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| 1 | The significance of clinical practice guidelines on adult varicocele detection and management显示文摘精索静脉曲张是男因素不孕的最普通的可改正的病原学。然而,精索静脉曲张的察觉和管理没被标准化。这在男不孕上关于精索静脉曲张的效果导致了争论的十年,随后,是否修理,导致改进富饶地位。调查精索静脉曲张和 varicocelectomy 的角色的证据的当前的身体弱、冲突。AUA 和 ASRM 拿的位置建议有不够的结果数据支持基于证据的指南,引用过去常提供建议通常具有低优秀水平的电流的证据。在另一方面, EAU 指南为临床上摸得出的精索静脉曲张的管理给水平证据的 1a,与低于正常的精液分析和有的不同 unexplained 富饶联系了。除与临床的精索静脉曲张察觉和管理帮助以外,临床的实践意见陈述和指南试图指导并且加强未来研究的基础结构。我们在实践与他们的申请的焦点在精索静脉曲张和管理察觉考察意见陈述和指南的当前的地位。 | Anand Shridharani Ryan C Owen Osama O Elkelany Edward D Kim | 2016 | Asian Journal of Andrology2016，18，2： | 11 |
| 2 | 毛细管电泳法分析蜂花粉中黄酮类化合物(英文)显示文摘使用毛细管电泳法(CE)检测了健康食品中常见的六种黄酮类化合物:橙皮甙、海棠甙、异鼠李素、山奈酚、槲皮素、芦丁。研究了一系列的试验参数,如:pH、缓冲溶液浓度、分离电压以及UV检测器波长等,以确定出最佳条件。使用H3BO3-Na2B4O7缓冲液(pH9.2),各分析物可在8min内分出。相对标准偏差(RSD):8次进样的迁移时间为0.77%~0.93%;峰面积为3.8%~8.6%;各检测限(S/N=3)范围为0.34μg/ml~2.9μg/ml,回收率为80.4%~113.9%。方法简单、灵敏,重现性高,线性好,无须固相萃取前处理,用于蜂花粉分析结果准确。 | 卢挺 Edward P C Lai Jorn C C Yu 胡风祖 | 2006 | 食品科学2006，27，12： | 9 |
| 3 | Murine lung eosinophil activation and chemokine production in allergic airway inflammation显示文摘Eosinophils play important roles in asthma and lung infections.Murine models are widely used for assessing the functional significance and mechanistic basis for eosinophil involvements in these diseases.However,little is known about tissue eosinophils in homeostasis.In addition,little data on eosinophil chemokine production during allergic airway inflammation are available.In this study,the properties and functions of homeostatic and activated eosinophils were compared.Eosinophils from normal tissues expressed costimulation and adhesion molecules B7-1,B7-2 and ICAM-1 for Ag presentation but little major histocompatibility complex(MHC)class II,and were found to be poor stimulators of T-cell proliferation.However,these eosinophils expressed high levels of chemokine mRNA including C10,macrophage inflammatory protein(MIP)-1a,MIP-1c,MIP-2,eotaxin and monocyte chemoattractant protein-5(MCP-5),and produced chemokine proteins.Eosinophil intracellular chemokines decreased rapidly with concomitant surface marker downregulation upon in vitro culturing consistent with piecemeal degranulation.Lung eosinophils from mice with induced allergic airway inflammation exhibited increased chemokines mRNA expression and chemokines protein production and upregulated MHC class II and CD11c expression.They were also found to be the predominant producers of the CCR1 ligands CCL6/C10 and CCL9/MIP-1c in inflamed lungs.Eosinophil production of C10 and MIP-1c correlated with the marked influx of CD11bhigh lung dendritic cells during allergic airway inflammation and the high expression of CCR1 on these dendritic cells(DCs).The study provided baseline information on tissue eosinophils,documented the upregulation of activation markers and chemokine production in activated eosinophils,and indicated that eosinophils were a key chemokine-producing cell type in allergic lung inflammation. | C Edward Rose Jr Joanne A Lannigan Paul Kim James J Lee Shu Man Fu Sun-sang J Sung | 2010 | Cellular & Molecular Immunology2010，7，5： | 6 |
| 4 | Through-needle all-optical ultrasound imaging in vivo: a preclinical swine study显示文摘High-frequency ultrasound imaging can provide exquisite visualizations of tissue to guide minimally invasive procedures.Here,we demonstrate that an all-optical ultrasound transducer,through which light guided by optical fibers is used to generate and receive ultrasound,is suitable for real-time invasive medical imaging in vivo.Broad-bandwidth ultrasound generation was achieved through the photoacoustic excitation of a multiwalled carbon nanotube-polydimethylsiloxane composite coating on the distal end of a 300-μm multi-mode optical fiber by a pulsed laser.The interrogation of a high-finesse Fabry–Pérot cavity on a single-mode optical fiber by a wavelength-tunable continuous-wave laser was applied for ultrasound reception.This transducer was integrated within a custom inner transseptal needle(diameter 1.08 mm;length 78 cm)that included a metallic septum to acoustically isolate the two optical fibers.The use of this needle within the beating heart of a pig provided unprecedented realtime views(50 Hz scan rate)of cardiac tissue(depth:2.5 cm;axial resolution:64μm)and revealed the critical anatomical structures required to safely perform a transseptal crossing:the right and left atrial walls,the right atrial appendage,and the limbus fossae ovalis.This new paradigm will allow ultrasound imaging to be integrated into a broad range of minimally invasive devices in different clinical contexts. | Malcolm C Finlay Charles A Mosse Richard J Colchester Sacha Noimark Edward Z Zhang Sebastien Ourselin Paul C Beard Richard J Schilling Ivan P Parkin Ioannis Papakonstantinou Adrien E Desjardins | 2017 | Light(Science & Applications)2017，6，1： | 6 |
| 5 | Fatty liver in hepatitis C patients post-sustained virological response with direct-acting antivirals显示文摘AIM To determine steatosis and fibrosis prevalence in hepatitis C patients after a sustained virological response achieved with direct-acting antivirals.METHODS Transient elastography with controlled attenuation parameter(CAP) was used to assess hepatic steatosis post-sustained virological response(SVR);the CAP technology was not available in the United States at study initiation.Liver stiffness/fibrosis was measured before and 47 wk after treatment completion.Patients with genotype 3 and patients with cirrhosis were excluded.RESULTS One hundred and one patients were included in the study.Post-SVR there were decreases from baseline in alanine aminotransferase(ALT)(63.1 to 17.8 U/L),aspartate aminotransferase(51.8 to 21.5 U/L) and fibrosis score(7.4 to 6.1 k Pa)(P < 0.05).Post-SVR,48 patients(47.5%) had steatosis on CAP;of these,6.25% had advanced fibrosis.Patients with steatosis had higher body mass index(29.0 vs 26.1 kg/m2),glucose(107.8 vs 96.6 mg/d L),ALT(20.4 vs 15.3 mg/d L),CAP score(296.3 vs 212.4 d B/m) and fibrosis score(7.0 vs 5.3 k Pa);P < 0.05.Interestingly,compared to baseline,both patients with and without steatosis had change in fibrosis score post-SVR(7.7 k Pa vs 7.0 k Pa and 7.0 k Pa vs 5.3 k Pa);alternatively,(P < 0.05) and therefore patients with steatosis continued to have clinically significant stiffness(≥ 7 k Pa).CONCLUSION Fatty liver is very common in hepatitis C virus(HCV) patients post-SVR.These patients continue to have elevated mean fibrosis score(≥ 7 k Pa) compared to those without fatty liver;some have advanced fibrosis.Long term follow up is needed to assess steatosis and fibrosis in HCV patients post-SVR. | Mazen Noureddin Micaela M Wong Tsuyoshi Todo Shelly C Lu Arun J Sanyal Edward A Mena | 2018 | World Journal of Gastroenterology2018，24，11： | 6 |
| 6 | Clinical update for the diagnosis and treatment of Clostridium difficile infection显示文摘Clostridium difficile infection(CDI)presents a rapidly evolving challenge in the battle against hospitalacquired infections.Recent advances in CDI diagnosis and management include rapid changes in diagnostic approach with the introduction of newer tests,such as detection of glutamate dehydrogenase in stool and polymerase chain reaction to detect the gene for toxin production,which will soon revolutionize the diagnostic approach to CDI.New medications and multiple medical society guidelines have introduced changing concepts in the definitions of severity of CDI and the choice of therapeutic agents,while rapid expansion of data on the efficacy of fecal microbiota transplantation heralds a revolutionary change in the management of patients suffering multiple relapses of CDI.Through a comprehensive review of current medical literature,this article aims to offer an intensive review of the current state of CDI diagnosis,discuss the strengths and limitations of available laboratory tests,compare both current and future treatments options and offer recommendations for best practice strategies. | Edward C Oldfield Ⅳ Edward C Oldfield Ⅲ David A Johnson | 2014 | World Journal of Gastrointestinal Pharmacology and Therapeutics2014，5，1： | 6 |
| 7 | Approach to medical therapy in perianal Crohn’s disease显示文摘Perianal Crohn’s disease remains a challenging condition to treat and can have a substantial negative impact on quality of life.It often requires combined surgical and medical interventions.Anti-tumor necrosis factor(anti-TNF)therapy,including infliximab and adalimumab,remain preferred medical therapies for perianal Crohn’s disease.Infliximab has been shown to be efficacious in improving fistula closure rates in randomized controlled trials.Clinicians can be faced with a number of questions relating to the optimal use of anti-TNF therapy in perianal Crohn’s disease.Specific issues include evaluation for the presence of perianal sepsis,the treatment target of therapy,the ideal time to commence treatment,whether additional medical therapy should be used in conjunction with anti-TNF therapy,and the duration of treatment.This article will discuss key studies which can assist clinicians in addressing these matters when they are considering or have already commenced anti-TNF therapy for the treatment of perianal Crohn’s disease.It will also discuss current evidence regarding the use of vedolizumab and ustekinumab in patients who are failing to achieve a response to anti-TNF therapy for perianal Crohn’s disease.Lastly,new therapies such as local injection of mesenchymal stem cell therapy will be discussed. | Abhinav Vasudevan David H Bruining Edward V Loftus Jr William Faubion Eric C Ehman Laura Raffals | 2021 | World Journal of Gastroenterology2021，27，25： | 4 |
| 8 | Recurrent ectopic pancreatitis of the jejunum and mesentery over a 30-year period显示文摘BACKGROUND:Ectopic pancreas is defined as pancreatic tissue found outside its usual anatomical position,with no ductal or vascular communication with the native pancreas. We describe a case of ectopic pancreas of the small bowel and mesentery causing recurrent episodes of pancreatitis, initially suspected on computed tomography(CT)and magnetic resonance cholangiopancreatography(MRCP),and confirmed on histological review of the resection. METHODS:A 67-year-old woman presented with clinical symptoms and biochemical evidence of pancreatitis.She had similar episodes over the past 30 years with unrevealing investigations,and was concluded to have idiopathic pancreatitis. She underwent CT and MRCP,with findings suggestive of ectopic pancreas,a diagnosis confirmed on histology of the resection. RESULTS:MRCP identified a mass in the proximal small bowel mesentery isointense to the native pancreas,with a small duct draining into a proximal jejunal loop.The resected specimen consisted of normal parenchyma with lobulated acinar tissue with scattered islets of Langerhans,an occasional ductular structure,and admixed areas of adipose tissue.The patient remained asymptomatic with normal biochemistry six months post-operatively. CONCLUSION:In an individual with abdominal pain,elevated serum amylase/lipase,but imaging findings of a normal native pancreas,ectopic pancreatitis should be considered,and can be evaluated by CT and MRCP. | John CT Wong Charlotte Robinson Edward C Jones Alison Harris Charles Zwirewich Robert Wakefield Richard K Simons Eric M Yoshida | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，2： | 4 |
| 9 | Anti-rods/rings autoantibody generation in hepatitis Cpatients during interferon-α/ribavirin therapy显示文摘Chronic inflammation associated with hepatitis C virus(HCV) infection can lead to disabling liver diseases with progression to liver cirrhosis and hepatocellular carcinoma. Despite the recent availability of more effective and less toxic therapeutic options, in most parts of the world the standard treatment consists of a weekly injection of pegylated interferon α(IFN-α) together with a daily dose of ribavirin. HCV patients frequently present circulating non-organ-specific autoantibodies demonstrating a variety of staining patterns in the indirect immunofluorescence assay for antinuclear antibodies(ANA). Between 20% to 40% of HCV patients treated with IFN-α and ribavirin develop autoantibodies showing a peculiar ANA pattern characterized as rods and rings(RR) structures. The aim of this article is to review the recent reports regarding RR structures and anti-rods/rings(antiRR) autoantibody production by HCV patients after IFN-α/ribavirin treatment. Anti-RR autoantibodies first appear around the sixth month of treatment and reach a plateau around the twelfth month. After treatment completion, anti-RR titers decrease/disappear in half the patients and remain steady in the other half. Some studies have observed a higher frequency of anti-RR antibodies in relapsers, i.e., patients in which circulating virus reappears after initially successful therapy. The main target of anti-RR autoantibodies in HCV patients is inosine-5'-monophosphate dehydrogenase 2(IMPDH2), the rate-limiting enzyme involved in the guanosine triphosphate biosynthesis pathway. Ribavirin is a direct IMPDH2 inhibitor and is able to induce the formation of RR structures in vitro and in vivo. In conclusion, these observations led to the hypothesis that anti-RR autoantibody production is a human model of immunologic tolerance breakdown that allows us to explore the humoral autoimmune response from the beginning of the putative triggering event: exposure to ribavirin and interferon. | Gerson Dierley Keppeke S John Calise Edward KL Chan Luis Eduardo C Andrade | 2016 | World Journal of Gastroenterology2016，22，6： | 4 |
| 10 | 腔内介入治疗血管性勃起功能障碍显示文摘过去一个世纪里,勃起功能障碍(ED)的治疗一直是一件引人关注的事情,涉及到泌尿、心血管以及手术领域的多个学科。随着ED与心血管疾病的相关性被充分证实,血管造影技术已被用来鉴别血管性阳痿。由于腔内血管药物洗脱支架植入术在治疗冠状动脉疾病获得成功,采用该技术来治疗血管性ED已激起了医务人员的浓厚兴趣。最近报道了针对阴茎流入血管狭窄的男性,植入药物洗脱支架绕过病变处动脉已获得了较高的成功率。同样,血管内栓塞治疗静脉闭塞功能障碍也取得了惊人的手术成功率。然而,查阅文献发现动脉介入只推荐应用于治疗年轻的孤立性血管损伤的患者,通常为那些先前经历过创伤的患者。该手术的短期功能恢复没有达到最佳,长期疗效也有待进一步观察。总之,用微创方法治疗勃起功能障碍的希望仍然存在,但是在获得普遍认可之前仍需要进一步的研究。 | Edward D Kim Ryan C Owen Gregory S White Osama O Elkelany Cyrus D Rahnema | 2015 | Asian Journal of Andrology2015，17，1： | 3 |
| 11 | Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis显示文摘 | Rayner Katey J Sheedy Frederick J Esau Christine C Hussain Farah N Temel Ryan E Parathath Saj van Gils Janine M Rayner Alistair J Chang Aaron N Suarez Yajaira Fernandez-Hernando Carlos Fisher Edward A Moore Kathryn J | 2011 | Journal of Clinical Investigation2011，，7： | 2 |
| 12 | 头颈部鳞癌术后中药治疗的评价──临床随机对照设计的应用显示文摘作者通过头颈部鳞癌术后中药治疗的研究实例,阐述了临床随机对照研究的科学设计、实施步骤和统计分析的具体方法。结果发现,kaplan-Meier生存曲线,经单因素Logrank检验,治疗组与对照组无统计学差别(P>0.05)。进一步做Cox模型多因素分析,在平衡了性别年龄、服药时间、病理分级、化疗等因素对生存函数的影响后,则发现对照组的死亡危险比是1.939,95%可信限在1.008~3.729之间,P<0.05;在众多预后因素中服药时间对生存函数的影响最大(P<0.001);提示中药治疗对头颈部鳞癌术后生存具有显著作用,是影响头颈部鳞癌患者术后生存的一项独立的预后因素。 | 曹阳 邱蔚六 陆昌语 林国础 郭一钦 Walter Guralnick William C Wood Chung-cheng Haich Thomas Albert Edward Evers | 1996 | 上海口腔医学1996，5，1： | 2 |
| 13 | p57, structurally distinct member is a candidate tumor suppressor gene 显示文摘 | Matsuoka M Edwards MC Bai C | 1995 | Genes Der1995，9，6： | 2 |
| 14 | An iterative growing and pruning algorithm for classification tree design显示文摘 | Saul B Gelfand C S Ravishankar Edward J Delp | 1991 | IEEE Transaction on Pattern Analysis and Machine Intelligence1991，13，2： | 1 |
| 15 | Nonlinear robust fault reconstruction and estimation using a sliding mode observer显示文摘 | Xing Gang Yan Edwards C | 2007 | Automatica2007，43，： | 1 |
| 16 | A segmentation algorithm for noisy images: design and evaluation显示文摘 | Xu Y Olman V Edward C U | 1998 | Pattern Recognition Letters1998，19，13： | 1 |
| 17 | Technology of Cellulose Esters Pennsylvania 显示文摘 | EDWARD C W | 1921 | Eschenhach Printing Company1921，，： | 1 |
| 18 | Quantitative assessment of factors affects the recovery of indigenous and released thermophilic bacteria from compost 显示文摘 | AMNER W MCCARTHY A J EDWARDS C | 1988 | Applied Environmentd Microbiology1988，54，12： | 1 |
| 19 | Sentinel lymph node biopsy for breast cancer:impact of the number of sentinel nodes removed on the false-negative fate显示文摘 | Edwards MJ Chao C | 2001 | J Am Coll Surg2001，192，6： | 1 |
| 20 | Dose Reconstruction显示文摘 | Lloyd D C Edwards AA Protracted Overexposure to a 137Cs Source:Ⅰ | 1999 | Radiation Protection Dosimetry1999，81，2： | 1 |
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