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| 1 | Neuroprotective potential of Quercetin in combination with piperine against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity显示文摘1-Methy-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)is a neurotoxin that selectively damages dopaminergic neurons in the substantia nigra pars compacta and induces Parkinson’s like symptoms in rodents.Quercetin(QC)is a natural polyphenolic bioflavonoid with potent antioxidant and anti-inflammatory properties but lacks of clinical attraction due to low oral bioavailability.Piperine is a well established bioavailability enhancer used pre-clinically to improve the bioavailability of antioxidants(e.g.,Quercetin).Therefore,the present study was designed to evaluate the neuroprotective potential of QC together with piperine against MPTP-induced neurotoxicity in rats.MPTP(100μg/μL/rat,bilaterally)was injected intranigrally on days 1,4 and 7 using a digital stereotaxic apparatus.QC(25 and 50 mg/kg,intragastrically)and QC(25 mg/kg,intragastrically)in combination with piperine(2.5 mg/kg,intragastrically)were administered daily for 14 days starting from day 8 after the 3^(rd) injection of MPTP.On day 22,animals were sacrificed and the striatum was isolated for oxidative stress parameter(thiobarbituric acid reactive substances,nitrite and glutathione),neuroinflammatory cytokine(interleukin-1β,interleukin-6,and tumor necrosis factor-α)and neurotransmitter(dopamine,norepinephrine,serotonin,gamma-aminobutyric acid,glutamate,3,4-dihydroxyphenylacetic acid,homovanillic acid,and 5-hydroxyindoleacetic acid)evaluations.Bilateral infusion of MPTP into substantia nigra pars compacta led to significant motor deficits as evidenced by impairments in locomotor activity and rotarod performance in open field test and grip strength and narrow beam walk performance.Both QC(25 and 50 mg/kg)and QC(25 mg/kg)in combination with piperine(2.5 mg/kg),in particular the combination therapy,significantly improved MPTP-induced behavioral abnormalities in rats,reversed the abnormal alterations of neurotransmitters in the striatum,and alleviated oxidative stress and inflammatory response in the striatum.These findings indicate that piperine can enhance the antioxidant and anti-inflammatory properties of QC,and QC in combination with piperine exhibits strong neuroprotective effects against MPTP-induced neurotoxicity. | Shamsher Singh Sumit Jamwal Puneet Kumar | 2017 | Neural Regeneration Research2017，12，7： | 6 |
| 2 | Bioavailable curcumin formulations:A review of pharmacokinetic studies in healthy volunteers显示文摘Curcumin is a widely studied natural compound which has shown tremendous in vitro therapeutic potential. Despite that, the clinical efficacy of the native curcumin is weak due to its low bioavailability and high metabolism in the gastrointestinal tract. During the last decade, researchers have come up with different formulations with a focus on improving the bioavailability of curcumin. As a result, a significant number of bioavailable curcumin-based formulations were introduced with the varying range of enhanced bioavailability. The purpose of this review is to collate the published clinical studies of curcumin products with-improved bioavailability over conventional(unformulated) curcumin. Based on the literature search, 11 curcumin formulations with available human bioavailability and pharmacokinetics data were included in this review. Further, the data on clinical study design, analytical method, pharmacokinetic parameters and other relevant details of each formulation were extracted. Based on a review of these studies, it is evident that better bioavailability of formulated curcumin products is mostly attributed to improved solubility, stability, and possibly low first-pass metabolism. The review hopes to provide a quick reference guide for anyone looking information on these bioavailable curcumin formulations. Based on the published reports, NovaSol~?(185), CurcuWin~?(136) and LongVida~?(100)exhibited over 100-fold higher bioavailability relative to reference unformulated curcumin. Suggested mechanisms accounting for improved bioavailability of the formulations and details on the bioanalysis methods are also discussed. | Rohitash Jamwal | 2018 | Journal of Integrative Medicine2018，16，6： | 4 |
| 3 | Performance of Externally FRP Reinforced Columns for Changes in Angle and Thickness of the Wrap and Concrete Strength显示文摘 | PARVIN A JAMWAL A S | 2006 | Composite Struetures2006，73，4： | 1 |
| 4 | Cut slope stability evaluation of NH-21 along Nalayan-Gambhrola section,Bilaspur district,Himachal Pradesh,India显示文摘 | Sharma R K Mehta B S Jamwal C S | | 0，，： | 1 |
| 5 | Piperine enhances the protective effect of curcumin against 3-NP induced neurotoxicity: possible neurotransmitters modulation mechanism显示文摘 | Singh S Jamwal S Kumar P | 2015 | Neurochem Res2015，40，8： | 1 |
| 6 | Can hormone replacement therapy priorto oocyte donation cycle in women with premature ovarian failure improve pregnancy rate显示文摘 | Naredi N Sandeep K Jamwal V D S | 2013 | Medical Journal Armed Forces India2013，69，4： | 1 |
| 7 | Redox reactionsinnon- aqueousmedia : Determination of organicisothiocy anatesalone, in form ulations andinimportant mixtures显示文摘 | Verma B C Kalia S B Jamwal V S | | Talanta0，38，2： | 1 |
| 8 | Pregnancy-related liver disorders显示文摘 | GOEL A JAMWAL KD RAMACHANDRAN A | 2014 | J Clin Exp Hepatol2014，4，2： | 1 |
| 9 | Pregnancy-re- lated liver disorders 显示文摘 | Goel A Jamwal KD Ramachandran A | 2014 | J Clin Exp Hepatol2014，4，2： | 1 |
| 10 | An intrinsically compli- ant robotic orthosis for treadmill training 显示文摘 | Hussain S Xie SQ Jamwal PK | 2012 | Med Eng Phys2012，34，10： | 1 |
| 11 | Climate vulnerability and adaptation of water provisi oning in developing countries: approaches to disciplinary and re- search-practice integration显示文摘 | Sprinivasan V Thomas B-K Jamwal P | 2013 | Current Optinion in En- vironmental Sustainability2013，5，34： | 1 |
| 12 | Cloning and functional characterization of nitrilase from Fusarium proliferatum AUF - 2 for detoxification of nitriles显示文摘 | Yusuf F Rather I Jamwal U | 2015 | Funct Integr Genomics2015，15，4： | 1 |
| 13 | Pregnancy-related liver disorders显示文摘 | Goel A Jamwal KD | 2014 | J Clin Exp Hepatol2014，4，2： | 1 |
| 14 | An iterative fuzzy controller for pneumatic muscle driven rehabilitation robot 显示文摘 | Xie S Q P K Jamwal | 2011 | Expert Systems with Applications (S0957-4174)2011，38，7： | 1 |
| 15 | Nano Pd(0)supported on cellulose:A highly efficient and recyclable heterogeneous catalyst for the Suzuki coupling and aerobic oxidation of benzyl alcohols under liquid phase catalysis显示文摘 | Jamwal N Sodhi R K Gupta P | | 0，，5： | 1 |
| 16 | Forward Kinematics Modelling of a Parallel Ankle Rehabili-tation Robot Using Modified Fuzzy Inference显示文摘 | Jamwal P K Xie S Q Tsoi Y H | | 0，，11： | 1 |
| 17 | Kinematic design optimization of a parallel ankle rehabilitation robot using modified genetic algorithm 显示文摘 | Prashant Kumar Jamwal Xie Shengquan Aw K C | 2009 | Robotics and Autonomous Systems2009，57，10： | 1 |
| 18 | An adaptive wearable parallel robot for the treatment of ankle injuries显示文摘 | JAMWAL P K XIE S Q HUSSAIN S | 2014 | IEEE/ASME Transactions on Mechatronics2014，19，1： | 1 |
| 19 | Late-developing supernumerary mandibular premolar: a case report 显示文摘 | Jamwal RS Sharma P Sharma R | 2010 | World J Orthod2010，11，4： | 1 |
| 20 | Kinematic Design Optimization of a Parallel Ankle Rehabilita-tion Robot Using Modified Genetic Algorithm显示文摘 | Jamwal P K Xie Shengquan Kean C A | | 0，，10： | 1 |
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