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| 1 | 重组活化因子Ⅶ在急性颅内出血中的应用 | Mayer S.A. Brun N.C. Begtrup K. 郭俊 | 2005 | 世界核心医学期刊文摘(神经病学分册)2005，0，8： | 32 |
| 2 | 急性胰腺炎的外科治疗显示文摘 | Hans Guenther Beger Bettina Rau Rainer Isenmann Jens Mayer 刘斌 吴在德 | 2001 | 中华外科杂志2001，39，4： | 28 |
| 3 | IGF信号通路关键蛋白IGF1、IGF1R和AKT在原发性肺腺癌中的表达及意义显示文摘目的检测IGF信号通路关键蛋白IGF 1,IGF 1R和AKT在原发性肺腺癌中的表达,探讨其与临床病理学特征和生存时间的关系。方法采用免疫组化方法和免疫印迹技术检测IGF 1,IGF 1R和AKT在31例原发性肺腺癌及12例良性肺病变组织中的表达。结果IGF 1、IGF 1R和AKT在肺腺癌中的表达率分别为41.9%(13/31)、67.7%(21/31)和51.6%(16/31),显著高于良性肺组织(P值分别为0.0252、0.0016和0.0071)。IGF 1和IGF 1R及IGF 1和AKT在肺腺癌中表达呈显著相关(P值分别为0.0344和0.0179)。晚期肺癌(Ⅲ+Ⅳ)IGF 1和IGF 1R表达显著高于早期(Ⅰ+Ⅱ)(P值分别为0.0109和0.0303)。IGF 1、IGF 1R和AKT在伴有淋巴结转移肺癌中的表达显著高于无淋巴结转移肺癌(P值分别为0.0468、0.0490和0.0443)。低分化肺癌中IGF 1和IGF 1R表达显著高于中或高分化肺癌(P值分别为0.0484和0.0291)。IGF 1和IGF 1R阳性患者的生存时间显著短于阴性者(IGF 1:10比14个月,P=0.0103;IGF 1R:13比26个月,P=0.0056)。IGF 1和IGF 1R是肺腺癌预后的影响因素,AKT无预后意义。结论IGF信号通路关键蛋白IGF 1、IGF 1R和AKT表达在肺腺癌的发生和发展中可能起重要作用,进一步的研究有望展示其在肺癌预后和治疗方面的意义。 | 廖永德 周晟 赵金平 袁永辉 黄畦 Doris Mayer | 2006 | 实用肿瘤杂志2006，21，1： | 17 |
| 4 | 新型ERβ在肺腺癌和鳞癌组织中的表达及其与外周血雌二醇水平的相关性研究显示文摘目的研究新型雌激素受体(ER)β在肺腺癌和鳞癌组织中的表达,探讨其与肺癌临床病理学特征、吸烟和外周血雌激素水平的关系。方法采用免疫组织化学和免疫印迹技术检测ERβ在26例肺腺癌和38例肺鳞癌(共有37例含癌旁肺组织)及15例良性肺病变组织中的表达。切片内阳性细胞数≥20%为ERβ阳性。结果ERβ在肺癌组织中的表达主要定位于细胞核,其表达率为48.4%(31/64),而在癌旁肺组织和肺良性病变组织中无明显表达。ERβ在鳞癌、腺癌中阳性表达率分别为28.9%(11/38),76.9%(20/26),腺癌组织中ERβ表达率显著高于鳞癌(P=0.000 2)。吸烟组ERβ阳性表达率(67.6%,25/37)显著高于非吸烟组(22.2%,6/27)(P=0.000 5),ERβ阳性表达组外周血雌二醇水平(nmol/L)显著高于ERβ阴性组(225.7±75.2 vs 159.5±54.8,P=0.000 1)。结论新型ERβ在肺腺癌和鳞癌中过表达。ERβ与肺癌尤其是肺腺癌的发生可能有关联。吸烟可能与ERβ过表达相关联。肺癌组织ERβ过表达与外周血雌二醇水平增高相一致,肺癌可能分泌雌激素。 | 廖永德 赵金平 马伦超 周晟 黄畦 Doris Mayer | 2005 | 华中科技大学学报(医学版)2005，34，5： | 12 |
| 5 | IGF1和IGF2表达与非小细胞肺癌淋巴结转移的相关性显示文摘目的研究胰岛素样生长因子1和2(IGF1、IGF2,合称为IGFs)在非小细胞肺癌(NSCLC)组织中的表达,探讨其与NSCLC区域淋巴结转移的关系。方法采用免疫组织化学和免疫印迹技术检测IGF1和IGF2在65例NSCLC、29例癌旁肺组织和19例良性肺病变组织中的表达。结果IGF1和IGF2在NSCLC中的表达率显著高于良性肺组织。IGF1和IGF2在伴有区域淋巴结转移肺癌中的表达显著高于无淋巴结转移肺癌组织。IGF1和IGF2在伴有N2或≥5个转移淋巴结肺癌组织中的表达显著高于在仅伴有N1或<5个转移淋巴结肺癌组织。IGF2在伴有多组转移淋巴结肺癌组织中的表达显著高于仅有一组转移淋巴结肺癌组织。结论IGFs不仅在NSCLC中过表达,而且与区域淋巴结转移的部位、数量及组数相关联,提示IGFs在NSCLC发生和发展中可能起重要作用,IGFs为NSCLC生物学行为尤其是淋巴结转移的判断提供一个新的有意义的指标。 | 廖永德 赵金平 周晟 付圣灵 万燕青 Mayer Doris | 2006 | 肿瘤防治研究2006，33，12： | 9 |
| 6 | Alimentary tract duplications in newborns and children: Diagnostic aspects and the role of laparoscopic treatment显示文摘Alimentary tract duplications are rare congenital lesions normally diagnosed in newborns and children that can occur anywhere from the mouth to the anus and have a reported incidence of approximately 1 in 4500 life births. Symptoms and clinical presentation vary greatly. The presentation varies according to age and location. The treatment finally is surgical; total resection when possible should be the aim of the intervention. In pediatric surgery minimally invasive surgical procedures became more and more important over the last decades. In consequence the operative procedure on alimentary tract duplications changed in this manner. We review on case reports and clinical reports on minimally invasive surgery in the treatment of alimentary tract duplications, determine the importance of minimally invasive techniques in the treatment of this rare entity and rule out that further studies in the field should be performed. | Jan Patio Mayer Marcos Bettolli | 2014 | World Journal of Gastroenterology2014，20，39： | 7 |
| 7 | 类癌显示文摘 | Kulke MA Mayer RJ | 2000 | 世界医学杂志2000，4，10： | 6 |
| 8 | 血压变异性预测自发性脑出血患者的院内不良预后显示文摘越来越多的证据表明,较高的收缩压变异性(systolicblood pressure variability ,SBPV)可能与脑出血患者的不良预后相关。该研究探讨了 SB PV 与院内脑出血预后之间的关系。研究者在2个医疗系统中收集了10年的自发性脑出血患者的连续数据。记录人口统计学、病史、实验室测试、计算机断层扫描数据、院内治疗情况以及神经和功能评估。在入院后24h内获取血压记录。 | 刘青 叶鹏 Divani AA Liu X Di Napoli M Lattanzi S Ziai W James ML Jafarli A Jafari M Saver JL Hemphill JC Vespa PM Mayer SA Petersen A | 2019 | 中华高血压杂志2019，27，8： | 6 |
| 9 | 胰岛素样生长因子1在非小细胞肺癌中的表达及其预后价值显示文摘目的:研究胰岛素样生长因子1(IGF1)在非小细胞肺癌组织中的表达,探讨其与肺癌临床病理学特征和生存时间的关系。方法:采用免疫组织化学和免疫印迹技术检测IGF1在29例肺鳞癌和22例肺腺癌(25例含癌旁肺组织)及12例良性肺病变组织中的表达。采用χ2检验检测其与临床病理学特征的关系,Log-rank检验IGF1表达与生存时间的关系,Cox模型作单因素和多因素预后分析。结果:IGF1在肺癌中的阳性表达率为51%(26/51),表达率和强度显著高于良性肺组织(P分别为0.0143和0.0039)。晚期肺癌(Ⅲ+Ⅳ)IGF1阳性表达率和强度显著高于早期肺癌(Ⅰ+Ⅱ)(P分别为0.0032和0.0094)。IGF1在伴有局部淋巴结转移肺癌组织中的阳性表达率显著高于无淋巴结转移肺癌组织中的表达(P=0.0074)。IGF1阳性表达患者的中位生存时间显著短于IGF1阴性者(12个月比35个月,P=0.0001),Cox模型分析表明,IGF1表达是非小细胞肺癌的独立预后因素。结论:本研究结果提示,IGF1过表达在非小细胞肺癌的发生和发展中可能起重要作用,检测IGF1表达有望成为判断非小细胞肺癌预后的参考指标之一。 | 廖永德 龙庆红 周晟 赵金平 黄畦 Doris MAYER | 2005 | 中国癌症杂志2005，15，4： | 6 |
| 10 | 保留十二指肠的胰头切除术治疗良性肿瘤、囊性肿瘤及神经内分泌瘤的系统分析显示文摘背景保留十二指肠的胰头切除术是替代胰十二指肠切除术治疗良性肿瘤、囊性肿瘤及神经内分泌瘤的可行之选。方法检索Pubmed、Embase及Cochrane数据库中保留十二指肠胰头切除术的研究结果。根据手术指征、围手术期并发症及微创应用等纳入1994年1月至2021年3月的38项队列研究共702例患者的临床资料。结果共702例患者分别因良性肿瘤、癌前病变、囊性肿瘤、胰腺神经内分泌肿瘤、十二指肠乳头周围腺瘤等行保留十二指肠的胰头切除术。702例患者中,214例(30.5%)行保留十二指肠的部分胰头切除术,488例(69.5%)行保留十二指肠的全胰头切除术,后者中微创手术占17.3%。两种术式的术后早期严重并发症发生率(术后B及C级胰瘘、胆瘘、腹腔出血及腹腔脓肿)均<10%,围手术期病死率分别为0和1.02%。经中位时间为(50.7±21.1)个月的随访,局部复发率为2.8%(15/404)。结论保留十二指肠的胰头切除术应作为胰头部分支胰管型导管内乳头状肿瘤、实性假乳头状肿瘤、黏液性囊腺瘤、>2 cm的有或无功能的良性内分泌肿瘤外科治疗的首选术式。 | Hans G.Beger Benjamin Mayer Yinmo Yang Bertram Poch | 2021 | 中华外科杂志2021，59，7： | 6 |
| 11 | Maintenance infliximab for Crohn’s disease: the ACCENT I randomised trial显示文摘 | Stephen B Hanauer Brian G Feagan Gary R Lichtenstein Lloyd F Mayer S Schreiber Jean Frederic Colombel Daniel Rachmilewitz Douglas C Wolf Allan Olson Weihang Bao Paul Rutgeerts | 2002 | The Lancet2002，，9317： | 6 |
| 12 | Buses retrofitting with diesel particle filters: Real-world fuel economy and roadworthiness test considerations显示文摘Retrofitting older vehicles with diesel particulate filter(DPF) is a cost-effective measure to quickly and efficiently reduce particulate matter emissions. This study experimentally analyzes real-world performance of buses retrofitted with CRT DPFs. 18 in-use Euro III technology urban and intercity buses were investigated for a period of 12 months. The influence of the DPF and of the vehicle natural aging on buses fuel economy are analyzed and discussed. While the effect of natural deterioration is about 1.2%–1.3%, DPF contribution to fuel economy penalty is found to be 0.6% to 1.8%, depending on the bus type. DPF filtration efficiency is analyzed throughout the study and found to be in average 96% in the size range of 23–560 nm. Four different load and non-load engine operating modes are investigated on their appropriateness for roadworthiness tests. High idle is found to be the most suitable regime for PN diagnostics considering particle number filtration efficiency. | Rafael Fleischman Ran Amiel Jan Czerwinski ANDreas Mayer Leonid Tartakovsky | 2018 | Journal of Environmental Sciences2018，30，5： | 6 |
| 13 | An App knock-in rat model for Alzheimer’s disease exhibiting Aβand tau pathologies,neuronal death and cognitive impairments显示文摘A major obstacle in Alzheimer’s disease(AD)research is the lack of predictive and translatable animal models that reflect disease progression and drug efficacy.Transgenic mice overexpressing amyloid precursor protein(App)gene manifest non-physiological and ectopic expression of APP and its fragments in the brain,which is not observed in AD patients.The App knock-in mice circumvented some of these problems,but they do not exhibit tau pathology and neuronal death.We have generated a rat model,with three familiar App mutations and humanized Aβsequence knocked into the rat App gene.Without altering the levels of full-length APP and other APP fragments,this model exhibits pathologies and disease progression resembling those in human patients:deposit of Aβplaques in relevant brain regions,microglia activation and gliosis,progressive synaptic degeneration and AD-relevant cognitive deficits.Interestingly,we have observed tau pathology,neuronal apoptosis and necroptosis and brain atrophy,phenotypes rarely seen in other APP models.This App knock-in rat model may serve as a useful tool for AD research,identifying new drug targets and biomarkers,and testing therapeutics. | Keliang Pang Richeng Jiang Wei Zhang Zhengyi Yang Lin-Lin Li Makoto Shimozawa Simone Tambaro Johanna Mayer Baogui Zhang Man Li Jiesi Wang Hang Liu Ailing Yang Xi Chen Jiazheng Liu Bengt Winblad Hua Han Tianzi Jiang Weiwen Wang Per Nilsson Wei Guo Bai Lu | 2022 | Cell Research2022，32，2： | 6 |
| 14 | Hypoxia in cancer: significance and impact on clinical outcome显示文摘 | Peter Vaupel Arnulf Mayer | 2007 | Cancer and Metastasis Reviews2007，，2： | 5 |
| 15 | 胰岛素样生长因子结合蛋白3在非小细胞肺癌中的表达研究显示文摘目的:检测胰岛素样生长因子结合蛋白3(IGFBP3)在非小细胞肺癌(NSCLC)组织中的表达,探讨其与肺癌临床病理学特征和生存时间的关系。方法:采用免疫组织化学和免疫印迹技术检测IGFBP3在34例肺鳞癌和25例肺腺癌(共21例含癌旁肺组织)及15例良性肺病变组织中的表达。结果:IGFBP3在良性肺组织中表达定位于细胞质;而在肺癌组织中表达定位于细胞质和细胞核(分别称为IGFBP3质表达和核表达),后二者阳性率为44%(26/59)和29%(17/59)。IGFBP3使表达在肺癌和良性肺组织间差异无统计学意义。在伴有局部淋巴结转移肺癌组织中IGFBP3核表达显著低于无淋巴结转移肺癌组织,P=0.0029;在低分化肺癌组织中IGFBP3核表达显著低于中或高分化肺癌,P=0.0292。IGFBP3质表达与胰岛素样生长因子1(IGF1)在肺癌组织中的表达显著相关,P=0.0007。IGFBP3质表达阳性者预后差,而IGFBP3核表达阳性者预后优于阴性表达者。结论:在NSCLC组织中,IGFBP3质表达可能与调节IGF作用有关,而核表达则可能与抑制肿瘤生长有关,IGFBP3质或核表达具有一定的预后意义。 | 廖永德 万燕青 周晟 赵金平 付向宁 Doris Mayer | 2006 | 中华肿瘤防治杂志2006，13，2： | 5 |
| 16 | Accuracy of training blood volume quantifi cation using a visual estimation tool显示文摘BACKGROUND:We investigated whether the use of a specially designed visual estimation tool may improve accuracy in quantifying blood volumes related to surface spreading.METHODS:A prospective,paired-control,single-blinded experimental study was performed at a medical university.Anesthesiologists and emergency medical personnel estimated various blood volumes on surfaces with varying absorptivity(carpet,towel,polyvinyl chloride,wooden fl ooring)in an experimental setting.We assessed the sensitivity of training blood volume quantifi cation using a self-designed visual estimation tool by comparing the accuracy of visual blood volume estimations before and after practical training with the tool.RESULTS:A total of 352 estimations by 44 participants were evaluated.Accurate estimations improved significantly from pre-training to post-training(P<0.05).The sensitivity of blood volume quantifi cation was 33.0%after training with the visual estimation tool.Estimations did not depend on age,profession,gender or years of the estimator’s professional experience.CONCLUSIONS:Training with a visual estimation tool by professional rescuers can improve the estimation accuracy of blood volumes spread on surfaces with varying absorptivity. | Janett Kreutziger Philip Puchner Stefan Schmid Wolfgang Mayer Harald Prossliner Wolfgang Lederer | 2021 | World Journal of Emergency Medicine2021，12，3： | 5 |
| 17 | 脂肪乳对内毒素诱导急性肺损伤小鼠的干预作用显示文摘目的比较以橄榄油为主的脂肪乳Clinoleic20%○R和豆油为主的脂肪乳Lipoven20%○R对脂多糖(LPS)诱导急性肺损伤(ALI)小鼠炎症反应的作用。方法雄性Balb/C小鼠按随机数字表法分为生理盐水(NaCl)、Clino和Lipo3组。用微量泵分别向3组小鼠泵入质量分数为0.9%的NaCl、20%Clinoleic和20%Lipoven,并在进行取血和肺泡灌洗前8h和24h向气管内喷洒LPS制备ALI模型。观察3组小鼠LPS诱导8h和24h时的存活率、肺组织湿/干重比、支气管肺泡灌洗液(BALF)中白细胞计数、肿瘤坏死因子-α(TNF-α)、巨噬细胞炎性蛋白-2(MIP-2)、肺组织髓过氧化物酶(MPO)活性及血清花生四烯酸(AA)、油酸、亚油酸含量。结果LPS诱导后可引起BALF中白细胞计数、TNF-α、MIP-2,肺组织MPO活性、W/D比例及血清AA水平显著升高。Lipoven显著降低ALI小鼠24h后的存活率(P均<0.01),而Clino组与NaCl组之间差异无显著性;肺组织MPO活性在24h后两个脂肪乳组明显高于NaCl组(P均<0.01),而两个脂肪乳之间差异无显著性。注射ALI8h后,Lipo组BALF中MIP-2和血清AA均较NaCl组和Clino组升高,24h后BALF中白细胞、TNF-α、AA水平也均显著高于NaCl组和Clino组(P均<0.01);而肺组织水肿程度和油酸、亚油酸含量在3组间比较差异均无显著性。结论Lipoven20%加重ALI小鼠的炎症反应,降低实验动物的存活率,可能与其增加AA产生有关;而Clinoleic20%对炎症反应的影响较轻。 | 毕铭华 王宝恩 Martina Schafer Konstantin Mayer 张淑文 李敏 王惠吉 | 2006 | 中国危重病急救医学2006，18，12： | 5 |
| 18 | Clear cell hepatocellular carcinoma: origin,metabolic traits and fate of glycogenotic clear and ground glass cells显示文摘Clear cell hepatocellular carcinoma(CCHCC)has hitherto been considered an uncommon, highly differentiated variant of hepatocellular carcinoma(HCC) with a relatively favorable prognosis. CCHCC is composed of mixtures of clear and/or acidophilic ground glass hepatocytes with excessive glycogen and/or fat and shares histology, clinical features and etiology with common HCCs. Studies in animal models of chemical, hormonal and viral hepatocarcinogenesis and observations in patients with chronic liver diseases prone to develop HCC have shown that the majority of HCCs are preceded by, or associated with, focal or diffuse excessive storage of glycogen(glycogenosis) which later may be replaced by fat(lipidosis/steatosis). In ground glass cells, the glycogenosis is accompanied by proliferation of the smooth endoplasmic reticulum, which is closely related to glycogen particles and frequently harbors the hepatitis B surface antigen(HBs Ag).From the findings in animal models a sequence of changes has been established, commencing with preneoplastic glycogenotic liver lesions, often containing ground glass cells, and progressing to glycogen-poor neoplasms via various intermediate stages, including glycogenotic/lipidotic clear cell foci, clear cell hepatocellular adenomas(CCHCA) rich in glycogen and/or fat, and CCHCC. A similar process seems to take place in humans, with clear cells frequently persisting in CCHCC and steatohepatitic HCC, which presumably represent intermediate stages in the development rather than particular variants of HCC. During the progression of the preneoplastic lesions,the clear and ground glass cells transform into cells characteristic of common HCC. The sequential cellular changes are associated with metabolic aberrations, which start with an activation of the insulin signaling cascade resulting in preneoplastic hepatic glycogenosis. The molecular and metabolic changes underlying the glycogenosis/lipidosis are apparently responsible for the dramatic metabolic shift from gluconeogenesis to the pentose phosphate pathway and Warburg-type glycolysis, which provide precursors and energy for an ever increasing cell proliferation during progression. | Peter Bannasch Silvia Ribback Qin Su Doris Mayer | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，6： | 4 |
| 19 | Identification of Early Nuclear Target Genes of Plastidial Redox Signals that Trigger the Long- Term Response of Arabidopsis to Light Quality Sh∽ts显示文摘自然照明条件是高度可变的并且因为他们的无柄的生活方式,植物在细胞、分子的水平被强迫到 acclimate 到他们。在轻紧张或质量的变化在减小 / 氧化(氧化还原作用) 导致变化为包括光合作用和新陈代谢的功能、结构的调整的补偿环境适应回答充当一个扳机的光合的电子链的状态。如此的回答在原子核和细胞器在植物基因表示包括控制氧化还原作用的变化。这里,我们在模型有机体 Arabidopsis thaliana 的原子核为早调整氧化还原作用的基因(尔格) 的鉴定描述策略显著地回答 30 或在在光合的电子运输链的一个减小信号的产生以后的 60min。由把野类型的植物的反应与环境适应异种 stn7 的作比较,我们能明确地识别尔格。结果为 mitochondrial 电子运输链, tetrapyrrole 生合成,糖类新陈代谢,和发信号的类脂化合物合成包括基因在不同原子基因组上揭示叶绿体氧化还原作用信号的重要影响。这些表示侧面与响应光合的电子 transportby 的减小观察的那些清楚地不同高轻的处理。因此,识别的尔格对在光合的电子运输的氧化还原作用不平衡唯一并且然后被使用分析潜在的氧化还原作用应答的 cis 元素, trans 因素,和 chromosomal 规章的热点。数据识别一个新奇氧化还原作用应答的元素并且在在 epigenetic 进程上指向氧化还原作用信号的崭新的影响的 transcriptional 和 chromosomal 层次显示广泛的氧化还原作用控制。 | Lars Dietzel Christine Glaeer Monique Liebers Stefan Hiekel Florence Courtois Olaf Czarneckit Hagen Schlicke Yan Zubo Thomas Borner Klaus Mayer Bernhard Grimm Thomas Pfannschmidt | 2015 | Molecular Plant2015，8，8： | 4 |
| 20 | Inflammatory Bowel Disease Is a Risk Factor for Recurrent Venous Thromboembolism显示文摘 | Gottfried Novacek Ansgar Weltermann Anna Sobala Herbert Tilg Wolfgang Petritsch Walter Reinisch Andreas Mayer Thomas Haas Arthur Kaser Thomas Feichtenschlager Harry Fuchssteiner Peter Knoflach Harald Vogelsang Wolfgang Miehsler Reingard Platzer Wolfgang T | 2010 | Gastroenterology2010，，3： | 4 |
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