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| 1 | Cold-chain transportation in the frozen food industry may have caused a recurrence of COVID-19 cases in destination:Successful isolation of SARS-CoV-2 virus from the imported frozen cod package surface显示文摘Coronavirus disease 2019(COVID-19)pandemic has spread in 220 countries/regions towreak havoc to human beings around theworld.At present,the second wave of COVID-19 has begun in many European countries.The complete control of COVID-19 is very urgent.Although China quickly brought the virus under control,there have been eight sporadic outbreaks in China since then.Both in Xinfadi of Beijing and Dalian outbreak of COVID-19,environmental swab samples related to imported cold chain food were tested nucleic acid positive for SARS-CoV-2.In this outbreak in Qingdao,we directly isolated SARS-CoV-2 from the cod outer package's surface swab samples.This is the first time worldwide,SARS-CoV-2 were isolated from the imported frozen cod outer package's surface,which showed that imported frozen food industry could import SARS-CoV-2 virus. | Peipei Liu Mengjie Yang Xiang Zhao Yuanyuan Guo Liang Wang Jing Zhang Wenwen Lei Weifang Han Fachun Jiang William J.Liu George F.Gao Guizhen Wu | 2020 | Biosafety and Health2020，2，4： | 41 |
| 2 | Epidemiological Characteristics of Newly-Reported HIV Cases Among Youth Aged 15−24 Years-China, 2010−2019显示文摘Summary What is already known about this topic?An estimated 1,400 new cases of human immunodeficiency virus(HIV)occur every day among youths globally.However,HIV distribution among youth aged 15–24 years in China has not been researched extensively. | Hao Zhao Hui Liu Lu Wang Xuan Yang Shaorong Wang Mengjie Han Jian Li | 2020 | China CDC weekly2020，2，48： | 23 |
| 3 | Recent advances in energy storage mechanism of aqueous zinc-ion batteries显示文摘Aqueous rechargeable zinc-ion batteries(ZIBs)have recently attracted increasing research interest due to their unparalleled safety,fantastic cost competitiveness and promising capacity advantages compared with the commercial lithium ion batteries.However,the disputed energy storage mechanism has been a confusing issue restraining the development of ZIBs.Although a lot of efforts have been dedicated to the exploration in battery chemistry,a comprehensive review that focuses on summarizing the energy storage mechanisms of ZIBs is needed.Herein,the energy storage mechanisms of aqueous rechargeable ZIBs are systematically reviewed in detail and summarized as four types,which are traditional Zn^(2+)insertion chemistry,dual ions co-insertion,chemical conversion reaction and coordination reaction of Zn^(2+)with organic cathodes.Furthermore,the promising exploration directions and rational prospects are also proposed in this review. | Duo Chen Mengjie Lu Dong Cai Hang Yang Wei Han | 2021 | Journal of Energy Chemistry2021，30，3： | 12 |
| 4 | Progress Towards the 90-90-90 Targets for Controlling HIV --China, 2018显示文摘What is already known about this topic?Since the Joint United Nations Programme on HIV and AIDS(UNAIDS)announced the 90-90-90 targets to control the global HIV epidemic in 2014,many countries have undertaken innovative measures to achieve this goal.The National Center for AIDS/STD Control and Prevention(NCAIDS)of China CDC convenes experts annually to evaluate the national progress towards these indicators.The most recent progress of 90-90-90 targets in China has not been previously published.What is added by this report?At the end of 2018,the percentage of living with HIV(PLWH)who had received a confirmed HIV diagnosis in China was 68.9%(61.5%-78.3%).The antiretroviral treatment coverage of diagnosed PLWH was 83.4%,and among patients on treatment for at least 12 months,94.2%achieved viral suppression.This provides most recent progress of 90-90-90 target in China.What are the implications for public health practice?China has made significant strides in curbing the HIV epidemic,but analysis on progress for the first 90 target for HIV testing remains out of reach.Innovative testing strategies may need to be developed to ensure that more PLWH can be identified. | Yan Zhao Mengjie Han Ye Ma Dongmin Li | 2019 | China CDC weekly2019，1，1： | 7 |
| 5 | A data-driven model predictive control for lighting system based on historical occupancy in an office building: Methodology development显示文摘The lighting system accounts for 8%of the total electricity consumption in commercial buildings in the United States and 12%of the total electricity consumption in public buildings globally.This consumption share can be effectively reduced using the demand-response control.The traditional lighting system control method commonly depends on the real-time occupancy data collected using the passive infrared(PIR)sensor.However,the detection inaccuracy of the PIR sensor usually results in false-offs.To diminish the false-error frequency,the existing lighting system control simply deploys a delayed reaction period(e.g.,5 to 20 min),which is not sufficiently accurate for the demand-response operation.Therefore,in this research,a novel data-driven model predictive control(MPC)method that is based on the temporal sequential-based artificial neural network(TS-ANN)is proposed to overcome this challenge using an updated historical occupancy status.Using an office as case study,the proposed model is also compared with the traditional lighting system control method.In the proposed model,the occupancy data was trained to predict the occupancy pattern to improve the control.It was found that the occupancy prediction mainly correlates with the historical occupancy ratio and the time sequential feature.The simulation results indicated that the proposed method achieved higher accuracy(97.4%)and fewer false-offs(from 79.5 with traditional time delay method to 0.6 times per day)are achieved by the MPC model.The proposed TS-ANN-MPC method integrates the analysis of the occupant behavior routine into on-site control and has the potential to further enhance the control performance practice for maximum energy conservation. | Yuan Jin Da Yan Xingxing Zhang Jingjing An Mengjie Han | 2021 | Building Simulation2021，14，1： | 6 |
| 6 | Discrimination of False Negative Results in RT-PCR Detection of SARS-CoV-2 RNAs in Clinical Specimens by Using an Internal Reference显示文摘Reverse transcription-polymerase chain reaction(RT-PCR)is an essential method for specific diagnosis of SARS-CoV-2 infection.Unfortunately,false negative test results are often reported.In this study,we attempted to determine the principal causes leading to false negative results of RT-PCR detection of SARS-CoV-2 RNAs in respiratory tract specimens.Multiple sputum and throat swab specimens from 161 confirmed COVID-19 patients were tested with a commercialfluorescent RT-PCR kit targeting the ORF1 ab and N regions of SARS-CoV-2 genome.The RNA level of a cellular housekeeping gene ribonuclease P/MRP subunit p30(RPP30)in these specimens was also assessed by RT-PCR.Data for a total of 1052 samples were retrospectively re-analyzed and a strong association between positive results in SARS-CoV-2 RNA tests and high level of RPP30 RNA in respiratory tract specimens was revealed.By using the ROC-AUC analysis,we identified Ct cutoff values for RPP30 RT-PCR which predicted false negative results for SARS-CoV-2 RT-PCR with high sensitivity(95.03%–95.26%)and specificity(83.72%–98.55%)for respective combination of specimen type and ampli-fication reaction.Using these Ct cutoff values,false negative results could be reliably identified.Therefore,the presence of cellular materials,likely infected host cells,are essential for correct SARS-CoV-2 RNA detection by RT-PCR in patient specimens.RPP30 could serve as an indicator for cellular content,or a surrogate indicator for specimen quality.In addition,our results demonstrated that false negativity accounted for a vast majority of contradicting results in SARS-CoV-2 RNA test by RT-PCR. | Yafei Zhang Changtai Wang Mingfeng Han Jun Ye Yong Gao Zhongping Liu Tengfei He Tuantuan Li Mengyuan Xu Luping Zhou Guizhou Zou Mengji Lu Zhenhua Zhang | 2020 | Virologica Sinica2020，35，6： | 5 |
| 7 | Inducible Rubicon facilitates viral replication by antagonizing interferon production显示文摘The RUN domain Beclin-1-interacting cysteine-rich-containing(Rubicon)protein is involved in the maturation step of autophagy and the endocytic pathway as a Beclin-1-binding partner,but little is known regarding the role of Rubicon during viral infection.Here,we performed functional studies of the identified target in interferon(IFN)signaling pathways associated with Rubicon to elucidate the mechanisms of viral resistance to IFN.The Rubicon protein levels were elevated in peripheral blood mononuclear cells,sera and liver tissues from patients with hepatitis B virus(HBV)infection relative to those in healthy individuals.Assays of the overexpression and knockdown of Rubicon showed that Rubicon significantly promoted HBV replication.In addition,Rubicon knockdown resulted in the inhibition of enterovirus 71,influenza A virus and vesicular stomatitis virus.The expression o0f Rubicon led to the suppression of virus-induced type-I interferon(IFN-αand IFN-β)and type-III interferon(IFN-λ1).Translocation of activated IRF3 and IRF7 from the cytoplasm to the nucleus was involved in this process,and the NF-κB essential modulator(NEMO),a key factor in the IFN pathway,was the target with which Rubicon interacted.Our results reveal a previously unrecognized function of Rubicon as a virus-induced protein that binds to NEMO,leading to the inhibition of type-I interferon production.Rubicon thus functions as an important negative regulator of the innate immune response,enhances viral replication and may play a role in viral immune evasion. | Yushun Wan Wei Cao Tao Han Sheng Ren Jian Feng TieLong Chen Jun Wang Ruth Broering Mengji Lu Ying Zhu | 2017 | Cellular & Molecular Immunology2017，14，7： | 4 |
| 8 | HIV Prevention and Health Poverty Alleviation-Liangshan Prefecture,Sichuan Province,China,2017-2020显示文摘BACKGROUND Liangshan,officially the Liangshan Yi Autonomous Prefecture,is an autonomous prefecture occupying much of the southern portion of Sichuan Province.It has been a remote and deeply impoverished area and also has the largest population of ethnic Yi people in China(1).For many years,due to geographical environment conditions,traffic conditions,and other historic restrictions,the human immunodeficiency virus(HIV)epidemic in Liangshan Prefecture has become the focus of HIV prevention and control in China since the first acquired immunodeficiency syndrome(AIDS)case was reported in this area in 1995(2-3). | Zhongfu Liu Xuefeng Tang Yufen Liu Linglin Zhang Yihui Yang Yongli Zheng Weixin Liu Chunnong Jike Hong Mai Heying Fan Gang Yu Mengjie Han George F.Gao | 2021 | China CDC weekly2021，3，48： | 4 |
| 9 | Spatial Analysis of HIV/AIDS Cases Among Out-of-School Youth Aged 15-24 Years-China,2010-2020显示文摘Summary What is already known about this topic?There are 4,000 new HIV infections every day worldwide,and 31%of which are in adolescents aged 15–24 years old.However,previous study is not aware of the distribution of out-of-school youth among this age group. | Shaorong Wang Junjie Wang Peng Xu Wanting Lyu Mengjie Han | 2021 | China CDC weekly2021，3，48： | 3 |
| 10 | Consideration of Monkeypox Surveillance in China,2022显示文摘Since the first monkeypox cases were confirmed in England in May 2022(1),100 countries worldwide have reported 53,027 confirmed cases and 15 deaths as of September 2(2).This is the largest and most widespread monkeypox epidemic in the world since monkeypox virus was discovered and identified in 1958,involving the largest number of countries and transmitting primarily in non-endemic countries(3).Moreover,the currently ongoing monkeypox epidemic also has some characteristics that are different from previous outbreaks(4).For example,most cases have a history of sexual contact,with an overwhelming majority of men who have sex with men(MSM)(5).On July 23,the WHO declared the global monkeypox outbreak a Public Health Emergency of International Concern(PHEIC)in order to address the ongoing outbreak with the required urgency(6). | Lei Zhou Yali Wang Dan Li Mengjie Han Guoqing Shi Qun Li | 2022 | China CDC weekly2022，4，41： | 2 |
| 11 | Hybrid Dirac semimetal-based photodetector with efficient low-energy photon harvesting显示文摘Despite the considerable effort,fast and highly sensitive photodetection is not widely available at the low-photon-energy range(~meV)of the electromagnetic spectrum,owing to the challenging light funneling into small active areas with efficient conversion into an electrical signal.Here,we provide an alternative strategy by efficiently integrating and manipulating at the nanoscale the optoelectronic properties of topological Dirac semimetal PtSe_(2)and its van der Waals heterostructures.Explicitly,we realize strong plasmonic antenna coupling to semimetal states near the skin-depth regime(λ/10^(4)),featuring colossal photoresponse by in-plane symmetry breaking.The observed spontaneous and polarization-sensitive photocurrent are correlated to strong coupling with the nonequilibrium states in PtSe_(2)Dirac semimetal,yielding efficient light absorption in the photon range below 1.24 meV with responsivity exceeding∼0.2 A/W and noise-equivalent power(NEP)less than~38 pW/Hz^(0.5),as well as superb ambient stability.Present results pave the way to efficient engineering of a topological semimetal for high-speed and low-energy photon harvesting in areas such as biomedical imaging,remote sensing or security applications. | Lin Wang Li Han Wanlong Guo Libo Zhang Chenyu Yao Zhiqingzi Chen Yulu Chen Cheng Guo Kaixuan Zhang Chia-Nung Kuo Chin Shan Lue Antonio Politano Huaizhong Xing Mengjie Jiang Xianbin Yu Xiaoshuang Chen Wei Lu | 2022 | Light(Science & Applications)2022，11，3： | 2 |
| 12 | HIV-Related Knowledge, Attitude, and Practices Research Among College Students-Six Chinese Cities, 2021显示文摘Summary What is already known about this topic?The number of newly diagnosed human immunodeficiency virus(HIV)cases among Chinese youth 15–24 years of age shows an upward trend between 2010 and 2019.What is added by this report?This survey is on a larger scale as compared to previous studies.It shows inadequate HIV knowledge—especially on HIV treatment,self-testing,and postexposure prophylaxis—among college students.A significant gap exists between knowledge and behavior as indicated by the low condom use rate despite a high knowledge level. | Hui Liu Qiyu Zhu Lei Zhang Yujing Liu Peng Xu Maohe Yu Jixiang Fan Xiaohong Pan Xi Chen Huifang Xu Qinying He Mengjie Han | 2022 | China CDC weekly2022，4，47： | 2 |
| 13 | Studies on Surface Properties and Cell Adhesion Properties of BSA Modified DBM Scaffold显示文摘As a scaffold material for bone tissue engineering, demineralized bone matrix(DBM) has such a limited ability to load cells and growth factors that the surface of the DBM scaffold was modified with bovine serum albumin(BSA) with different concentrations to improve the protein stmcture and physicochemical properties of the scaffold surface so as to enhance the adhesion of the cells. And the appropriate BSA concentration was explored. Compared with DBM, the scaffold with BSA coating had a smaller pore size and a lower porosity, also, the degradation rate was accelerated and the hydrophilic property was improved. Cells adhesion was observed inside the DBM seaffold before and after it had been modified, and the BSA modified scaffold had a good cell compatibility. Wlien the concentration of BSA was 20 mg/mL, the adhesion ability of the cells to modified scaffold was significantly increased, and the cell proliferation was facilitated. | SUN Mengjie FENG Wei WANG Bowei HAN Bing ZOU Jundong YANG Chunying LIU Zhihui | 2019 | Chemical Research in Chinese Universities2019，35，4： | 1 |
| 14 | Achieving simultaneous Cu particles anchoring in meso-porous TiO_(2) nanofabrication for enhancing photo-catalytic CO_(2) reduction through rapid charge separation显示文摘A facile solvo-thermal approach was successfully employed to prepare titanium oxide (TiO_(2)) nano-aggregates with simultaneous copper particles anchoring. The as-synthesized composite could convert CO_(2) into CH_(4) and CO products under simulated solar irradiation. The impact of copper loading amounts on the photo-reduction capability was evaluated. It was found proper amount of Cu loading could enhance the activity of CO_(2) photo-reduction. As a result, the optimal composite (TiO_(2)^(-)Cu-5%) consisting of TiO_(2) supported with 5% (mole ratio) Cu exhibits 2.2 times higher CH_(4) yield and 3 times higher CO yield compared with pure TiO_(2). Conduction band calculated from the band gap and valence X-ray photoelectron spectroscopy (XPS) indicated TiO_(2) nano-aggregates have suitable band edge alignment with respect to the CO_(2)/CH_(4) and CO_(2)/CO redox potential. Furthermore, with involving of Cu particles, an efficient separation of photo-generated charges was achieved on the basis of photocurrent response and photoluminescence spectra results, which contributed to the improved photo-catalytic performance. The present work suggested that the Cu-decorated TiO_(2) could serve as an efficient photo-catalyst for solar-driven CO_(2) photo-reduction. | Jinyan Xiong Mengmeng Zhang Mengjie Lu Kai Zhao Chao Han Gang Cheng Zhipan Wen | 2022 | Chinese Chemical Letters2022，33，3： | 1 |
| 15 | High Risk Behaviors for HIV and STIs Among Men Who Have Sex with Men Aged 15−19 Years—Guangzhou City and Tianjin Municipality,China,2018显示文摘What is already known on this topic?There has been a steady increase of new reported HIV infections in individuals aged 15–24 years,primarily from self-reported men who have sex with men(MSM).What is added by this report?MSM aged 15–19 years practiced behaviors that put them at high risk for HIV and other sexually transmitted infections(STIs).Systems to address their unique risks and vulnerabilities in both school settings and in high impact HIV interventions may be inadequate.What are the implications for public health practice?Special needs of MSM aged 15–19 years must be met by starting sex education in junior high school and sensitizing health workers in and out of school settings on quality counselling,testing,and referral.Piloting approaches that address age of consent issues are also suggested. | Hui Liu GJohnston Lisa Lei Zhang Mengjie Han Hao Zhu Jie Yang Jingyan Li Lu Liu Yujing Liu Mark Prabhu Shirley | 2020 | China CDC weekly2020，2，26： | 1 |
| 16 | Safety and immunogenicity of a mosaic vaccine booster against Omicron and other SARS-CoV-2 variants:a randomized phase 2 trial显示文摘An ongoing randomized,double-blind,controlled phase 2 trial was conducted to evaluate the safety and immunogenicity of a mosaic-type recombinant vaccine candidate,named NVSI-06-09,as a booster dose in subjects aged 18 years and older from the United Arab Emirates(UAE),who had administered two or three doses of inactivated vaccine BBIBP-CorV at least 6 months prior to enrollment.The participants were randomly assigned with 1:1 to receive a booster dose of NVSI-06-09 or BBIBP-CorV.The primary outcomes were immunogenicity and safety against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron variant,and the exploratory outcome was cross-immunogenicity against other circulating strains.Between May 25 and 30,2022,516 adults received booster vaccination with 260 in NVSI-06-09 group and 256 in BBIBP-CorV group.Interim results showed a similar safety profile between two booster groups,with low incidence of adverse reactions of grade 1 or 2.For immunogenicity,by day 14 post-booster,the fold rises in neutralizing antibody geometric mean titers(GMTs)from baseline elicited by NVSI-06-09 were remarkably higher than those by BBIBP-CorV against the prototype strain(19.67 vs 4.47-fold),Omicron BA.1.1(42.35 vs 3.78-fold),BA.2(25.09 vs 2.91-fold),BA.4(22.42 vs 2.69-fold),and BA.5 variants(27.06 vs 4.73-fold).Similarly,the neutralizing GMTs boosted by NVSI-06-09 against Beta and Delta variants were also 6.60-fold and 7.17-fold higher than those by BBIBP-CorV.Our findings indicated that a booster dose of NVSI-06-09 was well-tolerated and elicited broad-spectrum neutralizing responses against divergent SARS-CoV-2 variants,including Omicron and its sub-lineages. | Nawal Al Kaabi Yun Kai Yang Yu Liang Ke Xu Xue Feng Zhang Yun Kang Yu Qin Jin Jun Wei Hou Jing Zhang Tian Yang Salah Hussein Mohamed Saif ElDein Ze Hua Lei Hao Zhang Shuai Shao Zhao Ming Liu Ning Liu Xiang Zheng Ji Guo Su Sen Sen Yang Xiangfeng Cong Yao Tan Wenwen Lei Xue Jun Gao Zhiwei Jiang Hui Wang Meng Li Hanadi Mekki Mekki Walid Zaher Sally Mahmoud Xue Zhang Chang Qu Dan Ying Liu Jing Zhang Mengjie Yang Islam Eltantawy Peng Xiao Fu Jie Shen Jin Juan Wu Zi Bo Han Li Fang Du Fang Tang Shi Chen Zhi Jing Ma Fan Zheng Ya Nan Hou Xin Yu Li Xin Li Zhao Nian Wang Jin Liang Yin Xiao Yan Mao Jin Zhang Liang Qu Yun Tao Zhang Xiao Ming Yang Guizhen Wu Qi Ming Li | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 17 | Driving forces behind the spatiotemporal heterogeneity of land-use and land-cover change:A case study of the Weihe River Basin,China显示文摘The impact of socioeconomic development on land-use and land-cover change(LUCC)in river basins varies spatially and temporally.Exploring the spatiotemporal evolutionary trends and drivers of LUCC under regional disparities is the basis for the sustainable development and management of basins.In this study,the Weihe River Basin(WRB)in China was selected as a typical basin,and the WRB was divided into the upstream of the Weihe River Basin(UWRB),the midstream of the Weihe River Basin(MWRB),the downstream of the Weihe River Basin(DWRB),the Jinghe River Basin(JRB),and the Luohe River Basin(LRB).Based on land-use data(cultivated land,forestland,grassland,built-up land,bare land,and water body)from 1985 to 2020,we analyzed the spatiotemporal heterogeneity of LUCC in the WRB using a land-use transfer matrix and a dynamic change model.The driving forces of LUCC in the WRB in different periods were detected using the GeoDetector,and the selected influencing factors included meteorological factors(precipitation and temperature),natural factors(elevation,slope,soil,and distance to rivers),social factors(distance to national highway,distance to railway,distance to provincial highway,and distance to expressway),and human activity factors(population density and gross domestic product(GDP)).The results indicated that the types and intensities of LUCC conversions showed considerable disparities across different sub-basins,where complex conversions among cultivated land,forestland,and grassland occurred in the LRB,JRB,and UWRB,with higher dynamic change before 2000.The conversion of other land-use types to built-up land was concentrated in the UWRB,MWRB,and DWRB,with substantial increases after 2000.Additionally,the driving effects of the influencing factors on LUCC in each sub-basin also exhibited distinct diversity,with the LRB and JRB being influenced by the meteorological and social factors,and the UWRB,MWRB,and DWRB being driven by human activity factors.Moreover,the interaction of these influencing factors indicated an enhanced effect on LUCC.This study confirmed the spatiotemporal heterogeneity effects of socioeconomic status on LUCC in the WRB under regional differences,contributing to the sustainable development of the whole basin by managing sub-basins according to local conditions. | WU Jingyan LUO Jungang ZHANG Han YU Mengjie | 2023 | Journal of Arid Land2023，15，3： | 0 |
| 18 | HIV incidenee and risk factors among transgender women and cisgender men who have sex with men in two cities of China:a prospective cohort study显示文摘Background:HIV epidemic among men who have sex with men(MSM)remains a major public health concern in China.Despite a growing body of research on transgender women worldwide,little is known about Chinese transgender women within MSM.We sought to estimate HIV incidence and distinguish risk factors of HIV acquisition among them from that among cisgener(non-transgender)MSM(cis-MSM).Methods:We conducted an open cohort study among Chinese MSM,including those who were identifed as transgender in Shanghai and Tianjin.Participants were initially recruited by local community-based organizations from January to June,2016,and were followed up approximately every 6 months until June 2018.At each visit,a structured questionnaire was used to gather information on demographics,sexual risk behaviors,and HIV status.HIV incidence was calculated as the number of seroconversions divided by total number of person-years of follow-up among HIV-negatives at baseline.Risk factors of HIV acquisition were assessed by univariate and multivariate Cox regression models with time-dependent variables.Results:A total of 1056 participants contributed 1260.53 person-years(PYs)of follow-up,33 HIV seroconversions occurred during the follow-up period,yielding an estimated HIV incidence of 2.62(95%CI 1.80–3.68)per 100 PYs.HIV incidence among transgender women was 4.42 per 100 PYs,which was signifcantly higher than that of 1.35 per 100 PYs among cis-MSM,demonstrating a threefold higher odds of HIV infection than cis-MSM.For transgender women,those lived locally≤2 years(adjusted hazard ratio[aHR]=1.76,95%CI 1.13–2.76)and unprotected anal sex last time(aHR=4.22,95%CI 1.82–9.79)were more likely to acquire HIV.For cis-MSM,factors associated with HIV acquisition were frequency of anal sex≥3 times in past one month(aHR=4.19,95%CI 1.06–16.47)and unprotected anal sex last time(aHR=5.33,95%CI 1.52–18.73).Conclusions:Compared to cis-MSM,transgender women were at higher risk of HIV acquisition,highlighting an urgent need of tailored prevention.Future HIV program should consider to include them to ensure that this population in China are not left behind. | Duo Shan Zhen Ning Maohe Yu Huang Zheng Jie Yang Hui Gong Jian Li Hui Liu Lu Liu Vania Wang Xiong Ran Mengjie Han Dapeng Zhang | 2022 | Infectious Diseases of Poverty2022，11，2： | 0 |
| 19 | Bacteria-mediated tumor-targeted delivery of tumstatin(54-132)significantly suppresses tumor growth in mouse model by inhibiting angiogenesis and promoting apoptosis显示文摘Tumor growth is an angiogenesis-dependent process and accompanied by the formation of hypoxic areas.Tumstatin is a tumor-specific angiogenesis inhibitor that suppresses the proliferation and induces the apoptosis of tumorous vascular endothelial cells.VNP20009,an attenuated Salmonella typhimurium strain,preferentially accumulates in the hypoxic areas of solid tumors.In this study,a novel Salmonella-mediated targeted expression system of tumstatin(VNP-Tum5)was developed under the control of the hypoxia-induced J23100 promoter to obtain anti-tumor efficacy in mice.Treatment with VNP-Tum5 effectively suppressed tumor growth and prolonged survival in the mouse model of B16F10 melanoma.VNP-Tum5 exhibited a higher efficacy in inhibiting the proliferation and inducing the necrosis and apoptosis of B16F10 cells in vitro and in vivo compared with VNP(control).VNP-Tum5 significantly inhibited the proliferation and migration of mouse umbilical vascular endothelial cells to impede angiogenesis.VNP-Tum5 downregulated the expression of anti-vascular endothelial growth factor A,platelet endothelial cell adhesion molecule-1,phosphorylated phosphoinositide 3 kinase,and phosphorylated protein kinase B and upregulated the expression of cleaved-caspase 3 in tumor tissues.This study is the first to use tumstatin-transformed VNP20009 as a tumor-targeted system for treatment of melanoma by combining anti-tumor and anti-angiogenic effects. | Feifei Bao Mengjie Liu Wenhua Gai Yuwei Hua Jing Li Chao Han Ziyu Zai Jiahuang Li Zichun Hua | 2022 | Frontiers of Medicine2022，16，6： | 0 |
| 20 | Self-shrinking supramolecular nanoparticles syndicate energy suppression and NIR-II mild photothermal amplification of mitochondrial oxidative stress for breast cancer therapy显示文摘Photothermal therapy(PTT)may lead to healthy tissue damage,tumor metastasis,and recurrence,which makes mild photothermal therapy(mild PTT)stand out.However,overcoming heat resistance,insufficient therapeutic effect,and poor photothermal conversion efficiency has become new challenge.Herein,we report a dynamic supramolecular nanocarrier formed from amide-sericin and aldehyde-polyhydroxy glucan(denoted as SDA),the loose cavity of which can be filled by using the pharmaceutical combination of lonidamine(LND)and NIR-II photothermal agent of IR-1061,producing SDLI with a tighter inner hole,smaller and uniform particle size and excellent stability due to multiple pulling forces.Moreover,the intricate internal network structure prevents the hydrophobic IR-1061 from forming aggregates in the small cavity,and the photothermal conversion efficiency(PCE)can reach 48.9%.At the acidic tumor microenvironment of pH 6.5,the controlled release of LND can solve the problem of heat resistance of NIR-II mild PTT and significantly improve the therapeutic effect of NIR-II mild PTT.Meanwhile,SDLI also shows a reasonable tumor inhibition rate,so the synergistic strategy of inhibiting tumor energy metabolism and NIR-II mild PTT to magnify mitochondrial oxidative stress,continuous cell stress state-induced immunogenic cell death to promote the induction of tumor apoptosis is proposed to achieve more effective cancer treatment. | Hongmei Liu Jiming Xu Mengjie Ye Hengbo Zhang Linlin Han Jingting Wang Peng Xue Yuejun Kang Zhigang Xu | 2024 | Nano Research2024，17，5： | 0 |
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