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| 1 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 2 | Phosphodiester- ase-5 inhibition augments endogenous antitumor immunity by reducing myeloid- derived suppressor cell function 显示文摘 | SERAFIN! P MECKEL K KELSO M | 2006 | J Exp Med2006，203，： | 1 |
| 3 | The persistent trigeminal ar- tery:development,imaging anatomy,variants,and associated vascular pathologies显示文摘 | Meckel S Spittau B McAuliffe W | 2013 | Neuroradiology2013，55，1： | 1 |
| 4 | Endovascular treatment of complex aneurysms at the vertebrobasilar junction with flow- diverting stents : initial experience 显示文摘 | Meckel S McAuliffe W Fiorella D | 2013 | Neurosurgery2013，73，： | 1 |
| 5 | Single-molecule detection and tracking in plants显示文摘 | Langhans M Meckel T | 2014 | Protoplasma2014，，： | 1 |
| 6 | Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function显示文摘 | Serafini P Meckel K Kelso M | 2006 | J Exp Med2006，203，12： | 1 |
| 7 | Endovascular treatment of complex aneurysms at the vertebrobasilar junction with flow-diverting stents: initial experience显示文摘 | MeckelS McAuliffeW FiorellaD | 2013 | Neurosurgery2013，73，3： | 1 |
| 8 | Cerebral venous thrombosis: diagnostic accuracy of combined, dynamic and static, contrast-enhanced 413 MR venography 显示文摘 | Meckel S Reisinger C Bremerich J | 2010 | AJNR Am J Neuroradiol2010，31，3： | 1 |
| 9 | Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function显示文摘 | Serafini P Meckel K Kelso M | | 0，，12： | 1 |
| 10 | The persistent trigeminal artery : development, imaging anatomy, variants, and associated vascular pathologies显示文摘 | Meckel S Spittau B Mc Auliffe W | 2013 | Neuroradiology2013，55，： | 1 |
| 11 | Endovascular treatment us- ing predominantly stent-assisted coil embolization and antiplatelet and anticoagulation management of ruptured blood blister - like a- neurysms显示文摘 | Meckel S Singh T P Undreen P | 2011 | AJNR Am J Neuroradiol2011，32，4： | 1 |
| 12 | Relationship Among Repeated Sprint Tests, Aerobic Fitness, and Anaerobic Fitness in Elite Adolescent Soccer Players 显示文摘 | Y Meckel O Machnai A Eliakim | 2009 | J of Strength and Cond Res2009，23，1： | 1 |
| 13 | Something in the water: contaminated drinking water and infant health 显示文摘 | CURRIE J GRAFF Z J MECKEL K | 2013 | Canadian Journal of Economics/Revue Canadienne D''rconomique2013，46，3： | 1 |
| 14 | Cerebral venous thrombosis:diagnostic accuracy of combined,dynamic and static,contrast-enhanced 4D MR venography显示文摘 | Meckel S Reisinger C Bremerich J | 2010 | Am J Neuroradiol2010，31，3： | 1 |
| 15 | Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function 显示文摘 | Serafini P Meckel K Kelso M | 2006 | J Exp Med2006，203，12： | 1 |
| 16 | Cerebral venous thrombosis: diagnostic accuracy of combined, dynamic and static,contrast-enhanced 4D MR venography显示文摘 | Meckel S Reisinger C Bremerich J | 2010 | AJNR Am J Neuroradiol2010，31，3： | 1 |
| 17 | Intracranial artery velocity measurement using 4D PC MRI at 3T: comparison with transcra- nial ultrasound techniques and 2D PC MRI 显示文摘 | Meckel S Leitner L Bonati LH | 2012 | Neuroradiology2012，，： | 1 |
| 18 | Tumor suppressors miR-143 and miR-145 and predicted target proteins AP/5,ERK5, K-RAS,and IRS-1 are differentially expr-essed in proximal and distal colon 显示文摘 | Pekow J Meckel K Dougherty U | 2015 | Am J Physiol Gastrointest Liver Physiol2015，308，3： | 1 |
| 19 | Cerebral venousthrombosis: diagnostic accuracy of combined, dynamic and static, contrast-enhanced 4D MR venography 显示文摘 | Meckel S Reisinger C Bremerich J | 2010 | AJNR Am J Neuroradiol2010，31，3： | 1 |
| 20 | Tumor suppressors miR- 143 and miR-145 and predicted target proteins APIS, ERKS, K- RAS, and IRS-1 are differentially expressed in proximal and distal colon 显示文摘 | Pekow J Meckel K Dougherty U | 2015 | Am Physiol-Gastr L2015，308，3： | 1 |
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