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| 1 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 2 | Bone marrow transplantation from partially HLA-mismatched family donors for acute leukemia;ingle-center experience of 201 patients显示文摘 | Mehta J Singhal S Gee AP | 2004 | Bone Marrow Transplantation2004，33，4： | 1 |
| 3 | Comparing serology,antigenemia as-say and polymerase chain reaction for the diagnosis of cytomegalovirus in-fection in renal transplant patients显示文摘 | Bhatia J Shan BV Mehta AP | 2004 | J Assoc Physicians India2004，52，2： | 1 |
| 4 | Lanparing serology ia assay and polymerase chain reaction for the diagnosis of cytomegalovirus infection in renal transplant patients显示文摘 | Bhatia J Shah BV Mehta AP | 2004 | J Assoc Physicians India2004，4，5： | 1 |
| 5 | Evaluation of a new phage amplification technology for rapid diagnosis of tuberculosis显示文摘 | Shenai S Rodrigucs C Mehta AP | 2002 | Indian J Med Microbial2002，20，4： | 1 |
| 6 | Inhibition of sulfathiazole crystal growth by polyvinylpyrrolidone显示文摘 | Mehta SC Higuchi WI | 1970 | J Pharm Sci1970，59，5： | 1 |
| 7 | Comparing serology,antigen- emia assay and polymerase chain reaction for the diagnosis of cy- tomegalovirus infection in renal transplant patients 显示文摘 | Bhatia J Shah B Mehta AP | 2004 | JAPI2004，52，： | 1 |
| 8 | Comparing serology, antigenemia assay and polymerase chain reaction for the diagnosis of cytomegalovirus infection in renal transplant patients显示文摘 | Bhatia J Shan BV Mehta AP | 2004 | J Assoe Physicians India2004，4，5： | 1 |
| 9 | Evaluation of a new phage amplification technology for rapid diagnosis of tuberculosis显示文摘 | Shenai S Rodrigues C Mehta AP | 2002 | Indian J Med Microbiol2002，20，4： | 1 |
| 10 | Bone marrow transplantation from partially HLA-mismatched family donors for acute leukemia: single-center experience of 201 patients显示文摘 | Mehta J Sing hal S Gee AP | 2007 | Bone Marrow Transplant2007，37，8： | 1 |
| 11 | Clinical study of location and reproducibility of three mandibular positions in relation to body pos- ture and muscle function显示文摘 | Tripodakis AP Smulow JB Mehta NR | 1995 | Prosthet Dent1995，73，2： | 1 |
| 12 | Coinfection with leprosy and tuberculosis in a renal transplant recipi- ent显示文摘 | Agarwal DK Mehta AR Sharma AP | 2000 | Nephrol Dial Transplant2000，15，10： | 1 |
| 13 | The effect of intraperitoneal lo- cal anesthesia in laparoscopic cholecystectomy: A systematic re- view and meta - analysis 显示文摘 | Boddy AP Mehta S Rhodes M | 2006 | Anesth Analg2006，103，3： | 1 |
| 14 | Clinical study of location and reproducibility of three mandibular positions in relation to body posture and muscle function显示文摘 | Smulow JB Mehta NA | 1995 | J Prosthet Dent1995，73，： | 1 |
| 15 | Comparing serology,antigenemia assay and polymerase chain reaction for the diagnosis of cytomegalovirus infection in renal transplant patients显示文摘 | Bhatia J Shah BV Mehta AP | | 0，，： | 1 |
| 16 | Bone marrow transplantation from partially HIA-mismatehed family donomrs for acute leukemia:single-center experience of 201 patients显示文摘 | Mehta J Singhal S Gee AP | 2007 | Bone Marrow Transplant2007，37，8： | 1 |
| 17 | Comparing serology,antigenemia assay and polymerase chain reaction for thediagnosis of cytomegalovirus infection in renal transplant patients显示文摘 | Bhatia J Shah B Mehta AP | 2004 | JAPI2004，52，： | 1 |
| 18 | DNA damage-induced inhibition of securin expression is mediated by p53 显示文摘 | Zhou Y Mehta KR Choi AP | 2003 | Biol Chem2003，278，1： | 1 |
| 19 | Clinical study of location and reproducibility of three mandibular positions in relation to body posture and muscle function显示文摘 | Tripodakis AP Smulow JB Mehta NR | 1995 | J Prosthet Dent1995，73，2： | 1 |
| 20 | Comparing serology,antigenemia assay and polymerase chain reaction for the diagnosis of cytomegalovirus infection in renal transplant patients 显示文摘 | Bhatia J Shan BV Mehta AP | 2004 | J Assoc Physicians India2004，4，5： | 1 |
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