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| 1 | 异位妊娠显示文摘 | McCarthy A(主编) Hunter B(主编) 顾婷婷(译) 梁旭东(校) | 2006 | 中国妇产科临床杂志2006，7，1： | 14 |
| 2 | Metformin revisited: Does this regulator of AMP-activated protein kinase secondarily affect bone metabolism and prevent diabetic osteopathy?显示文摘Patients with long-term type 1 and type 2 diabetes mellitus(DM) can develop skeletal complications or 'diabetic osteopathy'. These include osteopenia, osteoporosis and an increased incidence of low-stress fractures. In this context, it is important to evaluate whether current anti-diabetic treatments can secondarily affect bone metabolism. Adenosine monophosphateactivated protein kinase(AMPK) modulates multiple metabolic pathways and acts as a sensor of the cellular energy status; recent evidence suggests a critical role for AMPK in bone homeostasis. In addition, AMPK activation is believed to mediate most clinical effects of the insulin-sensitizer metformin. Over the past decade, several research groups have investigated the effects of metformin on bone, providing a considerable body of pre-clinical(in vitro, ex vivo and in vivo) as well as clinical evidence for an anabolic action of metformin on bone. However, two caveats should be kept in mind when considering metformin treatment for a patient with type 2 DM at risk for diabetic osteopathy. In the first place, metformin should probably not be considered an antiosteoporotic drug; it is an insulin sensitizer with proven macrovascular benefits that can secondarily improve bone metabolism in the context of DM. Secondly, we are still awaiting the results of randomized placebo-controlled studies in humans that evaluate the effects of metformin on bone metabolism as a primary endpoint. | Antonio Desmond McCarthy Ana María Cortizo Claudia Sedlinsky | 2016 | World Journal of Diabetes2016，7，6： | 9 |
| 3 | Estrogen prevents glucocorticoid-induced apoptosis in osteoblasts in vivo and in vitro显示文摘 | Gohel A McCarthy MB Gronowicz G | 1999 | Endocrinology1999，140，： | 2 |
| 4 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 5 | Quantitative assessment of factors affects the recovery of indigenous and released thermophilic bacteria from compost 显示文摘 | AMNER W MCCARTHY A J EDWARDS C | 1988 | Applied Environmentd Microbiology1988，54，12： | 1 |
| 6 | Enzymatic Degradability of Poly(lactide) :Effects of chain stereochemistry and material crystallinity 显示文摘 | REEVE M MCCARTHY S P GROSS R A | 1996 | Macromolecules1996，29，23： | 1 |
| 7 | Who wants a caesarean section? A study of women's personal experience of vaginal and caesarean delivery显示文摘 | Al-Mufti R McCarthy A Fisk NM | 2003 | J Obstet Gynaecol2003，23，4： | 1 |
| 8 | A cost, profit, and efficiency analysis of performing carpal tunnel surgery in the operating room versus the clinic setting in the United States显示文摘 | Chatterjee A McCarthy J E Montagne S A | 2011 | Ann Plast Surg2011，66，3： | 1 |
| 9 | Role of the Q-tip test in evaluating stress urinary incontinence显示文摘 | Bergman A McCarthy TA Ballard CA | | 0，，： | 1 |
| 10 | Preliminary Views on the Potential of Foamed Concrete as a Structural Material显示文摘 | Jones M R McCarthy A | 2005 | Magazine of Con crete Research2005，57，1： | 1 |
| 11 | Mdeling of Bird Strike on an Aircraft wing Leading Edge Made from Fiber Metal Laminates Partl : Material Modeling 显示文摘 | McCarthy M A Xiao J R Petrinic C T | 2004 | Aplied Com- posite Materials2004，11，5： | 1 |
| 12 | Activation of human prefrontal cortex during spatial and nonspatial working memory tasks measured by functional MRI显示文摘 | McCarthy G Puce A Constable R T | 1996 | Cereb Cortex1996，6，： | 1 |
| 13 | 1 l-Ketotigogenin cellobioside (pamaqueside): a potent cholesterol absorption inhibitor in the hamster显示文摘 | McCarthy P A DeNinno M P Morehouse L A | 1996 | J Med Chem1996，39，10： | 1 |
| 14 | Redefining the stormwater first flush phenomenon 显示文摘 | BACH P M MCCARTHY D T DELETIC A | 2010 | Water Research2010，44，8： | 1 |
| 15 | Estrogenicity of pyrethroid insecticide metabolites显示文摘 | MCCARTHY A R THOMSON B M SHAW I C | 2006 | Journal of Environmental Monitoring2006，8，： | 1 |
| 16 | Clifford Algebra Expo- nentials and Planar Linkage Synthesis Equations 显示文摘 | Perez A McCarthy J M | | Journal of Mechanical Design0，127，5： | 1 |
| 17 | Using the Precede - proceed model of health program planning in breast cancer nursing re- search显示文摘 | Tramm R McCarthy A Yates P | 2012 | J Adv Nuts2012，68，8： | 1 |
| 18 | 显示文摘 | MARSHALL D J RUDNICK K A MCCARTHY S G | 2006 | Vaccine2006，24，3： | 1 |
| 19 | Inter-leukin-18 enhances Th1 immunity and tumor protec-tion of a DNA vaccine显示文摘 | Rudnick K A McCarthy S G | 2006 | Vaccine2006，24，： | 1 |
| 20 | Nutrient data on chestnuts consumed in the United States显示文摘 | McCARTHY M A MEREDITH F I | 1988 | Economic Botany1988，42，1： | 1 |
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