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| 1 | Chinese Multidisciplinary Expert Consensus on the Diagnosis and Treatment of Hyperuricemia and Related Diseases显示文摘 | Zou, He-Jian Wu, Hu-Sheng Zhou, Jing-Guo Zeng, Xue-Jun Dai, Lie Wu, Hua-Xiang Zhu, Xiao-Xia Mei, Chang-Lin Hao, Chuan-Ming Chen, Nan Liu, Bi-Cheng Chen, Jiang-Hua Yang, Li Nie, Jing Yu, Chen Peng, Ai Yu, Sheng-Qiang Li, Lin Ge, Jun-Bo Huo, Yong Zhang, Shu-Yang Chen, Yun-Dai Dong, Yu-Gang Liang, Chun Dai, Yu-Xiang Gao, Xin Li, Chang-Gui Zhao, Jia-Jun Chen, Hai-Bing Cheng, Zhi-Feng Lin, Huan-Dong Guan, Yang-Tai Wang, Kai Luo, Ben-Yan Dai, Ruo-Lian Jiang, Quan Xue, Luan Liang, Chao-Chao Chen, Ming Fan, Song | 2017 | Chinese Medical Journal2017，，20： | 30 |
| 2 | Altered trends in carbon uptake in China’s terrestrial ecosystems under the enhanced summer monsoon and warming hiatus显示文摘The carbon budgets in terrestrial ecosystems in China are strongly coupled with climate changes.Over the past decade,China has experienced dramatic climate changes characterized by enhanced summer monsoon and decelerated warming.However,the changes in the trends of terrestrial net ecosystem production(NEP)in China under climate changes are not well documented.Here,we used three ecosystem models to simulate the spatiotemporal variations in China's NEP during 1982–2010 and quantify the contribution of the strengthened summer monsoon and warming hiatus to the NEP variations in four distinct climatic regions of the country.Our results revealed a decadal-scale shift in NEP from a downtrend of–5.95 Tg C/yr^2(reduced sink)during 1982–2000 to an uptrend of 14.22 Tg C/yr^2(enhanced sink)during 2000–10.This shift was essentially induced by the strengthened summer monsoon,which stimulated carbon uptake,and the warming hiatus,which lessened the decrease in the NEP trend.Compared to the contribution of 56.3%by the climate effect,atmospheric CO2 concentration and nitrogen deposition had relatively small contributions(8.6 and 11.3%,respectively)to the shift.In conclusion,within the context of the global-warming hiatus,the strengthening of the summer monsoon is a critical climate factor that enhances carbon uptake in China due to the asymmetric response of photosynthesis and respiration.Our study not only revealed the shift in ecosystem carbon sequestration in China in recent decades,but also provides some insight for understanding ecosystem carbon dynamics in other monsoonal areas. | Honglin He Shaoqiang Wang Li Zhang Junbang Wang Xiaoli Ren Lei Zhou Shilong Piao Hao Yan Weimin Ju Fengxue Gu Shiyong Yu Yuanhe Yang Miaomiao Wang Zhongen Niu Rcmg Ge Huimin Yan Mei Huang Guoyi Zhou Yongfei Bai Zongqiang Xie Zhiyao Tang Bingfang Wu Leiming Zhang Nianpeng He Qiufeng Wang Guirui Yu | 2019 | National Science Review2019，6，3： | 24 |
| 3 | Induces Resistance Against Fusarium and Pink Rots by Acibenzolar-S-Methyl in Harvested Muskmelon (cv.Yindi)显示文摘Acibenzolar-S-methyl (ASM) is a chemical activator of systematic resistance in many plants. The effect of preharvest and postharvest application of ASM was evaluated for its ability to induce resistance in muskmelon fruit. The results indicated that 50 and 100 mg L-1 ASM or 1 mL L-1 imazalil at 1 week or 1 day before harvest were effective in reducing the lesion area with 100 mg L-1 ASM the most effective. No treatment inhibited the infection rate. The postharvest results showed that 50 and 100 mg L-1 ASM,and 0.1 mL L-1 imazalil were effective in reducing the lesion area with 100 mg L-1 ASM the most effective. No treatment inhibited the infection rate. There was a clear time-dependent response of the fruit to postharvest ASM treatment,in which treatments applied 1,3,and 5 day before inoculation provided the best results. ASM did not demonstrate any fungicide effect in vitro and suppressed lesion area in treated muskmelons,indicating that disease resistance was induced. The protection of ASM was associated with the activation of peroxidase (POD) in treated muskmelons. | GE Yong-hong BI Yang LI Xuan LI Mei | 2008 | Agricultural Sciences in China2008，7，1： | 19 |
| 4 | Treatment and outcomes of 1041 pediatric patients with neuroblastoma who received multidisciplinary care in China显示文摘Importance:Neuroblastoma is the most common extracranial malignant solid tumor in children.Multidisciplinary care is critical to improving the survival of pediatric patients with neuroblastoma.Objective:To systematically summarize the clinical characteristics of children with neuroblastoma and evaluate their prognosis with multidisciplinary care provided in a single center.Methods:This retrospective study analyzed the clinical data of 1041 patients with neuroblastoma who were diagnosed,treated,and followed-up in the Hematology-Oncology Center of Beijing Children’s Hospital from 2007 to 2019.Results:The median age at diagnosis was 34 months;80.8%of the patients were younger than 5 years of age.Notably,243 patients(23.3%)were classified as low-risk,249 patients(23.9%)were classified as intermediate-risk,and 549(52.7%)were classified as high-risk.Furthermore,956 patients underwent surgical resections;986(94.7%)patients received chemotherapy;and 176 patients with high-risk neuroblastoma received hematopoietic stem cell transplantation.The 5-year event-free survival(EFS)rate was 91.3%and 5-year overall survival(OS)rate was 97.5%in low-risk group;in the intermediate-risk group,these rates were 85.1%and 96.7%,respectively,while they were 37.7%and 48.9%in the high-risk group(P<0.001 for both).The 5-year EFS and OS rates were significantly higher in patients diagnosed between 2015 and 2019 than in patients diagnosed between 2007 and 2014(P<0.001).In total,278 patients(26.7%)exhibited tumor relapse or progression;the median interval until relapse or progression was 14 months.Of the 233 patients who died,83%died of relapse or progression of neuroblastoma and 4.3%died of therapy-related complications.Interpretation:The 5-year OS rate was low in high-risk patients,compared with low-and intermediate-risk patients.Multidisciplinary care is critical for improvement of survival in pediatric patients with neuroblastoma.Additional treatment strategies should be sought to improve the prognosis of patients with high-risk neuroblastoma. | Yan Su Hong Qin Chenghao Chen Shengcai Wang Shihan Zhang Dawei Zhang Mei Jin Yun Peng Lejian He Xiaoman Wang Suyun Qian Maoquan Qin Ming Ge Fuquan Zhang Qi Zeng Huanmin Wang Xiaoli Ma Xin Ni | 2020 | Pediatric Investigation2020，4，3： | 16 |
| 5 | Comparison of combined phacotrabeculectomy with trabeculectomy only in the treatment of primary angle-closure glaucoma显示文摘 | WANG Mei FANG Min BAI Yu-jing ZHANG Wei-zhong LIN Ming-kai LIU Bing-qian HAO Yuan-tao LING Yun-lan ZHUO Ye-hong GE Jian | 2012 | Chinese Medical Journal2012，，8： | 15 |
| 6 | LYRM03, an ubenimex derivative, attenuates LPS- induced acute lung injury in mice by suppressing the TLR4 signaling pathway显示文摘像使用费的受体(TLR4 ) 4 调停了表明戏在导致败血的尖锐的肺损害(ALI ) 的一个关键角色。LYRM03 (3-amino-2-hydroxy-4-phenyl-valyl-isoleucine ) 是 ubenimex 的新奇衍生物,广泛地使用的 antineoplastic 药。我们以前发现 LYRM03 在盲肠的结扎刺老鼠模型有反煽动性的效果。在这研究,我们决定了 LYRM03 是否在老鼠稀释了导致 LPS 的 ALI。导致 LPS 的 ALI 老鼠模型被与 LPS (5 mg/kg ) 的 intratracheal 注射质问老鼠建立,它随后与 LYRM03 被对待(10 mg/kg, ip ) 。LYRM03 管理显著地减轻了导致 LPS 的肺浮肿,煽动性的房间(neutrophils 和巨噬细胞) 渗入和 myeloperoxidase (军邮局) 活动,减少的支持 inflammatory 和趋化性的 cytokine (TNF- , IL-6, IL-1, MIP-2 ) 产生和在肺纸巾的 COX-2 表示。在有教养的老鼠在 vitro 的牙槽的巨噬细胞,有 LYRM03 (100 mol/L ) 的预告的处理由减少 Myd88 表示,增加 IB 稳定性并且禁止 p38 phosphorylation 压制了导致 LPS 的巨噬细胞激活。这些结果建议 LYRM03 有效地由在牙槽的巨噬细胞禁止支持 inflammatory 调停人和 Myd88 依赖的 TLR4 发信号小径的表示稀释导致 LPS 的 ALI。LYRM03 可以为调停败血的肺损害用作一个潜在的处理。 | Hui-qiong HE Ya-xian WU Yun-juan NIE Jun WANG Mei GE Feng QIAN | 2017 | Acta Pharmacologica Sinica2017，38，3： | 14 |
| 7 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 8 | Chinese expert consensus on the non-invasive imaging examination pathways of stable coronary artery disease显示文摘 | Yun-Dai CHEN Wei-Yi FANG Ji-Yan CHEN Zhan-Ming FAN Chuan-Yu GAO Jun-Bo GE Zuo-Xiang HE Yong HUO Lang LI Si-Jin LI Xi-Lie LU Bin LV Ju-Ying QIAN Ya-Jun SHI Zhu-Jun SHEN Jing WANG Yi-Ning WANG Lei XU Li YANG Bo YU Mei ZHANG Jun-Jie YANG Shu-Yang ZHANG Xiao-Li ZHANG Shi-Hua ZHAO Yang ZHENG Yu-Chi HAN Guang ZHI | 2018 | Journal of Geriatric Cardiology2018，15，1： | 10 |
| 9 | Establishing a human pancreatic stem cell line and transplanting induced pancreatic islets to reverse experimental diabetes in rats显示文摘The major obstacle in using pancreatic islet transplantation to cure type I and some type II diabetes is the shortage of the donors. One of ways to overcome such obstacle is to isolate and clone pancreatic stem cells as 'seed cells' and induce their differentiation into functional islets as an abundant trans-plantation source. In this study, a monoclonal human pancreatic stem cell (mhPSC) line was obtained from abortive fetal pancreatic tissues. Pancreatic tissues were taken from abortive fetus by sterile procedures, and digested into single cells and cell clusters with 0.1% type IV collagenase. Cultured in modified glucose-low DMEM with 10% fetal bovine serum (FBS), these single cells and cell clusters adhered to culture dishes, and then primary epidermal-like pancreatic stem cells started to clone. After digesting with 0.25% trypsin and 0.04% EDTA, fibroblasts and other cells were gradually eliminated and epithelioid pancreatic stem cells were gradually purified during generations. Using clone-ring selection, the mhPSCs were obtained. After addition of 10 ng/mL epidermal growth factor (EGF) in cell culture medium, the mhPSCs quickly grew and formed a gravelstone-like monolayer. Continuously proliferated, a mhPSC line, which was derived from a male abortive fetus of 4 months old, has been passed through 50 generations. More than 1×109 mhPSCs were cryo-preserved in liquid nitrogen. Karyotype analysis showed that the chromosome set of the mhPSC line was normal diploid. Immunocytochemistry results demonstrated that the mhPSC line was positive for the pdx1, glucagon, nestin and CK19, and negative for the insulin, CD34, CD44 and CD45 protein expression. RT-PCR revealed further that the mhPSCs expressed transcription factors of the pdx1, glucagon, nestin and CK19. Also, in vitro induced with β-mercaptoethanol, the mhPSCs differentiated into nerve cells that expressed the NF protein. Induced with nicotinamide, the mhPSCs differentiated into functional islet-like clusters, as identified by di-thizone staining, which expressed the transcription factor of the insulin and secreted the insulin and C-peptide. Furthermore, the transplantation of mhPSCs-induced pancreatic islets into the subcapsular region of the kidney in streptozotocin-induced diabetic rats could reduce blood glucose levels and prolong the life time. | XIAO Mei AN LiLong YANG XueYi GE Xin QIAO Hai ZHAO Ting MA XiaoFei FAN JingZhuang ZHU MengYang DOU ZhongYing | 2008 | Science China(Life Sciences)2008，51，9： | 9 |
| 10 | Bartonella Species Detected in the Plateau Pikas(Ochotona curzoiae) from Qinghai Plateau in China显示文摘Bartonella 种类能感染许多哺乳动物的主人并且在人引起许多疾病,但是在那里有不是在 Ochotonidae 的 Bartonella 感染的报告。这是第一研究在 Qinghai 高原在高原一种短耳野兔检测 Bartonella,提供为对在这个区域的人的 Bartonella 感染的风险评价的基线数据。我们与 18.99% 的积极的率在 Qinghai 的 Binggou 和 Maixiu 区域从 79 只一种短耳野兔获得了 15 Bartonella 紧张。基于基因定序的 Bartonella 柠檬酸盐 synthase (gltA ) 的种系发生的分析,大多数紧张是仔细与 B 有关。taylorii (3/15 ) 和 B。grahamii (12/15 ) 。后者是在人的病原的紧张。我们的结果建议相应预防和控制策略应该在 Qinghai 省被考虑。 | RAO Hua Xiang YU Juan GUO Peng MA Yong Cheng LIU Qi Yong JIAO Ming MA Zhong Wen GE Hua WANG Chun Xiang SONG Xiu Ping SHI Yan LI Dong Mei | 2015 | Biomedical and Environmental Sciences2015，28，9： | 8 |
| 11 | The 5.5 cal ka BP climate event, population growth, circumscription and the emergence of the earliest complex societies in China显示文摘The emergence of complex society is a milestone in the history of human society evolution. China is one of the few regions in the world where the earliest complex society appeared; however, its driving mechanisms remain unresolved. On the base of available evidence from both archaeology and Holocene climate, in combination with agency theory, this study attempts to address the driving mechanisms for the simultaneous emergence of complex societies in multiple areas of China around 5.5 cal ka BP. It is hypothesized that three factors, including climate change, population growth, and circumscription, jointly act and cause regional population-resource imbalance and trigger inter-group conflicts and wars. Such competitions provide the opportunity for some power-pursuing agents to break the restriction of social leveling mechanism and to become the centralized decision-making leaders, which further lead to the emergence of incipient large-scale complex societies. Increase in extreme climate events during 6.0–5.0 cal ka BP cooling period causes frequent occurrence of resource stress and increase in the frequency of inter-group competitions, which creates conditions for the legitimation, institutionalization, and persistence of centralized leadership, and finally leads to the formation of persistent institutionalized inequity. Our research result can explain not only the process and mechanism of complex society formation, but also two phenomena which cannot be reasonably explained by previous theories, that are, why the earliest complex societies in China emerge around 5.5 cal ka BP, and why they appear simultaneously in multiple regions. | WU WenXiang ZHENG HongBo HOU Mei GE QuanSheng | 2018 | Science China Earth Sciences2018，61，2： | 8 |
| 12 | Improvement of pristinamycin I(PI)production in Streptomyces pristinaespiralis by metabolic engineering approaches显示文摘Pristinamycin,produced by Streptomyces pristinaespiralis,which is a streptogramin-like antibiotic consisting of two chemically unrelated components:pristinamycin I(PI)and pristinamycin II(PII),shows potent activity against many antibiotic-resistant pathogens.However,so far pristinamycin production titers are still quite low,particularly those of PI.In this study,we constructed a PI single component producing strain by deleting the PII biosynthetic genes(snaE1 and snaE2).Then,two metabolic engineering approaches,including deletion of the repressor gene papR3 and chromosomal integration of an extra copy of the PI biosynthetic gene cluster(BGC),were employed to improve PI production.The final engineered strain DPIIDpapR3/PI produced a maximum PI level of 132 mg/L,with an approximately 2.4-fold higher than that of the parental strain S.pristinaespiralis HCCB10218.Considering that the PI biosynthetic genes are clustered in two main regions in the 210 kb“supercluster”containing the PI and PII biosynthetic genes as well as a cryptic polyketide BGC,these two regions were cloned separately and then were successfully assembled into the PI BGC by the transformation-associated recombination(TAR)system.Collectively,the metabolic engineering approaches employed is very efficient for strain improvement in order to enhance PI titer. | Jiali Meng Rongrong Feng Guosong Zheng Mei Ge Yvonne Mast Wolfgang Wohlleben Jufang Gao Weihong Jiang Yinhua Lu | 2017 | Synthetic and Systems Biotechnology2017，2，2： | 7 |
| 13 | Analysis of MYOC gene mutation in a Chinese glaucoma family with primary open-angle glaucoma and primary congenital glaucoma显示文摘背景绿内障是在世界上的盲目的领先的原因之一。主要开角度的绿内障(POAG ) 和主要先天的绿内障(PCG ) 是绿内障的子类型。Myocillin 是识别最近涉及 POAG 的第一基因, myocillin 变化在这上下文在 PCG 被发现了,我们报导了一个特殊绿内障家谱,它 PCG 和 POAG 病人是镇静的,并且分析了在这个家谱的 myocillin 的变化。MethodsThe 家庭由父母,一个儿子和一个女儿组成。家庭的所有成员经历了完全的 ophthalmologic 考试。myocilin 基因的所有编码的前 ons 1-3 和 flanking introns 被定序的聚合酶链反应和直接 DNA 为顺序改变屏蔽。结果儿子是在两只眼睛作为 PCG 被诊断的职业人员乐队。父亲在右眼睛作为 POAG 被诊断,左眼睛仍然是正常的。没有绿内障的眼的圆盘变化,姐妹和 theproband 的母亲有正常 intraocular 压力。变化 inintron 2 myocilin 基因在家庭被检测。当职业人员乐队和父亲是同型结合的时,母亲和姐妹为变化是异质接合的。在 intron 的结论 Homozygousmutation 2 myocilin 基因涉及 POAG 和 PCG 致病可能在 POAG 和 PCG 正在重叠,这被建议。 | ZHUO Ye-hong WANG Mei WEI Yan-tao HUANG Ya-lin GE Jian | 2006 | Chinese Medical Journal2006，，14： | 7 |
| 14 | ADAPTIVE CGF COMMANDER BEHAVIOR MODELING THROUGH HTN GUIDED MONTE CARLO TREE SEARCH显示文摘 | Xiao Xu Mei Yang Ge Li | 2018 | Journal of Systems Science and Systems Engineering2018，27，2： | 7 |
| 15 | A new neuroprotective bakkenolide from the rhizome of Petasites tricholobus显示文摘新 bakkenolide 类型混合物, bakkenolide-Va (1 ) ,从 Petasites tricholobus 的根茎被孤立。结构根据各种各样的 NMR 被描绘(1H, 13C, 1H 鈥 ? H 舒适, HMQC, HMBC 和 NOESY ) 并且集体 spectrometry 数据。bakkenolide-Va 的 neuroprotective 活动在组织缺氧葡萄糖剥夺和氧化侮辱的各种各样的类型对待的首先有教养的神经原被调查。 | Na Zhang Mei Li Guo Ge Zhang Run Ping Li | 2008 | Chinese Chemical Letters2008，19，7： | 7 |
| 16 | PERIODIC SOLUTIONS FOR NEUTRAL LINARD EQUATION WITH A STATEMENT-DEPENDENT DEVIATION VARIABLE显示文摘Using the theroy of topological degree, the paper studies the periodic solutions to a type of neutral Lienard equation with state-dependent deviation variable. A sufficient condition for the existence of periodic solution is obtained. | Liu Xiping Jia Mei Yang Liu Ge Weigao | 2005 | Annals of Differential Equations2005，21，3： | 6 |
| 17 | Sex determination mechanisms and sex control approaches in aquaculture animals显示文摘Aquaculture is one of the most efficient modes of animal protein production and plays an important role in global food security.Aquaculture animals exhibit extraordinarily diverse sexual phenotypes and underlying mechanisms,providing an ideal system to perform sex determination research,one of the important areas in life science.Moreover,sex is also one of the most valuable traits because sexual dimorphism in growth,size,and other economic characteristics commonly exist in aquaculture animals.Here,we synthesize current knowledge of sex determination mechanisms,sex chromosome evolution,reproduction strategies,and sexual dimorphism,and also review several approaches for sex control in aquaculture animals,including artificial gynogenesis,application of sex-specific or sex chromosome-linked markers,artificial sex reversal,as well as gene editing.We anticipate that better understanding of sex determination mechanisms and innovation of sex control approaches will facilitate sustainable development of aquaculture. | Xi-Yin Li Jie Mei Chu-Tian Ge Xiao-Li Liu Jian-Fang Gui | 2022 | Science China(Life Sciences)2022，65，6： | 5 |
| 18 | Smoking and Its Relation to Metabolic Status among Chinese Adults: Analysis of a Nationwide Survey显示文摘Objective To update the estimated prevalence rates of smoking and examine major metabolic diseases associated with smoking status in Chinese adults. Methods Using a complex, multistage, probability sampling design, we recruited a nationally representative sample of 98,658 Chinese adults aged ≥18 years in 2010. Information on current, former, never, and passive smoking status was obtained using a standard questionnaire. All estimates were weighted to represent the overall Chinese adult population. Results The estimated proportion of current smokers was 28.3% for Chinese adults aged ≥18 years. The corresponding values of former and passive smokers were 5.1% and 21.4%, respectively. Additionally, former smokers were found to have a less favorable metabolic risk profile among all categories of smoking status in both men and women. The prevalence of metabolic diseases such as diabetes and hypertension also increased with a greater number of smoking pack-years in men. Conclusion The prevalences of current smoking and passive smoking remain high in Chinese adults. | DING Lin XU Yu WANG Li Min JIANG Yong ZHANG Mei LI Yi Chong LU Jie Li XU Min WANG Tian Ge LI Mian ZHAO Zhi Yun DAI Meng WANG Wei Qing ZHAO Wen Hua WANG Lin Hong BI Yu Fang NING Guang 无 | 2016 | Biomedical and Environmental Sciences2016，29，9： | 5 |
| 19 | Expert consensus on early childhood caries management显示文摘Early childhood caries(ECC)is a significant chronic disease of childhood and a rising public health burden worldwide.ECC may cause a higher risk of new caries lesions in both primary and permanent dentition,affecting lifelong oral health.The occurrence of ECC has been closely related to the core microbiome change in the oral cavity,which may be influenced by diet habits,oral health management,fluoride use,and dental manipulations.So,it is essential to improve parental oral health and awareness of health care,to establish a dental home at the early stage of childhood,and make an individualized caries management plan.Dental interventions according to the minimally invasive concept should be carried out to treat dental caries.This expert consensus mainly discusses the etiology of ECC,caries-risk assessment of children,prevention and treatment plan of ECC,aiming to achieve lifelong oral health. | Jing Zou Qin Du Lihong Ge Jun Wang Xiaojing Wang Yuqing Li Guangtai Song Wei Zhao Xu Chen Beizhan Jiang Yufeng Mei Yang Huang Shuli Deng Hongmei Zhang Yanhong Li Xuedong Zhou | 2022 | International Journal of Oral Science2022，14，3： | 5 |
| 20 | Control of Postharvest Fusarium Rot and Trichothecium Rot in Harvested Muskmelon (cv. Yindi) by Harpin显示文摘Preharvest and postharvest application of Harpin was evaluated for its ability to induce resistance in muskmelon fruit and control rots. Preharvest treatments were 30 mg L-1, 60 mg L-1 Harpin or 1 mg L-1 Imazalil either 1 week or 1 day before harvest. The CK was untreated. Fruit were then inoculated with Fusarium semitectum or Trichothecium roseum 48 h after harvest, and stored at 23 ± 1°C, RH (relative humidity) 50-60% for 4 d. All treatments were effective in reducing the lesion area with 60 mg L-1 Harpin the most effectively. No treatments inhibited infection rate. Postharvest treatment was fruit dips of 30 mg L-1, 60 mg L-1 Harpin, 0.1 mg L-1 Imazalil. Fruit were inoculated with F. semitectum or T. roseum 24, 72, 120 or 168 h after treatment, and stored at 23 ± 1°C, RH 50-60% for 4 days. All treatments were effective in reducing the lesion area with 60 mg L-1 Harpin the most effectively. No treatments inhibited the infection rate. Postharvest Harpin treatment induced the peroxidase activity increase, peroxidase activity reached maximum after 8 d and the activation lasted at least 10 d. | GE Yong-hong BI Yang LI Mei LI Xuan | 2005 | Agricultural Sciences in China2005，4，12： | 5 |
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