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| 1 | 智慧教室:应用现状及其影响研究——基于高中物理学科学习的跟踪研究显示文摘以'智慧教室'为标志的智慧教育学习环境研究,推动了从数字化学习环境向智能化学习环境的根本转变。该文从某使用智慧教室系统的高中学校选取454个一年级学生样本,进行为期一年的跟踪研究,测查智慧教室使用现状、对物理学习转变深度等,同时基于时间和空间两维面板数据,建立固定效应模型以测查对不同层次、不同性别学生物理学习兴趣和物理学习成绩影响。结果显示,智慧教室系统总体使用频率和时间较高,具体功能使用频率不均,学生主导、复杂应用偏少;使用功能类型单一,主要集中在即时互动和资源共享;未达到预期'转变科学学习'方式的目标,主要以'强化'原有学习为主;整体对学生学习兴趣和学习成绩有正向显著影响,对低层次学生成绩影响高于高层次学生,而对其兴趣影响反而低于高层次学生;对男生的学习成绩影响高于女生,而对其兴趣影响反而低于女生。 | 翟小铭 孙伟 郭玉英 Meilan Zhang | 2016 | 中国电化教育2016，，9： | 26 |
| 2 | Responses of the Toll-like receptor and melanoma differentiation-associated protein 5 signaling pathways to avian infectious bronchitis virus infection in chicks显示文摘Avian infectious bronchitis virus(IBV) is a Gammacoronavirus in the family Coronaviridae and causes highly contagious respiratory disease in chickens. Innate immunity plays significant roles in host defense against IBV. Here, we explored the interaction between IBV and the host innate immune system. Severe histopathological lesions were observed in the tracheal mucosa at 3–5days post inoculation(dpi) and in the kidney at 8 dpi, with heavy viral loads at 1–11 and 1–28 dpi,respectively. The expression of m RNAs encoding Toll-like receptor(TLR) 3 and TLR7 were upregulated at 3–8 dpi, and that of TIR-domain-containing adapter-inducing interferon(IFN) β(TRIF) was upregulated at 21 dpi in the trachea and kidney. Myeloid differentiation primary response protein 88(My D88) was upregulated in the trachea during early infection. Tumor necrosis factor receptor-associated factor(TRAF) 3 and TRAF6 were upregulated expression in both tissues.Moreover, melanoma differentiation-associated protein 5(MDA5), laboratory of genetics and physiology 2(LGP2), stimulator of IFN genes(STING), and mitochondrial antiviral signaling protein(MAVS), as well as TANK binding kinase 1(TBK1), inhibitor of kappa B kinase(IKK) ?, IKKα, IKKβ,IFN regulatory factor(IRF) 7, nuclear factor of kappa B(NF-κB), IFN-α, IFN-β, various interleukins(ILs), and macrophage inflammatory protein-1β(MIP-1β) were significantly upregulated in the trachea and downregulated in the kidney. These results suggested that the TLR and MDA5 signaling pathways and innate immune cytokine were induced after IBV infection. Additionally,consistent responses to IBV infection were observed during early infection, with differential and complicated responses in the kidney. | Yining He Zhiwen Xie Jinglong Dai Yanjie Cao Jinlian Hou Yansheng Zheng Tianchao Wei Meilan Mo Ping Wei | 2016 | Virologica Sinica2016，31，1： | 14 |
| 3 | Experimental assessment and prediction of temporal scour depth around a spur dike显示文摘Spur dikes are river training structures that have been extensively used worldwide for towards enhancing flood control and the stability of embankments and riverbanks.However,scour around spur dikes can be a major problem affecting their stability and hydraulic performance.The precise computation of temporal scour depth at spur dikes is very important for the design of economical and safe spur dikes.This study focuses on experimentally assessing the temporal variation of scour depth around a vertical wall spur dike and identifying the parameters,which mostly influence spur dike performance for a channel bed surface comprised of sand-gravel mixtures.In the current study,the authors did physical experiments in a flume based study to obtain new data,aimed at deriving a new predictive model for spur dike scour and comparing its performance to others found in the literature.It was found that the dimensionless temporal scour depth variation increases with an increase in(i)the threshold velocity ratio,(ii)the densimetric Froude number of the bed surface sediment mixture,(iii)the flow shallowness(defined as the ratio of the approach flow depth,y,to the spur dike’s transverse length,l),and(iv)the flow depth-particle size ratio.It is also concluded that the temporal scour depth variation in the sediment mixture is influenced by the non-uniformity of sediment and decreases with an increase in the non-uniformity of the sediment mixture.A new mathematical model is derived for the estimation of temporal scour depths in sand-gravel sediment mixtures.The proposed equation has been calibrated and validated with the experimental data,demonstrating a good predictive capacity for the estimation of temporal scour depth evolution. | Manish Pandey Manousos Valyrakis Meilan Qi Anurag Sharma Ajay Singh Lodhi | 2021 | International Journal of Sediment Research2021，36，1： | 8 |
| 4 | Role of sorbent surface functionalities and microporosity in 2,2′,4,4′-tetrabromodiphenyl ether sorption onto biochars显示文摘The study provides insight into the combined effect of sorbent surface functionalities and microporosity on2,2 ′,4,4 ′-tetrabromodiphenyl ether (BDE-47) sorption onto biochars. A series of biochars prepared underdifferent conditionswere used to test their sorption behaviorswith BDE-47. The extents of sorption behaviorswere parameterized in terms of the single-point adsorption equilibrium constant (Koc ) at three equilibrium concentration (C e ) levels (0.001Sw (solubility), 0.005Sw , and 0.05Sw )whichwasdetermined using the Freundlich model. To elucidate the concentration-dependentdominant mechanisms for BDE-47 sorption onto biochars, K ocwas correlatedwith four major parameters using multiple parameter linear analysis accompaniedwith significance testing. The results indicated that at low concentration (Ce = 0.001Sw ), the surface microporosity term,which represented a pore-filling mechanism, contributed significantly to this relationship,while as concentrationwas increased to higher levels, surface functionality related to surface adsorption began to take thedominant role,whichwas further confirmed by the results of Polanyi-based modeling. Given the above results, adual mode model based on Dubinin-Radushkevich andde Boer-Zwikker equationswas adopted to quantitatively assess the changes of significance of surface adsorption aswell as that of pore fillingwith sorption processdevelopment. In addition, UV spectra of four typical aromatic compoundswhich represented the key structural fragments of biochars before and after interactionswith BDE-47were analyzed todetermine the active functional groups and supply complementary evidence for thedominant interaction force for surface adsorption, based onwhich π-π electron-donor-acceptor interactionwas proposed to contribute greatly to surface adsorption. | Jia Xin Ruilong Liu Hubo Fan Meilan Wang Miao Li Xiang Liu | 2013 | Journal of Environmental Sciences2013，25，7： | 6 |
| 5 | Exogenous Application of Abscisic Acid (ABA)Enhances Chilling Tolerance in Seedlings ofNapier Grass (Pennisetum purpureum Schum.)显示文摘Napier grass, an important forage crop with potentials in multi-purpose applications, is widely grown throughout the tropics and subtropics. Low temperature severely limits its productivity and geographical distribution in temperate regions of the world. In this study, we investigated the effect of exogenous abscisic Acid(ABA) on chilling tolerance of napier grass(Pennisetum purpureum Schum.) seedlings. Seven-day-old napier grass seedlings were cultured in dd H_2O or ABA solution at different concentrations and exposed to 1 ℃ for different time durations. The chilling injury, membrane stability index(MSI) and proline content were estimated from leaf samples. The results showed that there was obvious morphological injury of leaf blighting and restrained growth for the seedlings under chilling stress, but this damage can be largely reduced(by 2/3) when the seedlings were treated by 100 μmol/L ABA in the culture solution, and that the application of exogenous ABA can help to maintain a good stability of leaf cell membrane as expressed by a high MSI value and a low level of proline in leaf cells. These results suggested that exogenous ABA can significantly alleviate chilling injury in napier grass seedlings by maintaining the stability of leaf cell membrane during chilling stress, and that the chilling tolerance was not ensured by a proline accumulation although a passive accumulation of proline was observed in the seedlings under chilling stress. Our results lay a preliminary foundation for future investigations on the molecular mechanisms of ABA induced chilling or freezing tolerance in napier grass. | Yong WANG Meilan ZHU Yanqing YANG Intikhab ALAM Xi CHENG Tao QIN Yunhai LU | 2017 | Agricultural Science & Technology2017，18，3： | 5 |
| 6 | Expression Analysis of Genes Related to Auxin Metabolism at Different Growth Stages of Pak Choi显示文摘Pak choi is a low-temperature vernalized plant that readily undergoes premature bolting during spring, but little is known about the governing molecular regulation of vernalization. In order to enhance our understanding of mechanism about premature bolting, we discussed the relationship between auxin(indole-3-acetic acid, IAA) and flowering of pak choi. During vernalization, hormone metabolism is an important regulatory pathway, and IAA plays a specific role. IAA metabolism has been studied in Arabidopsis thaliana and other plants, but not in pak choi. In this paper, the IAA content in pak choi shoot apices during vernalization and different growth stages was compared. The IAA content decreased significantly after low-temperature treatment(4 °C) and then increased rapidly during vegetative growth. During floral bud initiation,the IAA content decreased rapidly and was the lowest. Expressions of genes encoding key IAA metabolic enzymes were analyzed, and a major synthetase-encoding gene was downregulated, while a key degrading enzyme-encoding gene was upregulated during each comparison period,resulting in decreased IAA content. Expressions of four genes(Bra034975, Bra030246, Bra012239 and Bra040296) were consistent with changes in the IAA content. The functions of differentially expressed genes(DEGs) were analyzed, and 15 DEGs were found to be related to IAA metabolism.The findings illuminated the molecular mechanism regulating IAA content during vernalization in pak choi. | Yuxiang Hou Xueting Wang Zhujun Zhu Mengxia Sun Meilan Li Leiping Hou | 2020 | Horticultural Plant Journal2020，6，1： | 4 |
| 7 | Protective effects of a new metalloporphyrin on paraquat-induced oxidative stress and apoptosis in N27 cells显示文摘Paraquat (PQ, 1,1'-dimethyl-4,4'-bipyridinium ) ,使用得广泛地的除草剂,为 Parkinson 的疾病的发展作为一个潜在的 etiologic 因素被建议了。在最近的年里,许多研究集中于 PQ neurotoxicity 的机制。在这研究,我们检验了锰( III )的 neuroprotective 效果 meso-tetrakis ( N , N'-diethylimidazolium )卟啉( MnTDM ),超级氧化物 dismutase/catalase 模仿,在在 1RB ( 3 )的 导致PQ 的氧化应力和 apoptosis 上一( 27 )( N27 )房间,一根 dopaminergic neuronal 房间线。结果显示 MnTDM 显著地稀释了房间生存能力,谷胱甘肽弄空,和反应的氧种类生产的导致 PQ 的损失。MnTDM 也改善了 apoptosis 的导致 PQ 的词法原子变化和 apoptosis 的增加的率。另外,我们的数据提供 MnTDM 压制了导致 PQ 的 caspase-3 劈开的直接证据,可能 PQ neurotoxicity 的一个关键事件。这些观察建议了那个氧化压力, apoptosis 在导致 PQ 的 neurotoxicity 被含有,这毒性能被 MnTDM 阻止。这些调查结果也为 Parkinson 与氧化应力联系的疾病和另外的混乱建议了一条新奇治疗学的途径。 | Ping Chen Ang Li Mengjie Zhang Meilan He Zhen Chen Xiaokang Wu Chunjun Zhao Shilong Wang Liping Liang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，2： | 4 |
| 8 | Salvia miltiorrhiza-asarum ointment combined with Chinese medical massage alleviates symptoms of osteoarthritis in a rat model through the Notch1/matrix metalloproteinase-13 signaling pathway显示文摘OBJECTIVE:This study investigated the effect of salvia miltiorrhiza-asarum ointment(SMAO)plus Chinese medical massage on knee osteoarthritis in a rat model.METHODS:Hulth's method was used to establish a Sprague-Dawley rat model of knee osteoarthritis(OA).The levels of matrix metalloproteinase-13(MMP-13),collagen-Ⅱ,aggrecan,interleukin(IL)-1β,tumor necrosis factor-α(TNF-α),and IL-6 were measured by enzyme-linked immunosorbent assays.The joint space was assessed by a Perlove X-ray system.Histopathology was examined by hematoxylin-eosin and Safranin O staining.The mRNA and protein expression levels of Notch1,MMP-13,collagen-Ⅱ,and aggrecan were measured by quantitative reverse transcription-polymerase chain reaction and Western blotting,respectively.RESULTS:SMAO plus Chinese medical massage significantly decreased the levels of MMP-13,IL-1β,TNF-α,and IL-6,and increased serum collagen-Ⅱ and aggrecan levels.Pathological injury of the knee joint was improved by SMAO treatment.mRNA and protein expression of Notch1 and MMP-13 was remarkably downregulated,but collagen-Ⅱ and aggrecan levels were significantly upregulated in cartilage tissues.CONCLUSION:SMAO combined with Chinese medical massage effectively relieves OA symptoms,which may involve inhibiting inflammation through the Notch1/MMP-13 signaling pathway. | LAI Qingzhong ZHANG Xianjie CHEN Meilan HAN Zhicun | 2021 | Journal of Traditional Chinese Medicine2021，41，4： | 3 |
| 9 | Decolorization of azo dyes by a salt-tolerant Staphylococcus cohnii strain isolated from textile wastewater显示文摘 | Bin YAN Cuihong DU Meilan XU Wenchao LIAO | 2012 | Frontiers of Environmental Science & Engineering2012，6，6： | 2 |
| 10 | OsCYCP4s coordinate phosphate starvation signaling with cell cycle progression in rice显示文摘Phosphate starvation leads to a strong reduction in shoot growth and yield in crops.The reduced shoot growth is caused by extensive gene expression reprogram-ming triggered by phosphate deficiency,which is not itself a direct consequence of low levels of shoot phosphorus.However,how phosphate starvation inhibits shoot growth in rice is still unclear.In this study,we determined the role of OsCYCP4s in the regulation of shoot growth in response to phosphate starvation in rice.We demonstrate that the ex-pression levels of OsCYCP4s,except OsCYCP4;3,were induced by phosphate starvation.Overexpression of the phosphate starvation induced OsCYCP4s could compete with the other cyclins for the binding with cyclin-dependent kinases,therefore suppressing growth by reducing cell proliferation.The phosphate starvation induced growth inhibition in the loss-of-function mutants cycp4;1,cycp4;2,and cycp4;4 is par-tially compromised.Furthermore,the expression of some phosphate starvation inducible genes is negatively modu-lated by these cyclins,which indicates that these OsCYCP4s may also be involved in phosphate starvation signaling.We conclude that phosphate starvation induced OsCYCP4s might coordinate phosphate starvation signaling and cell cycle progression under phosphate starvation stress. | Lei Xu Fang Wang Ruili Li Minjuan Deng Meilan Fu Huiying Teng Keke Yi | 2020 | Journal of Integrative Plant Biology2020，62，7： | 2 |
| 11 | Early imaging characteristics of 62 cases of cerebral venous sinus thrombosis显示文摘 | Hui Qu Meilan Yang | 2013 | Experimental and Therapeutic Medicine2013，，1： | 2 |
| 12 | Complete Genome Sequences of Two Chinese Virulent Avian Coronavirus Infectious Bronchitis Virus Variants显示文摘 | Meilan Mo Baicheng Huang Ping Wei Tianchao Wei Qiuying Chen Xiuying Wang Meng Li Wensheng Fan | 2012 | Journal of Virology2012，，19： | 2 |
| 13 | Activation tagging of a dominant gibberellin catabolism gene (GA 2-oxidase) from poplar that regulates tree stature显示文摘 | BUSOV V B MEILAN R PEARCE D W | 2003 | Plant Physiol2003，132，3： | 1 |
| 14 | An Agrobacterium tumefaciens transformation protocol effective on a variety of cottonwood hybrids (genus Populus)显示文摘 | Han K H Meilan R Ma C | 2000 | Plant Cell Rep2000，19，： | 1 |
| 15 | Mechanisms of membrane fouling controlled by online ultrasound in an anaerobic membrane bioreactor for digestion of waste activated sludge 显示文摘 | Xua Meilan Wen Xianghua Huang Xia | 2013 | Journal of Membrane Science2013，445，： | 1 |
| 16 | Risk factors for oesophageal cancer in Linzhou,China;a case-control study显示文摘 | Xibib S Meilan H Moller H | 2003 | Asian Pac J Cancer Prey2003，4，2： | 1 |
| 17 | Bacterio-opsin gene overexpression fails to elevate fungal disease resistance in transgenic poplar (Populus) 显示文摘 | Meilan R Ostry M E | 2001 | Can J For Res2001，31，： | 1 |
| 18 | Thirteen-week repeated dose toxicity of Siraitia grosvenori extract inWistar Hannover(GALAS)rats显示文摘 | JIN Meilan MUGURUMA M MOTO M | 2007 | Food Chem Toxi-col2007，45，7： | 1 |
| 19 | Floral induction in woody angio sperms显示文摘 | Meilan R | 1997 | New-Forests1997，，14： | 1 |
| 20 | Intravenous umbilical cord mesenchymal stem cell infusion for the treatment of combined malnutrition nonunion of the humerus and radial nerve injury显示文摘 | Guofang Xue Meilan He Jie Zhao Yan Chen Yun Tian Baozhen Zhao Bo Niu | 2011 | Regenerative medicine2011，6，6： | 1 |
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