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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Memberanous bone Lengthening:a serial histological study显示文摘 | Karp NS McCarthy JG Schreiber JS | 1992 | Ann Plast Surg1992，29，： | 1 |
| 3 | Antinociceptive potentiation and attenuation of tolerance byintrathecal co- infusion of magnesium sulfate and morphinein rats显示文摘 | McCarthy RJ Kroin JS Tuman KJ | 1998 | Anesth Analg1998，86，13： | 1 |
| 4 | Membranous bone lengthening: a serial histological study 显示文摘 | Karp NS McCarthy JG Schreiber JS | 1992 | Ann Plast Surg1992，29，1： | 1 |
| 5 | Membraneous bone lengthening: a serial histological study显示文摘 | Karp NS McCarthy JG Schreiber JS | 1992 | Ann Plast Surg1992，29，1： | 1 |
| 6 | Magnesium sul- fate potentiates morphine antinociception at the spinal level 显示文摘 | Kroin JS McCarthy R J Von Roenn N | 2000 | Anesthesia & Analgesia2000，90，4： | 1 |
| 7 | Common in- fections in diabetes: pathogenesis, management and rela- tionship to glycaemic control 显示文摘 | Peleg AY Weerarathna T McCarthy JS | 2007 | Diabetes Metab Res Rev2007，23，1： | 1 |
| 8 | Power Doppler sonography of synovitis: assessment of therapeutic response-preliminary observations显示文摘 | Newman JS Laing TJ McCarthy CJ | 1996 | Radiology1996，，： | 1 |
| 9 | Membranous bone lengthening: a serial histological study显示文摘 | Karp NS McCarthy JG Schreiber JS | 1992 | Ann Plast Surg1992，29，1： | 1 |
| 10 | Vertebral osteomyelitis and discitis associated with Abiotrophia adiaceus (nutritionally va- riant streptococcus) infection显示文摘 | Heath CH Bowen SF McCarthy JS | 1998 | Aust N Z J Med1998，28，5： | 1 |
| 11 | Diagnosis of uterine anomalies:relative accuracy of MR imaging,endovaginal sonography,and hysterosalpingography显示文摘 | Pellerito JS McCarthy SM Doyle MB | 1992 | Radiology1992，183，3： | 1 |
| 12 | Common infections in diabetes:pathogenesis,management and relationship to glycaemic control显示文摘 | Peleg AY Weerarathna T Mccarthy JS | 2007 | Diabetes Metab Res Rev2007，23，1： | 1 |
| 13 | Lengthening the human mandible by gradual distraction显示文摘 | McCarthy JG Sehreiber JS Karp NS | 1992 | Plast Reeonstr Surg1992，89，1： | 1 |
| 14 | Permanent and functional male-to-female sex reversal in d-rR strain medaka (Oryzias latipes)following egg microinjection of o,p'-DDT显示文摘 | McCarthy RA Ramsdell JS | 2000 | Environ Health Perspect2000，108，： | 1 |
| 15 | Intrathecal magnesium prolongs fentanyl analgesia : a prospective, randomized, controlled trial显示文摘 | BUVANENDRAN A McCARTHY RJ KROIN JS | 2002 | Anesth Analg2002，95，3： | 1 |
| 16 | Intrathecal magnesium prolongs fentanyl analgesia: a prospective, randomized, controlled trial显示文摘 | Buvanendran A McCarthy RJ Kroin JS | 2002 | Anesth Analg2002，95，： | 1 |
| 17 | A Phase Ⅱ trial of docetaxel and cisplatin in patients with recurrent or metastaic nasopharyngeal carcinoma显示文摘 | Mccarthy JS Tannock IF Degendorfer P | 2002 | Oral Oncal2002，38，7： | 1 |
| 18 | Modelling the dynamics of Plosmodium falciparum histidine-fich protein 2 in human malaria to better understand malaria rapid diagnostic test performance显示文摘 | Marquart L Butterworth A McCarthy JS | 2012 | Malaria J2012，11，： | 1 |
| 19 | Evaluation of 64Cu-ATSM in vitro and in vivo in a hypoxic tumor model 显示文摘 | Lewis JS McCarthy DW McCarthy TJ | 1999 | J Nucl Med1999，40，： | 1 |
| 20 | Common infections in diabetes: pathogenesis, management and relationship to glycaemic con- trol显示文摘 | Peleg AY Weerarathna T McCarthy JS | 2007 | Diabetes Metab Res Rev2007，23，： | 1 |
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