|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Mycoplasma infections and different human carcinomas显示文摘AIM To explore relationships between human carcinomas and mycoplasma infection.METHODS Monoclonal antibody PD4, which specifically recognizes a distinct protein from mycoplasma hyorhinis, was used to detect mycoplasma infection in different paraffinembedded carcinoma tissues with immunohistochemistry. PCR was applied to amplify the mycoplasma DNA from the positive samples for confirming immunohistochemistry.RESULTS Fifty of 90 cases (56%) of gastric carcinoma were positive for mycoplasma hyorhinis. In other gastric diseases, the mycoplasma infection ratio was 28% (18/49) in chronic superficial gastritis, 30% (14/ 46) in gastric ulcer and 37% (18/ 49) in intestinal metaplasia. The difference is significant with gastric cancer (X2=12.06, P<0.05). In colon carcinoma, the mycoplasma infection ratio was 55.1% (32/58), but it was 20.9% (10/49) in adenomarous polyp (X2=13.46, P<0.005).Gastric and colon cancers with high differentiation had a higher mycoplasma infection ratio than those with low differentiation (P< 0.05). Mycoplasma infection in esophageal cancer, lung cancer, breast cancer and glioma was 50.9% (27/53), 52.6% (31/ 59), 39.7%(25/63) and 41% (38/91), respectively. The mycoplasma DNA was successfully amplified with the DNA extracted from the cancer tissues that were positive for mycoplasma infection (detected with antibody PD4).CONCLUSION There was high correlation between mycoplasma infection and different cancers, which suggests the possibility of an association between the two. The mechanism involved in oncogenesis by mycoplasma remains unknown. | Su Huang Ji You Li Jan Wu Lin Meng Cheng Chao Shou Beijing Institute for Cancer Research, Peking University School of Oncology, Beijing 100034. ChinaSu Huang, received B. A from Jiangxi Medical College of China in 1994. Now she is a graduate student pursuing a Ph. D degree at the Peking University School of Oncology. | 2001 | World Journal of Gastroenterology2001，7，2： | 18 |
| 3 | 肿瘤坏死因子及其受体在鼠失血性休克引起的急性肺损伤中的作用显示文摘目的 探讨失血性休克引起的急性肺损伤与肿瘤坏死因子 α(TNF α)在肺组织表达的相关性。方法 通过心腔穿刺对C5 7小鼠采取 30 %全血容量复制失血性休克模型。肺组织TNF α表达采用酶联免疫吸附法方法进行测定。肺组织中性粒细胞 (PMN)浸润采用数字荧光显微镜免疫荧光技术进行检测。肺微血管通透性 (肺水肿 )采用伊文氏蓝方法进行测定。结果 ( 1)虽然失血性休克仅引起肺组织TNF α水平轻度和短暂的升高 ,且肺组织中性粒细胞 (PMN)浸润时相上早于TNF α水平的升高。但在TNF基因剔除 (KO)小鼠 ,失血性休克引起的肺组织PMN浸润和肺损伤明显轻于C5 7野生型小鼠 ;( 2 )给予失血前TNFKO小鼠低水平的重组TNF α即可导致失血性休克引起肺组织PMN浸润和急性肺损伤 ;( 3)失血性休克引起的肺组织PMN浸润和急性肺损伤在p5 5TNF受体KO动物显著减轻 ,而在p75TNFKO动物则不产生影响。结论 肺组织低水平TNF α足以介导失血性休克引起的PMN浸润和急性肺损伤 ;p5 5TNF受体在失血性休克引起的肺部急性炎症反应中起主导作用。 | 宋勇 施毅 Alden H Harken Xianzhong Meng Christopher D Raeburn | 2003 | 中华医学杂志2003，83，8： | 12 |
| 4 | Comparison of HER-2/neu,ER and PCNA expression in premenopausal and postmenopausal patients with breast carcinoma显示文摘 | Zheng W Zheng J Ma L Meng F Huang L Ma D | 2005 | 第二军医大学学报2005，26，8： | 4 |
| 5 | 非甾体抗炎药应用中,环氧合酶2、不对称二甲基精氨酸与心血管危害的关系显示文摘已有大规模、安慰剂对照试验确定了非甾体类抗炎药(nonsteroidal anti—inflammatory drugs,NSAIDs)具有心血管危害性:这归因于环氧合酶2(cyclooxygenase,COX-2)的心脏保护产物受到抑制,尤其是前列环素(prostacyclin,PG12)。NSAID降低心脏保护作用的另一种机制可能是通过增强肾脏中甲基精氨酸的形成来限制一氧化氮在整个脉管系统中的作用。 | Ricciotti E Castro C Tang SY Briggs WTE West JA Malik D Rhoades SD Meng H Li X Lahens NF Sparks JA Karlson EW Weljie AM Griffin JL FitzGerald GA6 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 3 |
| 6 | Panda X-III: Searching for neutrinoless double beta decay with high pressure ^(136)Xe gas time projection chambers显示文摘Searching for the neutrinoless double beta decay(NLDBD)is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation experiments.Panda X-III(particle and astrophysical xenon experiment III)will search for the NLDBD of136Xe at the China Jin Ping Underground Laboratory(CJPL).In the first phase of the experiment,a high pressure gas Time Projection Chamber(TPC)will contain 200 kg,90%136Xe enriched gas operated at10 bar.Fine pitch micro-pattern gas detector(Microbulk Micromegas)will be used at both ends of the TPC for the charge readout with a cathode in the middle.Charge signals can be used to reconstruct the electron tracks of the NLDBD events and provide good energy and spatial resolution.The detector will be immersed in a large water tank to ensure~5 m of water shielding in all directions.The second phase,a ton-scale experiment,will consist of five TPCs in the same water tank,with improved energy resolution and better control over backgrounds. | Xun Chen Chang Bo Fu Javier Galan Karl Giboni Franco Giuliani Ling Hui Gu Ke Han Xiang Dong Ji Heng Lin Jiang Lai Liu Kai Xiang Ni Hiroki Kusano Xiang Xiang Ren Shao Bo Wang Yong Yang Dan Zhang Tao Zhang Li Zhao Xiang Ming Sun Shou Yang Hu Si Yu Jian Xing Long Li Xiao Mei Li Hao Liang Huan Qiao Zhang Ming Rui Zhao Jing Zhou Ya Jun Mao Hao Qiao Si Guang Wang Ying Yuan Meng Wang Amir N.Khan Neill Raper Jian Tang Wei Wang Jia Ning Dong Chang Qing Feng Cheng Li Jian Bei Liu Shu Bin Liu Xiao Lian Wang Dan Yang Zhu Juan F.Castel Susana Cebri'an Theopisti Dafni Javier G.Garza Igor G.Irastorza Francisco J.Iguaz Gloria Luz ′on Hector Mirallas Stephan Aune Eric Berthoumieux Yann Bedfer Denis Calvet Nicole d'Hose Alain Delbart Maria Diakaki Esther Ferrer-Ribas Andrea Ferrero Fabienne Kunne Damien Neyret Thomas Papaevangelou Franck Sabatie Maxence Vanderbroucke AnDi Tan Wick Haxton Yuan Mei Chinorat Kobdaj Yu-Peng Yan | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，6： | 2 |
| 7 | Integrated dynamic wet spinning of core-sheath hydrogel fibers for optical-to-brain/tissue communications显示文摘Hydrogel optical light-guides have received substantial interest for applications such as deep-tissue biosensors,optogenetic stimulation and photomedicine due to their biocompatibility,(micro)structure control and tissue-like Young’s modulus.However,despite recent developments,large-scale fabrication with a continuous synthetic methodology,which could produce core-sheath hydrogel fibers with the desired optical and mechanical properties suitable for deep-tissue applications,has yet to be achieved.In this study,we report a versatile concept of integrated light-triggered dynamic wet spinning capable of continuously producing core-sheath hydrogel optical fibers with tunable fiber diameters,and mechanical and optical propagation properties.Furthermore,this concept also exhibited versatility for various kinds of core-sheath functional fibers.The wet spinning synthetic procedure and fabrication process were optimized with the rational design of the core/sheath material interface compatibility[core=poly(ethylene glycol diacrylate-co-acrylamide);sheath=Ca-alginate],optical transparency,refractive index and spinning solution viscosity.The resulting hydrogel optical fibers exhibited desirable low optical attenuation(0.18±0.01 d B cm^(-1) with 650 nm laser light),excellent biocompatibility and tissue-like Young’s modulus(<2.60 MPa).The optical waveguide hydrogel fibers were successfully employed for deep-tissue cancer therapy and brain optogenetic stimulation,confirming that they could serve as an efficient versatile tool for diverse deep-tissue therapy and brain optogenetic applications. | Guoyin Chen Gang Wang Xinrong Tan Kai Hou Qingshuo Meng Peng Zhao Shun Wang Jiayi Zhang Zhan Zhou Tao Chen Yanhua Cheng D Benjamin S.Hsiao Elsa Reichmanis Meifang Zhu | 2021 | National Science Review2021，8，9： | 2 |
| 8 | Facile Synthesis of Straight Polyaniline Nanostick in Hydrogel 显示文摘 | Meng L H Lu Y Wang X D | 2007 | Macromolecules2007，40，9： | 1 |
| 9 | Adaptive staggering time estimation for target tracking in periodic nonuniform sampling system显示文摘 | Liu Y J Meng H D Wang D S | 2007 | Electronics Letters2007，43，24： | 1 |
| 10 | Fabrication of ordered ferromagnetic-nonmagnetic alloy nanowire arrays and their magnetic property dependence on annealing temperature显示文摘 | WANG Y W ZHANG L D MENG G W | 2002 | J Phys Chem B2002，106，10： | 1 |
| 11 | Promotion of seminomatous tumors by targeted overexpression of glial cell line - derived neurotrophic factor in mouse testis 显示文摘 | MENG X DeROOI J D G WESTERDAHL K | 2001 | Cancer Res2001，61，8： | 1 |
| 12 | Ionizing radiation and busulfan induce premature senescence in murine bone marrow hematopoietic cells 显示文摘 | Meng A Wang Y Van Zant G Zhou D | 2003 | Cancer Res2003，63，17： | 1 |
| 13 | Study on the chemical constituents from the roots and stems of Sphaerophy sasalgula (Pall) DC显示文摘 | Ma Z J Meng D L Li X | 2003 | Plant Cell2003，20，2： | 1 |
| 14 | The mierostruetural evolu- tion of an Al-Zn-Mg-Cu during homogenization显示文摘 | FAN X JIANG D MENG Q | 2006 | Materials Let- ters2006，60，： | 1 |
| 15 | Improved model for mercury emission, transport and deposition显示文摘 | Gbor P K Wen D Y Meng F | 2006 | Atmospheric Environment2006，40，5： | 1 |
| 16 | The cotton GhNHX1 gene encoding a novel putative tonoplast Na^+/H^+ antiporter plays an important role in salt stress显示文摘 | WU C A YANG G D MENG Q W | 2004 | Plant and Cell Physiology2004，45，5： | 1 |
| 17 | Circulating tumor cells in patients with breast cancer dormancy显示文摘 | Meng S Tripathy D Frenkel EP | 2004 | Clin Cancer Res2004，10，24： | 1 |
| 18 | Modeling CO2 emissions from fossil fuel co- mbustion usin~ the logistic equation显示文摘 | MENG M NIU D X | 2011 | Energy2011，36，： | 1 |
| 19 | Coordinated stabilization of tumbling targets using tethered space manipulators 显示文摘 | Wang D K I-Iuang P F Meng Z J | 2015 | IEEE Transactions on Aerospace and Electronic Systems2015，51，3： | 1 |
| 20 | Antiserum to recombinant virus coat protein detects rupestris stem pitting associated virus in grapevines显示文摘 | MENG B CREDI R PETROVIC N TOMAZIC I GONSALVES D | 2003 | Plant Disease2003，87，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员