ork of liquid phase that is detrim ental to strength andelongation . | Z. M. Xiu1) , L. X. Ding2) , Z. J. Zhao3) , J. You3) , Z. Zhang3) , F. M. He1)and X. D. Sun1)1) School of Materials and Metallurgy , Northeastern University , Shenyang 110006 , China2) Department of Materials , School of Mechan | 1999 | Acta Metallurgica Sinica(English Letters)1999，12，5： | 25 |
| 13 | Investigation of changes in properties of water under the action of a magnetic field显示文摘The properties of water and their changes under the action of a magnetic field were gathered by the spectrum techniques of infrared, Raman, visible, ultraviolet and X-ray lights, which may give an insight into molecular and atomic structures of water. It was found that some properties of water were changed, and a lot of new and strange phenomena were discovered after magnetization. Magnetized water really has magnetism, which has been verified by a peak shift of X-ray diffraction of magnetized water + Fe3O4 hybrid relative to that of pure water + Fe3O4 hybrid, that is a saturation and memory effect. The properties of infrared and ultraviolet absorp-tions, Raman scattering and X-ray diffraction of magnetized water were greatly changed relative to those of pure water; their strengths of peaks were all increased, the frequencies of some peaks did also shift, and some new peaks, for example, at 5198, 8050 and 9340 cm?1, occurred at 25℃ after water was magnetized. In the meanwhile, the magnetized effects of water are related to the magnetized time, the intensity of an externally applied magnetic field, and the temperature of water, but they are not a linear relationship. The study also showed a lot of new and unusual properties of magnetized water, for example, the six peaks in 3000-3800 cm?1 in infrared absorption, the exponential increase of ultraviolet absorption of wave with the decreasing wavelength of light of 200-300 nm, the frequency-shifts of peaks, a strange irreversible effect in the increasing and decreasing processes, as well as a stronger peak of absorption occurring at 50℃, 70℃ and 80℃, the existence of many models of motion from 85℃ to 95℃ in 8000-10000 cm?1, and so on. These results show that the molecular structure of water is very complicated, which needs further study. Furthermore, the macroscopic feature of mechanics, for instance, surface tension force of magnetized water, was also measured. Experiments dis-covered that the size in contact angles of magnetized water on the surface of hy-drophobic materials decreases, thus the surface tension force of magnetized water decreases relative to that of pure water. It is seen from the above results that the clustering structure of hydrogen-bonded chains and polarization effects of water molecules are enhanced after magnetization. These results are helpful in revealing the mechanism of magnetization of water. | PANG XiaoFeng1,2 & DENG Bo1 1 Institute of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China 2 International Centre for Materials Physics, Chinese Academy of Sciences, Shenyang 110015, China | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，11： | 23 |
| 14 | OXIDATION OF A TWO-PHASE Cu-75Cr ALLOY IN AIRAT 700-900℃显示文摘The cormsion in air of a two-phase Cu-75Cr alloy was studied at 700-900℃. Thealloy cormded nearly parabolically at 700-800℃, but at 900℃ its instantaneousparabolic mte constant decreased with time. The scales were complex and consistedof an outermost layer of copper oxide generally followed bg a layer of the double ox-ide Cu2 Cr2 O4 sometimes containing particles of unoxidized chromium surmunded bya chromia layer. An innermost layer of chromia was also observed in some cases.Finally metallic copper was al8o frequently mixed with chromia particles. No Cr de-pletion was observed in the alloy close to the inteffoce with the scale. In any case,this alloy was not able to form an exclusive continuous protective chromia layer. Thespecial cormsion behavior Of this alloy is typical of two-phase binary systems with alange solubility gaP in which the outwaof dthesion fiux of the most-reactive componentin the alloy is strongly reduced and may be inswncient to fOrm a protective externallayer of the cormsponding oxide. In paTticular, the presence of particles of Cr withina double oxide layer is very unusual and is allowed only for the kinetic reason. | F. Gesmundo Y Niu F. Vianiand D.L. Douglass(Universita di Genova, Fiera del Mare, Pad. D,16129 Genova, Italy)(State Key Lab. for Corrosion and Protection, Institute of Corrosion and Protection of Metals, theChinese Academy of Sciences, Shenyang 110015, Ch | 1997 | Acta Metallurgica Sinica(English Letters)1997，10，4： | 21 |
| 15 | Changed clinical aspects of primary liver cancer in China during the past 30 years显示文摘BACKGROUND: Primary liver cancer (PLC) is one of the most frequently seen tumors in China. Thirty years ago, patients with PLC were often detected at relatively late stage, with a palpable mass or marked clinical symptoms and poor prognosis. In the past 30 years, the diagnosis and treatment of PLC have been greatly improved with better prognosis. METHODS: In order to study the changes of PLC during the 30 years, the clinical data of 3250 patients with PLC from 10 medical institutions of China were collected, ana- lyzed , and compared with those of 3254 PLC patients be- fore the 30 years. RESULTS: In the 3250 patients aged 1-80 years, with an average age of 49.1 years, the male to female ratio (2.3:1) was lower than that before the 30 years. 73.5% of the 3250 patients sought medical advice within 3 months after the onset of the disease in contrast to 63.8% before the 30 years. Compared with those patients before the 30 years the symptoms and signs were alleviated generally. The HBsAg positive rate was 81.0%, but the HCV-Ab positive rate was 13.2%. The AFP level in 75% of patients was elevated, but in the remaining 25% was normal. 1912 patients (58.8%) were confirmed pathologically. Among them 1755 patients (91.8%) had hepatocellular carcinoma. The overall resec- tion rate was 46.3%. Those who had early, middle, late stage carcinoma accounted for 29.9%, 51.5%, and 18.6%respectively in contrast to 0.4%, 47.0%, and 52.6% repor- ted before the 30 years. The 1-, 3-, 5-year survival rates of the patients were 66.1%, 39.7%, and 32.5% respectively, whereas 93.5%, 70.1%, and 59.1% for the early stage pa- tients, and 65.3%, 30.5%, and 23.5% for the middle stage patients. The half and 1-year survival rates of the late stage patients were 52.5%, and 14.7%, respectively. CONCLUSION: Comparison with the clinical data before and after the 30 years show that PLC can be diagnosed ear- ly. More PLC patients tend to undergo resection while re- ceiving a better conservative treatment, which ensures a prognosis. | Bing-Hui Yang, Jing-Lin Xia, Li-Wen Huang, Zhao-You Tang, Ming-Shan Chen, Jin-Qing Li, An-Min Liang, Qin-Guo Mo, Hui-Shan Lu, Chao-Liu Dai, Lu-Nan Yan, Zhi-Jian Yu, Rong-Sheng Rao, Le-Qun Li, Zhi-Xiong Su, Zhuang-Wei Fang Shanghai, China Liver Cancer Institute & Zhongshan Hospital, Fudan University, Shanghai 200032, China Tumor Hospital, Zhongshan University, Guangzhou 510000, China Tumor Hospital, Guangxi Medical Universi- ty, Nanning 530000, China Xiehe Hospital, Fujian Medical University, Fuzhou 350000, China Second Hos- pital, Chinese Medical University, Shenyang 110000, China Huaxi Hospital, Sichuan University, Chengdu 610041, China Hospital Affiliated to Nantong Medical University, Nantong 226000 , China Second Hospital, Jiangxi Medical University, Nanchang 330000 , China First Hospital Affiliated to Guangxi Medical University, Nanning 530000 , China People’s Hospital of Hainan Province, Haikou 570000, China | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，2： | 20 |
| 16 | Medusoid Fossils from the Sinian Xingmincun Formation of Southern Liaoning Province显示文摘Abundant medusoid soft-bodied metazoan fossils have been found in the Sinian Xingmincun Formation(with an isotopic age of 650 Ma) at Qipanmo, Qidingshan and Yangtun of the Dalian-Jinzhou area, southern Liaoning Province; in addition, a number of macroscopic algal fossils have been discovered for the first time in the Getun Formation overlying the Xingmincun Formation. Medusoid fossils include 3 genera and 6 species(all of which are new). Judging from their biological characters, these medusoid fossils are considered to have an intimate affinity with the Ediacara fauna in the terminal Precambrian of Australia, as their characters are close to each other. The authors suggest that these medusoids and the Edicara fauna might be the products of the same period. The discovery of the medusoid fauna in the Xingmincun Formation marks an important event in the evolution of the terminal Precambrian organisms in China, and it is of major practical significance in the study of the Sinian System of China and the correlation of the Sinian strata of northern and southern China. | Hong Zuomin, Huang Zhenfu, Yang Xinde, Lan Jing, Xian Bingcai, Yang Yajun, Regional Geological Survey Party, Bureau of Geology and Mineral Resources of Liaoning Province, Jinzhou, Liaoning and Liu Xiaoliang Shenyang Institute of Geology and Resources, Chinese Academy of Geological Sciences, Shenyang, Liaoning Fang Xinzhong | 1989 | Acta Geologica Sinica(English Edition)1989，63，1： | 20 |
| 17 | Fractionation of heavy metals in shallow marine sediments from Jinzhou Bay,China显示文摘This work investigated the distribution and speciation of Cd, Cu, Pb, Fe and Mn in the shallow sediments of Jinzhou Bay, Northeast China, which has been heavily contaminated by nonferrous smelting activities. The concentrations of Cd, Cu and Pb in sediments were found to be 100, 13 and 7 times, respectively, being higher than the national guideline (GB 18668-2002). Sequential extraction test showed that 39%-61% of Cd were exchangeable fractions, indicating that Cd in the sediments posed a high risk to local environments. While Cu and Pb were at moderate risk levels. According to the relationships between percentage of metal speciation and total metal concentration, it was concluded that the distributions of Cd, Cu and Pb in some geochemical fractions were dynamic in the process of pollutants migration and the stability of metals in sediments of Jinzhou Bay decreased in the order of Pb > Cu > Cd. | Shaofeng Wang, Yongfeng Jia, Shuying Wang, Xin Wang, He Wang, Zhixi Zhao, Bingzhu LiuKey Laboratory of Pollution Ecology and Environmental Engineering, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China. | 2010 | Journal of Environmental Sciences2010，22，1： | 20 |
| 18 | Transformation of Compound K from Saponins in Leaves of Panax notoginseng by Immobilized β-Glucanase显示文摘Objective To prepare an active anti-tumor component,compound K(C-K),from saponins in leaves of Panax notoginseng(SLPN) using immobilized β-glucanase.Methods Two entrapments,alginate gel-1(Alg 1) and alginate gel-2(Alg 2),were evaluated for their ability to immobilize β-glucanase.The amount and purity of C-K obtained from the transformation process were analyzed by HPLC,and the immobilizing parameters were optimized.Results β-Glucanase can be immobilized and reused with either of the entrapment.However,using Alg 1 resulted in higher enzyme activity than Alg 2.The optimal concentration of the immobilized enzyme was 10%;The optimal crosslinking time was 4-6 h;and the optimal concentration of the crosslinking agent was 6%- 7%.Conclusion Immobilized β-glucanase shows sustained enzyme activity,good ethanol tolerance,and was reusable for the preparation of C-K from SLPN. | DONG Hui-juan1,2,JIANG Bin-hui3,HAN Ying3,GENG Yong1,ZHAO Yu-qing4 1.Institute of Applied Ecology,Chinese Academy of Sciences,Shenyang 110016,China 2.Graduate School of Chinese Academy of Sciences,Beijing 100039,China 3.School of Resources and Civil Engineering,Northeastern University,Shenyang 110004,China 4.Shenyang Pharmaceutical University,Shenyang 110016,China | 2010 | Chinese Herbal Medicines2010，2，1： | 20 |
| 19 | Compound contamination and secondary ecological effects of Cd and As in soil-alfalfa ecosystems显示文摘CompoundcontaminationandsecondaryecologicaleffectsofCdandAsinsoil-alfalfaecosystems(ZhouQixing;GaoZhengmin)(InstituteofApplie... | Zhou Qixing Gao Zhengmin(Institute of Applied Ecology, Chinese academy of Sciences),Shenyang 10015,China) | 1994 | Journal of Environmental Sciences1994，6，3： | 20 |
| 20 | INFLUENCE OF PULSED MAGNETIC FIELD ON MICROSTRUC-TURES AND MACRO-SEGREGATION IN 2124 Al-ALLOY显示文摘The structures and macro-segregation of 2124 Al-alloy were studied when a pulsedmagnetic field (PMF) was applied during solidification. It is found through experi-ments that a remarkable change occurs in the solidification structures of 2124 Al-alloyunder pulsed magnetic field. The eutectic phase at grain boundaries change from thickcontinuous eutectic network to thin discontinuous one, and the distribution of soluteelements was also homogenized. The typical negative segregation phenomenon of Cu incommon solidification condition was restrained, and the segregation of Mg decreased. | C.Y.Ban,J.Z.Cui,Q.X.Ba,G.M.Lu and B.J.ZhangP.O. Box 317, The Key Laboratory of Electromagnetic Processing of Materials, Ministry of Education, Northeastern University, Shenyang 110004, China Manuscript received 10 October 2001 | 2002 | Acta Metallurgica Sinica(English Letters)2002，15，4： | 19 |
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