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| 1 | Exogenous plant MIR168a specifically targets mammalian LDLRAPI: evidence of cross-kingdom regulation by microRNA显示文摘 | Lin Zhang Dongxia Hou Xi Chen Donghai Li Lingyun Zhu Yuj ing Zhang Jing Li Zhen Bian Xiangying Liang Xing Cai Yuan Yin Cheng Wang Tianfu Zhang Dihan Zhu Dianmu Zhang Jie Xu Qun Chen Yi Ba Jing Liu Qiang Wang Jianqun Chen Jin Wang Meng Wang Qipeng Zhang Junfeng Zhang Ke Zen Chen-Yu Zhang | 2012 | Cell Research2012，22，1： | 155 |
| 2 | Large-area high quality PtSe2 thin film with versatile polarity显示文摘Two-dimensional(2D)materials have attracted increasing attention for their outstanding structural and electrical properties.However,for mass-production of field effect transistors(FETs)and potential applications in integrated circuits,large-area and uniform 2D thin films with high mobility,large on-off ratio,and desired polarity are needed to synthesize firstly.Here,a transfer-free growth method for platinum diselenide(PtSe2)films has been developed.The PtSe2 films have been synthesized with various thicknesses in centimeter-sized scale.Typical FET made from a few layer PtSe2 show p-type unipolar,with a high field-effect hole mobility of 6.2 cm^(2) V^(−1) s^(−1) and an on-off ratio of 5×10^(3).The versatile semimetal-unipolar-ambipolar transition in synthesized PtSe2 films is also firstly observed as the thickness thinning.This work realizes the large-scale preparation of PtSe2 with prominent electrical properties and provides a new strategy for polarity's modulation. | Wei Jiang Xudong Wang Yan Chen Guangjian Wu Kun Ba Ningning Xuan Yangye Sun Peng Gong Jingxian Bao Hong Shen Tie Lin Xiangjian Meng Jianlu Wang Zhengzong Sun | 2019 | InfoMat2019，1，2： | 5 |
| 3 | miR-10a inhibits cell proliferation and promotes cell apoptosis by targeting BCL6 in diffuse large B-cell lymphoma显示文摘BCL6 (B 房间淋巴瘤 6 ) 基因是经常在弥漫的大 B 房间淋巴瘤(DLBCL ) 被表示的 proto-oncogene。功能的 BCL6 损失能杀死 DLBCL 房间,证明 BCL6 为 DLBCL 房间的幸存是必要的并且能是一个治疗学的目标。在这研究,我们发现那 BCL6 蛋白质层次,建议那是一致地在 DLBCL 纸巾的 upregulated 而它的 mRNA 层次在纸巾随机变化了, post-transcriptional 机制涉及 BCL6 规定。我们使用了生物信息学分析寻找 miRNAs,它潜在地指向 BCL6,并且在 BCL6 的 3-untranslated 区域(3-UTR ) 为 miR-10a 识别了特定的指向的地点。我们进一步鉴别在 miR-10a 层次和 BCL6 蛋白质层次之间的反的关联,然而并非 mRNA 铺平,在 DLBCL 肿瘤织物样品。由 overexpressing 或在 DLBCL 房间将 miR-10a 击倒,我们试验性地直接验证了那 miR-10a 认出 BCL6 抄本和调整 BCL6 表示的 3-UTR。而且,我们证明否定地由 miR-10a 调整 BCL6 压制了增长并且支持了 DLBCL 房间的 apoptosis。 | Qian Fan Xiangrui Meng Hongwei Liang Huilai Zhang Xianming Liu Lanfang Li Wei Li Wu Sun Haiyang Zhang Ke Zen Chen-Yu Zhang Zhen Zhou Xi Chen Yi Ba | 2016 | Protein & Cell2016，7，12： | 5 |
| 4 | Surface nanostructure formation mechanism of 45 steel induced by supersonic fine particles pombarding显示文摘By means of supersonic fine particles bombarding (SFPB),a nanostructured surface layer up to 15 μm was fabricated on a 45 steel plate with ferrite and pearlite phases. To reveal the grain refinement mechanism of SFPB-treated 45 steel,microstructure features of various sections in the treated surface were systematically characterized by X-ray diffraction (XRD),scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Grain size increases with an increase of depth from the treated surface. Plastic deformation and grain refinement processes are accompanied by an increase in strain. Plastic deformation in the proeutectoid ferrite phases has precedence over the pearlite phases. Grain refinement in the ferrite phases involves: the onset of dis-location lines (Dls),dislocation tangles (DTs) and dense dislocation walls (DDWs) in the original grains; the formation of fine la-mellar and roughly equiaxed cells separated by DDWs; by dislocation annihilation and rearrangement,the transformation of DDWS into subboundaries and boundaries and the formation of submicron grains or subgrains; the successive subdivision of grains to finer and finer scale,resulting in the formation of highly misoriented nano-grains. By contrast,eutectoid cementite phase accommodated strain in a sequence as follows: onset of elongated,bended and shear deformation under deformation stress of ferrites,short and thin cementites with a width of about 20-50 nm and discontinuous length were formed. Shorter and thinner cementites were developed into ultra-fine pieces under the action of high density dislocation and strains. At the top surface,some cementites were decomposed under severe plastic deformation. Experimental evidences and analysis indicate that surface nanocrystallization of 45 steel results from dislocation activities,high strains and high strain rate are necessary for the formation of nanocrystallites. | Dema Ba Shining Ma Changqing Li Fanjun Meng | 2008 | Journal of University of Science and Technology Beijing2008，15，5： | 3 |
| 5 | Exosomal miR-155 from gastric cancer induces cancerassociated cachexia by suppressing adipogenesis and promoting brown adipose differentiation via C/EPBβ显示文摘Objective:The aim of this research was to identify whether exosomes were involved in impairing adipogenesis in cancer-associated cachexia(CAC)by detecting the adipodifferentiation capacity and the expressions of adipogenic proteins in gastric cancer(GC)-associated adipocytes.Methods:Western blotting and RT-PCR were used to investigate the expressions of C/EPBβ,C/EPBα,PPARγ,and UCP1 in adipose mesenchymal stem cells(A-MSCs)to evaluate the function of exosomal miR-155.BALB/c nude mice were intravenously injected in vivo with GC exosomes with different levels of miR-155 to determine changes in adipodifferentiation of A-MSCs.Results:Exosomes derived from GC cells suppressed adipogenesis in A-MSCs as characterized by decreased lipid droplets.Similarly,A-MSCs co-cultured with GC exosomes exhibited increased ATP production through brown adipose differentiation characterized by highly dense mitochondria and enhanced UCP1 expression(P<0.05).Mechanistically,exosomal miR-155 secreted from GC cells suppressed adipogenesis and promoted brown adipose differentiation by targeting C/EPBβ,accompanied by downregulated C/EPBαand PPARγand upregulated UCP1(P<0.05).Moreover,overexpression of miR-155 in GC exosomes improved CAC in vivo,which was characterized by fat loss,suppressed expressions of C/EPBβ,C/EPBα,and PPARγin A-MSCs,and high expression of UCP1(P<0.05).Decreasing the level of miR-155 in injected GC exosomes abrogated the improved CAC effects.Conclusions:GC exosomal miR-155 suppressed adipogenesis and enhanced brown adipose differentiation in A-MSCs by targeting C/EPBβof A-MSCs,which played a crucial role in CAC. | Ying Liu Meng Wang Ting Deng Rui Liu Tao Ning Ming Bai Guoguang Ying Haiyang Zhang Yi Ba | 2022 | Cancer Biology & Medicine2022，19，9： | 3 |
| 6 | Safety and efficacy of anti-EGFR monoclonal antibody (SCT200) as second-line therapy in advanced esophageal squamous cell carcinoma显示文摘Objective:The mainstay treatment of esophageal squamous cell carcinoma(ESCC)involves chemotherapy and immunotherapy.However,alternative therapies are required for patients who are refractory or intolerant to existing therapies.Methods:In this single-arm,multicenter,open-label phase Ib study,30 patients received an intravenous infusion of SCT200,an antiepidermal growth factor receptor(EGFR)monoclonal antibody,6.0 mg/kg once a week for 6 weeks,followed by 8.0 mg/kg once every 2 weeks until disease progression or intolerable toxicity.The primary endpoint was the objective response rate(ORR).The secondary endpoints were progression-free survival(PFS),overall survival(OS),and safety.Results:Thirty patients were enrolled between July 2018 and May 2019.The ORR was 16.7%(95%CI:5.6%–34.7%).The median PFS and OS were 3.1 months(95%CI:1.5–4.3)and 6.8 months(95%CI:4.7–10.1),respectively.A numerical difference without any statistical significance in ORR was observed in patients with different EGFR expressions(≥50%:25.0%vs.<50%:0%,P=0.140)or TP53 mutation abundance(<10%:23.8%vs.≥10%:0%,P=0.286).Improved median PFS(3.4 vs.1.4 months,P=0.006)and OS(8.0 vs.4.2 months,P=0.027)were associated with TP53 mutation abundance of<10%.The most common treatment-related adverse events of grade 3 or 4(occurring in≥2 patients)were hypomagnesemia[7(23.3%)]and rash[2(6.7%)].No treatmentrelated death occurred.Conclusions:SCT200 monotherapy as the second-or further-line treatment for advanced ESCC showed favorable efficacy,with an acceptable safety profile.TP53 mutation abundance might serve as a potential predictive biomarker. | Ming Bai Meng Wang Ting Deng Yuxian Bai Kai Zang Zhanhui Miao Wenlin Gai Liangzhi Xie Yi Ba | 2022 | Cancer Biology & Medicine2022，19，3： | 2 |
| 7 | Reduced pancreaticvolume and beta-cell area in patients with chronic pancreatitis显示文摘 | Schrader H Menge BA Schneider S | 2009 | Gastroenterology2009，136，2： | 1 |
| 8 | Discorvery of dapagliflozin: a potent, selective renal sodium-dependent glucose cotransporter 2(SGLT2) inhibitor for the treatment of type 2 diabetes显示文摘 | Meng W Ellsworth BA Nirschl AA | 2008 | J Med Chem2008，51，5： | 1 |
| 9 | Discovery of dapagliflozin:a potent,selective renal sodium-dependent glucose cotransporter 2 (SGLT2)inhibitor for the treatment of type 2 diabetes显示文摘 | Meng W Ellsworth BA Nirschl AA | 2008 | J Med Chem2008，51，5： | 1 |
| 10 | Discovery of dapagliflozin: a potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes 显示文摘 | Meng W Ellsworth BA Nirschl AA | 2008 | JMed Chem2008，51，5： | 1 |
| 11 | The association between bacterial colonization and inflammatory pattern in Chinese chronicrhinosinusitis patients with nasal polyps显示文摘 | Ba L Zhang N Meng J | 2011 | Allergy2011，66，10： | 1 |
| 12 | Discovery of dapagli- flozin : a potent, selective renal sodium-dependent glucose cotransporter 2 ( SGLT2 ) inhibitor for the treatment of type 2 diabetes 显示文摘 | Meng W Ellsworth BA Nirschl AA | 2008 | JMed Chem2008，1，5： | 1 |
| 13 | The remanufacturing system based on robot MAG surfacing显示文摘 | ZHU Sheng MENG Fanjun BA Dema | 2008 | Key Engineering Materials2008，，： | 1 |
| 14 | Hyperglycemia a- cutely lowers the postprandial excursions of glueagon-like Pep- tide-I and gastric inhibitory polypeptide in humans 显示文摘 | Vollmer K Gardiwal H Menge BA | 2009 | J Clin Endocrinol Metab2009，94，4： | 1 |
| 15 | The Remanufacturing System Based on Robot MAG Surfacing显示文摘 | Zhu Sheng Meng Fan Jun Ba De Ma | 2008 | Key Engineering Materials2008，，373： | 1 |
| 16 | Discovery of dapagliflozin: a potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes显示文摘 | Meng W Ellsworth BA Nirschl AA | 2008 | JMed Chem2008，51，5： | 1 |
| 17 | Partial pancreatectomy in adult humans does not provoke β-cell regeneration显示文摘 | Menge BA Tannapfel A Belyaev O | 2008 | Diabetes2008，57，： | 1 |
| 18 | A multicentre randomised trial comparing weekly paclitaxel<ce:hsp sp='0.25'/>+<ce:hsp sp='0.25'/>S-1 with weekly paclitaxel<ce:hsp sp='0.25'/>+<ce:hsp sp='0.25'/>5-fluorouracil for patients with advanced gastric cancer显示文摘 | Dingzhi Huang Yi Ba Jianping Xiong Nong Xu Zhao Yan Zhixiang Zhuang Zhuang Yu Huiping Wan Yang Zhang Ting Deng Rongsheng Zheng Zengqing Guo Chunhong Hu Meiling Wang Zhonghe Yu Yang Yao Jichang Meng | 2013 | European Journal of Cancer2013，，： | 1 |
| 19 | Discovery of dapaglifloz- in:a potent, selective renal sodiumdependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes 显示文摘 | Meng W Ellsworth BA Nirschl AA | 2008 | J Med Chem2008，51，5： | 1 |
| 20 | Aglycone exploration of C-arylglucoside inhibitors of renal sodium-dependent glucose transporter SGLT2显示文摘 | Ellsworth BA Meng W Patel M | 2008 | Bioorg Med Chem Lett2008，18，17： | 1 |
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