|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 2 | A review of an unfavorable subset of breast cancer: estrogen receptor positive progesterone receptor negative显示文摘 | Thakkar JP Mehta DG | 2011 | Oncologist2011，16，： | 1 |
| 3 | Mandibular reconstruction in 2004: an analysis of different techniques 显示文摘 | Mehta RP Deschler DG | 2004 | Current Opinion in Otolaryngology & Head & Neck Surgery2004，12，4： | 1 |
| 4 | Mandibular recon struction in 2004: an analysis of different techniques显示文摘 | Mehta RP Deschler DG | 2004 | Curr Opin Otolaryngol Head Neck Surg2004，12，4： | 1 |
| 5 | Mandibular reconstruction in 2004:an analysis of different techniques显示文摘 | Mehta RP Deschler DG | 2004 | Curr Opin Otolaryngol Head Neck Surg2004，12，4： | 1 |
| 6 | International Noso-comial Infection Control Consortium report,data summary for2002-2007,issued January 2008显示文摘 | Rosenthal VD Maki DG Mehta A | 2008 | Am J Infect Control2008，36，9： | 1 |
| 7 | A comparison of stemmed and unstemmed components in revision knee arthroplasty显示文摘 | Nazarian DG Mehta S Booth Jr RE | 2002 | Clin Orthop2002，404，： | 1 |
| 8 | International Nosoco- mial Infection Control Consortium report, data summary for 2002 - 2007, issued January 2008显示文摘 | Rosenthal VD Maki DG Mehta A | 2008 | Am J Infect Control2008，36，9： | 1 |
| 9 | A review of an unfavorable subset of breast cancer:estrogen receptor positive progesterone receptor negative显示文摘 | Thakkar JP Mehta DG | | 0，，： | 1 |
| 10 | A study of prue neuritie leprosy:clinical picture显示文摘 | Mahajan PM logaikar DG Mehta JM | 2004 | Lepr Rev2004，75，： | 1 |
| 11 | Mandibular reconstruction in 2004:an analysis of different techniques显示文摘 | Mehta RP Deschler DG | 2004 | Curr Opin Otolaryngol Head Neck Sury2004，12，4： | 1 |
| 12 | International Noso- comial Infection Control Consortium (INICC) report, data summary for2002-2007,issuedJanuary2008显示文摘 | Rosenthal VD Maki DG Mehta A et a l | 2008 | AmJ In- fect Control2008，，： | 1 |
| 13 | Intraoperative diagnosis of facial nerve schwannoma at parotidectomy显示文摘 | Mehta RP Deschler DG | | 0，，02： | 1 |
| 14 | A review of an unfavorable subset of breast cancer: estrogen receptor positive progesterone receptor negative 显示文摘 | Thakkar JP Mehta DG | 2011 | Oncologist2011，16，3： | 1 |
| 15 | Acute kidney injury network:report of an initiative to improve outcomes in acute kidney injury显示文摘 | Mehta RL Kellum JA Shah SV Molitoris BA Ronco C Wamock DG | | 0，，： | 1 |
| 16 | Intraoperative diagnosis of facial nerve schwannoma at parotidectomy显示文摘 | Mehta RP Deschler DG | 2008 | Am J Otolaryngol2008，29，2： | 1 |
| 17 | A review of an unfavorable subset of breast cancer: estrogen receptor positive progesterone receptor negative 显示文摘 | Thakkar JP Mehta DG | 2011 | Oncologist2011，16，3： | 1 |
| 18 | A review of an unfavorable subsetof breast cancer: estrogen receptor positive progesterone re- ceptor negative 显示文摘 | Thakkar JP Mehta DG | 2011 | Oncologist2011，16，3： | 1 |
| 19 | International Nosocomial Ifec-tion Control Consortium report,data summary for 2002 - 2007,issuedJanuary 2008 显示文摘 | Rosenthal VD Maki DG Mehta A | 2008 | Am J Infect Control2008，36，： | 1 |
| 20 | Neuroprotection during carotid artery stenting using the GORE flow reversal system:30-day outcomes in the EMPiRE Clinical Study显示文摘 | Clair DG Hopkins LN Mehta M | | 0，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员