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| 1 | The tumor-selective over-expression of the human Hsp 70 gene is attributed to the aberrant controls at both initiation and elongation levels of transcription显示文摘The tumor selective over-expression of the human Hsp70 gene has been well documented in human tumors,linked to the poor prognosis,being refractory to chemo-and radio-therapies as well as the advanced stage of tumorous lesions in particular.However,both the nature and details of aberrations in the control of the Hsp70 expression in tumor remain enigmatic.By comparing various upstream segments of the Hsp70 gene for each''s ability to drive the luciferase reporter genes in the context of the tumor cell lines varying in their p53 status and an immortal normal liver cell line,we demonstrated in a great detail the defects in the control mechanisms at the both initiation and elongation levels of transcription being instrumental to the tumor selective profile of its expression.Our data should not only offer new insights into our understanding of the tumor specific over-expression of the human Hsp70 gene,but also paved the way for the rational utilization of the tumor selective mechanism with the Hsp70 at the central stage fortargeting the therapeutic gene expression to human tumors. | LING CAI, JING DE ZHU,The State-key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, LN 25/2200, Xie-tu Road, Shanghai 200032, China | 2003 | Cell Research2003，13，2： | 13 |
| 2 | SYNTHESIS OF TETRAMETHYL SALVIANOLIC ACID F AND TRIMETHYL PRZEWALSKINIC ACID A显示文摘SYNTHESISOFTETRAMETHYLSALVIANOLICACIDFANDTRIMETHYLPRZEWALSKINICACIDA￥ChunBoAIandLianNiangLi(InstituteofMateriaMedicaChineseAc... | Al, CB Li, LN | 1996 | Chinese Chemical Letters1996，7，5： | 9 |
| 3 | Recovery of novel bacterial diversity from mangrove sediment显示文摘 | Liang JB Chen YQ Lan CY Tan NFY Zan QJ Huang LN | 2007 | 中国生物学文摘2007，21，7： | 7 |
| 4 | Biosorption of Cu^(2+) and Zn^(2+) by raw and autoclaved Rocella phycopsis显示文摘The behavior of Cu2+ and Zn2+ biosorption onto raw and modified Roccella phycopsis from aqueous solutions was studied. Modification process was applied by autoclavation at 121°C for 30 min. The effcts of pH, initial metal concentration and biosorbent dosage were investigated. The maximum Cu2+ biosorption was achieved at pH 5.0 and the maximum biosorption capacities of 31.5 and 37.8 mg/g were recorded for raw and modified biosorbent, respectively. In the case of Zn2+ biosorption, maximum biosorption capacities were obtained at pH 4.0 as 29.1 and 35.3 mg/g for raw and modified biosorbent, respectively. Biosorption of Zn2+ and Cu2+ on all form of R. phycopsis increased much quickly with increasing initial metal concentrations from 10 to 100 mg/L. After modification process, probable changes in the surface polarity of raw and modified R. phycopsis were investigated by contact angle measurements. As expected, R. phycopsis has a polar surface and shows a highest contact angle with water, while after autoclavation water contact angle of R. phycopsis was significantly decreased from 47.5° to 34.4°. | Emine Yalcln Kltigin avusoglu Kadir Klnalloglu | 2010 | Journal of Environmental Sciences2010，22，3： | 7 |
| 5 | 吻合口漏增加结肠癌根治术后远处转移率及长期死亡率:一项丹麦全国队列研究显示文摘背景和目的结直肠癌为世界最常见恶性肿瘤之一。全球每年约有120万新发病例,60万人死于本病。手术切除是患者长期无病生存的关键手段,但术后并发症却可对手术结局产生重要影响。吻合口瘘(anastomotic leak,AL)是结直肠癌根治手术的严重并发症类型,直接增加术后短期死亡率。根据不同手术类型,AL发生率约在3%至12%之间。目前仅有为数不多结果却彼此矛盾的研究关注结肠癌术后吻合口瘘对于肿瘤结局及长期生存的影响。而对于直肠癌患者的研究结果则一致显示AL与局部复发率及长期死亡率增加相关,而不影响远处转移发生率。与之相反,尚未有研究证实结肠癌术后AL与局部复发或远处转移相关。已有研究证实,AL可降低结肠癌患者的无病生存期及总生存期。本项针对结肠癌的丹麦全国性研究主要终点为确定AL对结肠癌术后存活超过120天以上患者局部复发及远处转移率的影响;次要终点为确定AL对患者长远期死亡率的影响。此外,通过一项亚组分析,评价AL对III期结肠癌患者实施辅助化疗(AC)的影响。方法本研究为一项丹麦全国范围的队列研究,所有9333例患者均来自丹麦结直肠癌研究组数据库,并结合丹麦病理登记系统与国家患者登记系统的相关数据。通过多变量Cox回归分析对混杂因素进行校正。结果研究结果表明,患者AL发生率为6.4%,术后120天内死亡744例。其余的8589例患者中,局部复发861例(10.0%),但与AL无关(校正风险比HR=0.78;95%CI:0.55~1.12;P=0.184)。远处转移1281例(14.9%),且AL患者远处转移发生率更高(校正HR=1.42,95%CI:1.13~1.178;P=0.003)。AL也与患者长期死亡率呈正相关(校正HR=1.20,95%CI:1.01~1.44;P=0.042)。在2841例III期患者中,AL与施行辅助化疗的可能性降低(校正HR=0.58,95%CI:0.45~0.74;P<0.001)以及初始治疗延迟显著相关(校16天,95%CI:12~20天;P<0.001)。结论结肠癌术后吻合口瘘显著增加远处转移发生率及长期全因死亡率。该结果或在部分程度上与取消或延迟辅助化疗相关。 | Krarup PM Nordholm-Carstensen A orgensen LN 张信华 | 2014 | 消化肿瘤杂志(电子版)2014，0，1： | 7 |
| 6 | Reduction of atherosclerosis in cholesterol-fed rabbits and decrease of expressions of intracellular adhesion molecule-1 and vascular endothelial growth factor in foam cells by a water-soluble fraction of Polygonum multiflorum显示文摘 | Yang PY Almofti MR Lu L Kang H Zhang J Li TJ Rui YC Sun LN Chen WS | 2006 | 第二军医大学学报2006，27，6： | 7 |
| 7 | The promoter analysis of the human C17orf25 gene, a novel chromosome 17pl3.3 gene显示文摘The human C17orf25 gene (Accession No. AF177342) is one of thirteen genes cloned from a region displaying a high score of loss of heterozygosity within chromosome 17p13.3 in human hepatocellular car-cinoma in China[l]. To unveil the underlying mechanisms for the transcription regulation of this gene and understand its implication to the hepatocellular carcinogenesis, we looked into the relevant aspects by both bioinformatic and experimental executions. We found: 1, The abundant expression of the C17orf25 gene was evident in all the cell lines and tissue samples tested, showing little hepatoma-selectivity; 2, Its tran-scription starts at a single site, locating at -60 from the translation initiation codon; 3, A 58 bp fragment containing the transcription start, extending from -112 to -55, represents the minimal promoter; 4, The consensus sequence within this fragment recognized by SP1 contributes predominantly to the activity of the minimal promoter; 5, The bioinformatic analysis suggests that the C17ort25 gene may encode a protein in the family of the glyoxalase. Our data has provided some deep insight into both function and regulation of the C17orf25 gene in the context of the normal liver and hepatocellular carcinoma. | JIAN YING GUO, JIAN XU, DA QIN MAO, LI LI FU, JIAN REN GU, JING DE ZHUThe State-Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ln 2200/25, Xie-Tu Road, Shanghai 200032, China | 2002 | Cell Research2002，12，5： | 7 |
| 8 | 猪霉菌毒素中毒的新概念显示文摘霉菌毒素是真菌的次级代谢产物,可以降低畜禽生产性能和改变新陈代谢(wannemacher等,1991)。动物采食被霉菌毒素污染的饲料而引发的病理状态称为霉菌毒素中毒。猪霉菌毒素中毒会对养猪生产造成严重的不良影响。本文综述了各种霉菌毒素对猪生长性能、繁殖性能和免疫功能的影响,各种霉菌毒素间的协同作用以及猪霉菌毒素中毒的最新研究成果。 | Trevor K Smith Gabriel Diaz Swamy H V LN 苗朝华(摘译) | 2007 | 养猪2007，，5： | 6 |
| 9 | 噪声条件下听力测试的应用显示文摘 | Wong LN Chan CY Soli SD | 2009 | 听力学及言语疾病杂志2009，17，4： | 5 |
| 10 | Neural Respiratory Drive Measured Using Surface Electromyography of Diaphragm as a Physiological Biomarker to Predict Hospitalization of Acute Exacerbation of Chronic Obstructive Pulmonary Disease Patients显示文摘Background: Neural respiratory drive (NRD) using diaphragm electromyography through an invasive transesophageal multi?electrode catheter can be used as a feasible clinical physiological parameter in patients with chronic obstructive pulmonary disease (COPD) to provide useful information on the treatment response. However, it remains unknown whether the surface diaphragm electromyogram (EMGdi) could be used to identify the deterioration of clinical symptoms and to predict the necessity of hospitalization in acute exacerbation of COPD (AECOPD) patients. Methods: COPD patients visiting the outpatient department due to acute exacerbation were enrolled in this study. All patients who were subjected to EMGdi and classical parameters such as spirometry parameters, arterial blood gas analysis, COPD assessment test (CAT) score, and the modified early warning score (MEWS) in outpatient department, would be treated effectively in the outpatient or inpatient settings according to the Global Initiative for Chronic Obstructive Lung Disease guideline. When the acute exacerbation of the patients was managed, all the examination above would be repeated. Results: We compared the relationships of admission?to?discharge changes (Δ) in the normalized value of the EMGdi, including the change of the percentage of maximal EMGdi (ΔEMGdi%max) and the change of the ratio of minute ventilation to the percentage of maximal EMGdi (ΔVE/EMGdi%max) with the changes of classical parameters. There was a significant positive association between ΔEMGdi%max and ΔCAT,ΔPaCO2, and ΔpH. The change (Δ) of EMGdi%max was negatively correlated with ΔPaO2/FiO2 in the course of the treatment of AECOPD. Compared with the classical parameters including forced expiratory volume in 1 s, MEWS, PaO2/FiO2, the EMGdi%max (odds ratio 1.143, 95% confidence interval 1.004–1.300) has a higher sensitivity when detecting the early exacerbation and enables to predict the admission of hospital in the whole cohort. Conclusions: The changes of surface EMGdi parameters had a direct correlation with classical measures in the whole cohort of AECOPD. The measurement of NRD by surface EMGdi represents a practical physiological biomarker, which may be helpful in detecting patients who should be hospitalized timely. | Dan-Dan Zhang Gan Ln Xaan-Feng Zhu Ling-Ling Zhang Jia Gao Li-Cheng Shi Jian-Hua Gu Jian-Nan Liu | 2018 | Chinese Medical Journal2018，，23： | 5 |
| 11 | 结肠癌术后吻合口瘘与患者不良结局有关显示文摘结肠癌术后吻合口瘘是否可增加病情复发风险,目前尚无翔实证据。哥本哈根大学Peter-Martin Krarup博士等人进行了一项研究,该研究对象为经结肠癌根治性切除手术治疗后存活120天的结肠癌患者,目的为考查结肠癌术后吻合口瘘对患者病情复发与长期死亡的影响。这项研究结果发表于2013年9月16日在线出版的《外科学年鉴》( Annals of Surgery )杂志上。 这是一项对登记于丹麦结直肠癌研究组数据库中的9333例患者进行的前瞻性研究。研究结果表明,患者结肠癌术后吻合口瘘发生率为6.4%,有744例患者于120天内死亡。在其余的8589例患者中,有861例(10.0%)出现局部复发,但与结肠癌术后吻合口瘘无关。1281例(14.9%)患者出现远端复发,远端复发常发生于结肠癌术后吻合口瘘后。结肠癌术后吻合口瘘也与患者远期死亡率有关。在2841例III期患者中,结肠癌术后吻合口瘘与辅助化疗可能性增加和初始治疗延迟有关。 | Krarup PM Nordholm-Carstensen A Jorgensen LN | 2013 | 中华结直肠疾病电子杂志2013，2，4： | 4 |
| 12 | Interleukin-10 gene polymorphisms and hepatocellular carcinoma susceptibility:A meta-analysis显示文摘AIM: To assess the association between Interleu-kin-10 (IL-10) gene IL-10-1082 (G/A), IL-10-592(C/A), IL-10-819 (T/C) polymorphisms and hepatocellular carcinoma (HCC) susceptibility.METHODS: Two investigators independently searched the Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine Database. Summary odds ratios (ORs) and 95% conf idence intervals (95% CIs) for IL-10 polymorphisms and HCC were cal-culated in a fixed-effects model (the Mantel-Haenszel method) and a random-effects model (the DerSimonian and Laird method) when appropriate. RESULTS: This meta analysis included seven eligiblestudies, which included 1012 HCC cases and 2308 controls. Overall, IL-10-1082 G/A polymorphism was not associated with the risk of HCC (AA vs AG + GG, OR = 1.11, 95% CI = 0.90-1.37). When stratifying for ethnicity, the results were similar (Asian, OR = 1.12, 95% CI = 0.87-1.44; non-Asian, OR = 1.10, 95% CI = 0.75-1.60). In the overall analysis, the IL-10 polymorphism at position -592 (C/A) was identified as a genetic risk factor for HCC among Asians; patients carrying the IL-10-592*C allele had an increased risk of HCC (OR = 1.29, 95% CI = 1.12-1.49). No association was observed between the IL-10-819 T/C polymorphism and HCC susceptibility (TT vs TC + CC, OR = 1.02, 95% CI = 0.79-1.32).CONCLUSION: This meta-analysis suggests that IL-10-592 A/C polymorphism may be associated with HCC among Asians. IL-10-1082 G/A and IL-10-819 T/C polymorphisms were not detected to be related to the risk for HCC. | Yong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin YangYong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin Yang, Department of Liver and Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Prov- ince, China Author contributions: Wei YG and Liu F designed the study, collected and analyzed the data and wrote the manuscript Li B collected and analyzed the data and wrote the manuscript Chen X and Ma Y collected and analyzed the data Yan LN analyzed the data and contributed to the discussion Wen TF and Xu MQ revised the manuscript Wang WT and Yang JY contributed to the discussion Wei YG and Liu F contributed equally to this work. | 2011 | World Journal of Gastroenterology2011，17，34： | 3 |
| 13 | 抗生素作为严重急性营养不良治疗的一部分显示文摘背景:严重急性营养不良每年导致100万儿童死亡。营养治疗中常规加入抗生素可能提高社区中治疗的严重急性营养不良儿童的恢复率,并降低死亡率。 | Trehan I Goldbach HS LaGrone LN 柏振江 汪健 | 2013 | 中华实用儿科临床杂志2013，28，11： | 3 |
| 14 | SALVIAFLASIDE AND SALVIAFLASIDE METHYL ESTER TWO NEW DEPSIDIC GLYCOSIDES FROM SALVIA FLAVA显示文摘SALVIAFLASIDEANDSALVIAFLASIDEMETHYLESTERTWONEWDEPSIDICGLYCOSIDESFROMSALVIAFLAVA￥LiMinAHAO;WenYiHE;XiaoTianLIANGandLianNiangLI... | Zhao, LM He, WY Liang, XT Li, LN | 1996 | Chinese Chemical Letters1996，7，5： | 3 |
| 15 | Cultivation-dependent and cultivation-independent characterization of the microbial community in acid mine drainage associated with acidic Pb/ Zn mine tailings at Lechang, Guangdong, China显示文摘 | Tan GL Shu WS Hallberg KB Li F Lan CY Huang LN | 2007 | 中国生物学文摘2007，21，7： | 3 |
| 16 | Prokaryotic osmoregulation: genetics and physiology显示文摘 | Csonka LN Hanson AD | 1991 | Annu Rev Microbiol1991，45，： | 2 |
| 17 | Hepatic adenylate energy charge levels in patients with hepatoma after hepatic artery embolization显示文摘HepaticadenylateenergychargelevelsinpatientswithhepatomaafterhepaticarteryembolizationLILi1,YANLuNan1,CHENXiaoLi1,LUWuShe... | Li, L Yan, LN Chen, XL Lu, WS Xie, XD Wu, YT | 1998 | World Journal of Gastroenterology1998，4，2： | 2 |
| 18 | 心肺复苏指导对模拟儿童心脏骤停期间胸部按压中断的影响显示文摘目的确定心肺复苏(cardiopulmonaryresuscitation,CPR)指导者对模拟儿科心脏骤停期间按压停顿频率和持续时间的影响。设计本研究为一项前瞻性多中心研究视频数据的二次分析。共计40个历时18min的模拟儿科心脏骤停场景(20个无指导者团队和20个有指导者团队)。由3名临床专家进行审查,以记录每次胸外按压暂停前后发生的事件。场所加拿大和美国的4家儿科学术医疗中心。对象200名医疗服务提供者组成每组5人的跨专业复苏团队,其中包括1名CPR指导者或1名不具备CRP指导资格的临床医疗工作者。干预措施团队随机包括1名CPR指导者或额外1名不具备CRP指导资格的临床医疗工作者。测量方法与主要结果根据结果变量的分布和类型来记录每次胸部按压中断的频率、持续时间和相关因素,采用t检验、Wilcoxon秩和检验或卡方检验进行组间比较。采用混合效应线性模型探讨CPR指导对按压暂停持续时间的影响,并考虑到团队内暂停持续时间的多重测量。共确定655次暂停(非指导组n=304,指导组n=351)。与非指导组相比,接受心肺复苏指导组的总平均暂停时间(98.6比120.85 s,P=0.04)和插管暂停时间(中位4.0比15.5 s,P=0.002)降低,平均暂停频率(17.6比15.2 s,P=0.33)接近。有心肺复苏指导者的团队更有可能用语言表达暂停需求(86.5%比73.7%,P<0.001),以及协调按压者更换,心律检查和脉搏检查(31.7%比23.2%,P=0.05)。校正暂停数量及暂停期间执行任务类型后,有CPR指导者的团队按压暂停时间较短。结论与没有CPR指导者的团队相比,纳入训练有素的CPR指导者可优化暂停前语言指示,缩短暂停时间,缩短插管期间暂停时间,并更好的协调胸外按压暂停期间的关键任务。 | 方伯梁(译) 钱素云(校) Kessler DO Grabinski Z Shepard LN | 2021 | 中国小儿急救医学2021，28，10： | 2 |
| 19 | Functions and applications of polypyridyl complexes in DNA显示文摘The syntheses and desymmetration of a series of novel polypyridyl ligands as well as their complexes, and their DNA-binding properties are reported in this review. The stresses are focused on the functions and potential applications of such complexes as DNA structural probe, DNA molecular light switches, anti-cancer drugs, and photoactivated cleavage agents. | Ji, LN Zhang, QL Chao, H | 2001 | Chinese Science Bulletin2001，46，16： | 2 |
| 20 | Cranial base approaches to intracr-anialaneurysms in the subarachno-id space 显示文摘 | Sekhar LN Kalia KK Yonas H | 1994 | Neurosurgery1994，35，3： | 2 |
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